IMP: Integrative Multi-species Prediction

Danio rerio

4 genes annotated in zebrafish

erk1 and erk2 cascade

An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "erk1 and erk2 cascade"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "erk1 and erk2 cascade" (in gray)

Name	Description	Probability	Func Analog Organism
efnb2a	ephrin B2a	0.615
pdgfaa	platelet-derived growth factor alpha a	0.614	Human
nf1a	neurofibromin 1a	0.547
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.511
evx1	even-skipped homeobox 1	0.452
ywhaba	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a	0.433	Fly
fzd7a	frizzled homolog 7a	0.391
ywhae1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	0.381	Fly
ywhabb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b	0.360
ywhabl	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like	0.346	Fly
ywhai	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide	0.333	Fly
fgf3	fibroblast growth factor 3	0.305
ywhaqb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b	0.290	Fly
irx2a	iroquois homeobox protein 2, a	0.280
hoxa2b	homeo box A2b	0.279
esr1	estrogen receptor 1	0.276	Rat
fes	feline sarcoma oncogene	0.267
ywhaqa	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a	0.251	Fly
wls	wntless homolog (Drosophila)	0.243
llgl2	lethal giant larvae homolog 2 (Drosophila)	0.234
celf1	cugbp, Elav-like family member 1	0.220
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.205
rnd3a	Rho family GTPase 3a	0.200
erbb3b	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b	0.186
yap1	Yes-associated protein 1	0.186
calm1a	calmodulin 1a	0.182
flt1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.179
spry4	sprouty (Drosophila) homolog 4	0.168
lef1	lymphocyte enhancer binding factor 1	0.167
odc1	ornithine decarboxylase 1	0.166
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.166
vegfc	vascular endothelial growth factor c	0.153
igf1	insulin-like growth factor 1	0.148
fn1b	fibronectin 1b	0.146
pax7b	paired box gene 7b	0.144
npnt	nephronectin	0.144
erbb3a	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a	0.141
atp6v0d1	ATPase, H+ transporting, V0 subunit D isoform 1	0.139
hdac4	histone deacetylase 4	0.139
dusp5	dual specificity phosphatase 5	0.139
zgc:112982	zgc:112982	0.138
hif1ab	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b	0.136
lama1	laminin, alpha 1	0.136
sox7	SRY-box containing gene 7	0.135
jag1b	jagged 1b	0.134
idh1	isocitrate dehydrogenase 1 (NADP+), soluble	0.132
fgfr3	fibroblast growth factor receptor 3	0.130	Human
nrg2a	neuregulin 2a	0.128
pigu	phosphatidylinositol glycan anchor biosynthesis, class U	0.128
fgfr2	fibroblast growth factor receptor 2	0.127	Mouse
smad9	MAD homolog 9 (Drosophila)	0.126
arrb2b	arrestin, beta 2b	0.126	Human
etv5b	ets variant 5b	0.125
ube2v2	ubiquitin-conjugating enzyme E2 variant 2	0.124
fgg	fibrinogen, gamma polypeptide	0.122
tfe3b	transcription factor binding to IGHM enhancer 3b	0.122
nod1	nucleotide-binding oligomerization domain containing 1	0.114
pea3	ETS-domain transcription factor pea3	0.113
fgb	fibrinogen, B beta polypeptide	0.112
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.108
foxo3b	forkhead box O3b	0.108
snai1a	snail homolog 1a (Drosophila)	0.107
cdh10	cadherin 10, type 2 (T2-cadherin)	0.106
aplp2	amyloid beta (A4) precursor-like protein 2	0.104
nr2f1a	nuclear receptor subfamily 2, group F, member 1a	0.104
shha	sonic hedgehog a	0.103
sdprb	serum deprivation response b	0.103	Mouse
notch2	notch homolog 2	0.101
arhgef7b	Rho guanine nucleotide exchange factor (GEF) 7b	0.099
polr2j	polymerase (RNA) II (DNA directed) polypeptide J	0.098
nod2	nucleotide-binding oligomerization domain containing 2	0.098	Mouse
tagln3b	transgelin 3b	0.097
col11a1a	collagen, type XI, alpha 1a	0.096
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.096
snx8	sorting nexin 8	0.096
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.095
wu:fv91b12	wu:fv91b12	0.093
tagln2	transgelin 2	0.093
ptgs1	prostaglandin-endoperoxide synthase 1	0.092
igf2a	insulin-like growth factor 2a	0.091
card14	caspase recruitment domain family, member 14	0.091
cmt4b2	Charcot-Marie-Tooth neuropathy 4B2 homolog (human)	0.090
sf3b1	splicing factor 3b, subunit 1	0.090
enc1	ectodermal-neural cortex (with BTB-like domain)	0.090
fzd2	frizzled homolog 2	0.087
wwp2	WW domain containing E3 ubiquitin protein ligase 2	0.087
sc:d812	sc:d812	0.086
lhx2b	LIM homeobox 2b	0.086
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.085
zbtb4	zinc finger and BTB domain containing 4	0.085
oprd1a	opioid receptor, delta 1a	0.085
podxl	podocalyxin-like	0.085
rbm39b	RNA binding motif protein 39b	0.084
pax7a	paired box gene 7a	0.084
drd2b	dopamine receptor D2b	0.083	Rat
nf1b	neurofibromin 1b	0.083
u2af1	U2(RNU2) small nuclear RNA auxiliary factor 1	0.083
cnr1	cannabinoid receptor 1	0.082
fgfr1b	fibroblast growth factor receptor 1b	0.082
ip6k2	inositol hexaphosphate kinase 2	0.082
gnb1a	guanine nucleotide binding protein (G protein), beta polypeptide 1a	0.081
cdc42	cell division cycle 42	0.080
acvr2a	activin receptor IIa	0.080
c9	complement component 9	0.080
aplnrb	apelin receptor b	0.079
kita	kit receptor a	0.079
esr2b	estrogen receptor 2b	0.079	Rat
fzd3a	frizzled homolog 3a	0.079
LOC567965	rho GTPase-activating protein 7-like	0.078
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.077
pmela	premelanosome protein a	0.077
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.077
spon1b	spondin 1b	0.076
sparc	secreted acidic cysteine rich glycoprotein	0.076
hmx2	H6 family homeobox 2	0.075
sulf1	sulfatase 1	0.075
dacha	dachshund a	0.074
crip2	cysteine-rich protein 2	0.074
plekhg4	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	0.073
xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5	0.073
wtip	Wilms tumor 1 interacting protein	0.072
LOC557072	caspase recruitment domain-containing protein 11-like	0.072
wif1	wnt inhibitory factor 1	0.072
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.072
ext1a	exostoses (multiple) 1a	0.071
hs2st1a	heparan sulfate 2-O-sulfotransferase 1a	0.071
jag1a	jagged 1a	0.070
rap1b	RAS related protein 1b	0.069	Mouse Rat
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.069
cx43	connexin 43	0.069
cxadr	coxsackie virus and adenovirus receptor	0.069
hs3st3b1a	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a	0.069
cnn2	calponin 2	0.067
csrnp1b	cysteine-serine-rich nuclear protein 1b	0.067
wnt2ba	wingless-type MMTV integration site family, member 2Ba	0.067
gpr182	G protein-coupled receptor 182	0.067
gstt1a	glutathione S-transferase theta 1a	0.066
dlx5a	distal-less homeobox gene 5a	0.066
nrp1a	neuropilin 1a	0.066	Mouse
pob	partial optokinetic response b	0.066
fzd10	frizzled homolog 10	0.066
clk4a	CDC-like kinase 4a	0.065
lmo4a	LIM domain only 4a	0.065
dio2	deiodinase, iodothyronine, type II	0.065
ube2i2	ubiquitin-conjugating enzyme E2I2	0.065
kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.065
adora2aa	adenosine A2a receptor a	0.065
sec24c	SEC24 family, member C (S. cerevisiae)	0.065
si:dkey-228g21.4	si:dkey-228g21.4	0.065
ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.065
rock2a	rho-associated, coiled-coil containing protein kinase 2a	0.064
zgc:123296	zgc:123296	0.064
rps6kal	ribosomal protein S6 kinase, like	0.064	Mouse
calrl	calreticulin like	0.064
ptk2.1	protein tyrosine kinase 2a	0.063
vegfaa	vascular endothelial growth factor Aa	0.063
naa50	N(alpha)-acetyltransferase 50, NatE catalytic subunit	0.063
brd4	bromodomain containing 4	0.063
crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.063
pald	paladin	0.062
mc4r	melanocortin 4 receptor	0.062
luc7l	LUC7-like (S. cerevisiae)	0.062
itgb3b	integrin beta 3b	0.062
epor	erythropoietin receptor	0.062
adora2b	adenosine A2b receptor	0.061
gas6	growth arrest-specific 6	0.061	Human
tac1	tachykinin 1	0.060
zgc:86598	zgc:86598	0.060
jak1	Janus kinase 1	0.060
sepw1	selenoprotein W, 1	0.059
kiss1rb	KISS1 receptor b	0.059
lasp1	LIM and SH3 protein 1	0.059
grifin	galectin related inter-fiber protein	0.059
krit1	KRIT1, ankyrin repeat containing	0.059
cpne1	copine I	0.058
psen1	presenilin 1	0.058
pcf11	cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)	0.057
prdm5	PR domain containing 5	0.057
xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.057
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.057
aplnra	apelin receptor a	0.056
grhl2b	grainyhead-like 2b (Drosophila)	0.056
hhex	hematopoietically expressed homeobox	0.056
elovl1b	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b	0.056
trnau1apl	tRNA selenocysteine 1 associated protein 1, like	0.056
comta	catechol-O-methyltransferase a	0.055
si:dkey-222f8.3	si:dkey-222f8.3	0.055
epha4b	eph receptor A4b	0.055
calm2a	calmodulin 2a (phosphorylase kinase, delta)	0.055
ccnt2b	cyclin T2b	0.055
aox3	aldehyde oxidase 3	0.054
otud5a	OTU domain containing 5a	0.054
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.053
ryk	receptor-like tyrosine kinase	0.053
LOC568230	similar to CHD3	0.053
pitx3	paired-like homeodomain transcription factor 3	0.053
thbs1	thrombospondin 1	0.053
jak3	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	0.053
snai2	snail homolog 2 (Drosophila)	0.052
rbm39a	RNA binding motif protein 39a	0.052	Fly
csgalnact2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.052
ryr2a	ryanodine receptor 2a (cardiac)	0.052
large	like-glycosyltransferase	0.052
avpl	arginine vasopressin-like	0.052
lmx1b.2	LIM homeobox transcription factor 1, beta 2	0.051
lft1	lefty1	0.051
si:dkeyp-50f5.1	si:dkeyp-50f5.1	0.051
glcci1	glucocorticoid induced transcript 1	0.050
galca	galactosylceramidase a	0.050
si:dkeyp-7c9.1	si:dkeyp-7c9.1	0.050
lingo1b	leucine rich repeat and Ig domain containing 1b	0.050
tes	testis derived transcript (3 LIM domains)	0.050
bmp7b	bone morphogenetic protein 7b	0.049
card9	caspase recruitment domain family, member 9	0.049
si:dkeyp-63d11.7	si:dkeyp-63d11.7	0.049
ube2q2	ubiquitin-conjugating enzyme E2Q family member 2	0.049
LOC100537975	thyroid receptor-interacting protein 11-like	0.049
lpp	LIM domain containing preferred translocation partner in lipoma	0.049
pomt1	protein-O-mannosyltransferase 1	0.049
tmem131	transmembrane protein 131	0.049
si:ch73-60e21.1	si:ch73-60e21.1	0.048
smad1	MAD homolog 1 (Drosophila)	0.048
arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	0.048
rras	related RAS viral (r-ras) oncogene homolog	0.048	Human
zgc:73328	zgc:73328	0.048
rhag	Rhesus blood group-associated glycoprotein	0.048
egfra	epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	0.047	Human
colec11	collectin sub-family member 11	0.047
gpr126	G protein-coupled receptor 126	0.047
dda1	DET1 and DDB1 associated 1	0.047
th2	tyrosine hydroxylase 2	0.047
parp3	poly (ADP-ribose) polymerase family, member 3	0.047
dachd	dachshund d	0.046
syne1a	spectrin repeat containing, nuclear envelope 1a	0.046
itih2	inter-alpha (globulin) inhibitor H2	0.046
rnd3b	Rho family GTPase 3b	0.046
zgc:63663	zgc:63663	0.046
appb	amyloid beta (A4) precursor protein b	0.046
uxs1	UDP-glucuronic acid decarboxylase 1	0.046
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.046
fkbp4	FK506 binding protein 4	0.046
irx5a	iroquois homeobox protein 5a	0.045
zgc:56326	zgc:56326	0.045
zgc:100933	zgc:100933	0.045
ppp2cb	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	0.045
ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.045
si:ch211-184m19.1	si:ch211-184m19.1	0.045
ca8	carbonic anhydrase VIII	0.045
th	tyrosine hydroxylase	0.045
ddr2b	discoidin domain receptor family, member 2b	0.045
alk	anaplastic lymphoma kinase (Ki-1)	0.044
adipor1b	adiponectin receptor 1b	0.044
fshb	follicle stimulating hormone, beta polypeptide	0.044
si:ch211-195h23.3	si:ch211-195h23.3	0.044
cpa5	carboxypeptidase A5	0.044
k31	k31 gene	0.044
oprd1b	opioid receptor, delta 1b	0.044
kirrel3l	kin of IRRE like 3 like	0.044
zgc:85882	zgc:85882	0.044
tie2	endothelium-specific receptor tyrosine kinase 2	0.044	Human
cdh17	cadherin 17, LI cadherin (liver-intestine)	0.044
LOC558520	melanin-concentrating hormone receptor 2-like	0.043
h1m	linker histone H1M	0.043
huwe1	HECT, UBA and WWE domain containing 1	0.043
zgc:101614	zgc:101614	0.043
sema3fb	semaphorin 3fb	0.043
unc5c	unc-5 homolog C (C. elegans)	0.043
prpf39	PRP39 pre-mRNA processing factor 39 homolog (yeast)	0.043
bnc2	basonuclin 2	0.043
dip2ba	DIP2 disco-interacting protein 2 homolog Ba (Drosophila)	0.043
dedd1	death effector domain-containing 1	0.043
msna	moesin a	0.043
ccnl1	cyclin L1	0.043
tnpo3	transportin 3	0.043
csk	c-src tyrosine kinase	0.043
prdm2b	PR domain containing 2, with ZNF domain b	0.043
ptpra	protein tyrosine phosphatase, receptor type, A	0.043
ck2b	casein kinase 2 beta	0.042
sfswap	splicing factor, suppressor of white-apricot homolog (Drosophila)	0.042
sb:cb134	sb:cb134	0.042
rspo1	R-spondin homolog (Xenopus laevis)	0.042
slc25a22	solute carrier family 25 (mitochondrial carrier: glutamate), member 22	0.042
ubap2l	ubiquitin associated protein 2-like	0.042
plce1	phospholipase C, epsilon 1	0.042
mmp2	matrix metalloproteinase 2	0.042
phf8	PHD finger protein 8	0.042
sh3gl1b	SH3-domain GRB2-like 1b	0.042
ak3	adenylate kinase 3	0.042
plekhg5a	pleckstrin homology domain containing, family G (with RhoGef domain) member 5a	0.042
arl4ab	ADP-ribosylation factor-like 4ab	0.042
ppp3r1b	protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b	0.042
gna13b	guanine nucleotide binding protein (G protein), alpha 13b	0.042
polr2b	polymerase (RNA) II (DNA directed) polypeptide B	0.041
mbtps1	membrane-bound transcription factor protease, site 1	0.041
zbtb10	zinc finger and BTB domain containing 10	0.041
papolb	poly(A) polymerase beta (testis specific)	0.041
si:dkey-236e20.2	si:dkey-236e20.2	0.041
LOC555739	serine/threonine-protein kinase LMTK1-like	0.041
ncam2	neural cell adhesion molecule 2	0.041
hmx3	homeo box (H6 family) 3	0.041
stmn4l	stathmin-like 4, like	0.041
appl1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.040
dtnbp1a	dystrobrevin binding protein 1a	0.040
mapk6	mitogen-activated protein kinase 6	0.040
zgc:110343	zgc:110343	0.040
neo1	neogenin 1	0.040
runx1	runt-related transcription factor 1	0.040
cct2	chaperonin containing TCP1, subunit 2 (beta)	0.040
mllt10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	0.040
zgc:77155	zgc:77155	0.039
lrrtm1	leucine rich repeat transmembrane neuronal 1	0.039
axin2	axin 2 (conductin, axil)	0.039
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.039
actn1	actinin, alpha 1	0.039
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.039
agtr2	angiotensin II receptor, type 2	0.039
per2	period homolog 2 (Drosophila)	0.039
zeb1	zinc finger E-box binding homeobox 1	0.039
fam84a	family with sequence similarity 84, member A	0.039
hsp47	heat shock protein 47	0.039
gng12a	guanine nucleotide binding protein (G protein), gamma 12a	0.039
zgc:56049	zgc:56049	0.039
mknk2b	MAP kinase-interacting serine/threonine kinase 2b	0.039
mllt11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	0.039
gna12	guanine nucleotide binding protein (G protein) alpha 12	0.039
bmp2a	bone morphogenetic protein 2a	0.039	Human
cldn2	claudin 2	0.039
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.039
copb2	coatomer protein complex, subunit beta 2	0.039
stc1l	stanniocalcin 1, like	0.039
zgc:112018	zgc:112018	0.039
zgc:92194	zgc:92194	0.039
mpz	myelin protein zero	0.038
eif4e3	eukaryotic translation initiation factor 4E family member 3	0.038
spata2	spermatogenesis associated 2	0.038
zgc:110682	zgc:110682	0.038
LOC570459	bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1-like	0.038
gna13a	guanine nucleotide binding protein (G protein), alpha 13a	0.038
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.038
ppp4r1	protein phosphatase 4, regulatory subunit 1	0.038
suz12b	suppressor of zeste 12 homolog (Drosophila) b	0.038
zgc:114108	zgc:114108	0.038
fas	Fas (TNF receptor superfamily, member 6)	0.038
notch3	notch homolog 3	0.038
fktn	fukutin	0.038
vtnb	vitronectin b	0.038
rhcgl1	Rhesus blood group, C glycoprotein, like 1	0.038
oxsr1a	oxidative-stress responsive 1a	0.038
cyp2p6	cytochrome P450, family 2, subfamily P, polypeptide 6	0.038
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.038
si:dkey-117n7.5	si:dkey-117n7.5	0.038
vps39	vacuolar protein sorting 39 homolog (S. cerevisiae)	0.038
snrk1	SNF related kinase 1	0.038
gip	gastric inhibitory polypeptide	0.038
dusp7	dual specificity phosphatase 7	0.038
pou1f1	POU domain, class 1, transcription factor 1	0.037
bmpr1ab	bone morphogenetic protein receptor, type 1ab	0.037
raf1a	v-raf-1 murine leukemia viral oncogene homolog 1a	0.037
acsbg2	acyl-CoA synthetase bubblegum family member 2	0.037
myod1	myogenic differentiation 1	0.037
dip2c	DIP2 disco-interacting protein 2 homolog C (Drosophila)	0.037
sod1	superoxide dismutase 1, soluble	0.037
smu1	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	0.037
sept7a	septin 7a	0.037
sb:cb540	sb:cb540	0.037
lass2	LAG1 homolog, ceramide synthase 2 (S. cerevisiae)	0.037
kbp	kif1-binding protein	0.037
smchd1	structural maintenance of chromosomes flexible hinge domain containing 1	0.037
si:ch211-204d2.5	si:ch211-204d2.5	0.036
wdr45l	wdr45 like	0.036
ntrk2a	neurotrophic tyrosine kinase, receptor, type 2a	0.036
map2k2a	mitogen-activated protein kinase kinase 2a	0.036	Fly
pak2a	p21 (CDKN1A)-activated kinase 2a	0.036
usp25	ubiquitin specific protease 25	0.036
zgc:91968	zgc:91968	0.036
csrp1a	cysteine and glycine-rich protein 1a	0.036
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.036
kng1	kininogen 1	0.035
epn1	epsin 1	0.035
zgc:56064	zgc:56064	0.035
pdcd6ip	programmed cell death 6 interacting protein	0.035
nrp2a	neuropilin 2a	0.035
mecp2	methyl CpG binding protein 2	0.035
sb:eu563	sb:eu563	0.035
zgc:55936	zgc:55936	0.035
nog2	noggin 2	0.035
arl4cb	ADP-ribosylation factor-like 4Cb	0.035
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.035
lndc1	ly6/neurotoxin domain containing 1	0.035
srrm2	serine/arginine repetitive matrix 2	0.035
fhl3	four and a half LIM domains 3	0.035
atoh1b	atonal homolog 1b	0.035
myo1bl2	myosin 1b-like 2	0.035
vps35	vacuolar protein sorting 35 (yeast)	0.034
frzb	frizzled-related protein	0.034
sb:cb190	sb:cb190	0.034
nkx2.1a	NK2 homeobox 1a	0.034
si:ch211-114c12.2	si:ch211-114c12.2	0.034
sb:eu1661	sb:eu1661	0.034
cldna	claudin a	0.034
plag1	pleiomorphic adenoma gene 1	0.034
fabp11a	fatty acid binding protein 11a	0.034
ankrd13c	ankyrin repeat domain 13C	0.034
arhgap21b	Rho GTPase activating protein 21b	0.034
LOC556764	similar to Probable RNA-dependent helicase p72 (DEAD-box protein p72) (DEAD-box protein 17)	0.034
fbxl5	F-box and leucine-rich repeat protein 5	0.034
gatad2a	GATA zinc finger domain containing 2A	0.034
zgc:103530	zgc:103530	0.034
acvr2b	activin receptor IIb	0.034
zgc:63602	zgc:63602	0.034
hoxc11a	homeo box C11a	0.034
mapk7	mitogen-activated protein kinase 7	0.034
prox2	prospero homeobox 2	0.034
zgc:123010	zgc:123010	0.034
zgc:112211	zgc:112211	0.034
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.034
nr5a1b	nuclear receptor subfamily 5, group A, member 1b	0.034
amotl2a	angiomotin like 2a	0.033
ptrfb	polymerase I and transcript release factor b	0.033
ptena	phosphatase and tensin homolog A	0.033
ncoa3	nuclear receptor coactivator 3	0.033
dcun1d4	DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)	0.033
rag1	recombination activating gene 1	0.033
matn4	matrilin 4	0.033
rbms3	RNA binding motif, single stranded interacting protein	0.033
mmp15b	matrix metallopeptidase 15b	0.033
mapkapk2a	mitogen-activated protein kinase-activated protein kinase 2a	0.033
esrrb	estrogen-related receptor beta	0.033
igf2b	insulin-like growth factor 2b	0.033
metrnl	meteorin, glial cell differentiation regulator-like	0.033
stm	starmaker	0.033
otpa	orthopedia homolog a	0.033
arf2	ADP-ribosylation factor 2	0.033
p4ha2	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2	0.033
snx27	sorting nexin family member 27	0.033
si:ch211-216l23.2	si:ch211-216l23.2	0.033
valopb	vertebrate ancient long opsin b	0.033
cops6	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	0.033
adrm1b	adhesion regulating molecule 1b	0.033
tas2r200.1	taste receptor, type 2, member 200.1	0.033
gclc	glutamate-cysteine ligase, catalytic subunit	0.032
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.032
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.032
fli1a	friend leukemia integration 1a	0.032
gorab	golgin, rab6-interacting	0.032
kdm5c	lysine (K)-specific demethylase 5C	0.032
col11a1b	collagen type XI alpha-1b and collagen, type XI, alpha 1b	0.032
zgc:63947	zgc:63947	0.032
tppp3	tubulin polymerization-promoting protein family member 3	0.032
hoxb6b	homeo box B6b	0.032
plk3	polo-like kinase 3 (Drosophila)	0.032
rgs4	regulator of G-protein signalling 4	0.032
cdc14b	CDC14 cell division cycle 14 homolog B	0.032
prp	persistent plexus	0.032
LOC100002334	hypothetical protein LOC100002334	0.032
lhx9	LIM homeobox 9	0.032
jup	junction plakoglobin	0.032
hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.032
tbp	TATA box binding protein	0.032
foxa3	forkhead box A3	0.032
pkp2	plakophilin 2	0.032
slka	STE20-like kinase a	0.032
nedd1	neural precursor cell expressed, developmentally down-regulated 1	0.032
aldh8a1	aldehyde dehydrogenase 8 family, member A1	0.032
mobkl2a	MOB1, Mps One Binder kinase activator-like 2A (yeast)	0.032
pcbp2	poly(rC) binding protein 2	0.032
ctnnb1	catenin (cadherin-associated protein), beta 1	0.032
myo5b	myosin VB	0.032
irak4	interleukin-1 receptor-associated kinase 4	0.032
si:dkeyp-22b2.3	si:dkeyp-22b2.3	0.032
zgc:193613	zgc:193613	0.032
tfeb	transcription factor EB	0.032
mxa	myxovirus (influenza) resistance A	0.031
iqgap1	IQ motif containing GTPase activating protein 1	0.031
plekha1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.031
mapk12	mitogen-activated protein kinase 12	0.031
plcb3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.031
zgc:85746	zgc:85746	0.031
fgf2	fibroblast growth factor 2	0.031
nfybb	nuclear transcription factor Y, beta b	0.031
zgc:112329	zgc:112329	0.031
nras	neuroblastoma RAS viral (v-ras) oncogene homolog	0.031
zgc:55573	zgc:55573	0.031
ltk	leukocyte tyrosine kinase	0.031	Fly
apoc2	apolipoprotein C-II	0.031
ywhae2	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2	0.031	Fly
fbxw11b	F-box and WD-40 domain protein 11b	0.031
zgc:153953	zgc:153953	0.031
cacnb3a	calcium channel, voltage-dependent, beta 3a	0.031
mafk	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)	0.031
paqr8	progestin and adipoQ receptor family member VIII	0.031
sb:eu863	sb:eu863	0.031
ccng1	cyclin G1	0.031
tjp3	tight junction protein 3	0.031
tsc2	tuberous sclerosis 2	0.031
zgc:195154	zgc:195154	0.031
bat1	HLA-B associated transcript 1	0.031
gdf6a	growth differentiation factor 6a	0.031
vegfab	vascular endothelial growth factor Ab	0.031	Human Mouse
pgr	progesterone receptor	0.031
fabp11b	fatty acid binding protein 11b	0.030
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.030
igf1rb	insulin-like growth factor 1b receptor	0.030
spred1	sprouty-related, EVH1 domain containing 1	0.030
zgc:55695	zgc:55695	0.030
fzd7b	frizzled homolog 7b	0.030
bnc1	basonuclin 1	0.030
reep5	receptor accessory protein 5	0.030
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.030
atp6v1h	ATPase, H+ transporting, lysosomal, V1 subunit H	0.030
chpf	chondroitin polymerizing factor	0.030
casp8	caspase 8, apoptosis-related cysteine peptidase	0.030
ugdh	UDP-glucose dehydrogenase	0.030
rbm4.2	RNA binding motif protein 4.2	0.030
bhmt	betaine-homocysteine methyltransferase	0.030
spop	speckle-type POZ protein	0.030
LOC798577	NT-3 growth factor receptor-like	0.030
zgc:112958	zgc:112958	0.030
im:7141132	im:7141132	0.030
cdc37	cell division cycle 37 homolog (S. cerevisiae)	0.030
zgc:73134	zgc:73134	0.030
kdr	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.030	Human
egfl7	EGF-like-domain, multiple 7	0.030
capns1a	calpain, small subunit 1 a	0.030
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.030
rprmb	reprimo, TP53 dependent G2 arrest mediator candidate b	0.030
rnd1	Rho family GTPase 1	0.030
naa35	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	0.030
eif1b	eukaryotic translation initiation factor 1B	0.030
mmd2	progestin and adipoQ receptor 10	0.030
klhl11	kelch-like 11 (Drosophila)	0.030
psmb3	proteasome (prosome, macropain) subunit, beta type, 3	0.030
stk24b	serine/threonine kinase 24b (STE20 homolog, yeast)	0.030
slc9a8	solute carrier family 9 (sodium/hydrogen exchanger), member 8	0.030
hoxa4a	homeo box A4a	0.030
sb:eu2436	sb:eu2436	0.030
stat5.2	signal transducer and activator of transcription 5.2	0.030
LOC100007758	novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3)	0.030
atp1a3a	ATPase, Na+/K+ transporting, alpha 3a polypeptide	0.030
xpo6	exportin 6	0.030
git2a	G protein-coupled receptor kinase interactor 2a	0.030
LOC100534970	hypothetical protein LOC100534970	0.029
znrf1	zinc and ring finger 1	0.029
LOC569779	Heavy chain, Unconventional Myosin family member (hum-6)-like	0.029
golga5	golgi autoantigen, golgin subfamily a, 5	0.029
cdk10	cyclin-dependent kinase 10	0.029
egr2a	early growth response 2a	0.029
brd2a	bromodomain-containing 2a	0.029
kctd10	potassium channel tetramerisation domain containing 10	0.029
gsx1	GS homeobox 1	0.029
zgc:152990	zgc:152990	0.029
csnk1g2b	casein kinase 1, gamma 2b	0.029
helt	hey-like transcription factor	0.029
actr3	ARP3 actin-related protein 3 homolog (yeast)	0.029
nxn	nucleoredoxin	0.029
b3galnt2	beta-1,3-N-acetylgalactosaminyltransferase 2	0.029
cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.029
psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.029
b4galt5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	0.029
spry2	sprouty homolog 2	0.029
prkci	protein kinase C, iota	0.029
LOC100535037	leukotriene B4 receptor 1-like	0.029
cga	glycoprotein hormones, alpha polypeptide	0.029
apom	apolipoprotein M	0.029
etv2	ets variant gene 2	0.029
gstt1b	glutathione S-transferase theta 1b	0.029
par1	paraxis	0.029
nphs1l	nephrosis 1, congenital, Finnish type (nephrin)-like	0.029
rab11a	RAB11a, member RAS oncogene family	0.029
ptmab	prothymosin, alpha b	0.029
zgc:92242	zgc:92242	0.029
si:dkey-42i9.10	si:dkey-42i9.10	0.029
zgc:172101	zgc:172101	0.029
appa	amyloid beta (A4) precursor protein a	0.029
sec23a	Sec23 homolog A (S. cerevisiae)	0.029
wu:fa16f04	wu:fa16f04	0.029
aida	axin interaction partner and dorsalization antagonist	0.029
LOC564872	monocarboxylate transporter 7-like	0.029
slc39a10	solute carrier family 39 (zinc transporter), member 10	0.029
cry2a	cryptochrome 2a	0.029
arhgef1	rho guanine nucleotide exchange factor (GEF) 1	0.029
atm	ataxia telangiectasia mutated	0.029
zgc:56533	zgc:56533	0.029
si:dkey-18f23.10	si:dkey-18f23.10	0.029
ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.029	Fly
cdc42se1	CDC42 small effector 1	0.029
hsp70l	heat shock cognate 70-kd protein, like	0.029
si:dkey-199f5.8	si:dkey-199f5.8	0.029
zgc:56628	zgc:56628	0.029
prpf3	PRP3 pre-mRNA processing factor 3 homolog (yeast)	0.029
si:ch73-73d17.3	si:ch73-73d17.3	0.029
im:7137453	im:7137453	0.028
tmem115	transmembrane protein 115	0.028
crlf3	cytokine receptor-like factor 3	0.028
ntrk3b	neurotrophic tyrosine kinase, receptor, type 3b	0.028
mgrn1a	mahogunin, ring finger 1a	0.028
zgc:172136	zgc:172136	0.028
znf536	zinc finger protein 536	0.028
appl2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.028
zgc:63948	zgc:63948	0.028
atp1a1a.5	ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide	0.028
fibin	fin bud initiation factor	0.028
gng5	guanine nucleotide binding protein (G protein), gamma 5	0.028
sh2d3cb	SH2 domain containing 3Cb	0.028
zgc:73349	zgc:73349	0.028
erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog	0.028	Human
wnt10a	wingless-type MMTV integration site family, member 10a	0.028
lsm14ab	LSM14 homolog Ab (SCD6, S. cerevisiae)	0.028
zgc:92244	zgc:92244	0.028
tfe3a	transcription factor binding to IGHM enhancer 3a	0.028
pink1	PTEN induced putative kinase 1	0.028
acp5b	acid phosphatase 5b, tartrate resistant	0.028
tmem93	transmembrane protein 93	0.028
hcrt	hypocretin (orexin) neuropeptide precursor	0.028
zdhhc5a	zinc finger, DHHC-type containing 5a	0.028
smad3b	MAD, mothers against decapentaplegic homolog 3b (Drosophila)	0.028
si:ch1073-204j4.2	si:ch1073-204j4.2	0.028
abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.028
zgc:66242	zgc:66242	0.028
msxb	muscle segment homeobox B	0.028
capns1b	calpain, small subunit 1 b	0.028
nrp2b	neuropilin 2b	0.028
si:ch211-14k19.8	si:ch211-14k19.8	0.028
fgf8b	fibroblast growth factor 8 b	0.028
nkx2.5	NK2 transcription factor related 5	0.028
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.028
slc35b2	solute carrier family 35, member B2	0.028
calm3b	calmodulin 3b (phosphorylase kinase, delta)	0.028
pfn2	profilin 2	0.028
nadl1.1	neural adhesion molecule L1.1	0.028
sfrp1a	secreted frizzled-related protein 1a	0.028
rrp15	ribosomal RNA processing 15 homolog (S. cerevisiae)	0.027
ck2a2a	casein kinase 2 alpha 2a	0.027
bcor	BCL6 co-repressor	0.027
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.027
cdr2l	cerebellar degeneration-related protein 2-like	0.027
flii	flightless I homolog (Drosophila)	0.027
zgc:66100	zgc:66100	0.027
nudt9	nudix (nucleoside diphosphate linked moiety X)-type motif 9	0.027
epha2	eph receptor A2	0.027	Human
aim1a	absent in melanoma 1a	0.027
fbxo42	F-box protein 42	0.027
snx30	sorting nexin family member 30	0.027
ptges3a	prostaglandin E synthase 3a (cytosolic)	0.027
pcdh1a4	protocadherin 1 alpha 4	0.027
rasgef1bb	RasGEF domain family, member 1Bb	0.027
zgc:103697	zgc:103697	0.027
znf711	zinc finger protein 711	0.027
angpt1	angiopoietin 1	0.027
tmub1	transmembrane and ubiquitin-like domain containing 1	0.027
bsk146	brain specific kinase 146	0.027
elovl1a	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1a	0.027
zgc:63566	zgc:63566	0.027
pfn1	profilin 1	0.027
plcg1	phospholipase C, gamma 1	0.027
dkk2	dickkopf homolog 2 (Xenopus laevis)	0.027
depdc5	DEP domain containing 5	0.027
git2b	G protein-coupled receptor kinase interactor 2b	0.027
max	myc-associated factor X	0.027
serpina1l	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like	0.027
mapk15	mitogen-activated protein kinase 15	0.027
hk1	hexokinase 1	0.027
sdcbp	syndecan binding protein (syntenin)	0.027
zgc:101577	zgc:101577	0.027
tgif1	TGFB-induced factor homeobox 1	0.027
zgc:171495	zgc:171495	0.027
tsen54	tRNA splicing endonuclease 54 homolog (S. cerevisiae)	0.027
ppm1aa	protein phosphatase, Mg2+/Mn2+ dependent, 1Aa	0.027	Fly
ptpn11b	protein tyrosine phosphatase, non-receptor type 11, b	0.027
ppp1r14bb	protein phosphatase 1, regulatory (inhibitor) subunit 14Bb	0.027
ptpn23a	protein tyrosine phosphatase, non-receptor type 23, a	0.027
traf4a	tnf receptor-associated factor 4a	0.027
lmo1	LIM domain only 1	0.027
cstf3	cleavage stimulation factor, 3' pre-RNA, subunit 3	0.027
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.027
npdc1	neural proliferation, differentiation and control, 1	0.027
smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.027
ppp2r5ea	protein phosphatase 2, regulatory subunit B', epsilon isoform a	0.027
tas2r200.2	taste receptor, type 2, member 200.2	0.027
zgc:85866	zgc:85866	0.027	Human
ints1	integrator complex subunit 1	0.027
acss2	acyl-CoA synthetase short-chain family member 2	0.027
col5a3	collagen, type V, alpha 3	0.026
usp9	ubiquitin specific peptidase 9	0.026
ext1b	exostoses (multiple) 1b	0.026
tecpr2	tectonin beta-propeller repeat containing 2	0.026
bcas2	breast carcinoma amplified sequence 2	0.026
btbd9	BTB (POZ) domain containing 9	0.026
si:dkey-181m9.9	si:dkey-181m9.9	0.026
atf4b1	activating transcription factor 4b1 (tax-responsive enhancer element B67)	0.026
ppp4cb	protein phosphatase 4 (formerly X), catalytic subunit b	0.026
phf17	PHD finger protein 17	0.026
dcn	decorin	0.026
stk17b	serine/threonine kinase 17b (apoptosis-inducing)	0.026
zgc:92834	zgc:92834	0.026
htt	huntingtin	0.026
wu:fj68a07	wu:fj68a07	0.026
usp33	ubiquitin specific peptidase 33	0.026
eif3d	eukaryotic translation initiation factor 3, subunit D	0.026
tmtc2	transmembrane and tetratricopeptide repeat containing 2	0.026
angptl2	angiopoietin-like 2	0.026
dhrsx	dehydrogenase/reductase (SDR family) X-linked	0.026
tmem86b	transmembrane protein 86B	0.026
nkx2.3	NK2 transcription factor related 3	0.026
si:ch211-197g15.10	si:ch211-197g15.10	0.026
sgk1	serum/glucocorticoid regulated kinase 1	0.026
polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.026
nsun2	NOL1/NOP2/Sun domain family, member 2	0.026
fibpl	fibroblast growth factor (acidic) intracellular binding protein, like	0.026
dkk3l	dickkopf homolog 3 like (Xenopus laevis)	0.026
hectd1	HECT domain containing 1	0.026
gfod2	glucose-fructose oxidoreductase domain containing 2	0.026
pbxip1b	pre-B-cell leukemia homeobox interacting protein 1b	0.026
waca	WW domain containing adaptor with coiled-coil a	0.026
lpar1	lysophosphatidic acid receptor 1	0.026
nipblb	novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)	0.026
scinlb	scinderin like b	0.026
s100a10b	S100 calcium binding protein A10b	0.026
LOC100006417	transcription factor 20-like	0.026
btg2	B-cell translocation gene 2	0.026
ntrk2b	neurotrophic tyrosine kinase, receptor, type 2b	0.026
pdxdc1	pyridoxal-dependent decarboxylase domain containing 1	0.026
si:ch1073-351m12.1	si:ch1073-351m12.1	0.026
twist1a	twist1a	0.026
arpc5b	actin related protein 2/3 complex, subunit 5B	0.026
si:dkey-15j16.3	si:dkey-15j16.3	0.026
prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.026
col5a3b	collagen type V alpha-3b	0.026
apob	apolipoprotein B	0.026
tlr1	toll-like receptor 1	0.025
trit1	tRNA isopentenyltransferase 1	0.025
zgc:103467	myosin, light chain 9, regulatory	0.025
sult6b1	sulfotransferase family, cytosolic, 6b, member 1	0.025
hpca	hippocalcin	0.025
inhbab	inhibin, beta Ab	0.025
hdc	histidine decarboxylase	0.025
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.025
ephb4a	eph receptor B4a	0.025
skiv2l2	superkiller viralicidic activity 2-like 2	0.025
mapta	microtubule-associated protein tau a	0.025
mmp9	matrix metalloproteinase 9	0.025
kdrl	kinase insert domain receptor like	0.025
lhcgr	luteinizing hormone/choriogonadotropin receptor	0.025
tbpl2	TATA box binding protein like 2	0.025
zgc:114058	zgc:114058	0.025
tectb	tectorin beta	0.025
LOC100537818	SPARC-related modular calcium-binding protein 2-like	0.025
pax4	paired box 4	0.025
si:dkeyp-117b8.3	si:dkeyp-117b8.3	0.025
zgc:92658	zgc:92658	0.025