IMP: Integrative Multi-species Prediction

Danio rerio

20 genes annotated in zebrafish

divalent metal ion transport

The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "divalent metal ion transport"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "divalent metal ion transport" (in gray)

Name	Description	Probability	Func Analog Organism
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.657
wnt11r	wingless-type MMTV integration site family, member 11, related	0.318	Zebrafish
wnt10a	wingless-type MMTV integration site family, member 10a	0.239	Zebrafish
bcl2	B-cell leukemia/lymphoma 2	0.189	Human Mouse
fgf17	fibroblast growth factor 17	0.175
lama2	laminin, alpha 2	0.171
lcp1	lymphocyte cytosolic plastin 1	0.168
rag1	recombination activating gene 1	0.167
coro1a	coronin, actin binding protein, 1A	0.167	Mouse
oprm1	opioid receptor, mu 1	0.131	Rat
tgfb3	transforming growth factor, beta 3	0.118
rspo1	R-spondin homolog (Xenopus laevis)	0.113
wnt9a	wingless-type MMTV integration site family, member 9A	0.111	Zebrafish
tbx2a	T-box gene 2a	0.101
wnt9b	wingless-type MMTV integration site family, member 9B	0.099	Zebrafish
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.097	Zebrafish
otop1	otopetrin 1	0.094
ttna	titin a	0.093
tyr	tyrosinase	0.089
tnnt2a	troponin T2a, cardiac	0.087
cdh23	cadherin-like 23	0.085	Human
drd3	dopamine receptor D3	0.080
atp2a2a	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a	0.077	Human Mouse Rat Worm Fly
cacnb4b	calcium channel, voltage-dependent, beta 4b subunit	0.072	Zebrafish Mouse Worm
inha	inhibin, alpha	0.066
dusp6	dual specificity phosphatase 6	0.064
wnt3	wingless-type MMTV integration site family, member 3	0.063	Zebrafish
six1b	sine oculis homeobox homolog 1b	0.063
gpr126	G protein-coupled receptor 126	0.062
ndrg4	N-myc downstream regulated gene 4	0.056
foxp1b	forkhead box P1b	0.054
kitb	kit receptor b	0.054
atp1a3b	ATPase, Na+/K+ transporting, alpha 3b polypeptide	0.054
spock3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	0.049
wnt16	wingless-type MMTV integration site family, member 16	0.049
LOC100334210	growth/differentiation factor 5-like	0.049
smad1	MAD homolog 1 (Drosophila)	0.048
psen1	presenilin 1	0.045	Human
smo	smoothened homolog (Drosophila)	0.042
sid4	secreted immunoglobulin domain 4	0.042
mpx	myeloid-specific peroxidase	0.041
il7r	interleukin 7 receptor	0.039
bmp1a	bone morphogenetic protein 1a	0.038
satb2	SATB homeobox 2	0.038
runx1	runt-related transcription factor 1	0.037
tbx18	T-box 18	0.036
adrb2a	adrenergic receptor, beta 2a	0.035
ryr3	ryanodine receptor 3	0.035
chrna4	cholinergic receptor, nicotinic, alpha 4	0.034	Mouse
atp1b2a	ATPase, Na+/K+ transporting, beta 2a polypeptide	0.033
ptmaa	prothymosin, alpha a	0.033
pi4kb	phosphatidylinositol 4-kinase, catalytic, beta	0.033
lepr	leptin receptor	0.033
stac3	SH3 and cysteine rich domain 3	0.032
rc3	rabconnectin 3	0.032
zp2.2	zona pellucida glycoprotein 2.2	0.032
gli2b	GLI-Kruppel family member GLI2b	0.032
tbx5b	T-box 5b	0.031
wnt10b	wingless-type MMTV integration site family, member 10b	0.031	Zebrafish
cacnb2a	calcium channel, voltage-dependent, beta 2a	0.030
foxn1	forkhead box N1	0.028
zbtb4	zinc finger and BTB domain containing 4	0.028
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.028
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.028
fgf20a	fibroblast growth factor 20a	0.028
paqr8	progestin and adipoQ receptor family member VIII	0.028
mga	MAX gene associated	0.027
drd2b	dopamine receptor D2b	0.027	Human Rat
ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.027
thsd7a	thrombospondin, type I, domain containing 7A	0.026
pvalb4	parvalbumin 4	0.026
nbl1	neuroblastoma, suppression of tumorigenicity 1	0.026
dab1a	disabled homolog 1a (Drosophila)	0.025
churc1	churchill domain containing 1	0.025
smtnl	smoothelin, like	0.025
mtdha	metadherin a	0.025
nog3	noggin 3	0.025
ldb3b	LIM domain binding 3b	0.024
atp1a3a	ATPase, Na+/K+ transporting, alpha 3a polypeptide	0.024
mc4r	melanocortin 4 receptor	0.024
stm	starmaker	0.024
itgb3b	integrin beta 3b	0.023
trpc6	transient receptor potential cation channel, subfamily C, member 6	0.023	Mouse
slc1a2b	solute carrier family 1 (glial high affinity glutamate transporter), member 2b	0.023
sp2	sp2 transcription factor	0.023
egfra	epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	0.022
gnb5b	guanine nucleotide binding protein (G protein), beta 5b	0.022	Human
ighm	immunoglobulin heavy constant mu and immunoglobulin heavy constant mu	0.022
snap25b	synaptosome-associated protein 25b	0.022
wnt5a	wingless-type MMTV integration site family, member 5a	0.022	Zebrafish
dntt	deoxynucleotidyltransferase, terminal	0.022
ppp4cb	protein phosphatase 4 (formerly X), catalytic subunit b	0.022
LOC100004946	transient receptor potential cation channel subfamily M member 4-like	0.022
mapk1	mitogen-activated protein kinase 1	0.022
col1a1a	collagen, type I, alpha 1a	0.022
rer1	RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)	0.022
spry4	sprouty (Drosophila) homolog 4	0.021
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.021
LOC566708	FL cytokine receptor-like	0.021
wnt7bb	wingless-type MMTV integration site family, member 7Bb	0.021
slc12a2	solute carrier family 12 (potassium/chloride transporters), member 2	0.021
s100a1	S100 calcium binding protein A1	0.020	Rat
slc25a4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	0.020
si:dkey-229d11.5	si:dkey-229d11.5	0.020
map2k4b	mitogen-activated protein kinase kinase 4b	0.020
plagl2	pleiomorphic adenoma gene-like 2	0.020
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.020
f2rl1.2	coagulation factor II (thrombin) receptor-like 1.2	0.020
nanos3	nanos homolog 3	0.020
eya4	eyes absent homolog 4 (Drosophila)	0.020
ighz	immunoglobulin heavy constant zeta	0.019
jak1	Janus kinase 1	0.019
rhogb	ras homolog gene family, member Gb	0.019
skia	nuclear oncoprotein skia	0.019
tbx1	T-box 1	0.019
nos2b	nitric oxide synthase 2b, inducible	0.019
zp3a.2	zona pellucida glycoprotein 3a.2	0.019	Human
ncs1a	neuronal calcium sensor 1a	0.019	Rat
cxcr3.2	chemokine (C-X-C motif) receptor 3.2	0.019
mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.019
nadl1.1	neural adhesion molecule L1.1	0.018
aox3	aldehyde oxidase 3	0.018
chrnb3b	cholinergic receptor, nicotinic, beta polypeptide 3b	0.018
ckbb	creatine kinase, brain b	0.018
cdx4	caudal type homeo box transcription factor 4	0.018
tac1	tachykinin 1	0.018
nppa	natriuretic peptide precursor A	0.018
trpa1a	transient receptor potential cation channel, subfamily A, member 1a	0.018	Mouse
hspa5	heat shock protein 5	0.018
inhbaa	inhibin, beta Aa	0.018
ldb3a	LIM-domain binding factor 3a	0.018
ptger4a	prostaglandin E receptor 4 (subtype EP4) a	0.018
cmlc1	cardiac myosin light chain-1	0.018
LOC100332822	hypothetical protein LOC100332822	0.018
ryr1b	ryanodine receptor 1b (skeletal)	0.018
hoxa13b	homeo box A13b	0.017
lef1	lymphocyte enhancer binding factor 1	0.017
hmx2	H6 family homeobox 2	0.017
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.017
spag1	sperm associated antigen 1	0.017
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.017
vox	ventral homeobox	0.017
lman2la	lectin, mannose-binding 2-like a	0.017
adora2aa	adenosine A2a receptor a	0.017	Rat
wnt1	wingless-type MMTV integration site family, member 1	0.017	Zebrafish
cldni	claudin i	0.017
limk1	LIM domain kinase 1	0.017
st8sia5	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	0.016
LOC557722	similar to transient receptor potential cation channel, subfamily M, member 5	0.016
tal1	T-cell acute lymphocytic leukemia 1	0.016
irx4a	iroquois homeobox protein 4a	0.016
chat	choline acetyltransferase	0.016
drgx	dorsal root ganglia homeobox	0.016
pcyt2	phosphate cytidylyltransferase 2, ethanolamine	0.016
cacnb4a	calcium channel, voltage-dependent, beta 4a subunit	0.016	Zebrafish Mouse Worm
hnf1ba	HNF1 homeobox Ba	0.016
entpd3	ectonucleoside triphosphate diphosphohydrolase 3	0.016
cyp1b1	cytochrome P450, family 1, subfamily B, polypeptide 1	0.016
ephb4a	eph receptor B4a	0.015
fgf3	fibroblast growth factor 3	0.015
eif3hb	eukaryotic translation initiation factor 3, subunit H, b	0.015
ucn3l	urocortin 3, like	0.015
atp6v1g1	ATPase, H+ transporting, V1 subunit G isoform 1	0.015
fzd7b	frizzled homolog 7b	0.015
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.015
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.015
trpv4	transient receptor potential cation channel, subfamily V, member 4	0.015	Zebrafish Mouse
ilk	integrin linked kinase	0.015
her15.1	hairy and enhancer of split-related 15.1	0.015
zgc:101724	zgc:101724	0.015
plcxd3	phosphatidylinositol-specific phospholipase C, X domain containing 3	0.015
cldn2	claudin 2	0.015
calm1b	calmodulin 1b	0.015	Rat
LOC100333772	zona pellucida sperm-binding protein 4-like	0.015
nkx2.5	NK2 transcription factor related 5	0.014
esrra	estrogen-related receptor alpha	0.014
pitx3	paired-like homeodomain transcription factor 3	0.014
vmhc	ventricular myosin heavy chain	0.014
neb	nebulin	0.014
caprin2	caprin family member 2	0.014
trpm2	transient receptor potential cation channel, subfamily M, member 2	0.014
zgc:171818	zgc:171818	0.014
si:ch211-14a17.7	si:ch211-14a17.7	0.014
ppargc1al	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like	0.014
csrp3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.014
srl	sarcalumenin	0.014
rbm22	RNA binding motif protein 22	0.014
eps8l3	EPS8-like 3	0.014
tsc22d3	TSC22 domain family, member 3	0.014
rpz	rapunzel	0.014
arf1	ADP-ribosylation factor 1	0.014
ncam2	neural cell adhesion molecule 2	0.014
znf711	zinc finger protein 711	0.013
gdf11	growth differentiation factor 11	0.013
avpl	arginine vasopressin-like	0.013
tnfsf18	tumor necrosis factor (ligand) superfamily, member 18	0.013
her12	hairy-related 12	0.013
zgc:56376	zgc:56376	0.013
zgc:165344	zgc:165344	0.013
amph	amphiphysin	0.013
vent	ventral expressed homeobox	0.013
oaz2b	ornithine decarboxylase antizyme 2b	0.013
ptn	pleiotrophin	0.013
arpc1b	actin related protein 2/3 complex, subunit 1B	0.013
cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.013
boc	brother of CDO	0.013
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.013
bdnf	brain-derived neurotrophic factor	0.013
mcl1b	myeloid cell leukemia sequence 1b	0.013
LOC553366	hypothetical protein LOC553366	0.013
tmem38a	transmembrane protein 38A	0.013
xylt1	xylosyltransferase 1	0.013
zgc:86757	zgc:86757	0.013
hmx1	H6 homeo box 1	0.013
cd63	Cd63 antigen	0.012
spry2	sprouty homolog 2	0.012
nccrp1	nonspecific cytotoxic cell receptor protein 1	0.012
atp1b1b	ATPase, Na+/K+ transporting, beta 1b polypeptide	0.012
fbln1	fibulin 1	0.012
hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.012
LOC567602	cadherin-1-like	0.012
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.012
slco2a1	solute carrier organic anion transporter family, member 2A1	0.012
eno2	enolase 2	0.012
wt1b	wilms tumor 1b	0.012
foxn4	forkhead box N4	0.012
tfpi2	tissue factor pathway inhibitor 2	0.012
cahz	carbonic anhydrase	0.012
cyp19a1a	cytochrome P450, family 19, subfamily A, polypeptide 1a	0.012
mbnl1	muscleblind-like (Drosophila)	0.012
cyp24a1	cytochrome P450, family 24, subfamily A, polypeptide 1	0.012
rapsn	receptor-associated protein of the synapse, 43kD	0.012
trpc5	transient receptor potential cation channel, subfamily C, member 5	0.012	Human
ccr9b	chemokine (C-C motif) receptor 9b	0.011
dpysl5b	dihydropyrimidinase-like 5b	0.011
fscn2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.011
lhx6	LIM homeobox 6	0.011
zgc:162630	zgc:162630	0.011
ptmab	prothymosin, alpha b	0.011
LOC562316	klotho-like	0.011
LOC567566	short transient receptor potential channel 7-like	0.011
or102-1	odorant receptor, family C, subfamily 102, member 1	0.011
hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.011
desma	desmin a	0.011
wnt7aa	wingless-type MMTV integration site family, member 7Aa	0.011	Zebrafish
jag1b	jagged 1b	0.011
oep	one-eyed pinhead	0.011
dkk1b	dickkopf 1b	0.011
gpr161	G protein-coupled receptor 161	0.011
mef2a	myocyte enhancer factor 2a	0.011
nrp1a	neuropilin 1a	0.011
slc17a8	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	0.011
e2f5	E2F transcription factor 5	0.011
chrnd	cholinergic receptor, nicotinic, delta polypeptide	0.011
oprk1	opioid receptor, kappa 1	0.011
penka	proenkephalin a	0.011
drd1	dopamine receptor D1	0.011
cobl	cordon-bleu homolog (mouse)	0.011
klf4a	Kruppel-like transcription factor 4a	0.011
bmp8a	bone morphogenetic protein 8a	0.011
esrrb	estrogen-related receptor beta	0.011
mst1rb	macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b	0.011
drd2l	dopamine receptor D2 like	0.011
htr1aa	5-hydroxytryptamine (serotonin) receptor 1A a	0.011
calm2a	calmodulin 2a (phosphorylase kinase, delta)	0.011
alk	anaplastic lymphoma kinase (Ki-1)	0.011
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.011
mat2a	methionine adenosyltransferase II, alpha	0.011
clic1	chloride intracellular channel 1	0.010
LOC556849	ectonucleoside triphosphate diphosphohydrolase 5-like	0.010
helt	hey-like transcription factor	0.010
glcea	glucuronyl C5-epimerase a	0.010
zgc:101614	zgc:101614	0.010
a2ml	alpha-2-macroglobulin-like	0.010
si:ch73-9j13.1	si:ch73-9j13.1	0.010
ckma	creatine kinase, muscle a	0.010
irf6	interferon regulatory factor 6	0.010
bmper	BMP binding endothelial regulator	0.010
elovl1b	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b	0.010
atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.010	Worm Fly
gpia	glucose phosphate isomerase a	0.010
cx39.9	connexin 39.9	0.010
epas1b	endothelial PAS domain protein 1b	0.010
grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.010
nhsl1a	NHS-like 1a	0.010
zgc:91860	zgc:91860	0.010
cyp17a1	cytochrome P450, family 17, subfamily A, polypeptide 1	0.010