IMP: Integrative Multi-species Prediction

Danio rerio

12 genes annotated in zebrafish

cellular macromolecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in zebrafishInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular macromolecule catabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cellular macromolecule catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
psmb1	proteasome (prosome, macropain) subunit, beta type, 1	0.583
psma6a	proteasome (prosome, macropain) subunit, alpha type, 6a	0.498	Human Yeast
psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.477
psmd12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.390
smad5	MAD homolog 5 (Drosophila)	0.361
pcna	proliferating cell nuclear antigen	0.317	Human
psma8	proteasome (prosome, macropain) subunit, alpha type, 8	0.201	Yeast
psma1	proteasome (prosome, macropain) subunit, alpha type, 1	0.188
psmb3	proteasome (prosome, macropain) subunit, beta type, 3	0.141	Yeast
psmd4b	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b	0.133	Yeast Worm
psmc4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.131	Yeast
psmd13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.130	Yeast
rab1a	RAB1A, member RAS oncogene family	0.120
ef1a	elongation factor 1-alpha	0.108
psmb5	proteasome (prosome, macropain) subunit, beta type, 5	0.104
ccnb1	cyclin B1	0.096
rnaset2	ribonuclease T2	0.095
syvn1	synovial apoptosis inhibitor 1, synoviolin	0.085	Human
chuk	conserved helix-loop-helix ubiquitous kinase	0.082
nasp	nuclear autoantigenic sperm protein (histone-binding)	0.081
psmb7	proteasome (prosome, macropain) subunit, beta type, 7	0.080	Yeast
supt6h	suppressor of Ty 6 homolog	0.078
zgc:92775	zgc:92775	0.075
hspa5	heat shock protein 5	0.071	Yeast Mouse
max	myc-associated factor X	0.067
bsdc1	BSD domain containing 1	0.060
wdhd1	WD repeat and HMG-box DNA binding protein 1	0.060
vcp	valosin containing protein	0.059
ccna2	cyclin A2	0.059
mcts1	malignant T cell amplified sequence 1	0.058
tp53	tumor protein p53	0.056
tram1	translocating chain-associating membrane protein 1	0.056
psmb4	proteasome (prosome, macropain) subunit, beta type, 4	0.056	Yeast
sap18	sin3-associated polypeptide	0.054
psmc3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	0.053	Yeast
sumo3a	SMT3 suppressor of mif two 3 homolog 3a	0.052
psmc6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.052
h2afv	H2A histone family, member V	0.050	Yeast
puf60b	poly-U binding splicing factor b	0.048
acvr1b	activin A receptor, type IB	0.044
ube2g2	ubiquitin-conjugating enzyme E2G 2	0.044
psmd1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.043	Yeast
faf2	Fas associated factor family member 2	0.042
foxo3b	forkhead box O3b	0.041
psmb2	proteasome (prosome, macropain) subunit, beta type, 2	0.041	Yeast
ywhabb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b	0.040
smg5	Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.040
ncapd2	non-SMC condensin I complex, subunit D2	0.040
zgc:111944	zgc:111944	0.040
psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.039	Human Yeast
cnn2	calponin 2	0.039
smg1	PI-3-kinase-related kinase SMG-1	0.038	Human Worm
ctsc	cathepsin C	0.037	Rat
aurkb	aurora kinase B	0.037
zgc:112254	zgc:112254	0.036
usp5	ubiquitin specific protease 5	0.036	Human Fly
gps1	G protein pathway suppressor 1	0.036
gro2	groucho 2	0.036
bon	bonnie and clyde	0.036
tmem93	transmembrane protein 93	0.035
zgc:109901	zgc:109901	0.035
psma5	proteasome (prosome, macropain) subunit, alpha type,5	0.035	Yeast
psmc5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.035	Human Yeast Worm
ube2na	ubiquitin-conjugating enzyme E2Na	0.034	Human Mouse
terfa	telomeric repeat binding factor a	0.034
rbm4.2	RNA binding motif protein 4.2	0.034
e2f5	E2F transcription factor 5	0.033
snai1a	snail homolog 1a (Drosophila)	0.033
tia1l	cytotoxic granule-associated RNA binding protein 1, like	0.033	Yeast
zgc:123326	zgc:123326	0.033
smc4	structural maintenance of chromosomes 4	0.033
kif23	kinesin family member 23	0.033
LOC100330405	transmembrane protein 176B-like	0.032
psmd2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.032
eif2c4	eukaryotic translation initiation factor 2C, 4	0.032
fancl	Fanconi anemia, complementation group L	0.031
ilf2	interleukin enhancer binding factor 2	0.031
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.031
zgc:110116	zgc:110116	0.031
brca2	breast cancer 2, early onset	0.030
upf2	UPF2 regulator of nonsense transcripts homolog (yeast)	0.028
ubin	ataxin-1 ubiquitin-like interacting protein	0.028	Human
crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.028
upf1	upf1 regulator of nonsense transcripts homolog (yeast)	0.028
ddx42	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	0.027
ck2b	casein kinase 2 beta	0.027
adrm1b	adhesion regulating molecule 1b	0.027
wu:fb12e11	wu:fb12e11	0.027
ciapin1	cytokine induced apoptosis inhibitor 1	0.027
zgc:77817	zgc:77817	0.027
akirin2	akirin 2	0.026
smarce1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.026
btg2	B-cell translocation gene 2	0.026
elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.026
eif1b	eukaryotic translation initiation factor 1B	0.025
rlf	rearranged L-myc fusion	0.025
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.025
psmc1b	proteasome (prosome, macropain) 26S subunit, ATPase, 1b	0.025
smg6	Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.025
ube2d2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.024	Yeast
setd7	SET domain containing (lysine methyltransferase) 7	0.024
ccnb2	cyclin B2	0.024
zgc:64114	zgc:64114	0.024
fzd5	frizzled homolog 5	0.024
bactin2	bactin2	0.023
zgc:55671	zgc:55671	0.023
sox9b	SRY-box containing gene 9b	0.023
orc1	origin recognition complex, subunit 1	0.023
LOC570775	protein argonaute-1-like	0.022
ddx39b	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39b	0.022
xbp1	X-box binding protein 1	0.022	Mouse
cnot3b	CCR4-NOT transcription complex, subunit 3b	0.022
dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.022	Yeast
tra2a	transformer-2 alpha	0.022
rqcd1	RCD1 required for cell differentiation1 homolog (S. pombe)	0.021
rbmx	RNA binding motif protein, X-linked	0.021
wu:fa27a01	wu:fa27a01	0.021
ran	ras-related nuclear protein	0.021
ube2g1b	ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast)	0.021
gabarapa	GABA(A) receptor-associated protein a	0.021
ncaph	non-SMC condensin I complex, subunit H	0.020
cstf1	cleavage stimulation factor, 3' pre-RNA, subunit 1	0.020
gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.020	Human
drap1	DR1-associated protein 1 (negative cofactor 2 alpha)	0.020
srsf1a	serine/arginine-rich splicing factor 1a	0.020	Yeast
zgc:55813	zgc:55813	0.019
lancl1	LanC antibiotic synthetase component C-like 1 (bacterial)	0.019
dda1	DET1 and DDB1 associated 1	0.019
smad2	MAD homolog 2 (Drosophila)	0.019
ctsz	cathepsin Z	0.019
hspa4b	heat shock protein 4b	0.019
zgc:55461	zgc:55461	0.019
b4galt6	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6	0.018
exoc3	exocyst complex component 3	0.018
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.018
slc2a10	solute carrier family 2 (facilitated glucose transporter), member 10	0.018
psmd3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.018
cdt1	chromatin licensing and DNA replication factor 1	0.018
tmed2	transmembrane emp24 domain trafficking protein 2	0.018
snrpc	small nuclear ribonucleoprotein polypeptide C	0.018
rae1	RAE1 RNA export 1 homolog (S. pombe)	0.018
kpna4	karyopherin alpha 4 (importin alpha 3)	0.018
pxn	paxillin	0.017
anapc5	anaphase promoting complex subunit 5	0.017
ctsd	cathepsin D	0.017	Yeast
senp3a	SUMO1/sentrin/SMT3 specific peptidase 3a	0.017
fnta	farnesyltransferase, CAAX box, alpha	0.017
vasa	vasa homolog	0.017
srsf6a	serine/arginine-rich splicing factor 6a	0.017
rangap1	Ran GTPase activating protein 1	0.017
npc1	Niemann-Pick disease, type C1	0.017
arntl2	aryl hydrocarbon receptor nuclear translocator-like 2	0.017
myl9l	myosin, light polypeptide 9, like	0.017
ppp2cb	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	0.017	Mouse
sox32	SRY-box containing gene 32	0.017
LOC100149353	transient receptor potential cation channel subfamily M member 6-like	0.016
ung	uracil-DNA glycosylase	0.016
csnk1g2a	casein kinase 1, gamma 2a	0.016
zgc:55891	zgc:55891	0.016
fbxw11a	F-box and WD-40 domain protein 11a	0.016	Human Mouse
nploc4	nuclear protein localization 4 homolog (S. cerevisiae)	0.016	Worm
etf1	eukaryotic translation termination factor 1	0.016
zgc:153061	zgc:153061	0.016
xrn1	5'-3' exoribonuclease 1	0.016
ihha	Indian hedgehog homolog a	0.016
mapkapk2a	mitogen-activated protein kinase-activated protein kinase 2a	0.016
rnd3a	Rho family GTPase 3a	0.016
acp5b	acid phosphatase 5b, tartrate resistant	0.015
clk4a	CDC-like kinase 4a	0.015
ywhae1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	0.015
srsf11	serine/arginine-rich splicing factor 11	0.015
upf3a	UPF3 regulator of nonsense transcripts homolog A (yeast)	0.015	Worm
rxrba	retinoid x receptor, beta a	0.015
zgc:63721	zgc:63721	0.015
dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.015	Mouse
morf4l1	mortality factor 4 like 1	0.015
gro1	groucho 1	0.015
plk1	polo-like kinase 1 (Drosophila)	0.015	Human
wu:fb54a03	wu:fb54a03	0.015
ext1b	exostoses (multiple) 1b	0.015
fmr1	fragile X mental retardation 1	0.015
kpna3	karyopherin (importin) alpha 3	0.015
msh6	mutS homolog 6 (E. coli)	0.015
cnnm2a	cyclin M2a	0.015
capn2b	calpain 2, (m/II) large subunit b	0.015
ubc	ubiquitin C	0.015
snrnp70	small nuclear ribonucleoprotein 70 (U1)	0.014
zgc:103564	zgc:103564	0.014
gins2	GINS complex subunit 2	0.014
immt	inner membrane protein, mitochondrial (mitofilin)	0.014
map2k4a	mitogen-activated protein kinase kinase 4a	0.014
cnot3a	CCR4-NOT transcription complex, subunit 3a	0.014
safb	scaffold attachment factor B	0.014
ruvbl1	RuvB-like 1 (E. coli)	0.014
zgc:77456	zgc:77456	0.014
hyou1	hypoxia up-regulated 1	0.014
ncor1	nuclear receptor co-repressor 1	0.014
tnpo3	transportin 3	0.014
nfe2l3	nuclear factor (erythroid-derived 2)-like 3	0.014
zgc:56112	zgc:56112	0.014
s1pr1	sphingosine-1-phosphate receptor 1	0.014
si:ch211-69g19.2	si:ch211-69g19.2	0.014
LOC100003514	protein kinase C alpha type-like	0.014
zgc:113421	zgc:113421	0.014
maff	v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)	0.014
gna13a	guanine nucleotide binding protein (G protein), alpha 13a	0.014
flh	floating head	0.014
zgc:92661	zgc:92661	0.014
wdr18	WD repeat domain 18	0.013
zgc:92765	zgc:92765	0.013
chek1	CHK1 checkpoint homolog (S. pombe)	0.013
si:ch211-239j15.4	si:ch211-239j15.4	0.013
mga	MAX gene associated	0.013
arf2	ADP-ribosylation factor 2	0.013
cdk8	cyclin-dependent kinase 8	0.013	Yeast
dynlrb1	dynein, light chain, roadblock-type 1	0.013
creb3l3l	cAMP responsive element binding protein 3-like 3 like	0.013
zgc:56304	zgc:56304	0.013
cse1l	chromosome segregation 1-like (S. cerevisiae)	0.013
ywhaba	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a	0.013
prpf40a	PRP40 pre-mRNA processing factor 40 homolog A (yeast)	0.013
chd7	chromodomain helicase DNA binding protein 7	0.013
ctsf	cathepsin F	0.013
chd	chordin	0.013
zgc:56376	zgc:56376	0.013
atp6v0ca	ATPase, H+ transporting, lysosomal, V0 subunit c, a	0.013
plekha3	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3	0.013
pou2f1a	POU class 2 homeobox 1a	0.013
arpp19a	cAMP-regulated phosphoprotein 19a	0.013
psme1	proteasome activator subunit 1	0.013
fbxw11b	F-box and WD-40 domain protein 11b	0.013	Human Mouse
dusp1	dual specificity phosphatase 1	0.013
derl2	Der1-like domain family, member 2	0.012
fxr2	fragile X mental retardation, autosomal homolog 2	0.012
zgc:63962	zgc:63962	0.012
zgc:56200	zgc:56200	0.012
gdf6a	growth differentiation factor 6a	0.012
rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.012
lmna	lamin A	0.012
zgc:77052	zgc:77052	0.012
cxxc1	CXXC finger 1 (PHD domain)	0.012
zff9	zinc finger protein 9	0.012
LOC553527	hypothetical protein LOC553527	0.012
cd164	CD164 molecule, sialomucin	0.012
erh	enhancer of rudimentary homolog (Drosophila)	0.012
mcm3	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)	0.012
hsp90b1	heat shock protein 90, beta (grp94), member 1	0.012	Human
ppp2r5eb	protein phosphatase 2, regulatory subunit B', epsilon isoform b	0.012
prp19	PRP19/PSO4 homolog (S. cerevisiae)	0.012	Human Mouse
tbcb	tubulin folding cofactor B	0.012
zgc:86903	zgc:86903	0.012
zgc:101819	zgc:101819	0.012
khsrp	KH-type splicing regulatory protein	0.012
ube2i2	ubiquitin-conjugating enzyme E2I2	0.012	Rat
smarcb1a	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a	0.012
cand1	cullin-associated and neddylation-dissociated 1	0.012
psmb6	proteasome (prosome, macropain) subunit, beta type, 6	0.012	Yeast
zgc:55512	zgc:55512	0.012	Yeast Fly
hdac3	histone deacetylase 3	0.012
ddx19	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast)	0.012
ppp6c	protein phosphatase 6, catalytic subunit	0.012
gdi2	GDP dissociation inhibitor 2	0.012
ilf3a	interleukin enhancer binding factor 3a	0.012
usp10	ubiquitin specific peptidase 10	0.012
smndc1	survival motor neuron domain containing 1	0.011
rbm4.3	RNA binding motif protein 4.3	0.011
eif4h	eukaryotic translation initiation factor 4h	0.011
hspa8	heat shock protein 8	0.011
irx3a	iroquois homeobox protein 3a	0.011
tnrc6b	trinucleotide repeat containing 6B	0.011
cep70	centrosomal protein 70	0.011
ywhaqa	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a	0.011
magoh	mago-nashi homolog, proliferation-associated (Drosophila)	0.011	Human
hhip	hedgehog interacting protein	0.011
krml2.2	Kreisler (mouse) maf-related leucine zipper homolog 2.2	0.011
paf1	paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.011
chmp4b	chromatin modifying protein 4B	0.011
zgc:77304	zgc:77304	0.011
smc3	structural maintenance of chromosomes 3	0.011
zgc:110113	zgc:110113	0.011
csrp1a	cysteine and glycine-rich protein 1a	0.011
dcst1	DC-STAMP domain containing 1	0.011
ppp2r2d	protein phosphatase 2, regulatory subunit B, delta isoform	0.011	Fly
ndfip1	Nedd4 family interacting protein 1	0.011
rcbtb1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	0.011
trnau1apl	tRNA selenocysteine 1 associated protein 1, like	0.011
psmd11a	proteasome (prosome, macropain) 216S subunit, non-ATPase, 11a	0.011	Human Worm
ncl1	nicalin	0.011
si:dkey-97o5.1	si:dkey-97o5.1	0.010
gadd45aa	growth arrest and DNA-damage-inducible, alpha, a	0.010
cnot8	CCR4-NOT transcription complex, subunit 8	0.010	Human Fly
psmd10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.010	Human
zgc:56259	zgc:56259	0.010
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.010
arl8ba	ADP-ribosylation factor-like 8Ba	0.010
mxa	myxovirus (influenza) resistance A	0.010
tbx16	T-box gene 16	0.010
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.010
nedd8	neural precursor cell expressed, developmentally down-regulated 8	0.010