IMP: Integrative Multi-species Prediction

Danio rerio

18 genes annotated in zebrafish

cyclic purine nucleotide metabolic process

The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cyclic purine nucleotide metabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cyclic purine nucleotide metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
uts1	urotensin 1	0.947
avpl	arginine vasopressin-like	0.944	Mouse
mc4r	melanocortin 4 receptor	0.870
adra2b	adrenergic, alpha-2B-, receptor	0.816
mc2r	melanocortin 2 receptor	0.810
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.772
drd3	dopamine receptor D3	0.707	Human Rat
drd2b	dopamine receptor D2b	0.551	Human Rat
adrb2a	adrenergic receptor, beta 2a	0.506
ucn3l	urocortin 3, like	0.476
vipr2	vasoactive intestinal peptide receptor 2	0.461	Zebrafish
sst3	somatostatin 3	0.450
adra2db	adrenergic, alpha-2D-, receptor b	0.403
drd2a	dopamine receptor D2a	0.347	Human Rat
oprd1a	opioid receptor, delta 1a	0.301
rtn1a	reticulon 1a	0.298
mc1r	melanocortin 1 receptor	0.267	Zebrafish
mc3r	melanocortin 3 receptor	0.266	Human Zebrafish
adrb1	adrenergic receptor, beta 1	0.240	Human Zebrafish Rat
cyp11b2	cytochrome P450, family 11, subfamily B, polypeptide 2	0.223
rhag	Rhesus blood group-associated glycoprotein	0.212
oxtl	oxytocin-like	0.209	Mouse
uts2b	urotensin 2, beta	0.209
opn1lw1	opsin 1 (cone pigments), long-wave-sensitive, 1	0.204
mchr1a	melanin-concentrating hormone receptor 1a	0.192
inhbab	inhibin, beta Ab	0.155
dbh	dopamine beta hydroxylase	0.153
hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.148
cx55.5	connexin 55.5	0.144
ros1	v-ros UR2 sarcoma virus oncogene homolog 1 (avian)	0.137
chrnb3b	cholinergic receptor, nicotinic, beta polypeptide 3b	0.132
crygs2	crystallin, gamma S2	0.131
adra2c	adrenergic, alpha-2C-, receptor	0.130
opn4l	opsin 4, like	0.129
pdca	phosducin a	0.112
paqr8	progestin and adipoQ receptor family member VIII	0.110
atp1b2a	ATPase, Na+/K+ transporting, beta 2a polypeptide	0.109
cldn2	claudin 2	0.105
bmp8a	bone morphogenetic protein 8a	0.098
npy4r	neuropeptide Y receptor Y4	0.097
ptpra	protein tyrosine phosphatase, receptor type, A	0.097
mpp5b	membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b)	0.094
mc5rb	melanocortin 5b receptor	0.094	Human
mchr1b	melanin-concentrating hormone receptor 1b	0.093
LOC569642	hypothetical protein LOC569642	0.092
drd2l	dopamine receptor D2 like	0.092
adcyap1r1a	adenylate cyclase activating polypeptide 1 receptor 1a	0.092
adra2da	adrenergic, alpha-2D-, receptor a	0.089
alx4a	aristaless-like homeobox 4a	0.088
chrm2a	cholinergic receptor, muscarinic 2a	0.088
gucy2f	guanylate cyclase 2F, retinal	0.087
fgfrl1b	fibroblast growth factor receptor-like 1b	0.087
adipoql	adiponectin, C1Q and collagen domain containing, like	0.083
th2	tyrosine hydroxylase 2	0.080
npy8br	neuropeptide Y receptor Y8b	0.077
LOC569128	hypothetical protein LOC569128	0.074
or115-10	odorant receptor, family F, subfamily 115, member 10	0.072
calm1a	calmodulin 1a	0.069
htr1aa	5-hydroxytryptamine (serotonin) receptor 1A a	0.068
guca1c	guanylate cyclase activator 1C	0.068
rag1	recombination activating gene 1	0.068
cart1	cartilage paired-class homeoprotein 1	0.066
kif5c	kinesin family member 5C	0.063
mstnb	myostatin b	0.063
cps1	carbamoyl-phosphate synthase 1, mitochondrial	0.061
gdnf	glial cell derived neurotrophic factor	0.060
hdc	histidine decarboxylase	0.060
adra2a	adrenergic, alpha-2A-, receptor	0.059
slc8a4b	solute carrier family 8 (sodium/calcium exchanger), member 4b	0.059
si:rp71-40n14.1	si:rp71-40n14.1	0.057
flj13639	flj13639	0.055
palm	paralemmin	0.055	Mouse
dclk2	doublecortin-like kinase 2	0.054
hcrtr2	hypocretin (orexin) receptor 2	0.053
grk7a	G-protein-coupled receptor kinase 7a	0.053
si:ch211-14k19.8	si:ch211-14k19.8	0.053
gc2	guanylyl cyclase 2	0.053	Zebrafish Rat
atp6v0cb	ATPase, H+ transporting, lysosomal, V0 subunit c, b	0.051
gnrh2	gonadotropin-releasing hormone 2	0.051
LOC555482	tachykinin receptor 3-like	0.051
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.050
mtnr1ba	melatonin receptor type 1B a	0.049
gfra1b	gdnf family receptor alpha 1b	0.048
pp	pyrophosphatase (inorganic)	0.048
nras	neuroblastoma RAS viral (v-ras) oncogene homolog	0.048
ywhai	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide	0.047
pnrc2	proline-rich nuclear receptor coactivator 2	0.046
nt5e	5'-nucleotidase, ecto (CD73)	0.046
cnr1	cannabinoid receptor 1	0.046
prkcea	protein kinase C, epsilon a	0.046
mc5ra	melanocortin 5a receptor	0.044	Human Zebrafish
opn1mw4	opsin 1 (cone pigments), medium-wave-sensitive, 4	0.044
msi2a	musashi homolog 2a (Drosophila)	0.043
c1qtnf4	C1q and tumor necrosis factor related protein 4	0.043
cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.042
gsdf	gonadal somatic cell derived factor	0.042
saga	S-antigen; retina and pineal gland (arrestin) a	0.042
valopa	vertebrate ancient long opsin a	0.041
cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.041
fermt2	fermitin family homolog 2 (Drosophila)	0.041
pomca	proopiomelanocortin a	0.040
fshr	follicle stimulating hormone receptor	0.039
cyp2aa4	cytochrome P450, family 2, subfamily AA, polypeptide 4	0.039
or115-15	odorant receptor, family F, subfamily 115, member 15	0.039
gc3	guanylyl cyclase 3	0.039	Zebrafish Rat
cnr2	cannabinoid receptor 2	0.039
klf7l	Kruppel-like factor 7 (ubiquitous), like	0.036
nrl	neural retina leucine zipper	0.036
cryaba	crystallin, alpha B, a	0.035
cntfr	ciliary neurotrophic factor receptor	0.035
vdac3	voltage-dependent anion channel 3	0.034
ryr2a	ryanodine receptor 2a (cardiac)	0.034
gap43	growth associated protein 43	0.033
tert	telomerase reverse transcriptase	0.033
si:ch211-209p5.2	si:ch211-209p5.2	0.033
ttc39c	tetratricopeptide repeat domain 39C	0.032
otc	ornithine carbamoyltransferase	0.032
cadm2a	cell adhesion molecule 2a	0.032
mmp15a	matrix metallopeptidase 15a	0.032
chat	choline acetyltransferase	0.031
smtnb	smoothelin b	0.030
il22	interleukin 22	0.030
cldn8	claudin 8	0.030
grk1b	G protein-coupled receptor kinase 1 b	0.030
fgf20b	fibroblast growth factor 20b	0.029
slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.029
gdf9	growth differentiation factor 9	0.029
diaph2	diaphanous homolog 2 (Drosophila)	0.028
zgc:77123	zgc:77123	0.028
ncam2	neural cell adhesion molecule 2	0.028
snrk1	SNF related kinase 1	0.027
uts2a	urotensin 2, alpha	0.027
si:dkey-228g21.4	si:dkey-228g21.4	0.027
socs1	suppressor of cytokine signaling 1	0.026
pkm2a	pyruvate kinase, muscle, a	0.026
ca8	carbonic anhydrase VIII	0.025
gpr182	G protein-coupled receptor 182	0.025
cry1a	cryptochrome 1a	0.025
ahr1a	aryl hydrocarbon receptor 1a	0.025
si:dkey-3d4.3	si:dkey-3d4.3	0.024
sox5	SRY-box containing gene 5	0.024
hoxc12b	homeo box C12b	0.024
sagb	S-antigen; retina and pineal gland (arrestin) b	0.024
btbd2	BTB (POZ) domain containing 2	0.024
cspg4	chondroitin sulfate proteoglycan 4	0.024
zgc:55574	zgc:55574	0.024
vwf	von Willebrand factor	0.024
slc1a2a	solute carrier family 1 (glial high affinity glutamate transporter), member 2a	0.023
drd4a	dopamine receptor D4a	0.023	Human
exorh	extra-ocular rhodopsin	0.023
adrb2b	adrenergic receptor, beta 2b	0.023
bsk146	brain specific kinase 146	0.023
LOC563363	cholesterol side-chain cleavage enzyme, mitochondrial-like	0.023
fabp11a	fatty acid binding protein 11a	0.022
inha	inhibin, alpha	0.022
zgc:171495	zgc:171495	0.022
neurog3	neurogenin 3	0.022
esama	endothelial cell adhesion molecule a	0.022
nf1b	neurofibromin 1b	0.022	Mouse Fly
calcr	calcitonin receptor	0.022
adcyap1a	adenylate cyclase activating polypeptide 1a	0.022	Human Mouse
igfbp6a	insulin-like growth factor binding protein 6a	0.022
rag2	recombination activating gene 2	0.021
prdm15	PR domain containing 15	0.021
tgfbr1b	transforming growth factor, beta receptor 1 b	0.021
pyya	peptide YYa	0.021
thrb	thyroid hormone receptor beta	0.021
zgc:85717	zgc:85717	0.021
zgc:136878	zgc:136878	0.021
zgc:77752	zgc:77752	0.021
npb	neuropeptide B	0.021
pde6c	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	0.021
abcb3l1	ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 1	0.021
ptn	pleiotrophin	0.021
zgc:162213	zgc:162213	0.020
bhlha15	basic helix-loop-helix family, member a15	0.020
npy8ar	neuropeptide Y receptor Y8a	0.020
guca1b	guanylate cyclase activator 1B	0.020
cyb5r4	cytochrome b5 reductase 4	0.020
crhbp	corticotropin releasing hormone binding protein	0.020
dio2	deiodinase, iodothyronine, type II	0.020
inka1a	induced in neural crest by AP2, 1a	0.020
gria2b	glutamate receptor, ionotropic, AMPA 2b	0.020
slc6a4a	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A	0.019
LOC559201	similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)	0.019
zgc:91926	zgc:91926	0.019
arfip2a	ADP-ribosylation factor interacting protein 2a	0.019
hmgb1a	high-mobility group box 1a	0.019
rbp4l	retinol binding protein 4, like	0.019
tbx2a	T-box gene 2a	0.018
igfbp6b	insulin-like growth factor binding protein 6b	0.018
kiss1rb	KISS1 receptor b	0.018
LOC565839	tumor necrosis factor alpha-induced protein 2-like	0.018
onecut1	one cut domain, family member 1	0.017
adora2b	adenosine A2b receptor	0.017	Mouse Rat
mhc2dcb	major histocompatibility complex class II DCB gene	0.017
rap1b	RAS related protein 1b	0.017
ncs1b	neuronal calcium sensor 1b	0.017	Fly
mtnr1bb	melatonin receptor 1B b and melatonin receptor 1B	0.017
gnat2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	0.017
zgc:63587	zgc:63587	0.017
lifrb	leukemia inhibitory factor receptor alpha b	0.017
rgs4	regulator of G-protein signalling 4	0.017
si:dkeyp-72g9.4	si:dkeyp-72g9.4	0.017
rtn4rl2a	reticulon 4 receptor-like 2 a	0.017
sox4b	SRY-box containing gene 4b	0.017
angptl1	angiopoietin-like 1	0.017
pufa	PUF (Pumilio/FBF) domain-containing A	0.017
LOC799612	prolactin 2	0.017
slc18a3b	solute carrier family 18 (vesicular acetylcholine), member 3b	0.016
gng8	guanine nucleotide binding protein (G protein), gamma 8	0.016
LOC100006249	carbohydrate sulfotransferase 2-like	0.016
gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.016
wu:fv91b12	wu:fv91b12	0.016
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.016
efemp2	EGF-containing fibulin-like extracellular matrix protein 2	0.016
gnat1	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	0.016
ptp4a1	protein tyrosine phosphatase type IVA, member 1	0.016
LOC100004941	grpE protein homolog 2, mitochondrial-like	0.016
vegfab	vascular endothelial growth factor Ab	0.016
map1lc3b	microtubule-associated protein 1 light chain 3 beta	0.016
zgc:63633	zgc:63633	0.016
nptx2b	neuronal pentraxin 2b	0.015
plcb3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.015
ahrrb	aryl-hydrocarbon receptor repressor b	0.015
nr6a1b	nuclear receptor subfamily 6, group A, member 1b	0.015
fes	feline sarcoma oncogene	0.015
or107-1	odorant receptor, family D, subfamily 107, member 1	0.015
synj1	synaptojanin 1	0.015
LOC100150924	DNA polymerase subunit gamma-1-like	0.015
si:dkey-37m8.9	si:dkey-37m8.9	0.015
cd99l2	CD99 antigen-like 2	0.015
rhogc	ras homolog gene family, member Gc	0.015
eya4	eyes absent homolog 4 (Drosophila)	0.015
rs1	retinoschisis (X-linked, juvenile) 1	0.015
nppcl	natriuretic peptide precursor C-like protein	0.015
adcy5	adenylate cyclase 5	0.015
agtr2	angiotensin II receptor, type 2	0.015
mcamb	melanoma cell adhesion molecule b	0.015
celsr3	cadherin, EGF LAG seven-pass G-type receptor 3	0.015
uchl1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.014
zgc:65851	zgc:65851	0.014
rgs17	regulator of G-protein signaling 17	0.014
has3	hyaluronan synthase 3	0.014
vtg1	vitellogenin 1	0.014
ahrra	aryl-hydrocarbon receptor repressor a	0.014
furinb	furin (paired basic amino acid cleaving enzyme) b	0.014
mapk6	mitogen-activated protein kinase 6	0.014
defbl2	defensin, beta-like 2	0.014
cfdl	complement factor D (adipsin) like	0.014
tspan7b	tetraspanin 7b	0.014
glra4b	glycine receptor, alpha 4b	0.014
vamp2	vesicle-associated membrane protein 2	0.014
tagln2	transgelin 2	0.014
guca1d	guanylate cyclase activator 1d	0.014
cx52.6	connexin 52.6	0.014
adora2aa	adenosine A2a receptor a	0.013	Human Mouse
rho	rhodopsin	0.013
trpc1	transient receptor potential cation channel, subfamily C, member 1	0.013
ctsba	cathepsin B, a	0.013
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.013
scpp9	secretory calcium-binding phosphoprotein 9	0.013
slc6a8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.013
mao	monoamine oxidase	0.013
aqp10b	aquaporin 10b	0.013
zgc:109949	zgc:109949	0.013
scospondin	subcommissural organ spondin	0.013
sema3ga	semaphorin 3ga	0.013
phlda1	pleckstrin homology-like domain, family A, member 1	0.013
zgc:109987	zgc:109987	0.012
ntrk3b	neurotrophic tyrosine kinase, receptor, type 3b	0.012
clock	clock	0.012
dusp5	dual specificity phosphatase 5	0.012
nrip1b	nuclear receptor interacting protein 1b	0.012
fgf13a	fibroblast growth factor 13a	0.012
ywhag1	3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1	0.012
ghrhrl	growth hormone releasing hormone receptor, like	0.012
si:dkey-71d15.3	si:dkey-71d15.3	0.012
opn1sw1	opsin 1 (cone pigments), short-wave-sensitive 1	0.012
rassf2	Ras association (RalGDS/AF-6) domain family member 2	0.012
es1	es1 protein	0.012
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.012
mmd2	progestin and adipoQ receptor 10	0.012
pmch	pro-melanin concentrating hormone	0.012
npas2	neuronal PAS domain protein 2	0.012
sgk1	serum/glucocorticoid regulated kinase 1	0.012
hpca	hippocalcin	0.012
si:dkeyp-59a8.4	si:dkeyp-59a8.4	0.012
clrn1	clarin 1	0.012
drd4b	dopamine receptor D4b	0.012	Human
slco1f1	solute carrier organic anion transporter family, member 1F1	0.012
itgb1b.1	integrin, beta 1b.1	0.012
ifnphi4	interferon phi 4	0.012
bokb	BCL2-related ovarian killer b	0.012
upk1a	uroplakin 1a	0.011
esr1	estrogen receptor 1	0.011
zgc:73155	zgc:73155	0.011
hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.011
zgc:110179	zgc:110179	0.011
lepb	leptin b	0.011
alk	anaplastic lymphoma kinase (Ki-1)	0.011
chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.011
LOC100150997	similar to adenosine A1 receptor	0.011
rhcgb	Rhesus blood group, C glycoprotein b	0.011
LOC100332193	growth hormone secretagogue receptor type 1-like	0.011
atxn7l3	ataxin 7-like 3	0.011
zgc:136902	zgc:136902	0.011
illr4	immune-related, lectin-like receptor 4	0.011
elovl4a	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4a	0.011
si:ch73-56f16.1	si:ch73-56f16.1	0.011
insl3	insulin-like 3 (Leydig cell)	0.011
LOC559147	novel protein similar to vertebrate hairy and enhancer of split 2 (Drosophila) (HES2)	0.011
il6st	interleukin 6 signal transducer	0.011
trpc5	transient receptor potential cation channel, subfamily C, member 5	0.011
hs3st2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.011
LOC566040	protein notum homolog	0.011
opn1mw1	opsin 1 (cone pigments), medium-wave-sensitive, 1	0.011
cacnb2a	calcium channel, voltage-dependent, beta 2a	0.010
zgc:56548	zgc:56548	0.010
igfbp5a	insulin-like growth factor binding protein 5a	0.010
pygb	phosphorylase, glycogen; brain	0.010
ca4a	carbonic anhydrase IV a	0.010
zgc:73228	zgc:73228	0.010
sybu	syntabulin (syntaxin-interacting)	0.010
tcea2	transcription elongation factor A (SII), 2	0.010
tgfbr1a	transforming growth factor, beta receptor I a	0.010
sgcg	sarcoglycan, gamma	0.010
zgc:101581	zgc:101581	0.010
zgc:112320	zgc:112320	0.010
clec14a	C-type lectin domain family 14, member A	0.010
rtn4b	reticulon 4b	0.010