IMP: Integrative Multi-species Prediction

Danio rerio

0 genes annotated in zebrafish

osteochondrodysplasia

DOID:2256

A bone development disease that results in defective development of cartilage or bone.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "osteochondrodysplasia" (in gray)

Name	Description	Probability	Func Analog Organism
col1a1a	collagen, type I, alpha 1a	0.980	Human
col1a2	collagen, type I, alpha 2	0.968	Human
sparc	secreted acidic cysteine rich glycoprotein	0.833
runx2b	runt-related transcription factor 2b	0.678	Human
lect1	leukocyte cell derived chemotaxin 1	0.562
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.548
sox9a	SRY-box containing gene 9a	0.428	Human
pax7a	paired box gene 7a	0.303
col10a1	collagen, type X, alpha 1	0.298
runx2a	runt-related transcription factor 2a	0.287	Human
col5a1	procollagen, type V, alpha 1	0.279
ptch1	patched 1	0.254
dlx5a	distal-less homeobox gene 5a	0.213
col2a1a	collagen type II, alpha-1a	0.207	Human
col11a2	collagen type XI alpha-2	0.159
wt1a	wilms tumor 1a	0.158
col5a2l	collagen, type V, alpha 2-like	0.147
sp7	Sp7 transcription factor	0.143	Human
fgf8a	fibroblast growth factor 8 a	0.142
rcn3	reticulocalbin 3, EF-hand calcium binding domain	0.138
col9a2	procollagen, type IX, alpha 2	0.122
dlx3b	distal-less homeobox gene 3b	0.111
dlx2a	distal-less homeobox gene 2a	0.110
sox9b	SRY-box containing gene 9b	0.102
ntn1b	netrin 1b	0.094
dcn	decorin	0.094
chd	chordin	0.093
col1a1b	collagen, type I, alpha 1b	0.093	Human
col12a1	collagen, type XII, alpha 1	0.086
fras1	Fraser syndrome 1	0.082
postn	periostin, osteoblast specific factor	0.079
msxe	muscle segment homeobox E	0.074
fgfr1a	fibroblast growth factor receptor 1a	0.067
pax2a	paired box gene 2a	0.061
tmed9	transmembrane emp24 protein transport domain containing 9	0.055
snai1b	snail homolog 1b (Drosophila)	0.050
zgc:158626	zgc:158626	0.048
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.044
ptch2	patched 2	0.042
has3	hyaluronan synthase 3	0.039
mgp	matrix Gla protein	0.038
wnt8b	wingless-type MMTV integration site family, member 8b	0.038
dlx4a	distal-less homeobox gene 4a	0.036
tgfbi	transforming growth factor, beta-induced	0.036
myf5	myogenic factor 5	0.035
fstl1a	follistatin-like 1a	0.035
col27a1a	collagen, type XXVII, alpha 1a	0.034
wnt4a	wingless-type MMTV integration site family, member 4a	0.033
krt8	keratin 8	0.032
heatr5a	HEAT repeat containing 5a	0.032
matn4	matrilin 4	0.032
bmper	BMP binding endothelial regulator	0.031
bglap	bone gamma-carboxyglutamate (gla) protein	0.031
ankar	ankyrin and armadillo repeat containing	0.031
lamb1a	laminin, beta 1a	0.030
clock	clock	0.030
col9a3	collagen, type IX, alpha 3	0.029
efnb2a	ephrin B2a	0.029
crabp2a	cellular retinoic acid binding protein 2, a	0.028
frem3	Fras1 related extracellular matrix 3	0.028
col6a3	collagen, type VI, alpha 3	0.027
tshb	thyroid stimulating hormone, beta subunit	0.027
sox4b	SRY-box containing gene 4b	0.026
pdgfrl	platelet-derived growth factor receptor-like	0.026
rag1	recombination activating gene 1	0.025
myod1	myogenic differentiation 1	0.025
nkx3.2	NK3 homeobox 2	0.025
LOC100333762	collagen alpha-1(IX) chain-like	0.024
shhb	sonic hedgehog b	0.024
vax2	ventral anterior homeobox 2	0.024
acana	aggrecan a	0.024
col8a1a	collagen, type VIII, alpha 1a	0.024
furina	furin (paired basic amino acid cleaving enzyme) a	0.023
cdkl1	cyclin-dependent kinase-like 1 (CDC2-related kinase)	0.023
esr2a	estrogen receptor 2a	0.023
cdh2	cadherin 2, neuronal	0.022
prdm1a	PR domain containing 1a, with ZNF domain	0.022
pitx3	paired-like homeodomain transcription factor 3	0.022
bmp2b	bone morphogenetic protein 2b	0.022
cnr1	cannabinoid receptor 1	0.022
ihha	Indian hedgehog homolog a	0.022
th	tyrosine hydroxylase	0.022
ephb4a	eph receptor B4a	0.022
npas2	neuronal PAS domain protein 2	0.021
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.021
wdr96	WD repeat domain 96	0.021
sema3d	semaphorin 3d	0.021
lama5	laminin, alpha 5	0.021
arx	aristaless related homeobox	0.020
ihhb	Indian hedgehog homolog b	0.020
wnt10a	wingless-type MMTV integration site family, member 10a	0.020
col11a1a	collagen, type XI, alpha 1a	0.020
slit3	slit (Drosophila) homolog 3	0.020
LOC100537720	hypothetical protein LOC100537720	0.019
cx43	connexin 43	0.019
tnfrsfa	tumor necrosis factor receptor superfamily, member a	0.019
egr2b	early growth response 2b	0.018
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.018
pou4f2	POU domain, class 4, transcription factor 2	0.018
vax1	ventral anterior homeobox 1	0.018
mylz2	myosin, light polypeptide 2, skeletal muscle	0.018
ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.018
hdlbp	high density lipoprotein-binding protein (vigilin)	0.017
LOC572312	similar to CG10038 CG10038-PB	0.017
fgfr2	fibroblast growth factor receptor 2	0.017
zgc:92533	zgc:92533	0.017
nog3	noggin 3	0.016
msxc	muscle segment homeobox C	0.016
rag2	recombination activating gene 2	0.016
ctgf	connective tissue growth factor	0.016
LOC561388	hypothetical protein LOC561388	0.016
klf4a	Kruppel-like transcription factor 4a	0.016
notch2	notch homolog 2	0.016
kdelr2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.016
osr1	odd-skipped related 1 (Drosophila)	0.016
gli1	GLI-Kruppel family member 1	0.016
satb2	SATB homeobox 2	0.016
robo3	roundabout homolog 3	0.016
piwil2	piwi-like 2 (Drosophila)	0.015
hoxa2b	homeo box A2b	0.015
march4	membrane-associated ring finger (C3HC4) 4	0.015
si:dkey-208b23.5	si:dkey-208b23.5	0.015
fgf20a	fibroblast growth factor 20a	0.015
fstl1b	follistatin-like 1b	0.015
lhx3	LIM homeobox 3	0.015
wnt3a	wingless-type MMTV integration site family, member 3A	0.015
shha	sonic hedgehog a	0.015
pmp22a	peripheral myelin protein 22a	0.014
otx1a	orthodenticle homolog 1a	0.014
LOC557001	tetratricopeptide repeat protein 34-like	0.014
LOC100333916	myomegalin-like	0.014
si:dkey-261h17.1	si:dkey-261h17.1	0.014
fsta	follistatin a	0.014
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.014
fzd2	frizzled homolog 2	0.014
epha4b	eph receptor A4b	0.014
cyp1b1	cytochrome P450, family 1, subfamily B, polypeptide 1	0.014
glra1	glycine receptor, alpha 1	0.014
dlx2b	distal-less homeobox gene 2b	0.014
pthlh	parathyroid hormone-like hormone	0.014
zgc:123017	zgc:123017	0.013
asph	aspartate beta-hydroxylase	0.013
irx7	iroquois homeobox protein 7	0.013
zgc:193801	zgc:193801	0.013
bmp2a	bone morphogenetic protein 2a	0.013
actc1b	actin, alpha, cardiac muscle 1b	0.013
frem1a	Fras1 related extracellular matrix 1a	0.013
sim1a	single-minded homolog 1a (Drosophila)	0.013
chrm2a	cholinergic receptor, muscarinic 2a	0.013
anxa1a	annexin A1a	0.013
cnn2	calponin 2	0.013
wu:fi26e04	wu:fi26e04	0.013
desma	desmin a	0.013
zgc:111821	zgc:111821	0.012
epyc	epiphycan	0.012
ednrb1	endothelin receptor B	0.012
ncam1a	neural cell adhesion molecule 1a	0.012
or115-15	odorant receptor, family F, subfamily 115, member 15	0.012
LOC100334210	growth/differentiation factor 5-like	0.012
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.012
plagl2	pleiomorphic adenoma gene-like 2	0.012
lrp2	low density lipoprotein-related protein 2	0.012
plp1a	proteolipid protein 1a	0.012
mmp2	matrix metalloproteinase 2	0.012
tbx22	T-box 22	0.012
snai2	snail homolog 2 (Drosophila)	0.012
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.012
mc4r	melanocortin 4 receptor	0.012
krt4	keratin 4	0.012
LOC792958	nuclear receptor coactivator 7-like	0.012
rnf32	ring finger protein 32	0.012
gbx2	gastrulation brain homeo box 2	0.011
notch3	notch homolog 3	0.011
slc12a3	solute carrier family 12 (sodium/chloride transporters), member 3	0.011
myoc	myocilin	0.011
tram2	translocation associated membrane protein 2	0.011
opn1lw1	opsin 1 (cone pigments), long-wave-sensitive, 1	0.011
dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.011
vipr2	vasoactive intestinal peptide receptor 2	0.011
eve1	even-skipped-like1	0.011
si:dkey-181i3.1	si:dkey-181i3.1	0.011
pmp22b	peripheral myelin protein 22b	0.011
si:dkey-151c10.1	si:dkey-151c10.1	0.011
egfl6	EGF-like-domain, multiple 6	0.011
c3orf33	c3orf33 homolog (H. sapiens)	0.011
zgc:114123	zgc:114123	0.011
lmna	lamin A	0.011
grem2	gremlin 2, cysteine knot superfamily	0.011
fem1a	fem-1 homolog a (C. elegans)	0.010
kdelr2l	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like	0.010
chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.010
mtnr1al	melatonin receptor type 1A like	0.010
esrrga	estrogen-related receptor gamma a	0.010
lft2	lefty2	0.010
esrrgb	estrogen-related receptor gamma b	0.010
LOC100331568	breast cancer anti-estrogen resistance protein 3 homolog	0.010
LOC556026	afadin- and alpha-actinin-binding protein-like	0.010
LOC100331651	zona pellucida sperm-binding protein 4-like	0.010
LOC100536191	dynein beta chain, ciliary-like	0.010
sox2	SRY-box containing gene 2	0.010
gfra1b	gdnf family receptor alpha 1b	0.010
loxl3b	lysyl oxidase-like 3b	0.010