IMP: Integrative Multi-species Prediction

Danio rerio

10 genes annotated in zebrafish

positive regulation of cysteine type endopeptidase activity involved in apoptotic process

Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of cysteine type endopeptidase activity involved in apoptotic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of cysteine type endopeptidase activity involved in apoptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
bcl2	B-cell leukemia/lymphoma 2	0.724	Zebrafish
mcl1a	myeloid cell leukemia sequence 1a	0.583	Zebrafish
mcl1b	myeloid cell leukemia sequence 1b	0.459	Zebrafish
bad	BCL2-antagonist of cell death	0.420	Mouse
bida	BH3 interacting domain death agonist	0.317
eif3ha	eukaryotic translation initiation factor 3, subunit H, a	0.212
stc1l	stanniocalcin 1, like	0.193
baxa	bcl2-associated X protein, a	0.177
sulf1	sulfatase 1	0.145
bbc3	BCL2 binding component 3	0.140
LOC567131	calcitonin gene-related peptide type 1 receptor-like	0.108
cct5	chaperonin containing TCP1, subunit 5 (epsilon)	0.106
tfe3b	transcription factor binding to IGHM enhancer 3b	0.101
rpsa	ribosomal protein SA	0.085
socs3a	suppressor of cytokine signaling 3a	0.077
bactin1	bactin1	0.076
caspa	caspase a	0.072
bcl2l1	bcl2-like 1	0.069	Zebrafish
gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.069	Human
plxnb2a	plexin b2a	0.065
dhfr	dihydrofolate reductase	0.064
serpinb1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.060
casp8	caspase 8, apoptosis-related cysteine peptidase	0.059
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.058
foxo3b	forkhead box O3b	0.056
satb2	SATB homeobox 2	0.050
myca	myelocytomatosis oncogene a	0.047
irf6	interferon regulatory factor 6	0.046
duox	dual oxidase	0.046
jun	jun proto-oncogene	0.044
cct6a	chaperonin containing TCP1, subunit 6A (zeta 1)	0.044
adipor1b	adiponectin receptor 1b	0.043
mre11a	meiotic recombination 11 homolog A (S. cerevisiae)	0.040
pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.040
ran	ras-related nuclear protein	0.040
ptgs1	prostaglandin-endoperoxide synthase 1	0.040
ahcy	S-adenosylhomocysteine hydrolase	0.040
fadd	Fas (tnfrsf6)-associated via death domain	0.039
eif3s2	eukaryotic translation initiation factor 3, subunit 2 beta	0.038
ogg1	8-oxoguanine DNA glycosylase	0.038
hmgb2a	high-mobility group box 2a	0.036
fanci	Fanconi anemia, complementation group I	0.036
zgc:64114	zgc:64114	0.035
pabpc1a	poly A binding protein, cytoplasmic 1 a	0.035
eif3b	eukaryotic translation initiation factor 3, subunit B	0.035
pcna	proliferating cell nuclear antigen	0.034
crfa31.2	IL-4RA-like protein 2	0.034
lass2	LAG1 homolog, ceramide synthase 2 (S. cerevisiae)	0.034
fech	ferrochelatase	0.034
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.032
s100a10b	S100 calcium binding protein A10b	0.032
igfbp1a	insulin-like growth factor binding protein 1a	0.032
zgc:92237	zgc:92237	0.031
eif3d	eukaryotic translation initiation factor 3, subunit D	0.031
hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.031
tlr9	toll-like receptor 9	0.031
gtpbp4	GTP binding protein 4	0.031
ctgf	connective tissue growth factor	0.031	Rat
chac1	ChaC, cation transport regulator-like 1	0.030
per2	period homolog 2 (Drosophila)	0.030
immt	inner membrane protein, mitochondrial (mitofilin)	0.029
rpl7a	ribosomal protein L7a	0.029
fas	Fas (TNF receptor superfamily, member 6)	0.028	Zebrafish
tnfsf10l2	tumor necrosis factor (ligand) superfamily, member 10 like 2	0.028	Human
eif4a3	eukaryotic translation initiation factor 4A, isoform 3	0.028
f2rl1.2	coagulation factor II (thrombin) receptor-like 1.2	0.027
gata5	GATA-binding protein 5	0.027
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.027
ndufv1	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.025
zgc:66317	zgc:66317	0.025
pitrm1	pitrilysin metalloproteinase 1	0.025
si:ch211-235f6.2	si:ch211-235f6.2	0.025
limk1	LIM domain kinase 1	0.025
met	met proto-oncogene (hepatocyte growth factor receptor)	0.025
eif3ea	eukaryotic translation initiation factor 3, subunit E, a	0.024
dhdds	dehydrodolichyl diphosphate synthase	0.024
ppia	peptidylprolyl isomerase A (cyclophilin A)	0.024
LOC100535854	ubiquitin carboxyl-terminal hydrolase CYLD-like	0.023
hoxa4a	homeo box A4a	0.023
rps11	ribosomal protein S11	0.023
mycl1b	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b	0.023
rps3a	ribosomal protein S3A	0.023
dnmt5	DNA (cytosine-5-)-methyltransferase 5	0.022
egr1	early growth response 1	0.022
chchd10	coiled-coil-helix-coiled-coil-helix domain containing 10	0.022
pkp2	plakophilin 2	0.022
lap3	leucine aminopeptidase 3	0.021
adipor2	adiponectin receptor 2	0.021
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.021	Zebrafish
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.021
cflar	CASP8 and FADD-like apoptosis regulator	0.021
mical3	flavoprotein oxidoreductase MICAL3	0.021
cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.020
psma6b	proteasome (prosome, macropain) subunit, alpha type, 6b	0.020
kitlgb	kit ligand b	0.020
dlx3b	distal-less homeobox gene 3b	0.020
dip2c	DIP2 disco-interacting protein 2 homolog C (Drosophila)	0.020
LOC566020	Gig2-like protein DreO	0.020
si:rp71-39b20.7	si:rp71-39b20.7	0.020
fbxo32	F-box protein 32	0.020
hmgb1a	high-mobility group box 1a	0.019
LOC100000934	hypothetical protein LOC100000934	0.019
rps3	ribosomal protein S3	0.019
fabp2	fatty acid binding protein 2, intestinal	0.019
pccb	propionyl Coenzyme A carboxylase, beta polypeptide	0.019
rhoad	ras homolog gene family, member Ad	0.019
irgq1	immunity-related GTPase family, q1	0.019
psmb5	proteasome (prosome, macropain) subunit, beta type, 5	0.018
phlda2	pleckstrin homology-like domain, family A, member 2	0.018
hprt1	hypoxanthine phosphoribosyltransferase 1	0.018
ndufa9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9	0.018
rdh10b	retinol dehydrogenase 10b	0.018
bmf1	Bcl2 modifying factor 1	0.018
spry2	sprouty homolog 2	0.018
pld1a	phospholipase D1a	0.018
psma8	proteasome (prosome, macropain) subunit, alpha type, 8	0.018
actn1	actinin, alpha 1	0.018
LOC557722	similar to transient receptor potential cation channel, subfamily M, member 5	0.018
cish	cytokine inducible SH2-containing protein	0.018
stab2	stabilin 2	0.017
rpa2	replication protein A2	0.017
il8	interleukin 8	0.017
mycbp2	MYC binding protein 2	0.017
igf2a	insulin-like growth factor 2a	0.017
cd247	CD247 antigen	0.016
mcm4	MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)	0.016
pmpca	peptidase (mitochondrial processing) alpha	0.016
zwilch	Zwilch, kinetochore associated, homolog (Drosophila)	0.016
ints6	integrator complex subunit 6	0.016
ehd2	EH-domain containing 2	0.016
ihha	Indian hedgehog homolog a	0.016
gins2	GINS complex subunit 2	0.016
LOC100004946	transient receptor potential cation channel subfamily M member 4-like	0.016
rpl13	ribosomal protein L13	0.016
rps6ka3a	ribosomal protein S6 kinase, polypeptide 3a	0.016
dnajb6b	DnaJ (Hsp40) homolog, subfamily B, member 6b	0.016
krt4	keratin 4	0.016
hmgb2b	high-mobility group box 2b	0.016
krcp	kelch repeat-containing protein	0.016
csnk1da	casein kinase 1, delta a	0.016
notch1a	notch homolog 1a	0.015
casrl	calcium-sensing receptor, like	0.015
sox11a	SRY-box containing gene 11a	0.015
hspa9	heat shock protein 9	0.015
hdr	hematopoietic death receptor	0.015
bnip3lb	BCL2/adenovirus E1B interacting protein 3-like b	0.015
cdc42l	cell division cycle 42, like	0.015
prmt1	protein arginine methyltransferase 1	0.015
dlst	dihydrolipoamide S-succinyltransferase	0.015
epas1b	endothelial PAS domain protein 1b	0.014
gpib	glucose phosphate isomerase b	0.014
atf3	activating transcription factor 3	0.014
myh11a	myosin, heavy polypeptide 11, smooth muscle a	0.014
nsa2	NSA2 ribosome biogenesis homolog (S. cerevisiae)	0.014
cbfb	core-binding factor, beta subunit	0.014
hmgb3b	high-mobility group box 3b	0.014
gpia	glucose phosphate isomerase a	0.014
slmo2	slowmo homolog 2 (Drosophila)	0.014
cdk7	cyclin-dependent kinase 7	0.014
il4r	interleukin 4 receptor	0.014
prpf8	pre-mRNA processing factor 8	0.014
capns1b	calpain, small subunit 1 b	0.014
irx5a	iroquois homeobox protein 5a	0.014
junb	jun B proto-oncogene	0.014
zgc:113054	zgc:113054	0.014
tcp1	t-complex polypeptide 1	0.013
prim1	primase polypeptide 1	0.013
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.013
zff9	zinc finger protein 9	0.013
fn1	fibronectin 1	0.013
mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.013
appl1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.013
ck2b	casein kinase 2 beta	0.013
zgc:92872	zgc:92872	0.013
sec23b	Sec23 homolog B (S. cerevisiae)	0.013
ptpn9a	protein tyrosine phosphatase, non-receptor type 9, a	0.013
fen1	flap structure-specific endonuclease 1	0.013
rpl19	ribosomal protein L19	0.013
hmgb3a	high-mobility group box 3a	0.013
setb	SET translocation (myeloid leukemia-associated) B	0.013
pdha1a	pyruvate dehydrogenase (lipoamide) alpha 1a	0.013
foxa2	forkhead box A2	0.013
rplp0	ribosomal protein, large, P0	0.012
nup93	nucleoporin 93	0.012
epor	erythropoietin receptor	0.012
got2b	glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)	0.012
hif1an	hypoxia-inducible factor 1, alpha subunit inhibitor	0.012
lgals2a	lectin, galactoside-binding, soluble, 2a	0.012
mos	v-mos Moloney murine sarcoma viral oncogene homolog	0.012
scrib	scribbled homolog (Drosophila)	0.012
poldip2	polymerase (DNA-directed), delta interacting protein 2	0.012
rb1	retinoblastoma 1	0.012
nasp	nuclear autoantigenic sperm protein (histone-binding)	0.012
zgc:152873	zgc:152873	0.012
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.012
idh3b	isocitrate dehydrogenase 3 (NAD+) beta	0.012
mycb	myelocytomatosis oncogene b	0.012	Human Mouse
rpl5b	ribosomal protein L5b	0.012
ecscr	endothelial cell-specific chemotaxis regulator	0.012
gata3	GATA-binding protein 3	0.012
ptrfb	polymerase I and transcript release factor b	0.012
hhex	hematopoietically expressed homeobox	0.012
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.012
wu:fj62d01	wu:fj62d01	0.012
zgc:123307	zgc:123307	0.012
zgc:92242	zgc:92242	0.012
th	tyrosine hydroxylase	0.012
zgc:73293	zgc:73293	0.012
zgc:100919	zgc:100919	0.012
ext1b	exostoses (multiple) 1b	0.011
mcm7	MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)	0.011
mesp2	mesoderm posterior 2 homolog (mouse)	0.011
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.011
eomesb	eomesodermin homolog b	0.011
rnf17	ring finger protein 17	0.011
cnpy1	canopy1	0.011
ssrp1a	structure specific recognition protein 1a	0.011
sdhb	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.011
fes	feline sarcoma oncogene	0.011
kpna2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.011
sdha	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.011
cops4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.011
rpl4	ribosomal protein L4	0.011
mkks	McKusick-Kaufman syndrome	0.011
thsd7a	thrombospondin, type I, domain containing 7A	0.011
eif2ak1	eukaryotic translation initiation factor 2-alpha kinase 1	0.011
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.011
zgc:92502	zgc:92502	0.011
eno2	enolase 2	0.011
vtg1	vitellogenin 1	0.011
adrb2a	adrenergic receptor, beta 2a	0.011
zgc:63599	zgc:63599	0.011
oc90	otoconin 90	0.011
mych	myelocytomatosis oncogene homolog	0.011
egln1	egl nine homolog 1 (C. elegans)	0.011
zgc:101606	zgc:101606	0.011
copeb	core promoter element binding protein	0.011
tbx5a	T-box 5a	0.011
ripk2	receptor-interacting serine-threonine kinase 2	0.010
ef1a	elongation factor 1-alpha	0.010
cdk2	cyclin-dependent kinase 2	0.010
tmprss4a	transmembrane protease, serine 4a	0.010
cap1	Cap1 CAP, adenylate cyclase-associated protein 1	0.010
zgc:86841	zgc:86841	0.010
hoxb1a	homeo box B1a	0.010
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.010
si:busm1-57f23.1	si:busm1-57f23.1	0.010
cldni	claudin i	0.010
rps2	ribosomal protein S2	0.010
nrg1	neuregulin 1	0.010
ptgs2b	prostaglandin-endoperoxide synthase 2b	0.010
ext1a	exostoses (multiple) 1a	0.010