IMP: Integrative Multi-species Prediction

Danio rerio

0 genes annotated in zebrafish

mitochondrial metabolism disease

DOID:700

An inherited metabolic disorder that involves mitochondrial metabolism dysfunction.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "mitochondrial metabolism disease" (in gray)

Name	Description	Probability	Func Analog Organism
uqcrc2b	ubiquinol-cytochrome c reductase core protein IIb	0.618
chchd10	coiled-coil-helix-coiled-coil-helix domain containing 10	0.618
ndufa8	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8	0.377
atp5g	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)	0.365
ndufb10	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10	0.339
prdx3	peroxiredoxin 3	0.334
atp5c1	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	0.304
ndufv1	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.249
suclg1	succinate-CoA ligase, GDP-forming, alpha subunit	0.220
cox5ab	cytochrome c oxidase subunit Vab	0.212
park7	parkinson disease (autosomal recessive, early onset) 7	0.195
etfa	electron-transfer-flavoprotein, alpha polypeptide	0.188
atp5d	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit	0.186
actn3a	actinin alpha 3a	0.182
ndufa12	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12	0.177
zgc:64133	zgc:64133	0.164
ndufs1	NADH dehydrogenase (ubiquinone) Fe-S protein 1	0.160
sdha	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.158	Human
atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.155
zgc:73198	zgc:73198	0.154
atp5h	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d	0.141
idh3b	isocitrate dehydrogenase 3 (NAD+) beta	0.126
sdhb	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.125
dldh	dihydrolipoamide dehydrogenase	0.119
ndufb6	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6	0.118
si:dkey-190g11.7	si:dkey-190g11.7	0.100
tufm	Tu translation elongation factor, mitochondrial	0.094
got2b	glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)	0.077
ndufa9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9	0.074	Human
zgc:66391	zgc:66391	0.074
ndufb4	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4	0.068
dlst	dihydrolipoamide S-succinyltransferase	0.065
uqcrc2a	ubiquinol-cytochrome c reductase core protein IIa	0.063
ndufs7	NADH dehydrogenase (ubiquinone) Fe-S protein 7, (NADH-coenzyme Q reductase)	0.060
zgc:112340	zgc:112340	0.059	Human
uqcrc1	ubiquinol-cytochrome c reductase core protein I	0.059
rpl13a	ribosomal protein L13a	0.055
ndufs5	NADH dehydrogenase (ubiquinone) Fe-S protein 5	0.054
zgc:73293	zgc:73293	0.050
actn3b	actinin alpha 3b	0.048
acadm	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	0.045
zgc:77820	zgc:77820	0.043
brp44	brain protein 44	0.041
aldh7a1	aldehyde dehydrogenase 7 family, member A1	0.039
lrpprc	leucine-rich PPR-motif containing	0.034
ndufb5	NADH dehydrogenase (ubiquinone) 1 beta subcomplex 5	0.033
cox7a2	cytochrome c oxidase, subunit VIIa 2	0.032
lap3	leucine aminopeptidase 3	0.032
pdha1a	pyruvate dehydrogenase (lipoamide) alpha 1a	0.031
hspd1	heat shock 60kD protein 1 (chaperonin)	0.031
zgc:86841	zgc:86841	0.031
immt	inner membrane protein, mitochondrial (mitofilin)	0.029
zgc:114172	zgc:114172	0.028
cyc1	cytochrome c-1	0.027
mrpl12	mitochondrial ribosomal protein L12	0.027
hprt1	hypoxanthine phosphoribosyltransferase 1	0.026
zgc:162204	zgc:162204	0.026
mrpl36	mitochondrial ribosomal protein L36	0.025
ndufb8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8	0.024
zgc:162919	zgc:162919	0.023
wu:fl07c04	wu:fl07c04	0.023
zgc:114150	zgc:114150	0.022
ivd	isovaleryl Coenzyme A dehydrogenase	0.022
polr2d	polymerase (RNA) II (DNA directed) polypeptide D	0.022
phb	prohibitin	0.021
si:ch211-15d5.5	si:ch211-15d5.5	0.021
atp5ib	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e, duplicate b	0.020
atp5f1	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1	0.020
zgc:152873	zgc:152873	0.020
sod1	superoxide dismutase 1, soluble	0.020
zgc:163091	zgc:163091	0.019
pccb	propionyl Coenzyme A carboxylase, beta polypeptide	0.019
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.019
hmgcl	3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)	0.018
mrpl28	mitochondrial ribosomal protein L28	0.018
zgc:92502	zgc:92502	0.017
uqcrq	ubiquinol-cytochrome c reductase, complex III subunit VII	0.017
si:ch211-239j9.2	si:ch211-239j9.2	0.016
ndufs6	NADH dehydrogenase (ubiquinone) Fe-S protein 6	0.016
cox17	COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)	0.016
idh3a	isocitrate dehydrogenase 3 (NAD+) alpha	0.016
zgc:92655	zgc:92655	0.015
ahcy	S-adenosylhomocysteine hydrolase	0.015
zgc:112986	zgc:112986	0.015
ephx1	epoxide hydrolase 1, microsomal (xenobiotic)	0.015
hccs	holocytochrome c synthase	0.014
gpia	glucose phosphate isomerase a	0.014
pinx1	pin2/trf1-interacting protein 1	0.014
atp6v0d1	ATPase, H+ transporting, V0 subunit D isoform 1	0.014
sdhdb	succinate dehydrogenase complex, subunit D, integral membrane protein b	0.013
atp5j	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6	0.013
hspa9	heat shock protein 9	0.013
eno3	enolase 3, (beta, muscle)	0.013
slc25a26	solute carrier family 25, member 26	0.013
si:ch211-194h13.2	si:ch211-194h13.2	0.013
got2a	glutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2)	0.013
ubb	ubiquitin B	0.013
nsdhl	NAD(P) dependent steroid dehydrogenase-like	0.013
zgc:73345	zgc:73345	0.013
aco2	aconitase 2, mitochondrial	0.013
gcm2	glial cells missing homolog 2 (Drosophila)	0.012
mrpl19	mitochondrial ribosomal protein L19	0.012
sf3b14	splicing factor 3B	0.012
zgc:92030	zgc:92030	0.012
hsd11b3a	hydroxysteroid (11-beta) dehydrogenase 3a	0.012
abcd3a	ATP-binding cassette, sub-family D (ALD), member 3a	0.012
sucla2	succinate-CoA ligase, ADP-forming, beta subunit	0.012
pgm1	phosphoglucomutase 1	0.012
zgc:112056	zgc:112056	0.012
zgc:92878	zgc:92878	0.012
acadl	acyl-Coenzyme A dehydrogenase, long chain	0.012
ldhba	lactate dehydrogenase Ba	0.012
zgc:194876	zgc:194876	0.012
hsdl2	hydroxysteroid dehydrogenase like 2	0.012
bactin2	bactin2	0.011
med10	mediator of RNA polymerase II transcription, subunit 10 homolog	0.011
pdss1	prenyl (decaprenyl) diphosphate synthase, subunit 1	0.011	Human
zgc:66195	zgc:66195	0.011
im:7155681	im:7155681	0.011
zgc:163000	zgc:163000	0.011
sdhc	succinate dehydrogenase complex, subunit C, integral membrane protein	0.011
ndufs4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, (NADH-coenzyme Q reductase)	0.011	Human
myhc4	myosin heavy chain 4	0.011
chuk	conserved helix-loop-helix ubiquitous kinase	0.011
ndufab1	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1	0.011
ndufs2	NADH dehydrogenase (ubiquinone) Fe-S protein 2	0.011
pdcd8	programmed cell death 8 (apoptosis-inducing factor)	0.011
mtx2	metaxin 2	0.010
LOC794625	up-regulated during skeletal muscle growth protein 5	0.010
nipa2	non imprinted in Prader-Willi/Angelman syndrome 2 (human)	0.010
zgc:56518	zgc:56518	0.010
zgc:92631	zgc:92631	0.010