IMP: Integrative Multi-species Prediction

Danio rerio

17 genes annotated in zebrafish

endodermal cell fate specification

The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endodermal cell fate specification"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "endodermal cell fate specification" (in gray)

Name	Description	Probability	Func Analog Organism
chd	chordin	1.000
flh	floating head	0.984
bmp4	bone morphogenetic protein 4	0.898
tbx1	T-box 1	0.865	Zebrafish
fn1	fibronectin 1	0.852
bmp2b	bone morphogenetic protein 2b	0.838
pax2a	paired box gene 2a	0.835
tbx16	T-box gene 16	0.821	Zebrafish
fgf3	fibroblast growth factor 3	0.800
foxi1	forkhead box I1	0.792
her7	hairy and enhancer of split related-7	0.770
hnf1ba	HNF1 homeobox Ba	0.745	Mouse
vent	ventral expressed homeobox	0.744
shha	sonic hedgehog a	0.743
jag2	jagged 2	0.724
wnt5b	wingless-type MMTV integration site family, member 5b	0.704
pcdh8	protocadherin 8	0.698
dusp6	dual specificity phosphatase 6	0.680
ndr2	nodal-related 2	0.677
fgf17	fibroblast growth factor 17	0.652
fgf8a	fibroblast growth factor 8 a	0.625
dlc	deltaC	0.622
ndr1	nodal-related 1	0.563
ved	ventrally expressed dharma/bozozok antagonist	0.527
hand2	heart and neural crest derivatives expressed transcript 2	0.505
cdh2	cadherin 2, neuronal	0.491
emx3	empty spiracles homeobox 3	0.473
lft1	lefty1	0.424
dkk1b	dickkopf 1b	0.408
notch1a	notch homolog 1a	0.406
lhx1a	LIM homeobox 1a	0.373
gbx2	gastrulation brain homeo box 2	0.371
oep	one-eyed pinhead	0.369
ntla	no tail a	0.353	Zebrafish
eya1	eyes absent homolog 1	0.351
myod1	myogenic differentiation 1	0.350
dharma	dharma	0.337
snai1a	snail homolog 1a (Drosophila)	0.334
cdx4	caudal type homeo box transcription factor 4	0.299
spry4	sprouty (Drosophila) homolog 4	0.298
osr2	odd-skipped related 2 (Drosophila)	0.292
foxd5	forkhead box D5	0.273
foxd3	forkhead box D3	0.271
btg2	B-cell translocation gene 2	0.263
pdgfaa	platelet-derived growth factor alpha a	0.260
foxh1	forkhead box H1	0.260
foxg1a	forkhead box G1a	0.256
fgfr4	fibroblast growth factor receptor 4	0.248	Zebrafish
efnb2a	ephrin B2a	0.245
six3a	sine oculis homeobox homolog 3a	0.240
gata3	GATA-binding protein 3	0.226
cdh1	cadherin 1, epithelial	0.224
mespa	mesoderm posterior a	0.223	Mouse
dld	deltaD	0.214
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.210
wif1	wnt inhibitory factor 1	0.208
fzd5	frizzled homolog 5	0.194
six4b	sine oculis homeobox homolog 4b	0.193
sox9a	SRY-box containing gene 9a	0.176	Zebrafish
jag1b	jagged 1b	0.169
evx1	even-skipped homeobox 1	0.164
her1	hairy-related 1	0.161
notch1b	notch homolog 1b	0.159	Zebrafish
tp63	tumor protein p63	0.156
admp	anti-dorsalizing morphogenic protein	0.144	Zebrafish
notch2	notch homolog 2	0.143	Zebrafish
has2	hyaluronan synthase 2	0.139
sox32	SRY-box containing gene 32	0.132
foxa1	forkhead box A1	0.132
hoxa2b	homeo box A2b	0.132
tbx2b	T-box 2b	0.131	Zebrafish
fgfr1a	fibroblast growth factor receptor 1a	0.129
fgf10a	fibroblast growth factor 10a	0.128
tbx20	T-box 20	0.126	Zebrafish
fzd8b	frizzled homolog 8b	0.123
rarab	retinoic acid receptor, alpha b	0.122
mmp2	matrix metalloproteinase 2	0.122
fzd10	frizzled homolog 10	0.122
her5	hairy-related 5	0.121
gli1	GLI-Kruppel family member 1	0.120
pitx2	paired-like homeodomain transcription factor 2	0.117
nanos3	nanos homolog 3	0.117
gsc	goosecoid	0.116
gli2a	GLI-Kruppel family member GLI2a	0.116
ephb4b	eph receptor B4b	0.116
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.115
irx1b	iroquois homeobox protein 1, b	0.115
runx2b	runt-related transcription factor 2b	0.114
fli1a	friend leukemia integration 1a	0.112
zp2.2	zona pellucida glycoprotein 2.2	0.110
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.109
bon	bonnie and clyde	0.108
eomesa	eomesodermin homolog a	0.107
pou3f3b	POU class 3 homeobox 3b	0.107
sox19b	SRY-box containing gene 19b	0.106	Zebrafish
otx1a	orthodenticle homolog 1a	0.105
hmx4	H6 family homeobox 4	0.104
wnt11	wingless-type MMTV integration site family, member 11	0.103	Worm
sox1a	SRY-box containing gene 1a	0.103	Zebrafish
chrna2a	cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)	0.102
og9x	OG9 homeobox gene	0.102
foxa3	forkhead box A3	0.100
lamb1a	laminin, beta 1a	0.100
prl	prolactin	0.096
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.096
mespb	mesoderm posterior b	0.093	Mouse
bmp7a	bone morphogenetic protein 7a	0.091
vasa	vasa homolog	0.091
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.088
gata5	GATA-binding protein 5	0.088
tbx6	T-box gene 6	0.085	Zebrafish
brd4	bromodomain containing 4	0.084
supt6h	suppressor of Ty 6 homolog	0.084
tll1	tolloid-like 1	0.081
dlx2a	distal-less homeobox gene 2a	0.081
six4a	sine oculis homeobox homolog 4a	0.080
msxe	muscle segment homeobox E	0.078
twist1a	twist1a	0.076
wnt9a	wingless-type MMTV integration site family, member 9A	0.074
vox	ventral homeobox	0.074
eve1	even-skipped-like1	0.071
myf5	myogenic factor 5	0.070
sall4	sal-like 4 (Drosophila)	0.068
nrarpa	notch-regulated ankyrin repeat protein a	0.068
hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.067
foxa2	forkhead box A2	0.067
gro1	groucho 1	0.066
cd8a	CD8 antigen, alpha polypeptide	0.064
lhx1b	LIM homeobox 1b	0.059
zfand5a	zinc finger, AN1-type domain 5a	0.059
pax6b	paired box gene 6b	0.058
bmp3	bone morphogenetic protein 3	0.057	Zebrafish
sox3	SRY-box containing gene 3	0.057	Zebrafish
tbx5a	T-box 5a	0.056	Zebrafish
msxb	muscle segment homeobox B	0.055
prickle1a	prickle-like 1 (Drosophila) a	0.054
mib	mind bomb	0.053
lft2	lefty2	0.053
hoxb2a	homeo box B2a	0.052
nkx2.3	NK2 transcription factor related 3	0.051
flt4	fms-related tyrosine kinase 4	0.050
dlb	deltaB	0.050
junbl	jun B proto-oncogene, like	0.049
junb	jun B proto-oncogene	0.049
etv2	ets variant gene 2	0.049
tp53	tumor protein p53	0.049
foxn4	forkhead box N4	0.048
irx4b	iroquois homeobox protein 4b	0.044
mab21l2	mab-21-like 2	0.044
axin1	axin 1	0.044
pou2f1a	POU class 2 homeobox 1a	0.042	Zebrafish
aplnra	apelin receptor a	0.039
lfng	lunatic fringe homolog	0.038
vax2	ventral anterior homeobox 2	0.037
nkx2.2a	NK2 transcription factor related 2a	0.037
frem3	Fras1 related extracellular matrix 3	0.036
tbpl2	TATA box binding protein like 2	0.036
hoxc6a	homeo box C6a	0.036
osr1	odd-skipped related 1 (Drosophila)	0.036
si:ch211-235f6.2	si:ch211-235f6.2	0.035
sox17	SRY-box containing gene 17	0.035	Zebrafish Mouse
pnx	posterior neuron-specific homeobox	0.035
hhip	hedgehog interacting protein	0.034
fzd7a	frizzled homolog 7a	0.034
lama5	laminin, alpha 5	0.034
mxtx2	mix-type homeobox gene 2	0.034
smo	smoothened homolog (Drosophila)	0.034
si:ch211-212m21.5	si:ch211-212m21.5	0.033
tgfbi	transforming growth factor, beta-induced	0.033
sox10	SRY-box containing gene 10	0.032
nkx2.5	NK2 transcription factor related 5	0.032
hapln3	hyaluronan and proteoglycan link protein 3	0.032
igf1rb	insulin-like growth factor 1b receptor	0.031
egr1	early growth response 1	0.031
ctgf	connective tissue growth factor	0.030
wnt8b	wingless-type MMTV integration site family, member 8b	0.030
jag1a	jagged 1a	0.030
ier2	immediate early response 2	0.030
hmx1	H6 homeo box 1	0.029
klf4	Kruppel-like factor 4	0.029
acvr1b	activin A receptor, type IB	0.029
brd2a	bromodomain-containing 2a	0.029
pea3	ETS-domain transcription factor pea3	0.029
neo1	neogenin 1	0.029
sox2	SRY-box containing gene 2	0.029	Human Zebrafish
waca	WW domain containing adaptor with coiled-coil a	0.029
grem2	gremlin 2, cysteine knot superfamily	0.029
pitx3	paired-like homeodomain transcription factor 3	0.028
ptch1	patched 1	0.028
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.028
gro2	groucho 2	0.028
msxc	muscle segment homeobox C	0.028
dlx4b	distal-less homeobox gene 4b	0.028
runx3	runt-related transcription factor 3	0.027
mmp15b	matrix metallopeptidase 15b	0.027
wnt11r	wingless-type MMTV integration site family, member 11, related	0.027	Worm
oprd1b	opioid receptor, delta 1b	0.027
ptgs1	prostaglandin-endoperoxide synthase 1	0.027
wu:fc23b05	wu:fc23b05	0.027
rx3	retinal homeobox gene 3	0.026
fgfrl1b	fibroblast growth factor receptor-like 1b	0.026
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.026
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.026
irx3a	iroquois homeobox protein 3a	0.026
spaw	southpaw	0.026
meis3	myeloid ecotropic viral integration site 3	0.026
lhx2b	LIM homeobox 2b	0.026
fsta	follistatin a	0.026
msgn1	mesogenin 1	0.025
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.025
erg	v-ets erythroblastosis virus E26 oncogene like (avian)	0.025
igfbp3	insulin-like growth factor binding protein 3	0.025
nog2	noggin 2	0.025	Zebrafish
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.025
nkx2.1b	NK2 homeobox 1b	0.024
acvr2b	activin receptor IIb	0.024
gpr126	G protein-coupled receptor 126	0.024
sfrp1a	secreted frizzled-related protein 1a	0.024
zgc:153997	zgc:153997	0.024
lhx8a	LIM homeobox 8a	0.024
alcamb	activated leukocyte cell adhesion molecule b	0.023
bmp2a	bone morphogenetic protein 2a	0.023	Zebrafish
krml2.2	Kreisler (mouse) maf-related leucine zipper homolog 2.2	0.023
celsr1a	cadherin EGF LAG seven-pass G-type receptor 1a	0.023
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.023
col8a1a	collagen, type VIII, alpha 1a	0.023
hcst	hematopoietic cell signal transducer	0.023
dmrt2a	doublesex and mab-3 related transcription factor 2a	0.023
otx1b	orthodenticle homolog 1b	0.023
pax8	paired box gene 8	0.023
socs3a	suppressor of cytokine signaling 3a	0.023
rx2	retinal homeobox gene 2	0.022
traf4a	tnf receptor-associated factor 4a	0.022
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.022
hoxc8a	homeo box C8a	0.022
fibin	fin bud initiation factor	0.022
prdm1a	PR domain containing 1a, with ZNF domain	0.022
col2a1a	collagen type II, alpha-1a	0.022
epha2	eph receptor A2	0.021
scinla	scinderin like a	0.021
runx1	runt-related transcription factor 1	0.021
fosl2	fos-like antigen 2	0.021
hhex	hematopoietically expressed homeobox	0.021
dlx5a	distal-less homeobox gene 5a	0.021
epha4b	eph receptor A4b	0.021
irf6	interferon regulatory factor 6	0.021
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.021
dmrta2	doublesex and mab-3 related transcription factor like family A2	0.021
cdh5	cadherin 5	0.020
atoh1a	atonal homolog 1a	0.020
rapgef1	Rap guanine nucleotide exchange factor (GEF) 1	0.020
snai1b	snail homolog 1b (Drosophila)	0.020
sox11a	SRY-box containing gene 11a	0.019
szl	sizzled	0.019
csrnp1b	cysteine-serine-rich nuclear protein 1b	0.019
metrn	meteorin, glial cell differentiation regulator	0.019
hspa12b	heat shock protein 12B	0.019
klf2a	Kruppel-like factor 2a	0.019
pax7a	paired box gene 7a	0.019
otpb	orthopedia homolog b	0.018
vsx1	visual system homeobox 1 homolog, chx10-like	0.018
hapln1a	hyaluronan and proteoglycan link protein 1a	0.018
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.018
im:7137555	im:7137555	0.018
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.018
vsx2	visual system homeobox 2	0.018
mapk4	mitogen-activated protein kinase 4	0.018
emx2	empty spiracles homeobox 2	0.018
atf3	activating transcription factor 3	0.018
etv5a	ets variant 5a	0.018
sox11b	SRY-box containing gene 11b	0.018
chd7	chromodomain helicase DNA binding protein 7	0.018
lef1	lymphocyte enhancer binding factor 1	0.018
pou3f2	POU class 3 homeobox 2	0.017
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.017
pcdh10b	protocadherin 10b	0.017
cltca	clathrin, heavy polypeptide a (Hc)	0.017
insm1b	insulinoma-associated 1b	0.017
fgfrl1a	fibroblast growth factor receptor-like 1a	0.017
wasb	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b	0.017
LOC567678	avidin-like	0.017
inab	internexin neuronal intermediate filament protein, alpha b	0.017
egr2a	early growth response 2a	0.017
hoxa11a	homeo box A11a	0.017
copeb	core promoter element binding protein	0.017
zfp36l1b	zinc finger protein 36, C3H type-like 1b	0.017
lmx1a	LIM homeobox transcription factor 1, alpha	0.016
ripply2	ripply2	0.016
pou3f3a	POU class 3 homeobox 3a	0.016	Zebrafish
hoxa9a	homeo box A9a	0.016
tgfb2	transforming growth factor, beta 2	0.016
hdac4	histone deacetylase 4	0.016
dlx3b	distal-less homeobox gene 3b	0.016
foxc1a	forkhead box C1a	0.016
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.016
shdb	Src homology 2 domain containing transforming protein D, b	0.016
neurod4	neurogenic differentiation 4	0.015
dsc2l	desmocollin 2 like	0.015
dbx1b	developing brain homeobox 1b	0.015
gsdf	gonadal somatic cell derived factor	0.015
bokb	BCL2-related ovarian killer b	0.015
sox19a	SRY-box containing gene 19a	0.015	Zebrafish
wnt10a	wingless-type MMTV integration site family, member 10a	0.015
ryk	receptor-like tyrosine kinase	0.015
tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.015
mecom	MDS1 and EVI1 complex locus	0.015
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.014
nkx2.2b	NK2 transcription factor related 2b	0.014
coe2	coe2	0.014
dspa	desmoplakin a	0.014
sp5l	Sp5 transcription factor-like	0.014
pbx4	pre-B-cell leukemia transcription factor 4	0.014
axin2	axin 2 (conductin, axil)	0.014
im:7165141	im:7165141	0.014
per3	period homolog 3 (Drosophila)	0.014
col14a1	collagen, type XIV, alpha 1	0.014
pde10a	phosphodiesterase 10A	0.014
wnt9b	wingless-type MMTV integration site family, member 9B	0.013
spry2	sprouty homolog 2	0.013
notch3	notch homolog 3	0.013	Zebrafish
tph1a	tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a	0.013
onecut1	one cut domain, family member 1	0.013
rargb	retinoic acid receptor, gamma b	0.013
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.013
krt4	keratin 4	0.013
neurod6a	neurogenic differentiation 6a	0.013
retsatl	retinol saturase (all-trans-retinol 13,14-reductase) like	0.013
eng2b	engrailed 2b	0.013
hoxb3a	homeo box B3a	0.013
phc2	polyhomeotic-like 2 (Drosophila)	0.013
uts2a	urotensin 2, alpha	0.013
wls	wntless homolog (Drosophila)	0.013	Worm
klf2b	Kruppel-like factor 2b	0.012
kif7	kinesin family member 7	0.012
nitr9	novel immune-type receptor 9	0.012
capn9	calpain 9	0.012
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.012
agr2	anterior gradient homolog 2 (Xenopus laevis)	0.012
musk	muscle, skeletal, receptor tyrosine kinase	0.012
zgc:92851	zgc:92851	0.012
adra2da	adrenergic, alpha-2D-, receptor a	0.012
nr2f1b	nuclear receptor subfamily 2, group F, member 1b	0.012
pax5	paired box gene 5	0.012
desma	desmin a	0.012
evx2	even-skipped homeobox 2	0.012
tead3a	TEA domain family member 3 a	0.012
dusp5	dual specificity phosphatase 5	0.012	Zebrafish
emp2	epithelial membrane protein 2	0.012
kirrela	kin of IRRE like a	0.012
dvr1	decapentaplegic and Vg-related 1	0.012	Zebrafish
rag2	recombination activating gene 2	0.012
myca	myelocytomatosis oncogene a	0.012
vangl2	vang-like 2 (van gogh, Drosophila)	0.012
perp	PERP, TP53 apoptosis effector	0.012
rerea	arginine-glutamic acid dipeptide (RE) repeats a	0.011
rag1	recombination activating gene 1	0.011
tmem2	transmembrane protein 2	0.011
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.011
lrrc50	leucine rich repeat containing 50	0.011
dvl3	dishevelled, dsh homolog 3 (Drosophila)	0.011	Worm
her12	hairy-related 12	0.011
dsg2	desmoglein 2	0.011
pkd2	polycystic kidney disease 2	0.011
bmp5	bone morphogenetic protein 5	0.011
hesx1	homeo box (expressed in ES cells) 1	0.011
rhoub	ras homolog gene family, member Ub	0.011
wt1a	wilms tumor 1a	0.011
dbx1a	developing brain homeobox 1a	0.011
mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.011
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.011
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.011
olig3	oligodendrocyte transcription factor 3	0.011
smad9	MAD homolog 9 (Drosophila)	0.011	Fly
msxd	muscle segment homeobox D	0.011
atoh7	atonal homolog 7	0.011
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.011
btg1	B-cell translocation gene 1	0.011
drd2a	dopamine receptor D2a	0.011
fli1b	friend leukemia integration 1b	0.011
il22	interleukin 22	0.011
kbtbd10b	kelch repeat and BTB (POZ) domain containing 10b	0.011
tob1a	transducer of ERBB2, 1a	0.011
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.011
mib2	mind bomb 2	0.011
il17rd	interleukin 17 receptor D	0.011
gata2a	GATA-binding protein 2a	0.010
ntf7	neurotrophin 7	0.010
nkx3.2	NK3 homeobox 2	0.010
hgfa	hepatocyte growth factor a	0.010
kitb	kit receptor b	0.010
rgs4	regulator of G-protein signalling 4	0.010
atp1a1a.5	ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide	0.010
acvr1l	activin A receptor, type I like	0.010
fbln1	fibulin 1	0.010
cldng	claudin g	0.010
slit3	slit (Drosophila) homolog 3	0.010
mpp6b	membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)	0.010