IMP: Integrative Multi-species Prediction

Danio rerio

11 genes annotated in zebrafish

Multi-species View

negative regulation of cell fate specification

GO:0009996

Any process that restricts, stops or prevents a cell from adopting a specific cell fate.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cell fate specification"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of cell fate specification" (in gray)

Name	Description	Probability	Func Analog Organism
hmx4	H6 family homeobox 4	0.632
notch2	notch homolog 2	0.495
pcdh8	protocadherin 8	0.494
bmp2b	bone morphogenetic protein 2b	0.493
dkk1b	dickkopf 1b	0.442
hoxa11a	homeo box A11a	0.437
mespa	mesoderm posterior a	0.370	Mouse
chd	chordin	0.285
otx1a	orthodenticle homolog 1a	0.169
bmp4	bone morphogenetic protein 4	0.161
foxa3	forkhead box A3	0.154
neo1	neogenin 1	0.153
msxc	muscle segment homeobox C	0.153
pea3	ETS-domain transcription factor pea3	0.114
foxi1	forkhead box I1	0.112
sfrp1a	secreted frizzled-related protein 1a	0.108
twist3	twist3	0.105
gbx2	gastrulation brain homeo box 2	0.102
notch3	notch homolog 3	0.095
pnx	posterior neuron-specific homeobox	0.088
foxd5	forkhead box D5	0.088
six4b	sine oculis homeobox homolog 4b	0.086
col14a1	collagen, type XIV, alpha 1	0.085
hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.082
nkx2.5	NK2 transcription factor related 5	0.080
gli1	GLI-Kruppel family member 1	0.078
sptb	spectrin, beta, erythrocytic	0.077
tbx16	T-box gene 16	0.077
her5	hairy-related 5	0.072
tbx18	T-box 18	0.070
fgf3	fibroblast growth factor 3	0.069
stm	starmaker	0.068
tll1	tolloid-like 1	0.068
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.063
frem3	Fras1 related extracellular matrix 3	0.063
wnt4a	wingless-type MMTV integration site family, member 4a	0.061
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.060
tbx6	T-box gene 6	0.054
nrg2a	neuregulin 2a	0.053
mespb	mesoderm posterior b	0.053	Mouse
wnt5b	wingless-type MMTV integration site family, member 5b	0.052
dusp6	dual specificity phosphatase 6	0.050
msxb	muscle segment homeobox B	0.048
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.047
boc	brother of CDO	0.047
fgfr4	fibroblast growth factor receptor 4	0.046	Zebrafish
fgf8b	fibroblast growth factor 8 b	0.046	Zebrafish
flh	floating head	0.046
notch1b	notch homolog 1b	0.046
vsx2	visual system homeobox 2	0.043	Zebrafish
egr2b	early growth response 2b	0.042
dspa	desmoplakin a	0.042
ef1	ETS-related factor1	0.042
fzd7a	frizzled homolog 7a	0.042
hoxd13a	homeo box D13a	0.042
waca	WW domain containing adaptor with coiled-coil a	0.041
jag1b	jagged 1b	0.041
lhx1b	LIM homeobox 1b	0.041
igf3	insulin-like growth factor 3	0.040
ntn1b	netrin 1b	0.040
gata4	GATA-binding protein 4	0.039
wnt11r	wingless-type MMTV integration site family, member 11, related	0.039
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.039
hmx2	H6 family homeobox 2	0.038
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.038
pitx3	paired-like homeodomain transcription factor 3	0.038
snai1b	snail homolog 1b (Drosophila)	0.037
fgfr2	fibroblast growth factor receptor 2	0.036	Zebrafish
uts2a	urotensin 2, alpha	0.036
plagl2	pleiomorphic adenoma gene-like 2	0.036
atoh1a	atonal homolog 1a	0.036
tbx20	T-box 20	0.036
lft1	lefty1	0.036
col5a2l	collagen, type V, alpha 2-like	0.035
hoxd11a	homeo box D11a	0.035
pcdh18a	protocadherin 18a	0.033
etv5b	ets variant 5b	0.032
zfand5a	zinc finger, AN1-type domain 5a	0.032
sox17	SRY-box containing gene 17	0.032	Mouse
wnt8b	wingless-type MMTV integration site family, member 8b	0.031
lama5	laminin, alpha 5	0.029
tp63	tumor protein p63	0.029
nkd1	naked cuticle homolog 1 (Drosophila)	0.029
met	met proto-oncogene (hepatocyte growth factor receptor)	0.029
vent	ventral expressed homeobox	0.029
ptch1	patched 1	0.028
ext1a	exostoses (multiple) 1a	0.028
rasl11b	RAS-like, family 11, member B	0.028
hoxb5a	homeo box B5a	0.027
jag1a	jagged 1a	0.027
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.027
zgc:193933	zgc:193933	0.027
slc8a4b	solute carrier family 8 (sodium/calcium exchanger), member 4b	0.027
sox32	SRY-box containing gene 32	0.026	Mouse
twist1b	twist1b	0.026
smad1	MAD homolog 1 (Drosophila)	0.026
ndr2	nodal-related 2	0.026
wif1	wnt inhibitory factor 1	0.024
pcdh10b	protocadherin 10b	0.024
bmp7a	bone morphogenetic protein 7a	0.024
brd2a	bromodomain-containing 2a	0.024
sall4	sal-like 4 (Drosophila)	0.024
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.024
tgfbr2	transforming growth factor, beta receptor II	0.024
gdnf	glial cell derived neurotrophic factor	0.023
or115-10	odorant receptor, family F, subfamily 115, member 10	0.023
actc1b	actin, alpha, cardiac muscle 1b	0.023
traf4a	tnf receptor-associated factor 4a	0.023
klf4a	Kruppel-like transcription factor 4a	0.023
mxtx2	mix-type homeobox gene 2	0.023
dmrt3a	doublesex and mab-3 related transcription factor 3a	0.023
eve1	even-skipped-like1	0.022
srf	serum response factor	0.022
bmper	BMP binding endothelial regulator	0.022
gfra1b	gdnf family receptor alpha 1b	0.022
perp	PERP, TP53 apoptosis effector	0.022
hmx3	homeo box (H6 family) 3	0.021
six4a	sine oculis homeobox homolog 4a	0.021
epb41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.021
oprk1	opioid receptor, kappa 1	0.021
chrna2a	cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)	0.021
hoxa13b	homeo box A13b	0.020
spon2a	spondin 2a, extracellular matrix protein	0.020
fgfr1a	fibroblast growth factor receptor 1a	0.020
her7	hairy and enhancer of split related-7	0.020
evx2	even-skipped homeobox 2	0.020
atoh1b	atonal homolog 1b	0.020
krt4	keratin 4	0.019
rxraa	retinoid X receptor, alpha a	0.019
mesp2	mesoderm posterior 2 homolog (mouse)	0.019
neurog3	neurogenin 3	0.019
ephb3a	eph receptor B3a	0.019
fgf10a	fibroblast growth factor 10a	0.019
tfeb	transcription factor EB	0.019
irx1a	iroquois homeobox protein 1, a	0.019
vasp	vasodilator-stimulated phosphoprotein	0.019
pou2f1a	POU class 2 homeobox 1a	0.018
og9x	OG9 homeobox gene	0.018
sparc	secreted acidic cysteine rich glycoprotein	0.018
rbp1b	retinol binding protein 1b, cellular	0.018
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.018
wnt10a	wingless-type MMTV integration site family, member 10a	0.018
ripply1	ripply1	0.017
chd7	chromodomain helicase DNA binding protein 7	0.017
mchr1a	melanin-concentrating hormone receptor 1a	0.017
raraa	retinoic acid receptor, alpha a	0.017
ppm1d	protein phosphatase 1D magnesium-dependent, delta isoform	0.017
ros1	v-ros UR2 sarcoma virus oncogene homolog 1 (avian)	0.017
jag2	jagged 2	0.017
vax2	ventral anterior homeobox 2	0.016
gsdf	gonadal somatic cell derived factor	0.016
and1	actinodin1	0.016
hhip	hedgehog interacting protein	0.016
col7a1l	collagen type VII alpha 1-like	0.016
her6	hairy-related 6	0.016
gpr126	G protein-coupled receptor 126	0.016
her3	hairy-related 3	0.016
fam76b	family with sequence similarity 76, member B	0.015
spry4	sprouty (Drosophila) homolog 4	0.015
pdpk1a	3-phosphoinositide dependent protein kinase-1a	0.015
tbpl2	TATA box binding protein like 2	0.015
tgfb2	transforming growth factor, beta 2	0.015
rarab	retinoic acid receptor, alpha b	0.015
otx5	orthodenticle homolog 5	0.015
epha7	eph receptor A7	0.015
plod1a	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a	0.015
wnt2ba	wingless-type MMTV integration site family, member 2Ba	0.015
tjp1	tight junction protein 1 (zona occludens 1)	0.015
fgf8a	fibroblast growth factor 8 a	0.014
cd9b	CD9 antigen, b	0.014
fstl1b	follistatin-like 1b	0.014
sim1a	single-minded homolog 1a (Drosophila)	0.014
ripk4	receptor-interacting serine-threonine kinase 4	0.014
gata2a	GATA-binding protein 2a	0.014
dlx4b	distal-less homeobox gene 4b	0.014
alas2	aminolevulinate, delta-, synthetase 2	0.014
nog1	noggin 1	0.014
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.014
scinla	scinderin like a	0.014
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.014
irf6	interferon regulatory factor 6	0.014
epha4b	eph receptor A4b	0.014
axin2	axin 2 (conductin, axil)	0.014
opn1mw4	opsin 1 (cone pigments), medium-wave-sensitive, 4	0.013
mmp2	matrix metalloproteinase 2	0.013
tnfsf10l3	tumor necrosis factor (ligand) superfamily, member 10 like 3	0.013
junbl	jun B proto-oncogene, like	0.013
alcamb	activated leukocyte cell adhesion molecule b	0.013
kif7	kinesin family member 7	0.013
btg2	B-cell translocation gene 2	0.013
evx1	even-skipped homeobox 1	0.013
gdf6a	growth differentiation factor 6a	0.013	Zebrafish
ryk	receptor-like tyrosine kinase	0.013
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.013
nt5c2l1	5'-nucleotidase, cytosolic II, like 1	0.013
hdr	hematopoietic death receptor	0.013
mapk3	mitogen-activated protein kinase 3	0.013
emx3	empty spiracles homeobox 3	0.013
hoxa2b	homeo box A2b	0.013
col5a1	procollagen, type V, alpha 1	0.013
cdh1	cadherin 1, epithelial	0.012
tfe3b	transcription factor binding to IGHM enhancer 3b	0.012
prickle1a	prickle-like 1 (Drosophila) a	0.012
mc5rb	melanocortin 5b receptor	0.012
LOC100000500	sclerostin-like	0.012
runx3	runt-related transcription factor 3	0.012
foxb1.2	forkhead box B1.2	0.012
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.012
sox11b	SRY-box containing gene 11b	0.012
foxg1a	forkhead box G1a	0.012
sb:cb81	sb:cb81	0.012
acvr2b	activin receptor IIb	0.012
gsnb	gelsolin b	0.012
kal1b	Kallmann syndrome 1b sequence	0.012
elk4	ELK4, ETS-domain protein	0.012
zgc:66100	zgc:66100	0.012
ccnt2b	cyclin T2b	0.012
hoxa10b	homeo box A10b	0.012
nlgn1	neuroligin 1	0.012
mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.011
dsc2l	desmocollin 2 like	0.011
notum3	notum 3	0.011
ednra	endothelin receptor type A	0.011
fzd5	frizzled homolog 5	0.011
oep	one-eyed pinhead	0.011
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.011
ptgs1	prostaglandin-endoperoxide synthase 1	0.011
oclna	occludin a	0.011
bmp3	bone morphogenetic protein 3	0.011	Zebrafish
tbx1	T-box 1	0.011
si:ch211-173o4.2	si:ch211-173o4.2	0.011
runx2b	runt-related transcription factor 2b	0.011
gata3	GATA-binding protein 3	0.011
tmprss4b	transmembrane protease, serine 4b	0.011
irx4b	iroquois homeobox protein 4b	0.011
alpi	alkaline phosphatase, intestinal	0.011
odz4	odd Oz/ten-m homolog 4	0.011
acvr1b	activin A receptor, type IB	0.011
fras1	Fraser syndrome 1	0.011
her1	hairy-related 1	0.011
bambib	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b	0.010
wu:fb36d12	wu:fb36d12	0.010
axin1	axin 1	0.010
krt8	keratin 8	0.010
rx2	retinal homeobox gene 2	0.010
hapln3	hyaluronan and proteoglycan link protein 3	0.010
efnb3b	ephrin B3b	0.010
il17rd	interleukin 17 receptor D	0.010
eng2b	engrailed 2b	0.010
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.010
ihhb	Indian hedgehog homolog b	0.010
fbln1	fibulin 1	0.010