IMP: Integrative Multi-species Prediction

Danio rerio

0 genes annotated in zebrafish

aplastic anemia

DOID:12449

An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "aplastic anemia" (in gray)

Name	Description	Probability	Func Analog Organism
fanca	Fanconi anemia, complementation group A	0.749
rpl36a	ribosomal protein L36A	0.652
rps19	ribosomal protein S19	0.615
zgc:92237	zgc:92237	0.523
rpl13a	ribosomal protein L13a	0.494
fanci	Fanconi anemia, complementation group I	0.470
brca2	breast cancer 2, early onset	0.465
rpl7	ribosomal protein L7	0.461
zgc:92868	zgc:92868	0.447
zgc:109888	zgc:109888	0.442
fancb	Fanconi anemia, complementation group B	0.393
zgc:77235	zgc:77235	0.388
rpl30	ribosomal protein L30	0.386
brip1	BRCA1 interacting protein C-terminal helicase 1	0.368
rpl14	ribosomal protein L14	0.355
zgc:123327	zgc:123327	0.345
rps26	ribosomal protein S26	0.345
rps18	ribosomal protein S18	0.344
rpl26	ribosomal protein L26	0.344
uba52	ubiquitin A-52 residue ribosomal protein fusion product 1	0.333
rpl27	ribosomal protein L27	0.331
rps15	ribosomal protein S15	0.304
rpl35a	ribosomal protein L35a	0.278
rpl11	ribosomal protein L11	0.261	Human
rps7	ribosomal protein S7	0.253	Human
eef1b2	eukaryotic translation elongation factor 1 beta 2	0.222
rpl23a	ribosomal protein L23a	0.189
rplp2l	ribosomal protein, large P2, like	0.174
rpl12	ribosomal protein L12	0.168
zgc:65996	zgc:65996	0.165
rpl23	ribosomal protein L23	0.164
rpl13	ribosomal protein L13	0.148
zgc:114188	zgc:114188	0.139	Human
rps4x	ribosomal protein S4, X-linked	0.138
rpl10a	ribosomal protein L10a	0.135
rps23	ribosomal protein S23	0.130
rps15a	ribosomal protein S15a	0.127
rps12	ribosomal protein S12	0.125
rps25	ribosomal protein S25	0.123
pno1	partner of NOB1 homolog (S. cerevisiae)	0.121
rps2	ribosomal protein S2	0.116
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.109
rps21	ribosomal protein S21	0.108
rpl15	ribosomal protein L15	0.108
rps3	ribosomal protein S3	0.106
rps3a	ribosomal protein S3A	0.091
LOC100000999	60S ribosomal protein L37-like	0.091
rpl3	ribosomal protein L3	0.085
eef1db	elongation factor-1, delta, b	0.084
faua	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed a	0.081
fancf	Fanconi anemia, complementation group F	0.081	Human
rpl21	ribosomal protein L21	0.080
rps11	ribosomal protein S11	0.078
slc30a4	solute carrier family 30 (zinc transporter), member 4	0.077
zgc:77702	zgc:77702	0.077	Human
rpl5a	ribosomal protein L5a	0.076	Human
fancg	Fanconi anemia, complementation group G	0.075
rpl22l1	ribosomal protein L22-like 1	0.073
palb2	partner and localizer of BRCA2	0.071
rps24	ribosomal protein S24	0.070	Human
rps9	ribosomal protein S9	0.065
zgc:171772	zgc:171772	0.063
rpsa	ribosomal protein SA	0.063
atp5d	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit	0.062
zgc:152930	zgc:152930	0.061
tpt1	tumor protein, translationally-controlled 1	0.061
rpl5b	ribosomal protein L5b	0.061	Human
rpl35	ribosomal protein L35	0.060
fance	Fanconi anemia, complementation group E	0.058	Human
naca	nascent polypeptide-associated complex alpha polypeptide	0.057
rps29	ribosomal protein S29	0.055	Human
neil3	nei endonuclease VIII-like 3 (E. coli)	0.055
rpl19	ribosomal protein L19	0.055
rpl34	ribosomal protein L34	0.055
zgc:136896	zgc:136896	0.054
buc	bucky ball	0.053
slc39a13	solute carrier family 39 (zinc transporter), member 13	0.051
rps10	ribosomal protein S10	0.050	Human
zgc:113143	zgc:113143	0.045
rpl6	ribosomal protein L6	0.045
rpl24	ribosomal protein L24	0.043
slc39a10	solute carrier family 39 (zinc transporter), member 10	0.043
zgc:92872	zgc:92872	0.042
rpl7a	ribosomal protein L7a	0.042
rpl39	ribosomal protein L39	0.042
rps5	ribosomal protein S5	0.040
mtm1	myotubularin 1	0.040
rpl38	ribosomal protein L38	0.040
mibp2	muscle-specific beta 1 integrin binding protein 2	0.038
cyp19a1b	cytochrome P450, family 19, subfamily A, polypeptide 1b	0.038
eif2s1	eukaryotic translation initiation factor 2, subunit 1 alpha	0.037
sec61g	Sec61 gamma subunit	0.037
rps16	ribosomal protein S16	0.037
rps14	ribosomal protein S14	0.036
cdc7	cell division cycle 7 homolog (S. cerevisiae)	0.036
rps8a	ribosomal protein S8a	0.036
otul	OTU like protein	0.035
LOC570775	protein argonaute-1-like	0.034
zgc:66242	zgc:66242	0.033
prdx4	peroxiredoxin 4	0.032
diaph2	diaphanous homolog 2 (Drosophila)	0.032
glb1	galactosidase, beta 1	0.032
nfix	nuclear factor I/X	0.031
capn2a	calpain 2, (m/II) large subunit a	0.031
pdcd2	programmed cell death 2	0.029
rps20	ribosomal protein S20	0.029
piwil1	piwi-like 1 (Drosophila)	0.029
slc39a3	solute carrier family 39 (zinc transporter), member 3	0.028
trmt2b	TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)	0.028
slc30a7	solute carrier family 30 (zinc transporter), member 7	0.027
rps27a	ribosomal protein S27a	0.027
eef1da	elongation factor-1, delta, a	0.026
rps26l	ribosomal protein S26, like	0.026
rpl28	ribosomal protein L28	0.026
amh	anti-Mullerian hormone	0.026
slc25a37	solute carrier family 25, member 37	0.026
nrxn1a	neurexin 1a	0.026
slc39a11	solute carrier family 39 (metal ion transporter), member 11	0.025
asz1	ankyrin repeat, SAM and basic leucine zipper domain containing 1	0.025
rpl36	ribosomal protein L36	0.024
rbpja	recombination signal binding protein for immunoglobulin kappa J region a	0.024
slc30a9	solute carrier family 30 (zinc transporter), member 9	0.023
kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.023
btf3	basic transcription factor 3	0.023
zgc:73262	zgc:73262	0.022
wu:fi25h02	wu:fi25h02	0.021
plg	plasminogen	0.021
lgals3l	lectin, galactoside-binding, soluble, 3 (galectin 3)-like	0.021
cnpy2	canopy 2	0.020
slc30a6	solute carrier family 30 (zinc transporter), member 6	0.020
eif2c4	eukaryotic translation initiation factor 2C, 4	0.020
rpl18a	ribosomal protein L18a	0.019
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.019
eef1g	eukaryotic translation elongation factor 1 gamma	0.018
nme2b.1	non-metastatic cells 2b.1, protein (NM23B) expressed in	0.018
rps28	ribosomal protein S28	0.018
ccm2	cerebral cavernous malformation 2	0.018
gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.018
setdb2	SET domain, bifurcated 2	0.018
rbp4	retinol binding protein 4, plasma	0.017
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.017
gip	gastric inhibitory polypeptide	0.017
tfr1a	transferrin receptor 1a	0.017
trdmt1	tRNA aspartic acid methyltransferase 1	0.017
phf21a	PHD finger protein 21A	0.017
syk	spleen tyrosine kinase	0.016
prdm5	PR domain containing 5	0.016
zgc:113210	zgc:113210	0.016
zgc:103564	zgc:103564	0.016
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.016
fas	Fas (TNF receptor superfamily, member 6)	0.016
zgc:56197	zgc:56197	0.016
zgc:92744	zgc:92744	0.016
ppib	peptidylprolyl isomerase B (cyclophilin B)	0.016
ung	uracil-DNA glycosylase	0.016
rpl4	ribosomal protein L4	0.016
ppm1ab	protein phosphatase, Mg2+/Mn2+ dependent, 1Ab	0.015
glrx	glutaredoxin (thioltransferase)	0.015
ef1	ETS-related factor1	0.015
tert	telomerase reverse transcriptase	0.015
rb1	retinoblastoma 1	0.015
atp5f1	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1	0.015
abcc5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	0.014
mipa	major intrinsic protein of lens fiber a	0.014
ssr4	signal sequence receptor, delta	0.014
slc39a4	solute carrier family 39 (zinc transporter), member 4	0.014
comta	catechol-O-methyltransferase a	0.014
vhl	von Hippel-Lindau tumor suppressor	0.014
capn1a	calpain 1, (mu/I) large subunit a	0.013
rpl9	ribosomal protein L9	0.013
bysl	bystin-like	0.013
stk36	serine/threonine kinase 36 (fused homolog, Drosophila)	0.013
zgc:153260	zgc:153260	0.013
atpif1	ATPase inhibitory factor 1	0.013
trim2a	tripartite motif-containing 2a	0.013
rogdi	rogdi homolog (Drosophila)	0.013
mcm3	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)	0.013
jmjd7	jumonji domain containing 7	0.013
faslg	Fas ligand (TNF superfamily, member 6)	0.013
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.013
hist1h4l	histone 1, H4, like	0.013
col5a3b	collagen type V alpha-3b	0.013
il13ra1	interleukin 13 receptor, alpha 1	0.013
gbgt1l1	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1	0.013
skiv2l2	superkiller viralicidic activity 2-like 2	0.012
zgc:136952	zgc:136952	0.012
glo1	glyoxalase 1	0.012
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.012
crfb5	cytokine receptor family member b5	0.012
serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.012
qrsl1	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	0.012
zgc:154089	zgc:154089	0.011
LOC560606	novel protein similar to human and mouse leishmanolysin-like (metallopeptidase M8 family) (LMLN)	0.011
crtc3	CREB regulated transcription coactivator 3	0.011
si:dkeyp-59a8.4	si:dkeyp-59a8.4	0.011
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.011
mylipa	myosin regulatory light chain interacting protein a	0.011
ndufa9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9	0.011
LOC100150924	DNA polymerase subunit gamma-1-like	0.011
spon2b	spondin 2b, extracellular matrix protein	0.011
zgc:114108	zgc:114108	0.011
zbtb1	zinc finger and BTB domain containing 1	0.011
fech	ferrochelatase	0.011
slc39a1	solute carrier family 39 (zinc transporter), member 1	0.011
ncapg2	non-SMC condensin II complex, subunit G2	0.011
zgc:92172	zgc:92172	0.011
eomesa	eomesodermin homolog a	0.011
nop10	NOP10 ribonucleoprotein homolog (yeast)	0.011
rpl10	ribosomal protein L10	0.011
nsa2	NSA2 ribosome biogenesis homolog (S. cerevisiae)	0.011
fancc	Fanconi anemia, complementation group C	0.011	Human
si:ch211-255l12.1	si:ch211-255l12.1	0.011
npm4	nucleophosmin/nucleoplasmin, 4	0.011
zgc:92850	zgc:92850	0.011
LOC565106	novel protein similar to vertebrate calpain 1 (CAPN1)	0.011
nfe2	nuclear factor, erythroid-derived 2	0.011
camk2d2	calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2	0.011
nrxn3a	neurexin 3a	0.010
dnajc2	DnaJ (Hsp40) homolog, subfamily C, member 2	0.010
eif2c3	eukaryotic translation initiation factor 2C, 3	0.010
zgc:77165	zgc:77165	0.010
zgc:110821	zgc:110821	0.010
lrrc42	leucine rich repeat containing 42	0.010
slc30a1	solute carrier family 30 (zinc transporter), member 1	0.010
wu:fj68a07	wu:fj68a07	0.010
glceb	glucuronyl C5-epimerase b	0.010
LOC100151531	zinc finger protein Gfi-1b-like	0.010
pbrm1	polybromo 1	0.010