IMP: Integrative Multi-species Prediction

Danio rerio

98 genes annotated in zebrafish

hepaticobiliary system development

The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "hepaticobiliary system development"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "hepaticobiliary system development" (in gray)

Name	Description	Probability	Func Analog Organism
gata6	GATA-binding protein 6	0.985
tbx1	T-box 1	0.958
gata5	GATA-binding protein 5	0.933
fgf3	fibroblast growth factor 3	0.926	Zebrafish
tp53	tumor protein p53	0.907
rarga	retinoic acid receptor gamma a	0.882
notch3	notch homolog 3	0.859
jag2	jagged 2	0.853
hnf1ba	HNF1 homeobox Ba	0.852
met	met proto-oncogene (hepatocyte growth factor receptor)	0.845
ahr2	aryl hydrocarbon receptor 2	0.803
bmp2a	bone morphogenetic protein 2a	0.773	Zebrafish
sec61al1	Sec61 alpha like 1	0.765
dld	deltaD	0.736
wnt5b	wingless-type MMTV integration site family, member 5b	0.718	Zebrafish
eya1	eyes absent homolog 1	0.712
cdx4	caudal type homeo box transcription factor 4	0.703	Zebrafish
foxa3	forkhead box A3	0.702	Rat
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.701
bhlhe40	basic helix-loop-helix family, member e40	0.694
fzd8a	frizzled homolog 8a	0.666	Zebrafish
gdf6a	growth differentiation factor 6a	0.643
flh	floating head	0.606
dkk1b	dickkopf 1b	0.590
bmp2b	bone morphogenetic protein 2b	0.589
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.586
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.562	Zebrafish
axin2	axin 2 (conductin, axil)	0.559
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.550
fzd7a	frizzled homolog 7a	0.542
osr1	odd-skipped related 1 (Drosophila)	0.532
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.530
id1	inhibitor of DNA binding 1	0.529
notch2	notch homolog 2	0.483
her6	hairy-related 6	0.458
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.456
LOC564872	monocarboxylate transporter 7-like	0.456
ahctf1	AT hook containing transcription factor 1	0.451
wnt3	wingless-type MMTV integration site family, member 3	0.444	Zebrafish
lef1	lymphocyte enhancer binding factor 1	0.433
wif1	wnt inhibitory factor 1	0.428
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.423
pea3	ETS-domain transcription factor pea3	0.402
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.402
tal1	T-cell acute lymphocytic leukemia 1	0.397
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.395
hhex	hematopoietically expressed homeobox	0.377
nf1a	neurofibromin 1a	0.373	Mouse
gata2a	GATA-binding protein 2a	0.363	Zebrafish
ndr2	nodal-related 2	0.363
dlc	deltaC	0.358	Zebrafish
gata4	GATA-binding protein 4	0.345
etv2	ets variant gene 2	0.319
pitx3	paired-like homeodomain transcription factor 3	0.318
krit1	KRIT1, ankyrin repeat containing	0.314
slc2a13	solute carrier family 2 (facilitated glucose transporter), member 13	0.311
nav3	neuron navigator 3	0.310
nrp2b	neuropilin 2b	0.295
hmgcs1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	0.293
lmo4a	LIM domain only 4a	0.291
egr2b	early growth response 2b	0.289
cdh1	cadherin 1, epithelial	0.280
kdrl	kinase insert domain receptor like	0.279
vps39	vacuolar protein sorting 39 homolog (S. cerevisiae)	0.277
vcana	versican a	0.274
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.272
tagln2	transgelin 2	0.269
jag1b	jagged 1b	0.265
fgfr1a	fibroblast growth factor receptor 1a	0.263
pax6b	paired box gene 6b	0.263
rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.261
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.257
map2k4a	mitogen-activated protein kinase kinase 4a	0.256
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.254
fn1	fibronectin 1	0.254
spry4	sprouty (Drosophila) homolog 4	0.253
ifnphi1	interferon phi 1	0.252
pcdh18a	protocadherin 18a	0.247
ftr82	finTRIM family, member 82	0.247
wnt11	wingless-type MMTV integration site family, member 11	0.245	Zebrafish
slc2a11l	solute carrier family 2 (facilitated glucose transporter), member 11-like	0.244	Zebrafish
bmp4	bone morphogenetic protein 4	0.243
prkci	protein kinase C, iota	0.240
tgfbr2	transforming growth factor, beta receptor II	0.238	Zebrafish
wnt2ba	wingless-type MMTV integration site family, member 2Ba	0.236	Zebrafish
tlr21	toll-like receptor 21	0.232
myh11a	myosin, heavy polypeptide 11, smooth muscle a	0.230
sox9b	SRY-box containing gene 9b	0.227
epb41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.226
snapc4	small nuclear RNA activating complex, polypeptide 4	0.225
myca	myelocytomatosis oncogene a	0.220
appb	amyloid beta (A4) precursor protein b	0.220
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.218
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.215
flt4	fms-related tyrosine kinase 4	0.209
ahcy	S-adenosylhomocysteine hydrolase	0.208
vent	ventral expressed homeobox	0.206
sox17	SRY-box containing gene 17	0.206	Zebrafish Mouse
dhrs9	dehydrogenase/reductase (SDR family) member 9	0.205
sec13	SEC13 homolog (S. cerevisiae)	0.205
spaw	southpaw	0.202
neo1	neogenin 1	0.195
mecom	MDS1 and EVI1 complex locus	0.195
mespa	mesoderm posterior a	0.191	Mouse
il17rd	interleukin 17 receptor D	0.190
vtg1	vitellogenin 1	0.188
LOC560602	novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)	0.184
tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.181
per3	period homolog 3 (Drosophila)	0.180
kctd15a	potassium channel tetramerisation domain containing 15a	0.179
nrarpb	notch-regulated ankyrin repeat protein b	0.179
runx2a	runt-related transcription factor 2a	0.173
rbm19	RNA binding motif protein 19	0.172
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.172
cp	ceruloplasmin	0.170
snrk1	SNF related kinase 1	0.169
traf4a	tnf receptor-associated factor 4a	0.165
slc2a12	solute carrier family 2 (facilitated glucose transporter), member 12	0.165
fgf10a	fibroblast growth factor 10a	0.163
tbx2b	T-box 2b	0.159
klf4a	Kruppel-like transcription factor 4a	0.158
yap1	Yes-associated protein 1	0.157
sox10	SRY-box containing gene 10	0.157
ptgs1	prostaglandin-endoperoxide synthase 1	0.157
her12	hairy-related 12	0.154
enc1	ectodermal-neural cortex (with BTB-like domain)	0.152
wnt10a	wingless-type MMTV integration site family, member 10a	0.150	Zebrafish
ier2	immediate early response 2	0.150
osr2	odd-skipped related 2 (Drosophila)	0.150
bmp15	bone morphogenetic protein 15	0.149
vsx2	visual system homeobox 2	0.147
frzb	frizzled-related protein	0.146	Zebrafish Mouse
gli1	GLI-Kruppel family member 1	0.146
mtmr8	myotubularin related protein 8	0.145
elovl2	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	0.144
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.143
six2a	sine oculis-related homeobox 2a	0.143
slc2a15b	solute carrier family 2 (facilitated glucose transporter), member 15b	0.143	Zebrafish
slc2a9l2	solute carrier family 2 (facilitated glucose transporter), member 9-like 2	0.143
krt4	keratin 4	0.143
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.141
gdf11	growth differentiation factor 11	0.141
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.139
rxrba	retinoid x receptor, beta a	0.138
arhgef7b	Rho guanine nucleotide exchange factor (GEF) 7b	0.135
esrp1	epithelial splicing regulatory protein 1	0.135
si:dkeyp-7c9.1	si:dkeyp-7c9.1	0.135
arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.134
snai1b	snail homolog 1b (Drosophila)	0.134
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.134
ros1	v-ros UR2 sarcoma virus oncogene homolog 1 (avian)	0.131
mt2	metallothionein 2	0.131
bmpr2a	bone morphogenetic protein receptor, type II a (serine/threonine kinase)	0.130	Zebrafish
tbx6	T-box gene 6	0.129
pcdh8	protocadherin 8	0.128
rxrga	retinoid x receptor, gamma a	0.128
aplnra	apelin receptor a	0.128
gata3	GATA-binding protein 3	0.128	Zebrafish
zgc:64114	zgc:64114	0.126
efnb1	ephrin B1	0.126
ccm2	cerebral cavernous malformation 2	0.124
pcsk5a	proprotein convertase subtilisin/kexin type 5a	0.123
gli2a	GLI-Kruppel family member GLI2a	0.123
wnt4a	wingless-type MMTV integration site family, member 4a	0.121	Zebrafish
c11orf2	c11orf2 homolog (H. sapiens)	0.121
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.120
hif1ab	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b	0.120
rhoub	ras homolog gene family, member Ub	0.116
klf4	Kruppel-like factor 4	0.116	Zebrafish
bmpr2b	bone morphogenetic protein receptor, type II b (serine/threonine kinase)	0.116	Zebrafish
tjp3	tight junction protein 3	0.114
col2a1a	collagen type II, alpha-1a	0.113
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.112
wnt8b	wingless-type MMTV integration site family, member 8b	0.112	Zebrafish
ctsl1b	cathepsin L, 1 b	0.111
eml2	echinoderm microtubule associated protein like 2	0.111
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.111
rarab	retinoic acid receptor, alpha b	0.110
idh1	isocitrate dehydrogenase 1 (NADP+), soluble	0.108
drl	draculin	0.108
adh5	alcohol dehydrogenase 5	0.107
foxi3a	forkhead box I3a	0.107
kita	kit receptor a	0.106
nkx6.2	NK6 transcription factor related, locus 2	0.105
cdh2	cadherin 2, neuronal	0.104
wnt10b	wingless-type MMTV integration site family, member 10b	0.104	Zebrafish
sox2	SRY-box containing gene 2	0.103	Zebrafish
LOC560358	solute carrier family 2, facilitated glucose transporter member 11-like	0.103
wnt9b	wingless-type MMTV integration site family, member 9B	0.103	Zebrafish
mapk4	mitogen-activated protein kinase 4	0.103
hk1	hexokinase 1	0.103
snap25a	synaptosome-associated protein 25a	0.102
sult1st4	sulfotransferase family 1, cytosolic sulfotransferase 4	0.102
nipblb	novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)	0.102
sox19b	SRY-box containing gene 19b	0.102	Zebrafish
cat	catalase	0.101
boc	brother of CDO	0.101
gstp1	glutathione S-transferase pi	0.100
LOC100000934	hypothetical protein LOC100000934	0.100
sox19a	SRY-box containing gene 19a	0.100	Zebrafish
slc2a11b	solute carrier family 2 (facilitated glucose transporter), member 11b	0.100	Zebrafish
dsc2l	desmocollin 2 like	0.099
bbs4	Bardet-Biedl syndrome 4	0.099
hoxa13b	homeo box A13b	0.098
fadd	Fas (tnfrsf6)-associated via death domain	0.096
nrg1	neuregulin 1	0.096
hdr	hematopoietic death receptor	0.095
atp2b1a	ATPase, Ca++ transporting, plasma membrane 1a	0.094
sid4	secreted immunoglobulin domain 4	0.094
sulf1	sulfatase 1	0.094
copeb	core promoter element binding protein	0.093
hgfa	hepatocyte growth factor a	0.092	Mouse
slc2a8	solute carrier family 2 (facilitated glucose transporter), member 8	0.092
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.092
jag1a	jagged 1a	0.092	Zebrafish
ef1a	elongation factor 1-alpha	0.091
socs1	suppressor of cytokine signaling 1	0.091
sfrp1b	secreted frizzled-related protein 1b	0.091	Zebrafish
snx17	sorting nexin 17	0.091
vhl	von Hippel-Lindau tumor suppressor	0.091
nr1d2b	nuclear receptor subfamily 1, group D, member 2b	0.091	Zebrafish
tll1	tolloid-like 1	0.090
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.089
fgf20b	fibroblast growth factor 20b	0.089
gpr126	G protein-coupled receptor 126	0.089
tgfb3	transforming growth factor, beta 3	0.088
mnx1	motor neuron and pancreas homeobox 1	0.088
polr3b	polymerase (RNA) III (DNA directed) polypeptide B	0.087
nhsl1b	NHS-like 1b	0.087
zgc:112056	zgc:112056	0.087
onecutl	one cut domain, family member, like	0.086	Zebrafish
acadl	acyl-Coenzyme A dehydrogenase, long chain	0.086
ctsl1a	cathepsin L, 1 a	0.086
six4b	sine oculis homeobox homolog 4b	0.086
ext1a	exostoses (multiple) 1a	0.086
cdh5	cadherin 5	0.086
gpx1a	glutathione peroxidase 1a	0.086
lmbr1l	limb region 1 like	0.085
csnk1da	casein kinase 1, delta a	0.085
hmx3	homeo box (H6 family) 3	0.084
wnt4b	wingless-type MMTV integration site family, member 4b	0.084	Zebrafish
erbb3a	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a	0.084
mib	mind bomb	0.084
bmp3	bone morphogenetic protein 3	0.083
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.083
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.083	Zebrafish
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.083
myd88	myeloid differentiation primary response gene (88)	0.083
lamb1a	laminin, beta 1a	0.083
zbtb4	zinc finger and BTB domain containing 4	0.083
perp	PERP, TP53 apoptosis effector	0.083
zgc:101606	zgc:101606	0.082
inka1a	induced in neural crest by AP2, 1a	0.082
slc2a1a	solute carrier family 2 (facilitated glucose transporter), member 1a	0.082	Zebrafish
aplnrb	apelin receptor b	0.082
grnb	granulin b	0.082	Zebrafish
foxe3	forkhead box E3	0.082
krml2.2	Kreisler (mouse) maf-related leucine zipper homolog 2.2	0.081
slc2a9l1	solute carrier family 2 (facilitated glucose transporter), member 9-like 1	0.081	Zebrafish
cldn5a	claudin 5a	0.081
esama	endothelial cell adhesion molecule a	0.080
robo1	roundabout homolog 1	0.080
runx1	runt-related transcription factor 1	0.080
fibin	fin bud initiation factor	0.080
rnd1l	Rho family GTPase 1 like	0.079
bhmt	betaine-homocysteine methyltransferase	0.079
ecscr	endothelial cell-specific chemotaxis regulator	0.079
pcna	proliferating cell nuclear antigen	0.079
neurog1	neurogenin 1	0.079
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.078
apoeb	apolipoprotein Eb	0.078
igf1	insulin-like growth factor 1	0.078
gpia	glucose phosphate isomerase a	0.078
slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.078
dlx4b	distal-less homeobox gene 4b	0.077
dnmt7	DNA (cytosine-5-)-methyltransferase 7	0.077
lamc1	laminin, gamma 1	0.077
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.076
zgc:110298	zgc:110298	0.076
selp	selectin P	0.076
pgm1	phosphoglucomutase 1	0.076
hbbe3	hemoglobin beta embryonic-3	0.076
mtor	mechanistic target of rapamycin (serine/threonine kinase)	0.076
thraa	thyroid hormone receptor alpha a	0.075	Zebrafish Rat
tp63	tumor protein p63	0.075
hoxd4a	homeo box D4a	0.075
sema3aa	semaphorin 3aa	0.075
spns2	spinster homolog 2 (Drosophila)	0.074
llgl2	lethal giant larvae homolog 2 (Drosophila)	0.074
esr2a	estrogen receptor 2a	0.073
erbb3b	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b	0.073
wnt1	wingless-type MMTV integration site family, member 1	0.073	Zebrafish
adh8b	alcohol dehydrogenase 8b	0.073
nf1b	neurofibromin 1b	0.072	Mouse
hoxa13a	homeo box A13a	0.072
mtp	microsomal triglyceride transfer protein	0.071
phex	phosphate regulating gene with homologues to endopeptidases on the X chromosome	0.071
pmp22a	peripheral myelin protein 22a	0.071
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.070
shhb	sonic hedgehog b	0.070
notch1a	notch homolog 1a	0.070	Zebrafish Mouse
pdlim3b	PDZ and LIM domain 3b	0.070
nrg2a	neuregulin 2a	0.070
celf1	cugbp, Elav-like family member 1	0.070
cds2	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2	0.069
gcm2	glial cells missing homolog 2 (Drosophila)	0.069
vcp	valosin containing protein	0.069
glcea	glucuronyl C5-epimerase a	0.069
fzd10	frizzled homolog 10	0.069	Zebrafish
wt1a	wilms tumor 1a	0.069
uros	uroporphyrinogen III synthase	0.069
tgfb1a	transforming growth factor, beta 1a	0.069
erg	v-ets erythroblastosis virus E26 oncogene like (avian)	0.069
adh8a	alcohol dehydrogenase 8a	0.069
loxl2b	lysyl oxidase-like 2b	0.069
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.069
cyp24a1	cytochrome P450, family 24, subfamily A, polypeptide 1	0.068
lin28a	lin-28 homolog A (C. elegans)	0.068
vcanb	versican b	0.068
aldob	aldolase b, fructose-bisphosphate	0.068
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.068
snai2	snail homolog 2 (Drosophila)	0.068
hdac1	histone deacetylase 1	0.068
irx2a	iroquois homeobox protein 2, a	0.067
ptmab	prothymosin, alpha b	0.067
tagln3b	transgelin 3b	0.067
sod1	superoxide dismutase 1, soluble	0.066
dnmt8	DNA (cytosine-5-)-methyltransferase 8	0.066
grhl2b	grainyhead-like 2b (Drosophila)	0.066
fes	feline sarcoma oncogene	0.066
wnt5a	wingless-type MMTV integration site family, member 5a	0.066	Zebrafish
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.066
tcf12	transcription factor 12	0.066
bmper	BMP binding endothelial regulator	0.065
pax2a	paired box gene 2a	0.065
prickle1a	prickle-like 1 (Drosophila) a	0.065
bhlhe41	basic helix-loop-helix family, member e41	0.065
efnb2a	ephrin B2a	0.065
syf2	SYF2 homolog, RNA splicing factor (S. cerevisiae)	0.065
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.065	Human
paics	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	0.064
lft1	lefty1	0.064
il13ra2	interleukin 13 receptor, alpha 2	0.064
mical3	flavoprotein oxidoreductase MICAL3	0.064
mvk	mevalonate kinase	0.063
stk11	serine/threonine kinase 11	0.063
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.063
kdr	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.063
dlx3b	distal-less homeobox gene 3b	0.063
mmp15b	matrix metallopeptidase 15b	0.063
scrib	scribbled homolog (Drosophila)	0.063
mst1	macrophage stimulating 1 (hepatocyte growth factor-like)	0.062
mga	MAX gene associated	0.062
appa	amyloid beta (A4) precursor protein a	0.062
smad3a	MAD homolog 3a (Drosophila)	0.061	Mouse
snx9l	sorting nexin 9-like	0.061
si:ch211-93f2.1	si:ch211-93f2.1	0.061
kif17	kinesin family member 17	0.061
hmx1	H6 homeo box 1	0.061
fgfr2	fibroblast growth factor receptor 2	0.061
twist2	twist2	0.061
fzd6	frizzled homolog 6 (Drosophila)	0.061
rhov	ras homolog gene family, member V	0.061
zgc:162630	zgc:162630	0.061
esrra	estrogen-related receptor alpha	0.061
wnt2	wingless-type MMTV integration site family member 2	0.061
odc1	ornithine decarboxylase 1	0.060
her7	hairy and enhancer of split related-7	0.060
hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase	0.060
cldn7b	claudin 7b	0.060
spna2	spectrin alpha 2	0.060
acox1	acyl-Coenzyme A oxidase 1, palmitoyl	0.060
axin1	axin 1	0.060
wnt8a	wingless-type MMTV integration site family, member 8a	0.060	Zebrafish
nos2a	nitric oxide synthase 2a, inducible	0.060	Zebrafish
wnt7bb	wingless-type MMTV integration site family, member 7Bb	0.060
nr5a2	nuclear receptor subfamily 5, group A, member 2	0.060
sim2	single-minded homolog 2 (Drosophila)	0.060
ulk2	unc-51-like kinase 2 (C. elegans)	0.060
nrarpa	notch-regulated ankyrin repeat protein a	0.060
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.059
kif3b	kinesin family member 3B	0.059
ntla	no tail a	0.059
jak2a	Janus kinase 2a	0.059	Zebrafish
fzd7b	frizzled homolog 7b	0.059	Zebrafish
smad3b	MAD, mothers against decapentaplegic homolog 3b (Drosophila)	0.059	Mouse
foxj1a	forkhead box J1a	0.059
otx5	orthodenticle homolog 5	0.059
gas6	growth arrest-specific 6	0.059
nr6a1a	nuclear receptor subfamily 6, group A, member 1a	0.059
rtn1a	reticulon 1a	0.058
ldha	lactate dehydrogenase A4	0.058
smo	smoothened homolog (Drosophila)	0.058
hbae3	hemoglobin alpha embryonic-3	0.058
sox11a	SRY-box containing gene 11a	0.058
insrb	insulin receptor b	0.058
wt1b	wilms tumor 1b	0.057
znf503	zinc finger protein 503	0.057
igf2b	insulin-like growth factor 2b	0.057
abcc1	ATP-binding cassette, sub-family C, member 1	0.057
sox3	SRY-box containing gene 3	0.056	Zebrafish
angptl2	angiopoietin-like 2	0.056
fzd2	frizzled homolog 2	0.056	Zebrafish
trim3a	tripartite motif-containing 3a	0.056
mespb	mesoderm posterior b	0.056	Mouse
pitx2	paired-like homeodomain transcription factor 2	0.056
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.056
limk2	LIM domain kinase 2	0.055
tlr9	toll-like receptor 9	0.055
tnfsf10l2	tumor necrosis factor (ligand) superfamily, member 10 like 2	0.055	Zebrafish
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.055
emx2	empty spiracles homeobox 2	0.055
vtg3	vitellogenin 3, phosvitinless	0.055
syt13	synaptotagmin XIII	0.055
sall1a	sal-like 1a (Drosophila)	0.055
foxj1b	forkhead box J1b	0.055
tnfrsfa	tumor necrosis factor receptor superfamily, member a	0.054
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.054
zgc:66433	zgc:66433	0.054
wtip	Wilms tumor 1 interacting protein	0.054
ap3m2	adaptor-related protein complex 3, mu 2 subunit	0.054
her1	hairy-related 1	0.054
rfng	radical fringe homolog (Drosophila)	0.054
zeb2a	zinc finger E-box binding homeobox 2a	0.054
fn1b	fibronectin 1b	0.053
a2ml	alpha-2-macroglobulin-like	0.053
zic4	zic family member 4	0.053
zgc:114199	zgc:114199	0.053
cd99l2	CD99 antigen-like 2	0.052
dnajc24	DnaJ (Hsp40) homolog, subfamily C, member 24	0.052
vax2	ventral anterior homeobox 2	0.052
col17a1b	collagen, type XVII, alpha 1b	0.052
lmo2	LIM domain only 2 (rhombotin-like 1)	0.052
diexf	digestive organ expansion factor homolog	0.052
ifng1-2	interferon, gamma 1-2	0.051
uqcrc1	ubiquinol-cytochrome c reductase core protein I	0.051
zgc:110343	zgc:110343	0.051
gbx1	gastrulation brain homeobox 1	0.051
ryk	receptor-like tyrosine kinase	0.051
rxrab	retinoid x receptor, alpha b	0.051
rhag	Rhesus blood group-associated glycoprotein	0.050
dazl	daz-like gene	0.050
klf2a	Kruppel-like factor 2a	0.050
fzd5	frizzled homolog 5	0.049
etv5a	ets variant 5a	0.049
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.049
cald1	caldesmon 1	0.049
ezh2	enhancer of zeste homolog 2 (Drosophila)	0.049
si:dkey-261h17.1	si:dkey-261h17.1	0.049
heyl	hairy/enhancer-of-split related with YRPW motif-like	0.049
arl4ab	ADP-ribosylation factor-like 4ab	0.049
epb4.1l4	erythrocyte protein band 4.1-like 4	0.049
sfrp1a	secreted frizzled-related protein 1a	0.049	Zebrafish
serinc1	serine incorporator 1	0.049
zgc:112522	zgc:112522	0.049
socs3a	suppressor of cytokine signaling 3a	0.048
slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	0.048
sesn1	sestrin 1	0.048
mst1rb	macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b	0.048
hand2	heart and neural crest derivatives expressed transcript 2	0.048
mmp9	matrix metalloproteinase 9	0.048	Zebrafish
nfe2	nuclear factor, erythroid-derived 2	0.048
slc25a37	solute carrier family 25, member 37	0.048
proc	protein C (inactivator of coagulation factors Va and VIIIa)	0.048
rasl11b	RAS-like, family 11, member B	0.048
epas1b	endothelial PAS domain protein 1b	0.048
lbr	lamin B receptor	0.048
celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.047
lpin1	lipin 1	0.047
edn1	endothelin 1	0.047
her5	hairy-related 5	0.047
alas2	aminolevulinate, delta-, synthetase 2	0.047
fli1a	friend leukemia integration 1a	0.047
tmie	transmembrane inner ear	0.047
pob	partial optokinetic response b	0.047
sox21a	SRY-box containing gene 21a	0.046
dctn1a	dynactin 1a	0.046
zgc:100933	zgc:100933	0.046
park7	parkinson disease (autosomal recessive, early onset) 7	0.046
mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.046
cx30.3	connexin 30.3	0.046
pdzk1	PDZ domain containing 1	0.046
esr2b	estrogen receptor 2b	0.046
smad1	MAD homolog 1 (Drosophila)	0.046
nog2	noggin 2	0.046
inhbaa	inhibin, beta Aa	0.045
hdlbp	high density lipoprotein-binding protein (vigilin)	0.045
mcoln1	mucolipin 1	0.045
sox11b	SRY-box containing gene 11b	0.045
micall2a	mical-like 2a	0.045
bactin2	bactin2	0.045
wu:fb80a07	wu:fb80a07	0.045
wnt7aa	wingless-type MMTV integration site family, member 7Aa	0.045	Zebrafish
gng2	guanine nucleotide binding protein (G protein), gamma 2	0.045
im:7162646	im:7162646	0.045
csnk1db	casein kinase 1, delta b	0.045
ptrfb	polymerase I and transcript release factor b	0.045
gbx2	gastrulation brain homeo box 2	0.045
erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog	0.045	Rat
rspo1	R-spondin homolog (Xenopus laevis)	0.045
alg1	asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase)	0.045
zdhhc8b	zinc finger, DHHC-type containing 8b	0.045
nfe2l2	nuclear factor (erythroid-derived 2)-like 2	0.044
tpbgl	trophoblast glycoprotein-like	0.044
lhx3	LIM homeobox 3	0.044
sb:cb166	sb:cb166	0.044
zgc:101614	zgc:101614	0.044
nr1d1	nuclear receptor subfamily 1, group d, member 1	0.044	Zebrafish
si:ch211-89f7.4	si:ch211-89f7.4	0.044
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.044
mbtps1	membrane-bound transcription factor protease, site 1	0.044
zfp36l1a	zinc finger protein 36, C3H type-like 1a	0.044
ptf1a	pancreas specific transcription factor, 1a	0.044
ripk2	receptor-interacting serine-threonine kinase 2	0.044
snai1a	snail homolog 1a (Drosophila)	0.043
igfbp1a	insulin-like growth factor binding protein 1a	0.043
spi1l	spleen focus forming virus (SFFV) proviral integration oncogene spi1 like	0.043
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.043
rnf2	ring finger protein 2	0.043
setd5	SET domain containing 5	0.043
wu:fc46h12	wu:fc46h12	0.043
dll4	delta-like 4 (Drosophila)	0.043	Zebrafish
tmprss4a	transmembrane protease, serine 4a	0.043
sgk1	serum/glucocorticoid regulated kinase 1	0.043
rorca	RAR-related orphan receptor C a	0.043
cad	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	0.043
sema3h	semaphorin 3h	0.043
igfbp7	insulin-like growth factor binding protein 7	0.043
mxtx2	mix-type homeobox gene 2	0.042
clec14a	C-type lectin domain family 14, member A	0.042
rorcb	RAR-related orphan receptor C b	0.042
LOC555739	serine/threonine-protein kinase LMTK1-like	0.042
dlb	deltaB	0.042	Zebrafish
mtch2	mitochondrial carrier homolog 2	0.042
spint1a	serine peptidase inhibitor, Kunitz type 1 a	0.042
gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.042
tlr3	toll-like receptor 3	0.042
tmem170a	transmembrane protein 170A	0.042
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.042
zgc:122977	zgc:122977	0.042
esrp2	epithelial splicing regulatory protein 2	0.042
stat1b	signal transducer and activator of transcription 1b	0.041
hoxb3a	homeo box B3a	0.041
glula	glutamate-ammonia ligase (glutamine synthase) a	0.041
dpysl5a	dihydropyrimidinase-like 5a	0.041
tph1b	tryptophan hydroxylase 1b	0.041
si:dkey-273o13.1	si:dkey-273o13.1	0.041
dharma	dharma	0.041
metrn	meteorin, glial cell differentiation regulator	0.041
foxc1a	forkhead box C1a	0.041
adipor1a	adiponectin receptor 1a	0.041
hoxc4a	homeo box C4a	0.041
ccng1	cyclin G1	0.041
hspa12b	heat shock protein 12B	0.041
lmx1a	LIM homeobox transcription factor 1, alpha	0.041
emx3	empty spiracles homeobox 3	0.041
igf2a	insulin-like growth factor 2a	0.040
polm	polymerase (DNA directed), mu	0.040
si:ch211-212m21.5	si:ch211-212m21.5	0.040
rorb	RAR-related orphan receptor B	0.040
lhx1b	LIM homeobox 1b	0.040
smarcd3b	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b	0.040
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.040
vps33b	vacuolar protein sorting 33B	0.040
krt18	keratin 18	0.040
igf3	insulin-like growth factor 3	0.040
grem2	gremlin 2, cysteine knot superfamily	0.040
twist3	twist3	0.040
tsc22d1	TSC22 domain family, member 1	0.040
tkt	transketolase	0.040
alpi	alkaline phosphatase, intestinal	0.039
gsna	gelsolin a	0.039
atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.039
fxyd1	FXYD domain containing ion transport regulator 1 (phospholemman)	0.039
slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	0.039
sb:eu2436	sb:eu2436	0.039
zgc:66242	zgc:66242	0.039
mllt11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	0.039
ssrp1a	structure specific recognition protein 1a	0.039
arl6ip1	ADP-ribosylation factor-like 6 interacting protein 1	0.039
rgma	RGM domain family, member A	0.039
aldh7a1	aldehyde dehydrogenase 7 family, member A1	0.039
robo3	roundabout homolog 3	0.039
fgfr1b	fibroblast growth factor receptor 1b	0.039	Zebrafish
duox	dual oxidase	0.039
pkp3	plakophilin 3	0.039
ihha	Indian hedgehog homolog a	0.039
nod1	nucleotide-binding oligomerization domain containing 1	0.039
mpx	myeloid-specific peroxidase	0.039
rab11bb	RAB11B, member RAS oncogene family, b	0.039
adob	2-aminoethanethiol (cysteamine) dioxygenase b	0.039
sult1st3	sulfotransferase family 1, cytosolic sulfotransferase 3	0.039
evla	Enah/Vasp-like a	0.039
slc13a1	solute carrier family 13 (sodium/sulphate symporters), member 1	0.039
pkd2	polycystic kidney disease 2	0.039	Human Mouse
musk	muscle, skeletal, receptor tyrosine kinase	0.039
cry3	cryptochrome 3	0.038
tal2	T-cell acute lymphocytic leukemia 2	0.038
gna12	guanine nucleotide binding protein (G protein) alpha 12	0.038
sec63	SEC63-like (S. cerevisiae)	0.038
tjp1	tight junction protein 1 (zona occludens 1)	0.038
ik	IK cytokine	0.038
il1b	interleukin 1, beta and interleukin 1, beta	0.038
cap1	Cap1 CAP, adenylate cyclase-associated protein 1	0.038
nort	notch-regulated transcript	0.038
alcamb	activated leukocyte cell adhesion molecule b	0.038
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.038
laptm4a	lysosomal-associated protein transmembrane 4 alpha	0.038
runx3	runt-related transcription factor 3	0.038
rnasel1	ribonuclease like 1	0.038
six4a	sine oculis homeobox homolog 4a	0.038
ugt1b1	UDP glucuronosyltransferase 1 family, polypeptide B1	0.037
plagl2	pleiomorphic adenoma gene-like 2	0.037
sall4	sal-like 4 (Drosophila)	0.037
sp5l	Sp5 transcription factor-like	0.037
rdh10a	retinol dehydrogenase 10a	0.037
wnt11r	wingless-type MMTV integration site family, member 11, related	0.037	Zebrafish
hsf2	heat shock factor 2	0.037
sh3gl3	SH3-domain GRB2-like 3	0.037
sardh	sarcosine dehydrogenase	0.037
stard3	START domain containing 3	0.037
hsd17b12b	hydroxysteroid (17-beta) dehydrogenase 12b	0.037
pdlim3a	PDZ and LIM domain 3a	0.037
f2	coagulation factor II (thrombin)	0.037
LOC554173	abnormal spindles	0.036
sult2st1	sulfotransferase family 2, cytosolic sulfotransferase 1	0.036
tsc22d3	TSC22 domain family, member 3	0.036
dkk3	dickkopf homolog 3 (Xenopus laevis)	0.036
zgc:66382	zgc:66382	0.036
cyp3c1	cytochrome P450, family 3, subfamily c, polypeptide 1	0.036
sat1b	spermidine/spermine N1-acetyl transferase 1b	0.036
git2b	G protein-coupled receptor kinase interactor 2b	0.036
angpt1	angiopoietin 1	0.036
sec31a	sec31 homolog A (S. cerevisiae)	0.036
hsp70	heat shock cognate 70-kd protein	0.036
tk1	thymidine kinase 1, soluble	0.036
atp1b1a	ATPase, Na+/K+ transporting, beta 1a polypeptide	0.036
shox2	short stature homeobox 2	0.036
pnp4b	purine nucleoside phosphorylase 4b	0.036
rxrgb	retinoid X receptor, gamma b	0.036
ncoa3	nuclear receptor coactivator 3	0.036
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.036
dla	deltaA	0.036	Zebrafish
cdc14b	CDC14 cell division cycle 14 homolog B	0.036
gstal	glutathione S-transferase, alpha-like	0.035
got2a	glutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2)	0.035
si:ch211-173b8.2	si:ch211-173b8.2	0.035
f2rl1.2	coagulation factor II (thrombin) receptor-like 1.2	0.035
zgc:92739	zgc:92739	0.035
sulf2l	sulfatase 2, like	0.035
tcf21	transcription factor 21	0.035
tbx20	T-box 20	0.035
glcci1	glucocorticoid induced transcript 1	0.035
pmp22b	peripheral myelin protein 22b	0.035
dnmt6	DNA (cytosine-5-)-methyltransferase 6	0.035
nanos3	nanos homolog 3	0.035
c20orf20	c20orf20 homolog (H. sapiens)	0.035
amotl2a	angiomotin like 2a	0.035
igfbp2b	insulin-like growth factor binding protein 2b	0.035
hoxc8a	homeo box C8a	0.035
gck	glucokinase (hexokinase 4, maturity onset diabetes of the young 2)	0.035
gale	UDP-galactose-4-epimerase	0.035
atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	0.035
pax3a	paired box gene 3a	0.035
cpt1b	carnitine palmitoyltransferase 1B (muscle)	0.035
hesx1	homeo box (expressed in ES cells) 1	0.035
ankrd6	ankyrin repeat domain 6	0.034
scp2	sterol carrier protein 2	0.034
dcn	decorin	0.034
mllt10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	0.034
supt6h	suppressor of Ty 6 homolog	0.034
smad2	MAD homolog 2 (Drosophila)	0.034
her11	hairy-related 11	0.034
zgc:112421	zgc:112421	0.034
ins	preproinsulin	0.034
gyltl1b	glycosyltransferase-like 1b	0.034
zgc:77778	zgc:77778	0.034
tyr	tyrosinase	0.034
six4.3	sine oculis homeobox homolog 4.3	0.034
lrrc6	leucine rich repeat containing 6	0.034
kbp	kif1-binding protein	0.034
flrt3	fibronectin leucine rich transmembrane 3	0.034
cdk5r1b	cyclin-dependent kinase 5, regulatory subunit 1b (p35)	0.034
zgc:55262	zgc:55262	0.034
mapk7	mitogen-activated protein kinase 7	0.034
pak1	p21/Cdc42/Rac1-activated kinase 1	0.034
ptn	pleiotrophin	0.033
dct	dopachrome tautomerase	0.033
msh2	mutS homolog 2 (E. coli)	0.033
adrb2b	adrenergic receptor, beta 2b	0.033
akap12b	A kinase (PRKA) anchor protein (gravin) 12b	0.033
zgc:123180	zgc:123180	0.033
sat2	spermidine/spermine N1-acetyltransferase family member 2	0.033
pdlim1	PDZ and LIM domain 1 (elfin)	0.033
phox2b	paired-like homeobox 2b	0.033
fgfrl1b	fibroblast growth factor receptor-like 1b	0.033
palm	paralemmin	0.033
stox1	storkhead box 1	0.033
tm4sf4	transmembrane 4 L six family member 4	0.033
ildr1b	immunoglobulin-like domain containing receptor 1b	0.033
foxb1.1	forkhead box B1.1	0.033
six1a	sine oculis homeobox homolog 1a	0.033
map2k7	mitogen-activated protein kinase kinase 7	0.033
cyp11a1	cytochrome P450, subfamily XIA, polypeptide 1	0.033
rbp2b	retinol binding protein 2b, cellular	0.033
nr1d2a	nuclear receptor subfamily 1, group D, member 2a	0.033	Zebrafish
dpyd	dihydropyrimidine dehydrogenase	0.033
nr0b1	nuclear receptor subfamily 0, group B, member 1	0.033
ctsd	cathepsin D	0.033
anxa11a	annexin A11a	0.032
rictor	RPTOR independent companion of MTOR, complex 2	0.032
prkcsh	protein kinase C substrate 80K-H	0.032
tuba1	tubulin, alpha 1	0.032
slc43a1a	solute carrier family 43, member 1a	0.032
nptnb	neuroplastin b	0.032
slco1f1	solute carrier organic anion transporter family, member 1F1	0.032
sc:d411	sc:d411	0.032
fmo5	flavin containing monooxygenase 5	0.032
mmp17a	matrix metallopeptidase 17a	0.032
LOC100332039	ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like	0.032
foxl1	forkhead box L1	0.032
runx2b	runt-related transcription factor 2b	0.032
ctsf	cathepsin F	0.032
zfyve26	zinc finger, FYVE domain containing 26	0.032
otx1b	orthodenticle homolog 1b	0.032
adhfe1	alcohol dehydrogenase, iron containing, 1	0.032
rel	v-rel reticuloendotheliosis viral oncogene homolog	0.032
mpp6b	membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)	0.032
otpb	orthopedia homolog b	0.032
sema3ab	semaphorin 3ab	0.032
nog3	noggin 3	0.032
mpped2	metallophosphoesterase domain containing 2	0.032
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.032
crbn	cereblon	0.032
nrn1	neuritin 1	0.031
oprm1	opioid receptor, mu 1	0.031
ek1	eph-like kinase 1	0.031
cx43.4	connexin 43.4	0.031
ifng1-1	interferon, gamma 1-1	0.031
pgrmc2	progesterone receptor membrane component 2	0.031
dnmt3	DNA (cytosine-5-)-methyltransferase 3	0.031
sb:cb541	sb:cb541	0.031
znfl2a	zinc finger-like gene 2a	0.031
eif3hb	eukaryotic translation initiation factor 3, subunit H, b	0.031
bnip3lb	BCL2/adenovirus E1B interacting protein 3-like b	0.031
onecut1	one cut domain, family member 1	0.031
twist1a	twist1a	0.031
zgc:100829	zgc:100829	0.031
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.031
exorh	extra-ocular rhodopsin	0.031