IMP: Integrative Multi-species Prediction

Danio rerio

0 genes annotated in zebrafish

amyotrophic lateral sclerosis

DOID:332

A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "amyotrophic lateral sclerosis" (in gray)

Name	Description	Probability	Func Analog Organism
safb	scaffold attachment factor B	0.555
hnrnph1l	heterogeneous nuclear ribonucleoprotein H1, like	0.431
snrnp70	small nuclear ribonucleoprotein 70 (U1)	0.264
ilf3b	interleukin enhancer binding factor 3b	0.170
hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.142
rbm17	RNA binding motif protein 17	0.139
ilf3a	interleukin enhancer binding factor 3a	0.137
sod2	superoxide dismutase 2, mitochondrial	0.117
hnrnpm	heterogeneous nuclear ribonucleoprotein M	0.112
srsf2	serine/arginine-rich splicing factor 2	0.089
ewsr1a	Ewing sarcoma breakpoint region 1a	0.086
sfrs3b	splicing factor, arginine/serine-rich 3b	0.084
hmga1a	high mobility group AT-hook 1a	0.083
hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.076
acadm	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	0.070
acadl	acyl-Coenzyme A dehydrogenase, long chain	0.059
srsf11	serine/arginine-rich splicing factor 11	0.058
tardbp	TAR DNA binding protein	0.054	Human
foxj1b	forkhead box J1b	0.054
zgc:92139	zgc:92139	0.050
si:ch211-59d15.5	si:ch211-59d15.5	0.048
ppp2cb	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	0.047
tardbpl	TAR DNA binding protein, like	0.045	Human
api5	apoptosis inhibitor 5	0.043
hsd17b12b	hydroxysteroid (17-beta) dehydrogenase 12b	0.043
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.041
usp7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.041
rbm8a	RNA binding motif protein 8A	0.039
sart1	squamous cell carcinoma antigen recognised by T cells	0.037
prpf40a	PRP40 pre-mRNA processing factor 40 homolog A (yeast)	0.036
zgc:77052	zgc:77052	0.035
atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.034
u2af2b	U2 small nuclear RNA auxiliary factor 2b	0.033
smarce1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.033
cd2bp2	CD2 antigen (cytoplasmic tail) binding protein 2	0.033
slc7a6os	solute carrier family 7, member 6 opposite strand	0.032
psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.032
zgc:158363	zgc:158363	0.032
LOC100535549	cytoplasmic polyadenylation element-binding protein 4-like	0.032
slc39a7	solute carrier family 39 (zinc transporter), member 7	0.029
ndrg1	N-myc downstream regulated gene 1	0.027
leo1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.027
sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.026
LOC100535373	hypothetical protein LOC100535373	0.026
nkd2	naked cuticle homolog 2 and naked 2a	0.026
hmgb3b	high-mobility group box 3b	0.026
hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.025
pnn	pinin, desmosome associated protein	0.025
tcea1	transcription elongation factor A (SII), 1	0.025
smu1	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	0.025
ef1a	elongation factor 1-alpha	0.025
psmb5	proteasome (prosome, macropain) subunit, beta type, 5	0.022
LOC796298	isotocin receptor-like 1	0.022
ilf2	interleukin enhancer binding factor 2	0.022
mstna	myostatin a	0.022
cpt2	carnitine palmitoyltransferase II	0.020
LOC556124	hypothetical LOC556124	0.020
zgc:77366	zgc:77366	0.020
got2a	glutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2)	0.020
casrl	calcium-sensing receptor, like	0.019
smarca5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.019
zgc:112425	zgc:112425	0.019
si:dkey-181m9.9	si:dkey-181m9.9	0.019
cirbp	cold inducible RNA binding protein	0.019
srsf6b	serine/arginine-rich splicing factor 6b	0.018
g3bp1	GTPase activating protein (SH3 domain) binding protein 1	0.018
acin1a	apoptotic chromatin condensation inducer 1a	0.018
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.018
prpf8	pre-mRNA processing factor 8	0.018
polr2b	polymerase (RNA) II (DNA directed) polypeptide B	0.018
bactin1	bactin1	0.018
ddx19	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast)	0.018
echs1	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	0.018
psmc1b	proteasome (prosome, macropain) 26S subunit, ATPase, 1b	0.017
ppig	peptidyl-prolyl isomerase G (cyclophilin G)	0.017
si:ch211-254d18.3	si:ch211-254d18.3	0.016
notum3	notum 3	0.016
zgc:123194	zgc:123194	0.016
si:dkey-250d21.1	si:dkey-250d21.1	0.016
ck2b	casein kinase 2 beta	0.016
si:ch211-51e12.7	si:ch211-51e12.7	0.016
fdx1	ferredoxin 1	0.016
keap1a	kelch-like ECH-associated protein 1a	0.016
anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.015
mapk3	mitogen-activated protein kinase 3	0.015
cat	catalase	0.015
hnrnpl2	heterogeneous nuclear ribonucleoprotein L2	0.015
srrt	serrate RNA effector molecule homolog (Arabidopsis)	0.014
rhoab	ras homolog gene family, member Ab	0.014
si:ch211-12e1.4	si:ch211-12e1.4	0.014
psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.014
nsdhl	NAD(P) dependent steroid dehydrogenase-like	0.014
arf2	ADP-ribosylation factor 2	0.013
sdf2	stromal cell-derived factor 2	0.013
rbmx	RNA binding motif protein, X-linked	0.013
usp5	ubiquitin specific protease 5	0.013
zgc:110256	zgc:110256	0.013
galcb	galactosylceramidase b	0.013
lnx2b	ligand of numb-protein X 2b	0.013
zgc:101761	zgc:101761	0.013
tm9sf3	transmembrane 9 superfamily member 3	0.013
pth1a	parathyroid hormone 1a	0.013
park7	parkinson disease (autosomal recessive, early onset) 7	0.013
rnaseh1	ribonuclease H1	0.013
zgc:77262	zgc:77262	0.012
c1qc	complement component 1, q subcomponent, C chain	0.012
mbnl2	muscleblind-like 2 (Drosophila)	0.012
zgc:110775	zgc:110775	0.012
luc7l	LUC7-like (S. cerevisiae)	0.012
mmp17a	matrix metallopeptidase 17a	0.012
atl3	atlastin 3	0.012
pbrm1l	polybromo 1, like	0.012
psma6a	proteasome (prosome, macropain) subunit, alpha type, 6a	0.012
hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.012
hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.012
zgc:153148	zgc:153148	0.012
qars	glutaminyl-tRNA synthetase	0.012
nup50	nucleoporin 50	0.011
cldnc	claudin c	0.011
ech1	enoyl CoA hydratase 1, peroxisomal	0.011
zgc:158852	zgc:158852	0.011
pdzd11	PDZ domain containing 11	0.011
rab5b	RAB5B, member RAS oncogene family	0.011
hmgb1b	high-mobility group box 1b	0.011
decr1	2,4-dienoyl CoA reductase 1, mitochondrial	0.011
hmgb2a	high-mobility group box 2a	0.011
ywhaqb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b	0.011
hnrnpa0l	heterogeneous nuclear ribonucleoprotein A0, like	0.011
akap8l	A kinase (PRKA) anchor protein 8-like	0.010
prkar2aa	protein kinase, cAMP-dependent, regulatory, type II, alpha A	0.010
acox1	acyl-Coenzyme A oxidase 1, palmitoyl	0.010
eif4h	eukaryotic translation initiation factor 4h	0.010
tra2a	transformer-2 alpha	0.010
rnf40	ring finger protein 40	0.010
ppp1cab	protein phosphatase 1, catalytic subunit, alpha isoform b	0.010
keap1b	kelch-like ECH-associated protein 1b	0.010
hnrnpd	heterogeneous nuclear ribonucleoprotein D	0.010