IMP: Integrative Multi-species Prediction

Danio rerio

10 genes annotated in zebrafish

Multi-species View

negative regulation of hydrolase activity

GO:0051346

Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of hydrolase activity"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of hydrolase activity" (in gray)

Name	Description	Probability	Func Analog Organism
shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	0.319
bhmt	betaine-homocysteine methyltransferase	0.252
sepp1b	selenoprotein P, plasma, 1b	0.242
adipor2	adiponectin receptor 2	0.176
adipoql	adiponectin, C1Q and collagen domain containing, like	0.136	Zebrafish
furina	furin (paired basic amino acid cleaving enzyme) a	0.109	Human
mcl1b	myeloid cell leukemia sequence 1b	0.092
prdx5	peroxiredoxin 5	0.079	Human
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.070
mcl1a	myeloid cell leukemia sequence 1a	0.067
rnasel1	ribonuclease like 1	0.056
s1pr3	sphingosine-1-phosphate receptor 3	0.055
ihha	Indian hedgehog homolog a	0.047
foxe3	forkhead box E3	0.042
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.041
adipoql2	adiponectin, C1Q and collagen domain containing, like 2	0.036	Zebrafish
mpp6b	membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)	0.036
pcsk7	proprotein convertase subtilisin/kexin type 7	0.034
atp5g	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)	0.032
ccng1	cyclin G1	0.032
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.031
dip2c	DIP2 disco-interacting protein 2 homolog C (Drosophila)	0.030
cdh4	cadherin 4, retinal	0.029
ces2	carboxylesterase 2 (intestine, liver)	0.026
fcho2	FCH domain only 2	0.026
adipor1b	adiponectin receptor 1b	0.026
uqcrb	ubiquinol-cytochrome c reductase binding protein	0.025
fgf20a	fibroblast growth factor 20a	0.025
mbnl1	muscleblind-like (Drosophila)	0.024
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.024
oc90	otoconin 90	0.023
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.023
rbm17	RNA binding motif protein 17	0.023
nadl1.1	neural adhesion molecule L1.1	0.022
insrb	insulin receptor b	0.021	Zebrafish
zgc:161979	zgc:161979	0.021
c6orf115	c6orf115 homolog (H. sapiens)	0.021
chac1	ChaC, cation transport regulator-like 1	0.021
xylt1	xylosyltransferase 1	0.020
mga	MAX gene associated	0.020
nf1a	neurofibromin 1a	0.020
per2	period homolog 2 (Drosophila)	0.019
agtr2	angiotensin II receptor, type 2	0.019
LOC564872	monocarboxylate transporter 7-like	0.019
hhip	hedgehog interacting protein	0.019
pcsk1	proprotein convertase subtilisin/kexin type 1	0.018
nphs1l	nephrosis 1, congenital, Finnish type (nephrin)-like	0.017
ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.017	Rat
pou3f2	POU class 3 homeobox 2	0.017
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.017
ripk2	receptor-interacting serine-threonine kinase 2	0.017
zgc:56530	zgc:56530	0.016	Human
pcsk2	proprotein convertase subtilisin/kexin type 2	0.016
copeb	core promoter element binding protein	0.016
bmp1a	bone morphogenetic protein 1a	0.016
ppp3ca	protein phosphatase 3, catalytic subunit, alpha isozyme	0.016
myh11a	myosin, heavy polypeptide 11, smooth muscle a	0.016
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.016
ptprsa	protein tyrosine phosphatase, receptor type, s, a	0.015
henmt1	HEN1 methyltransferase homolog 1 (Arabidopsis)	0.015
ncoa2	nuclear receptor coactivator 2	0.015
rrp15	ribosomal RNA processing 15 homolog (S. cerevisiae)	0.015
wu:fj39b01	wu:fj39b01	0.015
vps39	vacuolar protein sorting 39 homolog (S. cerevisiae)	0.015
cntfr	ciliary neurotrophic factor receptor	0.014
itgb1b	integrin, beta 1b	0.014
ppp4cb	protein phosphatase 4 (formerly X), catalytic subunit b	0.014
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.014
ednra	endothelin receptor type A	0.014
vwf	von Willebrand factor	0.014
ndufa9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9	0.014
nrg1	neuregulin 1	0.014
ldb1a	LIM-domain binding factor 1a	0.013
pcsk9	proprotein convertase subtilisin/kexin type 9	0.013
igfbp1b	insulin-like growth factor binding protein 1b	0.013
bbc3	BCL2 binding component 3	0.013
mtmr8	myotubularin related protein 8	0.013
LOC100007758	novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3)	0.012
fgb	fibrinogen, B beta polypeptide	0.012
zgc:158375	zgc:158375	0.012
ptger4b	prostaglandin E receptor 4 (subtype EP4) b	0.012
idh3b	isocitrate dehydrogenase 3 (NAD+) beta	0.012
atp5d	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit	0.012
zgc:92851	zgc:92851	0.012
tspan7b	tetraspanin 7b	0.012
brp44	brain protein 44	0.012
ctsba	cathepsin B, a	0.012
bmp15	bone morphogenetic protein 15	0.011
sod2	superoxide dismutase 2, mitochondrial	0.011
fkbp5	FK506 binding protein 5	0.011
plg	plasminogen	0.011
sec23ip	SEC23 interacting protein	0.011
rhag	Rhesus blood group-associated glycoprotein	0.011
wnt8a	wingless-type MMTV integration site family, member 8a	0.011
appa	amyloid beta (A4) precursor protein a	0.011	Human
numbl	numb homolog (Drosophila)-like	0.011
hbbe1.1	hemoglobin beta embryonic-1.1	0.011
zgc:112350	zgc:112350	0.011
cp	ceruloplasmin	0.011
usp5	ubiquitin specific protease 5	0.011
fgg	fibrinogen, gamma polypeptide	0.011
proc	protein C (inactivator of coagulation factors Va and VIIIa)	0.011
cryaba	crystallin, alpha B, a	0.011
zgc:55741	zgc:55741	0.011
polr1b	polymerase (RNA) I polypeptide B	0.011
slc2a1b	solute carrier family 2 (facilitated glucose transporter), member 1b	0.011
sardh	sarcosine dehydrogenase	0.011
sepw1	selenoprotein W, 1	0.010
wu:fc31g04	wu:fc31g04	0.010
trim13	tripartite motif-containing 13	0.010
adora2b	adenosine A2b receptor	0.010
suclg1	succinate-CoA ligase, GDP-forming, alpha subunit	0.010
cyp19a1a	cytochrome P450, family 19, subfamily A, polypeptide 1a	0.010
nup50	nucleoporin 50	0.010
alpi	alkaline phosphatase, intestinal	0.010
slmo2	slowmo homolog 2 (Drosophila)	0.010
eno3	enolase 3, (beta, muscle)	0.010