IMP: Integrative Multi-species Prediction

Danio rerio

13 genes annotated in zebrafish

positive regulation of hydrolase activity

Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of hydrolase activity"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of hydrolase activity" (in gray)

Name	Description	Probability	Func Analog Organism
sulf1	sulfatase 1	0.212
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.210
bida	BH3 interacting domain death agonist	0.143
bmp7a	bone morphogenetic protein 7a	0.141
wt1b	wilms tumor 1b	0.119
desma	desmin a	0.090
baxa	bcl2-associated X protein, a	0.082
flot2a	flotillin 2a	0.081
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.081
adrb2a	adrenergic receptor, beta 2a	0.079
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.079
ahnak	AHNAK nucleoprotein	0.079
tpm4	tropomyosin 4	0.078
sparc	secreted acidic cysteine rich glycoprotein	0.077
tfe3b	transcription factor binding to IGHM enhancer 3b	0.076
cx43	connexin 43	0.068
mcl1b	myeloid cell leukemia sequence 1b	0.061	Zebrafish Worm
ccna2	cyclin A2	0.061
dzip1	DAZ interacting protein 1	0.060
hells	helicase, lymphoid-specific	0.058
scinlb	scinderin like b	0.057
nf1a	neurofibromin 1a	0.056	Mouse Fly
rtcd1	RNA terminal phosphate cyclase domain 1	0.054
si:ch211-212m21.5	si:ch211-212m21.5	0.052
hmgb2b	high-mobility group box 2b	0.050	Human
mcm6	MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae)	0.050
dlx5a	distal-less homeobox gene 5a	0.050
podxl	podocalyxin-like	0.049
gata5	GATA-binding protein 5	0.046
fgfr3	fibroblast growth factor receptor 3	0.044	Human
egr2b	early growth response 2b	0.041
postn	periostin, osteoblast specific factor	0.039
olfml3b	olfactomedin-like 3b	0.039
ssrp1a	structure specific recognition protein 1a	0.039
wif1	wnt inhibitory factor 1	0.038
sox7	SRY-box containing gene 7	0.038	Human
unc5b	unc-5 homolog B (C. elegans)	0.037
s100a10b	S100 calcium binding protein A10b	0.036	Human
kdr	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.036
plxnb2a	plexin b2a	0.036
cnn2	calponin 2	0.036
bcl2	B-cell leukemia/lymphoma 2	0.036	Zebrafish Worm
mcl1a	myeloid cell leukemia sequence 1a	0.036	Zebrafish Worm
zgc:92867	zgc:92867	0.035
elmo1	engulfment and cell motility 1 (ced-12 homolog, C. elegans)	0.034	Fly
hmgb3a	high-mobility group box 3a	0.034
il8	interleukin 8	0.034
spry2	sprouty homolog 2	0.033
ptrfb	polymerase I and transcript release factor b	0.033
mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.033
evx1	even-skipped homeobox 1	0.033
ephb4b	eph receptor B4b	0.032
appb	amyloid beta (A4) precursor protein b	0.032
pitrm1	pitrilysin metalloproteinase 1	0.031
hmgb2a	high-mobility group box 2a	0.031	Human
msna	moesin a	0.031
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.031
s100v2	S100 calcium binding protein V2	0.030
wls	wntless homolog (Drosophila)	0.030
pole2	polymerase (DNA directed), epsilon 2	0.030
msh6	mutS homolog 6 (E. coli)	0.029	Human
pdlim1	PDZ and LIM domain 1 (elfin)	0.029
bcl2l1	bcl2-like 1	0.029	Zebrafish Worm
vegfaa	vascular endothelial growth factor Aa	0.028
nf1b	neurofibromin 1b	0.028	Mouse Fly
adipoql	adiponectin, C1Q and collagen domain containing, like	0.028
hspb1	heat shock protein, alpha-crystallin-related, 1	0.027
gsna	gelsolin a	0.027
fes	feline sarcoma oncogene	0.027
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.027
notch1a	notch homolog 1a	0.027
mycbp2	MYC binding protein 2	0.026
vtg1	vitellogenin 1	0.026
mmp2	matrix metalloproteinase 2	0.026
psme2	proteasome activator subunit 2	0.026
yrk	Yes-related kinase	0.026
flt1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.026	Human
ncapg2	non-SMC condensin II complex, subunit G2	0.026
perp	PERP, TP53 apoptosis effector	0.026	Human
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.025
hsp90a.2	heat shock protein 90-alpha 2	0.025
caspa	caspase a	0.025
gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.024	Human
dnmt5	DNA (cytosine-5-)-methyltransferase 5	0.024
pcna	proliferating cell nuclear antigen	0.023	Human
loxl2b	lysyl oxidase-like 2b	0.023
cep70	centrosomal protein 70	0.023
foxn4	forkhead box N4	0.023
rhoab	ras homolog gene family, member Ab	0.023
ihha	Indian hedgehog homolog a	0.023
plxnd1	plexin D1	0.023
LOC567131	calcitonin gene-related peptide type 1 receptor-like	0.022
wnt11r	wingless-type MMTV integration site family, member 11, related	0.022
icn	ictacalcin	0.022
dnmt4	DNA (cytosine-5-)-methyltransferase 4	0.022
disp1	dispatched homolog 1 (Drosophila)	0.021
msh2	mutS homolog 2 (E. coli)	0.021	Human
kdrl	kinase insert domain receptor like	0.021
whsc1	Wolf-Hirschhorn syndrome candidate 1	0.021
myca	myelocytomatosis oncogene a	0.021
bmp4	bone morphogenetic protein 4	0.020
pycard	PYD and CARD domain containing	0.020
ahr2	aryl hydrocarbon receptor 2	0.020
sec23a	Sec23 homolog A (S. cerevisiae)	0.020
stab2	stabilin 2	0.020
fibin	fin bud initiation factor	0.019
hif1an	hypoxia-inducible factor 1, alpha subunit inhibitor	0.019
bmper	BMP binding endothelial regulator	0.019
yap1	Yes-associated protein 1	0.019
col5a2l	collagen, type V, alpha 2-like	0.019
spry4	sprouty (Drosophila) homolog 4	0.019
tpm3	tropomyosin 3	0.019
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.019
dnmt7	DNA (cytosine-5-)-methyltransferase 7	0.019
wu:fv91b12	wu:fv91b12	0.019
suv39h1b	suppressor of variegation 3-9 homolog 1b	0.019
rdh10b	retinol dehydrogenase 10b	0.018
rpsa	ribosomal protein SA	0.018
ins	preproinsulin	0.018
mib	mind bomb	0.018
runx3	runt-related transcription factor 3	0.018
tgfb3	transforming growth factor, beta 3	0.018
tnfrsfa	tumor necrosis factor receptor superfamily, member a	0.018	Zebrafish
sip1	survival of motor neuron protein interacting protein 1	0.018
apoeb	apolipoprotein Eb	0.017
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.017
etv2	ets variant gene 2	0.017
mobkl2a	MOB1, Mps One Binder kinase activator-like 2A (yeast)	0.017
fgf24	fibroblast growth factor 24	0.017
sox11a	SRY-box containing gene 11a	0.017
zgc:92360	zgc:92360	0.017
hsp47	heat shock protein 47	0.017
hmgb1b	high-mobility group box 1b	0.017	Human
eif3s2	eukaryotic translation initiation factor 3, subunit 2 beta	0.017
gclc	glutamate-cysteine ligase, catalytic subunit	0.016
ptbp1b	polypyrimidine tract binding protein 1b	0.016
tomm34	translocase of outer mitochondrial membrane 34	0.016
mef2a	myocyte enhancer factor 2a	0.016
phlda2	pleckstrin homology-like domain, family A, member 2	0.016
nap1l1	nucleosome assembly protein 1, like 1	0.016
cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.016
atp6v1al	ATPase, H+ transporting, lysosomal V1 subunit A, like	0.016
fech	ferrochelatase	0.016
hspb12	heat shock protein, alpha-crystallin-related, b12	0.016
prox1	prospero-related homeobox gene 1	0.016
rnasel1	ribonuclease like 1	0.016
casp8	caspase 8, apoptosis-related cysteine peptidase	0.015
gna12	guanine nucleotide binding protein (G protein) alpha 12	0.015
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.015
pccb	propionyl Coenzyme A carboxylase, beta polypeptide	0.015
actc1a	actin, alpha, cardiac muscle 1a	0.015
id1	inhibitor of DNA binding 1	0.015
cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.015
immt	inner membrane protein, mitochondrial (mitofilin)	0.015
napa	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.015
aldh7a1	aldehyde dehydrogenase 7 family, member A1	0.015
foxn1	forkhead box N1	0.015
tagln2	transgelin 2	0.015
cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.014
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.014
hif1ab	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b	0.014
bmp7b	bone morphogenetic protein 7b	0.014
clpp	ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)	0.014
prkcea	protein kinase C, epsilon a	0.014
ptpn9a	protein tyrosine phosphatase, non-receptor type 9, a	0.014
zfpm2b	zinc finger protein, multitype 2b	0.014
mapre1l	microtubule-associated protein, RP/EB family, member 1, like	0.014
cxadr	coxsackie virus and adenovirus receptor	0.014
krt8	keratin 8	0.014
smyd1b	SET and MYND domain containing 1b	0.013
rorca	RAR-related orphan receptor C a	0.013
s1pr2	sphingosine-1-phosphate receptor 2	0.013
gna14	guanine nucleotide binding protein (G protein), alpha 14	0.013
adipor2	adiponectin receptor 2	0.013
fgf19	fibroblast growth factor 19	0.013
sh3gl1b	SH3-domain GRB2-like 1b	0.013
traf4a	tnf receptor-associated factor 4a	0.013
capns1b	calpain, small subunit 1 b	0.013
hprt1	hypoxanthine phosphoribosyltransferase 1	0.013
zgc:110540	zgc:110540	0.013
inhbb	inhibin, beta B	0.013
zfp36l1a	zinc finger protein 36, C3H type-like 1a	0.013
entpd4	ectonucleoside triphosphate diphosphohydrolase 4	0.013
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.013
bmp2a	bone morphogenetic protein 2a	0.013	Human
ncor1	nuclear receptor co-repressor 1	0.013
chrm2a	cholinergic receptor, muscarinic 2a	0.013
zgc:101080	zgc:101080	0.013
pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.013
nfe2l3	nuclear factor (erythroid-derived 2)-like 3	0.013
jup	junction plakoglobin	0.013
cfdl	complement factor D (adipsin) like	0.013
alcamb	activated leukocyte cell adhesion molecule b	0.013
ism1	isthmin 1	0.013
ighz2	immunoglobulin heavy constant zeta2	0.012
fgf4	fibroblast growth factor 4	0.012
ppme1	protein phosphatase methylesterase 1	0.012
zgc:101724	zgc:101724	0.012
dnaja1l	DnaJ (Hsp40) homolog, subfamily A, member 1, like	0.012	Yeast
optc	opticin	0.012
zgc:55259	zgc:55259	0.012
caspb	caspase b and caspase b-like	0.012	Rat Fly
sgpl1	sphingosine-1-phosphate lyase 1	0.012
rpa3	replication protein A3	0.012
capzb	capping protein (actin filament) muscle Z-line, beta	0.012
mef2cb	myocyte enhancer factor 2cb	0.012	Mouse
neo1	neogenin 1	0.012
elk4	ELK4, ETS-domain protein	0.012
ogg1	8-oxoguanine DNA glycosylase	0.012
igf1	insulin-like growth factor 1	0.012
ldb1a	LIM-domain binding factor 1a	0.012
zgc:56409	zgc:56409	0.012
iqgap1	IQ motif containing GTPase activating protein 1	0.012
dlst	dihydrolipoamide S-succinyltransferase	0.012
krt5	keratin 5	0.012
epas1b	endothelial PAS domain protein 1b	0.011
zgc:55418	zgc:55418	0.011
cmyb	transcription factor cmyb	0.011
loxl3b	lysyl oxidase-like 3b	0.011
col1a1a	collagen, type I, alpha 1a	0.011
zgc:101071	zgc:101071	0.011
ahctf1	AT hook containing transcription factor 1	0.011
cd63	Cd63 antigen	0.011
si:dkey-97i18.2	si:dkey-97i18.2	0.011
mylz2	myosin, light polypeptide 2, skeletal muscle	0.011
rplp0	ribosomal protein, large, P0	0.011
ckap5	cytoskeleton associated protein 5	0.011
tmem2	transmembrane protein 2	0.011
dnajb6b	DnaJ (Hsp40) homolog, subfamily B, member 6b	0.011	Human
wu:fb39a06	wu:fb39a06	0.011
il1b	interleukin 1, beta and interleukin 1, beta	0.011
ahcy	S-adenosylhomocysteine hydrolase	0.011
krml2.2	Kreisler (mouse) maf-related leucine zipper homolog 2.2	0.011
hmgb3b	high-mobility group box 3b	0.011
cfl2l	cofilin 2, like	0.011
zgc:92242	zgc:92242	0.011
gnaia	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	0.011
acsl4a	acyl-CoA synthetase long-chain family member 4a	0.011
hsp70l	heat shock cognate 70-kd protein, like	0.011
ube2d1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.011
hmgb1a	high-mobility group box 1a	0.010
zgc:101661	zgc:101661	0.010
rrbp1	ribosome binding protein 1 homolog (dog)	0.010
junb	jun B proto-oncogene	0.010
nt5e	5'-nucleotidase, ecto (CD73)	0.010
gna13b	guanine nucleotide binding protein (G protein), alpha 13b	0.010
rcn1	reticulocalbin 1, EF-hand calcium binding domain	0.010