IMP: Integrative Multi-species Prediction

Danio rerio

3 genes annotated in zebrafish

extrinsic apoptotic signaling pathway

A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "extrinsic apoptotic signaling pathway"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "extrinsic apoptotic signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
bcl2l1	bcl2-like 1	0.826	Mouse
nf1a	neurofibromin 1a	0.717	Mouse
cav1	caveolin 1	0.669	Human
igf1rb	insulin-like growth factor 1b receptor	0.664
osr1	odd-skipped related 1 (Drosophila)	0.615
tgfb3	transforming growth factor, beta 3	0.611
brd4	bromodomain containing 4	0.597
epas1b	endothelial PAS domain protein 1b	0.572
tnfrsfa	tumor necrosis factor receptor superfamily, member a	0.558	Human
fzd7b	frizzled homolog 7b	0.519
mapk6	mitogen-activated protein kinase 6	0.495
ptgs1	prostaglandin-endoperoxide synthase 1	0.487
erbb3b	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b	0.477	Human
tagln2	transgelin 2	0.475
kita	kit receptor a	0.421
epha4a	eph receptor A4a	0.405
erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog	0.386
ifnphi1	interferon phi 1	0.381
ptgds	prostaglandin D2 synthase	0.378	Mouse
mmp9	matrix metalloproteinase 9	0.366
nrg2a	neuregulin 2a	0.353
krt4	keratin 4	0.352	Mouse
baxa	bcl2-associated X protein, a	0.347	Human Mouse
stc1l	stanniocalcin 1, like	0.344
hmgb1b	high-mobility group box 1b	0.343
pax7b	paired box gene 7b	0.334
met	met proto-oncogene (hepatocyte growth factor receptor)	0.315
pcdh18b	protocadherin 18b	0.311
rxrbb	retinoid x receptor, beta b	0.304
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.303
fgfr3	fibroblast growth factor receptor 3	0.301	Human
ntn2	netrin 2	0.296
sema3aa	semaphorin 3aa	0.294
notch2	notch homolog 2	0.290
ywhai	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide	0.286
bnip3lb	BCL2/adenovirus E1B interacting protein 3-like b	0.284
eya1	eyes absent homolog 1	0.278	Mouse
ryk	receptor-like tyrosine kinase	0.276
tgfb2	transforming growth factor, beta 2	0.274	Human Mouse
hbbe1.1	hemoglobin beta embryonic-1.1	0.271
dlx4a	distal-less homeobox gene 4a	0.266
ldb1a	LIM-domain binding factor 1a	0.265
il6st	interleukin 6 signal transducer	0.262
igf1	insulin-like growth factor 1	0.256
lef1	lymphocyte enhancer binding factor 1	0.253
cmyb	transcription factor cmyb	0.250
rarga	retinoic acid receptor gamma a	0.249
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.248
ripk2	receptor-interacting serine-threonine kinase 2	0.247
hmx2	H6 family homeobox 2	0.246
jup	junction plakoglobin	0.244
gadd45aa	growth arrest and DNA-damage-inducible, alpha, a	0.233
prkcea	protein kinase C, epsilon a	0.233
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.227
bmp2b	bone morphogenetic protein 2b	0.227
igf1ra	insulin-like growth factor 1a receptor	0.226
mcl1a	myeloid cell leukemia sequence 1a	0.221	Human Mouse
sb:cb166	sb:cb166	0.219
acvr2a	activin receptor IIa	0.216
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.216
ywhabl	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like	0.212
metrnl	meteorin, glial cell differentiation regulator-like	0.211
dct	dopachrome tautomerase	0.209
anxa1a	annexin A1a	0.209
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.208
lhx2b	LIM homeobox 2b	0.205
il6r	interleukin 6 receptor	0.203
neo1	neogenin 1	0.201
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.201
ptp4a3	protein tyrosine phosphatase type IVA, member 3	0.201
sgk1	serum/glucocorticoid regulated kinase 1	0.195
tfec	transcription factor EC	0.194
lcp1	lymphocyte cytosolic plastin 1	0.192
twist2	twist2	0.185
apom	apolipoprotein M	0.183
krt8	keratin 8	0.173	Mouse
plekhg5a	pleckstrin homology domain containing, family G (with RhoGef domain) member 5a	0.172
gh1	growth hormone 1	0.171
cnn2	calponin 2	0.171
crestin	crestin	0.171
cyp24a1	cytochrome P450, family 24, subfamily A, polypeptide 1	0.170
she	Src homology 2 domain containing E	0.167
arpc1b	actin related protein 2/3 complex, subunit 1B	0.166
phox2b	paired-like homeobox 2b	0.164
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.164
wnt3	wingless-type MMTV integration site family, member 3	0.164
sox10	SRY-box containing gene 10	0.163
lass2	LAG1 homolog, ceramide synthase 2 (S. cerevisiae)	0.161
fadd	Fas (tnfrsf6)-associated via death domain	0.160
cyp3c1	cytochrome P450, family 3, subfamily c, polypeptide 1	0.160
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.160
notch3	notch homolog 3	0.160
mpx	myeloid-specific peroxidase	0.159
krml2.2	Kreisler (mouse) maf-related leucine zipper homolog 2.2	0.159
rag1	recombination activating gene 1	0.159
dip2c	DIP2 disco-interacting protein 2 homolog C (Drosophila)	0.156
plg	plasminogen	0.155
zgc:162126	zgc:162126	0.155
tlr3	toll-like receptor 3	0.154	Human
hoxd4a	homeo box D4a	0.153
tgfb1a	transforming growth factor, beta 1a	0.150	Human
wnt10a	wingless-type MMTV integration site family, member 10a	0.143
krt5	keratin 5	0.142	Mouse
inha	inhibin, alpha	0.141
nf1b	neurofibromin 1b	0.141	Mouse
ltk	leukocyte tyrosine kinase	0.141
ahr2	aryl hydrocarbon receptor 2	0.140
slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	0.140
nos1	nitric oxide synthase 1 (neuronal)	0.140
mmp2	matrix metalloproteinase 2	0.140
lyz	lysozyme	0.137
six1b	sine oculis homeobox homolog 1b	0.137
hbae1	hemoglobin alpha embryonic-1	0.137
pitx3	paired-like homeodomain transcription factor 3	0.137
col7a1l	collagen type VII alpha 1-like	0.136
foxc1a	forkhead box C1a	0.136
sumo1	SMT3 suppressor of mif two 3 homolog 1 (yeast)	0.135
fgb	fibrinogen, B beta polypeptide	0.133
si:dkeyp-22b2.3	si:dkeyp-22b2.3	0.132
bmp3	bone morphogenetic protein 3	0.132
sdcbp	syndecan binding protein (syntenin)	0.130
gnb1a	guanine nucleotide binding protein (G protein), beta polypeptide 1a	0.130
slc4a4a	solute carrier family 4, member 4a	0.130
lims1	LIM and senescent cell antigen-like domains 1	0.129
plxnb2a	plexin b2a	0.128
hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.127
rel	v-rel reticuloendotheliosis viral oncogene homolog	0.127
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.125
hif1ab	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b	0.125
nrp2a	neuropilin 2a	0.124
spna2	spectrin alpha 2	0.123
scrt1a	scratch homolog 1, zinc finger protein a (Drosophila)	0.123
dspa	desmoplakin a	0.123
crabp2b	cellular retinoic acid binding protein 2, b	0.123
igfbp3	insulin-like growth factor binding protein 3	0.122
timp2b	tissue inhibitor of metalloproteinase 2b	0.122
cpla2	cytosolic phospholipase a2	0.121
xbp1	X-box binding protein 1	0.121
tgfbi	transforming growth factor, beta-induced	0.120
hsp47	heat shock protein 47	0.120
fgf20a	fibroblast growth factor 20a	0.120
pea3	ETS-domain transcription factor pea3	0.120
si:dkeyp-7c9.1	si:dkeyp-7c9.1	0.118
col4a2	collagen, type IV, alpha 2	0.118
cldni	claudin i	0.117
itgb3b	integrin beta 3b	0.117
cntn2	contactin 2	0.117
scrt1b	scratch homolog 1, zinc finger protein b (Drosophila)	0.115
foxc1b	forkhead box C1b	0.115
zgc:136878	zgc:136878	0.114
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.114
lgmn	legumain	0.114
nadl1.2	neural adhesion molecule L1.2	0.113
cobl	cordon-bleu homolog (mouse)	0.113
wnt5a	wingless-type MMTV integration site family, member 5a	0.111
inhbaa	inhibin, beta Aa	0.111	Human
csnk1da	casein kinase 1, delta a	0.109
foxo3b	forkhead box O3b	0.109	Mouse
ptgesl	prostaglandin E synthase 2-like	0.109
gli1	GLI-Kruppel family member 1	0.109
lhcgr	luteinizing hormone/choriogonadotropin receptor	0.107
rtn4a	reticulon 4a	0.107
cbr1l	carbonyl reductase 1-like	0.107
cyp17a1	cytochrome P450, family 17, subfamily A, polypeptide 1	0.106
ptena	phosphatase and tensin homolog A	0.105
sh3gl1b	SH3-domain GRB2-like 1b	0.105
csf1ra	colony stimulating factor 1 receptor, a	0.104
rcn3	reticulocalbin 3, EF-hand calcium binding domain	0.104
sox7	SRY-box containing gene 7	0.103
erbb3a	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a	0.103	Human
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.103
nkx6.1	NK6 transcription factor related, locus 1 (Drosophila)	0.102
tlr21	toll-like receptor 21	0.102
wif1	wnt inhibitory factor 1	0.102
zfp36l1b	zinc finger protein 36, C3H type-like 1b	0.102
ass1	argininosuccinate synthetase 1	0.102
tfe3a	transcription factor binding to IGHM enhancer 3a	0.101
hgfb	hepatocyte growth factor b	0.101
bida	BH3 interacting domain death agonist	0.101
wnt9b	wingless-type MMTV integration site family, member 9B	0.100
per2	period homolog 2 (Drosophila)	0.100
LOC100000934	hypothetical protein LOC100000934	0.100
nt5e	5'-nucleotidase, ecto (CD73)	0.100
ap2a1	adaptor-related protein complex 2, alpha 1 subunit	0.099
ednrb1	endothelin receptor B	0.098
tpm4	tropomyosin 4	0.098
ildr1b	immunoglobulin-like domain containing receptor 1b	0.098
zgc:92533	zgc:92533	0.098
chrna4	cholinergic receptor, nicotinic, alpha 4	0.098
jak1	Janus kinase 1	0.098
mapk3	mitogen-activated protein kinase 3	0.097
zgc:101724	zgc:101724	0.097
prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.097
nos2a	nitric oxide synthase 2a, inducible	0.097
il7r	interleukin 7 receptor	0.096
gcm2	glial cells missing homolog 2 (Drosophila)	0.094
foxi3b	forkhead box I3b	0.094
zgc:64161	zgc:64161	0.094
gpr126	G protein-coupled receptor 126	0.094
sema3d	semaphorin 3d	0.093
gna12	guanine nucleotide binding protein (G protein) alpha 12	0.092
irgq1	immunity-related GTPase family, q1	0.092
tsc22d3	TSC22 domain family, member 3	0.091
tnfsf10l2	tumor necrosis factor (ligand) superfamily, member 10 like 2	0.091	Human Zebrafish Fly
nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.091
ism1	isthmin 1	0.091
top2b	topoisomerase (DNA) II beta	0.090
cdc42	cell division cycle 42	0.089
anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.089
bbc3	BCL2 binding component 3	0.089	Mouse
rhoab	ras homolog gene family, member Ab	0.089
mcf2l	MCF.2 cell line derived transforming sequence-like and mcf.2 cell line derived transforming sequence-like	0.088
col4a3	collagen, type IV, alpha 3	0.088
clock3	clock homolog 3 (mouse)	0.088
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.088
acvr2b	activin receptor IIb	0.088
mecp2	methyl CpG binding protein 2	0.088
egfl7	EGF-like-domain, multiple 7	0.087
ifng1-2	interferon, gamma 1-2	0.087
pnrc2	proline-rich nuclear receptor coactivator 2	0.087
zgc:110259	zgc:110259	0.087
mcl1b	myeloid cell leukemia sequence 1b	0.086	Human Mouse
pfn1	profilin 1	0.086
eng1a	engrailed 1a	0.085
map2k4a	mitogen-activated protein kinase kinase 4a	0.085
grhl2b	grainyhead-like 2b (Drosophila)	0.085
LOC555739	serine/threonine-protein kinase LMTK1-like	0.085
nrp1a	neuropilin 1a	0.085	Mouse
trim13	tripartite motif-containing 13	0.084
dvl3	dishevelled, dsh homolog 3 (Drosophila)	0.084
th	tyrosine hydroxylase	0.084
si:dkey-177p2.6	si:dkey-177p2.6	0.083
nrxn2a	neurexin 2a	0.083
igf3	insulin-like growth factor 3	0.082	Mouse Rat
cflar	CASP8 and FADD-like apoptosis regulator	0.082
uba1	ubiquitin-like modifier activating enzyme 1	0.082
tp63	tumor protein p63	0.082
zgc:113312	zgc:113312	0.082
zgc:56326	zgc:56326	0.082
zgc:73345	zgc:73345	0.081
fmnl2a	formin-like 2a	0.081
zgc:56306	zgc:56306	0.081
evpl	envoplakin	0.081
mapk4	mitogen-activated protein kinase 4	0.080
zbtb4	zinc finger and BTB domain containing 4	0.080
fgf10a	fibroblast growth factor 10a	0.079	Mouse
bmf1	Bcl2 modifying factor 1	0.079
trpv1	transient receptor potential cation channel subfamily V member 1	0.079
cyp1b1	cytochrome P450, family 1, subfamily B, polypeptide 1	0.079
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.078
elovl1b	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b	0.078
emx3	empty spiracles homeobox 3	0.078
cdh4	cadherin 4, retinal	0.078
angpt1	angiopoietin 1	0.078
fstl1b	follistatin-like 1b	0.077
alas2	aminolevulinate, delta-, synthetase 2	0.077
col4a4	collagen, type IV, alpha 4	0.077
col17a1a	collagen, type XVII, alpha 1a	0.077
cd63	Cd63 antigen	0.076
cnr1	cannabinoid receptor 1	0.076
zgc:195154	zgc:195154	0.076
tob1a	transducer of ERBB2, 1a	0.075
sox11b	SRY-box containing gene 11b	0.075
olfm1b	olfactomedin 1b	0.075
loxl2b	lysyl oxidase-like 2b	0.075
sod1	superoxide dismutase 1, soluble	0.075
fgfr4	fibroblast growth factor receptor 4	0.075
msi2b	musashi homolog 2b (Drosophila)	0.075
wu:fb63c04	wu:fb63c04	0.074
pgam5	phosphoglycerate mutase family member 5	0.074
hbbe3	hemoglobin beta embryonic-3	0.074
fsta	follistatin a	0.074
zgc:92061	zgc:92061	0.074
zgc:103670	zgc:103670	0.074
taf3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto	0.074
chst11	carbohydrate (chondroitin 4) sulfotransferase 11	0.074
ctnnb1	catenin (cadherin-associated protein), beta 1	0.074
fgg	fibrinogen, gamma polypeptide	0.074
barhl1.2	BarH-like 1.2	0.074
lhx6	LIM homeobox 6	0.073
shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	0.073
bnc2	basonuclin 2	0.073
COX1	cytochrome c oxidase subunit I	0.073
ptmaa	prothymosin, alpha a	0.072
akt2	v-akt murine thymoma viral oncogene homolog 2	0.072
snai1a	snail homolog 1a (Drosophila)	0.072
jag1b	jagged 1b	0.072
mapk14a	mitogen-activated protein kinase 14a	0.072
casp8	caspase 8, apoptosis-related cysteine peptidase	0.071	Human Mouse
a2ml	alpha-2-macroglobulin-like	0.071
ahcy	S-adenosylhomocysteine hydrolase	0.071
cdh6	cadherin 6	0.071
zgc:77155	zgc:77155	0.071
cnih	cornichon homolog (Drosophila)	0.070
ptrfb	polymerase I and transcript release factor b	0.070
ptmab	prothymosin, alpha b	0.070
hapln1a	hyaluronan and proteoglycan link protein 1a	0.070
tm9sf2	transmembrane 9 superfamily member 2	0.070
snx5	sorting nexin 5	0.070
sc:d812	sc:d812	0.069
zfyve26	zinc finger, FYVE domain containing 26	0.069
hoxa13a	homeo box A13a	0.069
rfng	radical fringe homolog (Drosophila)	0.069
st8sia6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	0.069
alk	anaplastic lymphoma kinase (Ki-1)	0.069
dcn	decorin	0.069
irf6	interferon regulatory factor 6	0.069
nrarpa	notch-regulated ankyrin repeat protein a	0.069
limk1	LIM domain kinase 1	0.069
mapkapk2a	mitogen-activated protein kinase-activated protein kinase 2a	0.069
vegfab	vascular endothelial growth factor Ab	0.068	Mouse
entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.068
slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.068
sdprb	serum deprivation response b	0.068
cdh11	cadherin 11, osteoblast	0.068
bmp6	bone morphogenetic protein 6	0.068
sdc2	syndecan 2	0.068
ppm1bb	protein phosphatase, Mg2+/Mn2+ dependent, 1Bb	0.068
rictor	RPTOR independent companion of MTOR, complex 2	0.068
nr2f6a	nuclear receptor subfamily 2, group F, member 6a	0.068
manf	mesencephalic astrocyte-derived neurotrophic factor	0.068
bactin2	bactin2	0.068
gabarapa	GABA(A) receptor-associated protein a	0.068	Human
dlg2	discs, large (Drosophila) homolog 2	0.068
ccz1	CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)	0.068
tfr1a	transferrin receptor 1a	0.067
tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.067
zgc:64115	zgc:64115	0.067
zeb2b	zinc finger E-box binding homeobox 2b	0.067
traf6	TNF receptor-associated factor 6	0.067
matn4	matrilin 4	0.067
elmo1	engulfment and cell motility 1 (ced-12 homolog, C. elegans)	0.067
txnrd1	thioredoxin reductase 1	0.067
star	steroidogenic acute regulatory protein	0.067
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.067
zgc:63831	zgc:63831	0.067
scarb1	scavenger receptor class B, member 1	0.067
appa	amyloid beta (A4) precursor protein a	0.066
pknox1.1	pbx/knotted 1 homeobox 1.1	0.066
ptpn11a	protein tyrosine phosphatase, non-receptor type 11, a	0.066
phox2a	paired-like homeobox 2a	0.066
hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase	0.066
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.066
arhgdig	Rho GDP dissociation inhibitor (GDI) gamma	0.066
irf3	interferon regulatory factor 3	0.066
lmo4a	LIM domain only 4a	0.065
mxb	myxovirus (influenza) resistance B	0.065
ctsl1a	cathepsin L, 1 a	0.065
zgc:55572	zgc:55572	0.065
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.065
psen1	presenilin 1	0.065
runx1	runt-related transcription factor 1	0.065
naa50	N(alpha)-acetyltransferase 50, NatE catalytic subunit	0.065
adora2b	adenosine A2b receptor	0.065
emx2	empty spiracles homeobox 2	0.065
gyltl1b	glycosyltransferase-like 1b	0.065
hfe2	hemochromatosis type 2	0.065
ptk6a	PTK6 protein tyrosine kinase 6a	0.064
LOC797331	novel protein similar to vertebrate solute carrier family 12, (potassium-chloride transporter) member 5 (SLC12A5)	0.064
ccng1	cyclin G1	0.064
zeb2a	zinc finger E-box binding homeobox 2a	0.064
pax9	paired box gene 9	0.064
tbx22	T-box 22	0.064
sult3st1	sulfotransferase family 3, cytosolic sulfotransferase 1	0.064
lhx9	LIM homeobox 9	0.064
cry2b	cryptochrome 2b	0.064
zgc:55886	zgc:55886	0.064
bmp15	bone morphogenetic protein 15	0.063
wu:fi25h02	wu:fi25h02	0.063
ctsd	cathepsin D	0.063
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.063
dyrk1b	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.063
kbp	kif1-binding protein	0.062
styk1	serine/threonine/tyrosine kinase 1	0.062
siah2l	seven in absentia homolog 2 (Drosophila)-like	0.062	Human
slc7a3	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	0.062
psma6b	proteasome (prosome, macropain) subunit, alpha type, 6b	0.062
gdf9	growth differentiation factor 9	0.062
wu:fv91b12	wu:fv91b12	0.062
pdk2	pyruvate dehydrogenase kinase, isoenzyme 2	0.062
si:ch211-14k19.8	si:ch211-14k19.8	0.062
ubtd2	ubiquitin domain containing 2	0.062
rer1	RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)	0.062
myb	myeloblastosis oncogene	0.062
nrp2b	neuropilin 2b	0.062
zgc:110343	zgc:110343	0.061
inka1a	induced in neural crest by AP2, 1a	0.061
sqstm1	sequestosome 1	0.061
scinlb	scinderin like b	0.061
ext1c	exostoses (multiple) 1c	0.061
cyt1	type I cytokeratin, enveloping layer	0.061
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.061
fn1	fibronectin 1	0.061
fshb	follicle stimulating hormone, beta polypeptide	0.061
ppp4cb	protein phosphatase 4 (formerly X), catalytic subunit b	0.060
ck2b	casein kinase 2 beta	0.060
sepw1	selenoprotein W, 1	0.060
shroom4	shroom family member 4	0.060
hgfa	hepatocyte growth factor a	0.060	Mouse
LOC100151531	zinc finger protein Gfi-1b-like	0.060
naa35	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	0.060
chd7	chromodomain helicase DNA binding protein 7	0.060
itgb1b	integrin, beta 1b	0.060
mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.059
gmfg	glia maturation factor, gamma	0.059
vasn	vasorin	0.059
rhcgb	Rhesus blood group, C glycoprotein b	0.059
stat1a	signal transduction and activation of transcription 1a	0.059
LOC792474	annexin A4-like	0.059
ptk2.1	protein tyrosine kinase 2a	0.059
c9	complement component 9	0.059
hoxa13b	homeo box A13b	0.059
spry4	sprouty (Drosophila) homolog 4	0.058
mif	macrophage migration inhibitory factor	0.058
tgfbr1b	transforming growth factor, beta receptor 1 b	0.058
fbxw2	F-box and WD repeat domain containing 2	0.058
gpx1a	glutathione peroxidase 1a	0.058
pob	partial optokinetic response b	0.058
oprd1b	opioid receptor, delta 1b	0.058
plaa	phospholipase A2-activating protein	0.058
dlx3b	distal-less homeobox gene 3b	0.058
zgc:113200	zgc:113200	0.057
mcamb	melanoma cell adhesion molecule b	0.057
ptpra	protein tyrosine phosphatase, receptor type, A	0.057
zgc:92360	zgc:92360	0.057
LOC566020	Gig2-like protein DreO	0.057
cp	ceruloplasmin	0.057
nr4a2b	nuclear receptor subfamily 4, group A, member 2b	0.057
crb2a	crumbs homolog 2a	0.057
adipor2	adiponectin receptor 2	0.057
angpt2	angiopoietin 2	0.057
xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5	0.057
flii	flightless I homolog (Drosophila)	0.057
tlr9	toll-like receptor 9	0.056
asph	aspartate beta-hydroxylase	0.056
ndel1b	nudE nuclear distribution gene E homolog like 1 (A. nidulans) B	0.056
smad2	MAD homolog 2 (Drosophila)	0.056
top1l	topoisomerase (DNA) I, like	0.056
syk	spleen tyrosine kinase	0.056
brd2a	bromodomain-containing 2a	0.056
vps35	vacuolar protein sorting 35 (yeast)	0.056
smc1al	structural maintenance of chromosomes 1A, like	0.056
arl6ip1	ADP-ribosylation factor-like 6 interacting protein 1	0.056
mt2	metallothionein 2	0.055
sema3e	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	0.055
rela	v-rel reticuloendotheliosis viral oncogene homolog A	0.055	Human Mouse
myh10	myosin, heavy polypeptide 10, non-muscle and myosin, heavy chain 10, non-muscle	0.055
glud1a	glutamate dehydrogenase 1a	0.055
mknk2b	MAP kinase-interacting serine/threonine kinase 2b	0.055	Mouse
b4galt5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	0.055
nucks1a	nuclear casein kinase and cyclin-dependent kinase substrate 1a	0.055
rcc2	regulator of chromosome condensation 2	0.055
ambpl	alpha-1-microglobulin/bikunin precursor, like	0.055
msna	moesin a	0.055
casc3	cancer susceptibility candidate 3	0.055
ext1b	exostoses (multiple) 1b	0.055
il11ra	interleukin 11 receptor, alpha	0.055
pomt2	protein-O-mannosyltransferase 2	0.054
her15.1	hairy and enhancer of split-related 15.1	0.054
flot1	flotillin 1	0.054
clptm1	cleft lip and palate associated transmembrane protein 1	0.054
csf3r	colony stimulating factor 3 receptor (granulocyte)	0.054
si:dkeyp-113d7.7	si:dkeyp-113d7.7	0.054
thrb	thyroid hormone receptor beta	0.054
ier2	immediate early response 2	0.054
chrna6	cholinergic receptor, nicotinic, alpha 6	0.054
tbx2b	T-box 2b	0.054
mobkl2a	MOB1, Mps One Binder kinase activator-like 2A (yeast)	0.054
zzef1	zinc finger, ZZ-type with EF hand domain 1	0.054
ywhae1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	0.054
plagx	pleiomorphic adenoma gene X	0.054
egr2b	early growth response 2b	0.054
slc25a22	solute carrier family 25 (mitochondrial carrier: glutamate), member 22	0.053
sema3gb	semaphorin 3gb	0.053
ret1	receptor tyrosine kinase	0.053	Human
LOC100004946	transient receptor potential cation channel subfamily M member 4-like	0.053
casp9	caspase 9, apoptosis-related cysteine protease	0.053
flt1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.053
ivns1abpa	influenza virus NS1A binding protein a	0.053
fbxl14b	F-box and leucine-rich repeat protein 14b	0.053
slc4a1b	solute carrier family 4, anion exchanger, member 1b	0.053
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.053
slc8a1b	solute carrier family 8 (sodium/calcium exchanger), member 1b	0.052
zgc:91976	zgc:91976	0.052
ahcyl2	S-adenosylhomocysteine hydrolase-like 2	0.052
stat5.2	signal transducer and activator of transcription 5.2	0.052
abcf2	ATP-binding cassette, sub-family F (GCN20), member 2	0.052
jun	jun proto-oncogene	0.052
ralgapa1	Ral GTPase activating protein, alpha subunit 1 (catalytic)	0.052
coro1a	coronin, actin binding protein, 1A	0.052
mxa	myxovirus (influenza) resistance A	0.052
gadd45ab	growth arrest and DNA-damage-inducible, alpha, b	0.052
fbxo32	F-box protein 32	0.052
gsc	goosecoid	0.052
kif5bb	kinesin family member 5B, b	0.052
selt1a	selenoprotein T, 1a	0.051
aida	axin interaction partner and dorsalization antagonist	0.051
psmd11b	proteasome (prosome, macropain) 216S subunit, non-ATPase, 11b	0.051
atm	ataxia telangiectasia mutated	0.051
LOC554173	abnormal spindles	0.051
inhbab	inhibin, beta Ab	0.051	Human
egr1	early growth response 1	0.051
smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.051
hmgb3a	high-mobility group box 3a	0.051
tph2	tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)	0.051
hmga1a	high mobility group AT-hook 1a	0.051
cfl1	cofilin 1 (non-muscle)	0.051
map2k2a	mitogen-activated protein kinase kinase 2a	0.051
xkrx	XK, Kell blood group complex subunit-related, X-linked	0.051
ubin	ataxin-1 ubiquitin-like interacting protein	0.050
itga7	integrin, alpha 7	0.050
dnajb12	DnaJ (Hsp40) homolog, subfamily B, member 12	0.050
dkk2	dickkopf homolog 2 (Xenopus laevis)	0.050
mxi1	max interacting protein	0.050
adcyap1r1	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	0.050
pmp22b	peripheral myelin protein 22b	0.050
kdsr	3-ketodihydrosphingosine reductase	0.050
atp6ap2	ATPase, H+ transporting, lysosomal accessory protein 2	0.050
rhoaa	ras homolog gene family, member Aa	0.050
myo1bl2	myosin 1b-like 2	0.050
pdzrn3	PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3	0.050
jazf1b	JAZF zinc finger 1b	0.050
spag1	sperm associated antigen 1	0.050
zgc:103440	zgc:103440	0.050
dsc2l	desmocollin 2 like	0.050
bglap	bone gamma-carboxyglutamate (gla) protein	0.050
crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.050
fbp1a	fructose-1,6-bisphosphatase 1a	0.049
cldn2	claudin 2	0.049
inhbb	inhibin, beta B	0.049
oc90	otoconin 90	0.049
dedd1	death effector domain-containing 1	0.049
ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.049
wu:fb80a07	wu:fb80a07	0.049
zgc:153154	zgc:153154	0.049	Mouse
adipor1a	adiponectin receptor 1a	0.049
kitb	kit receptor b	0.049
wwp1	WW domain containing E3 ubiquitin protein ligase 1	0.049
tyrp1b	tyrosinase-related protein 1b	0.049
pdip5	protein disulfide isomerase-related protein (provisional)	0.049
hug	HuG	0.049
rbp2b	retinol binding protein 2b, cellular	0.049
tg	thyroglobulin	0.048
ggps1	geranylgeranyl diphosphate synthase 1	0.048
slit2	slit (Drosophila) homolog 2	0.048
efna2	ephrin A2	0.048
pak2a	p21 (CDKN1A)-activated kinase 2a	0.048	Human
zgc:172101	zgc:172101	0.048
efnb2a	ephrin B2a	0.048
atp1a1a.2	ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide	0.048
elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	0.048
pdia4	protein disulfide isomerase associated 4	0.048
nrg1	neuregulin 1	0.048	Human
aox3	aldehyde oxidase 3	0.048
agtr2	angiotensin II receptor, type 2	0.048	Human
calm3b	calmodulin 3b (phosphorylase kinase, delta)	0.048
mapk15	mitogen-activated protein kinase 15	0.048
adra2b	adrenergic, alpha-2B-, receptor	0.048
plod1a	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a	0.048
ifi30	interferon gamma inducible protein 30	0.048
atp1a1a.5	ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide	0.048
h3f3b.1	H3 histone, family 3B.1	0.047
fzd5	frizzled homolog 5	0.047
ube2g2	ubiquitin-conjugating enzyme E2G 2	0.047
postn	periostin, osteoblast specific factor	0.047
akap12b	A kinase (PRKA) anchor protein (gravin) 12b	0.047
hbegfa	heparin-binding EGF-like growth factor a	0.047
rab22a	RAB22A, member RAS oncogene family	0.047
asah1b	N-acylsphingosine amidohydrolase (acid ceramidase) 1b	0.047
twist1b	twist1b	0.047
erg	v-ets erythroblastosis virus E26 oncogene like (avian)	0.047
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.047
LOC567131	calcitonin gene-related peptide type 1 receptor-like	0.047
plxna4	plexin A4	0.047
igfbp1b	insulin-like growth factor binding protein 1b	0.047
rnd3a	Rho family GTPase 3a	0.047
apaf1	apoptotic protease activating factor 1	0.047
fbxw11b	F-box and WD-40 domain protein 11b	0.047
mapk8b	mitogen-activated protein kinase 8b	0.047
zmynd11	zinc finger, MYND domain containing 11	0.047	Human
prkar1aa	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a	0.047
synpo2la	synaptopodin 2-like a	0.047
has3	hyaluronan synthase 3	0.046
bbs4	Bardet-Biedl syndrome 4	0.046
lifra	leukemia inhibitory factor receptor alpha	0.046
paqr7b	progestin and adipoQ receptor family member VII, b	0.046
net1	neuroepithelial cell transforming gene 1	0.046
ddr2b	discoidin domain receptor family, member 2b	0.046
mapk1	mitogen-activated protein kinase 1	0.046
cap1	Cap1 CAP, adenylate cyclase-associated protein 1	0.046
mipa	major intrinsic protein of lens fiber a	0.046
col4a6	collagen, type IV, alpha 6	0.046
ints2	integrator complex subunit 2	0.046
hnrpl	heterogeneous nuclear ribonucleoprotein L	0.046
tmbim1	transmembrane BAX inhibitor motif containing 1	0.046	Human
fbxw7	F-box and WD repeat domain containing 7	0.046
hccs	holocytochrome c synthase	0.046
dusp6	dual specificity phosphatase 6	0.046
shhb	sonic hedgehog b	0.046
odc1	ornithine decarboxylase 1	0.046
igf2a	insulin-like growth factor 2a	0.046
pgam1b	phosphoglycerate mutase 1b	0.046
asah1a	N-acylsphingosine amidohydrolase (acid ceramidase) 1a	0.046
dync1h1	dynein, cytoplasmic 1, heavy chain 1	0.046
glcci1	glucocorticoid induced transcript 1	0.046
fth1a	ferritin, heavy polypeptide 1a	0.046
nudt9	nudix (nucleoside diphosphate linked moiety X)-type motif 9	0.046
zgc:73237	zgc:73237	0.046
cry2a	cryptochrome 2a	0.046
unc5c	unc-5 homolog C (C. elegans)	0.046
card14	caspase recruitment domain family, member 14	0.045
tfap2e	transcription factor AP-2 epsilon	0.045
klf4	Kruppel-like factor 4	0.045
cyp2ad2	cytochrome P450, family 2, subfamily AD, polypeptide 2	0.045
diaph2	diaphanous homolog 2 (Drosophila)	0.045
psenen	presenilin enhancer 2 homolog	0.045
sulf1	sulfatase 1	0.045
gng5	guanine nucleotide binding protein (G protein), gamma 5	0.045
eif4e1c	eukaryotic translation initiation factor 4E family member 1c	0.045
fzd2	frizzled homolog 2	0.045
gldc	glycine dehydrogenase (decarboxylating)	0.045
si:rp71-1p14.10	si:rp71-1p14.10	0.045
fkbp5	FK506 binding protein 5	0.045
igfbp1a	insulin-like growth factor binding protein 1a	0.045
snx1	sorting nexin 1	0.045
arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.045
actn3a	actinin alpha 3a	0.045
olig1	oligodendrocyte lineage transcription factor 1	0.045
si:dkey-37m8.10	si:dkey-37m8.10	0.045
fuca2	fucosidase, alpha-L- 2, plasma	0.045
usp4	ubiquitin specific protease 4 (proto-oncogene)	0.045
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.045	Mouse
plag1	pleiomorphic adenoma gene 1	0.045
sec23b	Sec23 homolog B (S. cerevisiae)	0.045
zgc:158852	zgc:158852	0.045
brf1a	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIBa	0.044
ipo7	importin 7	0.044
fmr1	fragile X mental retardation 1	0.044
arf2	ADP-ribosylation factor 2	0.044
pitpnb	phosphotidylinositol transfer protein, beta	0.044
alad	aminolevulinate dehydratase	0.044
fmnl2b	formin-like 2b	0.044
mvp	major vault protein	0.044
nfe2l3	nuclear factor (erythroid-derived 2)-like 3	0.044
sqrdl	sulfide quinone reductase-like (yeast)	0.044
nes	nestin	0.044
igfbp7	insulin-like growth factor binding protein 7	0.043
pafah1b1a	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a	0.043
uck2a	uridine-cytidine kinase 2a	0.043
tp53bp2	tumor protein p53 binding protein, 2	0.043
zgc:101761	zgc:101761	0.043
azin1b	antizyme inhibitor 1b	0.043
dpf2l	D4, zinc and double PHD fingers family 2, like	0.043
creb3l3l	cAMP responsive element binding protein 3-like 3 like	0.043
zgc:136930	zgc:136930	0.043
rnaset2	ribonuclease T2	0.043
napa	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.043
psap	prosaposin	0.043
furinb	furin (paired basic amino acid cleaving enzyme) b	0.043
ptk2.2	protein tyrosine kinase 2b	0.043
zgc:55558	zgc:55558	0.043
zgc:92474	zgc:92474	0.043
si:dkey-12o15.1	si:dkey-12o15.1	0.043
mst1	macrophage stimulating 1 (hepatocyte growth factor-like)	0.043
tshr	thyroid stimulating hormone receptor	0.043
ctsl.1	cathepsin L.1	0.043
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.043
wu:fb11c03	wu:fb11c03	0.043
myoc	myocilin	0.043
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.043
cdk10	cyclin-dependent kinase 10	0.043
insrb	insulin receptor b	0.042
fzd7a	frizzled homolog 7a	0.042
si:dkey-261h17.1	si:dkey-261h17.1	0.042
atg5	ATG5 autophagy related 5 homolog (S. cerevisiae)	0.042
pou4f1	POU domain, class 4, transcription factor 1	0.042
prpf3	PRP3 pre-mRNA processing factor 3 homolog (yeast)	0.042
zgc:55347	zgc:55347	0.042
hpx	hemopexin	0.042
zgc:92242	zgc:92242	0.042
mmp13a	matrix metalloproteinase 13a	0.042
maff	v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)	0.042
arfgap2	ADP-ribosylation factor GTPase activating protein 2	0.042
zgc:65861	zgc:65861	0.042
myog	myogenin	0.042
zgc:110182	zgc:110182	0.042
smyhc1	slow myosin heavy chain 1	0.042
col12a1	collagen, type XII, alpha 1	0.042
gkap1	G kinase anchoring protein 1	0.042
tsc1a	tuberous sclerosis 1a	0.042
comta	catechol-O-methyltransferase a	0.042
prkcz	protein kinase C, zeta	0.042
lrp2	low density lipoprotein-related protein 2	0.042
serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.042
calr	calreticulin and calreticulin	0.042
grb10a	growth factor receptor-bound protein 10a	0.042
myhz2	myosin, heavy polypeptide 2, fast muscle specific	0.042
taf1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.041
marcksa	myristoylated alanine rich protein kinase C substrate a	0.041
dkk3l	dickkopf homolog 3 like (Xenopus laevis)	0.041
pcdh17	protocadherin 17	0.041
ube2h	ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)	0.041
col10a1	collagen, type X, alpha 1	0.041
waca	WW domain containing adaptor with coiled-coil a	0.041
fgfr1b	fibroblast growth factor receptor 1b	0.041	Mouse
frzb	frizzled-related protein	0.041
cx32.3	connexin 32.3	0.041
ythdf1	YTH domain family, member 1	0.041
sbf1	SET binding factor 1	0.041
pi4k2a	phosphatidylinositol 4-kinase type 2 alpha	0.041
rpa1	replication protein A1	0.041
hic1	hypermethylated in cancer 1	0.041
tmf1	TATA element modulatory factor 1	0.041
LOC557062	hypothetical protein LOC557062	0.041
cyp11a1	cytochrome P450, subfamily XIA, polypeptide 1	0.041
kif3b	kinesin family member 3B	0.041
plcg1	phospholipase C, gamma 1	0.041
zgc:153061	zgc:153061	0.041
ube2d1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.041
llgl2	lethal giant larvae homolog 2 (Drosophila)	0.041
klhl31	kelch-like 31 (Drosophila)	0.041
hgs	hepatocyte growth factor-regulated tyrosine kinase substrate	0.041
wu:fc31g04	wu:fc31g04	0.041
kctd10	potassium channel tetramerisation domain containing 10	0.041
exoc4	exocyst complex component 4	0.041
cfl2l	cofilin 2, like	0.041
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.041
rab11a	RAB11a, member RAS oncogene family	0.041
ptprsa	protein tyrosine phosphatase, receptor type, s, a	0.041
dynlrb1	dynein, light chain, roadblock-type 1	0.041
hcrt	hypocretin (orexin) neuropeptide precursor	0.041
rpe65b	retinal pigment epithelium-specific protein 65b	0.041
tgif1	TGFB-induced factor homeobox 1	0.040
olig4	oligodendrocyte transcription factor 4	0.040
zgc:63566	zgc:63566	0.040
meox1	mesenchyme homeobox 1	0.040
celsr1a	cadherin EGF LAG seven-pass G-type receptor 1a	0.040
sip1	survival of motor neuron protein interacting protein 1	0.040
lrp5	low density lipoprotein receptor-related protein 5	0.040
p2rx3b	purinergic receptor P2X, ligand-gated ion channel, 3b	0.040
prdx3	peroxiredoxin 3	0.040
jag2	jagged 2	0.040
slc6a4a	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A	0.040
elp4	elongation protein 4 homolog (S. cerevisiae)	0.040
wars	tryptophanyl-tRNA synthetase	0.040
zgc:193699	zgc:193699	0.040
hspa12b	heat shock protein 12B	0.040
kal1b	Kallmann syndrome 1b sequence	0.040
cyp2v2	cytochrome P450, family 2, subfamily V, polypeptide 2	0.040
sult6b1	sulfotransferase family, cytosolic, 6b, member 1	0.040