IMP: Integrative Multi-species Prediction

Danio rerio

10 genes annotated in zebrafish

rna splicing via transesterification reactions with bulged adenosine as nucleophile

Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "rna splicing via transesterification reactions with bulged adenosine as nucleophile"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "rna splicing via transesterification reactions with bulged adenosine as nucleophile" (in gray)

Name	Description	Probability	Func Analog Organism
snrnp70	small nuclear ribonucleoprotein 70 (U1)	0.942
srsf2	serine/arginine-rich splicing factor 2	0.834	Mouse Fly
hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.803	Fly
khdrbs1a	KH domain containing, RNA binding, signal transduction associated 1a	0.744	Fly
rbmx	RNA binding motif protein, X-linked	0.687	Human Rat
snrpd3l	small nuclear ribonucleoprotein D3 polypeptide, like	0.660
safb	scaffold attachment factor B	0.623	Fly
smu1	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	0.575	Worm
phf5a	PHD finger protein 5A	0.571	Human
nup50	nucleoporin 50	0.532
snrpd1	small nuclear ribonucleoprotein D1 polypeptide	0.517	Human
ewsr1b	Ewing sarcoma breakpoint region 1b	0.486
sf1	splicing factor 1	0.479
setb	SET translocation (myeloid leukemia-associated) B	0.462
srsf6a	serine/arginine-rich splicing factor 6a	0.441	Human Fly
snrpd3	small nuclear ribonucleoprotein D3 polypeptide	0.437	Human
snrpb2	small nuclear ribonucleoprotein polypeptide B2	0.398
ilf2	interleukin enhancer binding factor 2	0.393
hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.372	Fly
api5	apoptosis inhibitor 5	0.367
sart1	squamous cell carcinoma antigen recognised by T cells	0.360
tra2a	transformer-2 alpha	0.347	Human Fly
ilf3b	interleukin enhancer binding factor 3b	0.321
hnrnph1l	heterogeneous nuclear ribonucleoprotein H1, like	0.261
sfrs3b	splicing factor, arginine/serine-rich 3b	0.259
srsf6b	serine/arginine-rich splicing factor 6b	0.258	Human Fly
puf60b	poly-U binding splicing factor b	0.240	Fly
hnrnpa1	heterogeneous nuclear ribonucleoprotein A1	0.212	Mouse Fly
ilf3a	interleukin enhancer binding factor 3a	0.211
pcbp2	poly(rC) binding protein 2	0.198	Fly
srsf11	serine/arginine-rich splicing factor 11	0.190	Fly
u2af2b	U2 small nuclear RNA auxiliary factor 2b	0.187	Human Fly
cpsf2	cleavage and polyadenylation specific factor 2	0.185
sf3b4	splicing factor 3b, subunit 4	0.183	Mouse
elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.181	Worm
prpf31	PRP31 pre-mRNA processing factor 31 homolog (yeast)	0.165
ddx39aa	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa	0.165	Human Yeast Fly
prpf39	PRP39 pre-mRNA processing factor 39 homolog (yeast)	0.159
luc7l	LUC7-like (S. cerevisiae)	0.152	Yeast
eif4a1a	eukaryotic translation initiation factor 4A, isoform 1A	0.148
ddx19	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast)	0.138
ck2b	casein kinase 2 beta	0.132
rnps1	RNA binding protein S1, serine-rich domain	0.132	Human
zgc:77052	zgc:77052	0.126	Fly
hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.122	Fly
srsf5a	serine/arginine-rich splicing factor 5a	0.116	Fly
ube2nb	ubiquitin-conjugating enzyme E2Nb	0.115
ddx39b	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39b	0.113	Human Yeast Fly
ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.112
sf3b5	splicing factor 3b, subunit 5	0.110
sart3	squamous cell carcinoma antigen recognised by T cells 3	0.107
calm3b	calmodulin 3b (phosphorylase kinase, delta)	0.107
trnau1apl	tRNA selenocysteine 1 associated protein 1, like	0.107
usp10	ubiquitin specific peptidase 10	0.103
caprin1a	cell cycle associated protein 1a	0.100
myf5	myogenic factor 5	0.100
wu:fa99c08	wu:fa99c08	0.090
cwf19l1	CWF19-like 1, cell cycle control	0.089
srsf1b	serine/arginine-rich splicing factor 1b	0.087	Human Yeast
prpf8	pre-mRNA processing factor 8	0.086
snrnp40	small nuclear ribonucleoprotein 40 (U5)	0.086
hnrnpa0l	heterogeneous nuclear ribonucleoprotein A0, like	0.084
ube2v2	ubiquitin-conjugating enzyme E2 variant 2	0.082
zgc:112425	zgc:112425	0.081
pcf11	cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)	0.078
psmd11b	proteasome (prosome, macropain) 216S subunit, non-ATPase, 11b	0.077
tardbp	TAR DNA binding protein	0.076
gabpa	GA-binding protein transcription factor, alpha subunit	0.075
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.074
rnasen	ribonuclease type III, nuclear	0.073
rbm4.3	RNA binding motif protein 4.3	0.072
zgc:86598	zgc:86598	0.072
npm1	nucleophosmin 1	0.071	Mouse
ddx5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.071	Human Fly
xrn2	5'-3' exoribonuclease 2	0.071
g3bp1	GTPase activating protein (SH3 domain) binding protein 1	0.071
znf207a	zinc finger protein 207, a	0.070
eftud2	elongation factor Tu GTP binding domain containing 2	0.069	Yeast
rbm39a	RNA binding motif protein 39a	0.067	Fly
eif1b	eukaryotic translation initiation factor 1B	0.067
taf7	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.066
rbm4.2	RNA binding motif protein 4.2	0.065	Human
mbnl2	muscleblind-like 2 (Drosophila)	0.064	Mouse
snrpb	small nuclear ribonucleoprotein polypeptides B and B1	0.064
u2af1	U2(RNU2) small nuclear RNA auxiliary factor 1	0.063	Fly
zgc:136380	zgc:136380	0.061
smarca5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.060
zgc:112254	zgc:112254	0.060
zgc:77262	zgc:77262	0.059
c1d	C1D nuclear receptor co-repressor	0.059
pnn	pinin, desmosome associated protein	0.059
si:dkey-204a24.9	si:dkey-204a24.9	0.058
rltpr	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.057
ddx46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	0.056
ctbp1	C-terminal binding protein 1	0.054
ewsr1a	Ewing sarcoma breakpoint region 1a	0.054
srsf5b	serine/arginine-rich splicing factor 5b	0.054	Fly
anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	0.052
hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.051	Mouse
exosc6	exosome component 6	0.051
wu:fb58e05	wu:fb58e05	0.051
srrt	serrate RNA effector molecule homolog (Arabidopsis)	0.050
ddx42	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	0.050
snrpc	small nuclear ribonucleoprotein polypeptide C	0.050
etf1	eukaryotic translation termination factor 1	0.049
hnrpl	heterogeneous nuclear ribonucleoprotein L	0.046
ubtf	upstream binding transcription factor, RNA polymerase I	0.046
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.046
zgc:56148	zgc:56148	0.045
sap18	sin3-associated polypeptide	0.044	Human
hnrnpm	heterogeneous nuclear ribonucleoprotein M	0.043	Human
pqbp1l	polyglutamine binding protein 1-like	0.043	Human
h2afv	H2A histone family, member V	0.043
magoh	mago-nashi homolog, proliferation-associated (Drosophila)	0.042	Human
ef1a	elongation factor 1-alpha	0.042
syf2	SYF2 homolog, RNA splicing factor (S. cerevisiae)	0.041
h2afvl	H2A histone family, member V, like	0.041
rqcd1	RCD1 required for cell differentiation1 homolog (S. pombe)	0.040
leo1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.040
si:dkey-181m9.9	si:dkey-181m9.9	0.040
h3f3c	H3 histone, family 3C	0.039
eef2a.1	eukaryotic translation elongation factor 2a, tandem duplicate 1	0.039
ranbp1	RAN binding protein 1	0.038
snrpa	small nuclear ribonucleoprotein polypeptide A	0.037
ran	ras-related nuclear protein	0.035
lsm8	LSM8 homolog, U6 small nuclear RNA associated	0.035
nola1	nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)	0.034
ncl	nucleolin	0.033
zgc:158363	zgc:158363	0.033
med18	mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)	0.032
ubin	ataxin-1 ubiquitin-like interacting protein	0.031
hmgb1b	high-mobility group box 1b	0.031
anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.031
kdm1a	lysine (K)-specific demethylase 1a	0.030
arf2	ADP-ribosylation factor 2	0.030
cdk8	cyclin-dependent kinase 8	0.029
dbr1	debranching enzyme homolog 1 (S. cerevisiae)	0.029
eif4h	eukaryotic translation initiation factor 4h	0.029
eed	embryonic ectoderm development	0.029
naa15a	N(alpha)-acetyltransferase 15, NatA auxiliary subunit a	0.029
gng5	guanine nucleotide binding protein (G protein), gamma 5	0.027
polr2j	polymerase (RNA) II (DNA directed) polypeptide J	0.027
rbm39b	RNA binding motif protein 39b	0.026
srrm1	serine/arginine repetitive matrix 1	0.026
eng1b	engrailed 1b	0.026
cstf1	cleavage stimulation factor, 3' pre-RNA, subunit 1	0.026
srsf1a	serine/arginine-rich splicing factor 1a	0.026	Human Yeast
zgc:77155	zgc:77155	0.025
kpna4	karyopherin alpha 4 (importin alpha 3)	0.025
nolc1	nucleolar and coiled-body phosphoprotein 1	0.024
hnrnpl2	heterogeneous nuclear ribonucleoprotein L2	0.024
nop58	NOP58 ribonucleoprotein homolog (yeast)	0.024
clstn2	calsyntenin 2	0.024
rbl1	retinoblastoma-like 1 (p107)	0.023
zfr	zinc finger RNA binding protein	0.023
hug	HuG	0.023	Worm
ogt.2	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 2	0.023
bms1l	BMS1-like, ribosome assembly protein (yeast)	0.023
xab2	XPA binding protein 2	0.022
bcas2	breast carcinoma amplified sequence 2	0.022
khdrbs1b	KH domain containing, RNA binding, signal transduction associated 1b	0.022	Fly
cpsf6	cleavage and polyadenylation specific factor 6	0.022	Fly
sf3b1	splicing factor 3b, subunit 1	0.022
ssb	Sjogren syndrome antigen B (autoantigen La)	0.022
zgc:56304	zgc:56304	0.022
zgc:55870	zgc:55870	0.022
ctnna	catenin (cadherin-associated protein), alpha	0.022
hnrnpul1	heterogeneous nuclear ribonucleoprotein U-like 1	0.021
zgc:73265	zgc:73265	0.021
zgc:55695	zgc:55695	0.021
kop	askopos	0.021
tm9sf2	transmembrane 9 superfamily member 2	0.021
sumo3a	SMT3 suppressor of mif two 3 homolog 3a	0.021
ccnl1	cyclin L1	0.021
rnf113a	ring finger protein 113A	0.021
rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.021
gemin5	gem (nuclear organelle) associated protein 5	0.020
srrm2	serine/arginine repetitive matrix 2	0.020
celsr1a	cadherin EGF LAG seven-pass G-type receptor 1a	0.020
coil	coilin p80	0.020
tpd52l2b	tumor protein D52-like 2b	0.020
med7	mediator complex subunit 7	0.020
hnrpr	heterogeneous nuclear ribonucleoprotein R	0.019
lancl1	LanC antibiotic synthetase component C-like 1 (bacterial)	0.019
eny2	enhancer of yellow 2 homolog (Drosophila)	0.019
zgc:86607	zgc:86607	0.019
puf60a	poly-U binding splicing factor a	0.019	Fly
bub3	BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)	0.019
upf1	upf1 regulator of nonsense transcripts homolog (yeast)	0.019
rcc2	regulator of chromosome condensation 2	0.019
zgc:103692	zgc:103692	0.019
sf3a2	splicing factor 3a, subunit 2	0.018
arpc5a	actin related protein 2/3 complex, subunit 5A	0.018
rbm8a	RNA binding motif protein 8A	0.018	Human
smarce1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.018
zgc:110717	zgc:110717	0.018
wu:fb17g07	wu:fb17g07	0.018
elf2b	E74-like factor 2b (ets domain transcription factor)	0.017
atf4b2	activating transcription factor 4b2	0.017
akap8l	A kinase (PRKA) anchor protein 8-like	0.017
dhx16	DEAH (Asp-Glu-Ala-His) box polypeptide 16	0.017	Yeast
smn1	survival motor neuron 1	0.017
optc	opticin	0.017
thoc1	THO complex 1	0.017
dnajc5ga	DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a	0.017
ptbp2	polypyrimidine tract binding protein 2	0.017	Mouse
mphosph6	M-phase phosphoprotein 6	0.017
cse1l	chromosome segregation 1-like (S. cerevisiae)	0.016
eif4a2	eukaryotic translation initiation factor 4A, isoform 2	0.016	Fly
zgc:56596	zgc:56596	0.016
im:7153552	im:7153552	0.016
strap	serine/threonine kinase receptor associated protein	0.016	Human
si:ch211-59d15.5	si:ch211-59d15.5	0.015
srsf4	serine/arginine-rich splicing factor 4	0.015
paf1	paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.015
zgc:103663	zgc:103663	0.015
dopey2	dopey family member 2	0.015
eif2s1l	eukaryotic translation initiation factor 2, subunit 1 alpha, like	0.015
zgc:103440	zgc:103440	0.015
lppr3b	lipid phosphate phosphatase-related protein type 3b	0.015
hnrpkl	heterogeneous nuclear ribonucleoprotein K, like	0.015	Mouse
si:ch211-51e12.7	si:ch211-51e12.7	0.014
smx5	smx5	0.014
smek2	SMEK homolog 2, suppressor of mek1 (Dictyostelium)	0.014
cbll1	Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1	0.014
h3f3b.1	H3 histone, family 3B.1	0.014
tial1	TIA1 cytotoxic granule-associated RNA binding protein-like 1	0.014	Fly
fubp1	far upstream element (FUSE) binding protein 1	0.014
med27	mediator complex subunit 27	0.014
dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.014
zgc:110801	zgc:110801	0.014
med20	mediator complex subunit 20	0.014
zgc:153700	zgc:153700	0.014
nhp2	NHP2 ribonucleoprotein homolog (yeast)	0.014
rpn1	ribophorin I	0.013
gtf2a1	general transcription factor IIA, 1	0.013
tia1l	cytotoxic granule-associated RNA binding protein 1, like	0.013	Human Fly
calm1a	calmodulin 1a	0.013
adka	adenosine kinase a	0.013
dhx15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	0.013
ube2l3a	ubiquitin-conjugating enzyme E2L 3a	0.013
cobra1	cofactor of BRCA1	0.013
zgc:110682	zgc:110682	0.013	Mouse
zgc:112305	zgc:112305	0.013
psmd10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.013
prrc1	proline-rich coiled-coil 1	0.013
tdrd7	tudor domain containing 7	0.013
rbm4.1	RNA binding motif protein 4.1	0.013	Human
rnpc3	RNA-binding region (RNP1, RRM) containing 3	0.013
ints9	integrator complex subunit 9	0.013
oaz2a	ornithine decarboxylase antizyme 2a	0.012
snx12	sorting nexin 12	0.012
hhatla	hedgehog acyltransferase-like, a	0.012
acin1a	apoptotic chromatin condensation inducer 1a	0.012	Human
dbt	dihydrolipoamide branched chain transacylase E2	0.012
ck2a1	casein kinase 2 alpha 1	0.012
mapkapk2a	mitogen-activated protein kinase-activated protein kinase 2a	0.012
thoc7	THO complex 7	0.012
tomm40	translocase of outer mitochondrial membrane 40 homolog (yeast)	0.012
thoc6	THO complex 6 homolog (Drosophila)	0.012
ppp2r2d	protein phosphatase 2, regulatory subunit B, delta isoform	0.012
ctr9	Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.012
ivd	isovaleryl Coenzyme A dehydrogenase	0.012
anapc5	anaphase promoting complex subunit 5	0.012
rpn2	ribophorin II	0.011
nktr	natural killer-tumor recognition sequence	0.011
cpsf3	cleavage and polyadenylation specific factor 3	0.011
wu:fi04f09	wu:fi04f09	0.011
tdrd1	tudor domain containing 1	0.011
mios	missing oocyte, meiosis regulator, homolog (Drosophila)	0.011
eif4a3	eukaryotic translation initiation factor 4A, isoform 3	0.011	Mouse
ythdf1	YTH domain family, member 1	0.011
tada3l	transcriptional adaptor 3 (NGG1 homolog, yeast)-like	0.011
arglu1b	arginine and glutamate rich 1b	0.011
ogt.1	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1	0.011
scamp2	secretory carrier membrane protein 2	0.011
thoc4	THO complex 4	0.011
ppp1cab	protein phosphatase 1, catalytic subunit, alpha isoform b	0.011
celf1	cugbp, Elav-like family member 1	0.011	Mouse Fly
ntn2	netrin 2	0.011
nutf2	nuclear transport factor 2	0.010
c20orf14	c20orf14 homolog (H. sapiens)	0.010
matr3l	matrin 3-like	0.010
clptm1	cleft lip and palate associated transmembrane protein 1	0.010
bcam	basal cell adhesion molecule (Lutheran blood group)	0.010
bat1	HLA-B associated transcript 1	0.010	Human Yeast Fly
ttc4	tetratricopeptide repeat domain 4	0.010
zgc:110664	zgc:110664	0.010
polr3c	polymerase (RNA) III (DNA directed) polypeptide C	0.010
cand1	cullin-associated and neddylation-dissociated 1	0.010