IMP: Integrative Multi-species Prediction

Danio rerio

11 genes annotated in zebrafish

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of immune response"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of immune response" (in gray)

Name	Description	Probability	Func Analog Organism
grna	granulin a	0.523
meis1	myeloid ecotropic viral integration 1	0.500
LOC566708	FL cytokine receptor-like	0.491
c3b	complement component c3b	0.401
pcdh18b	protocadherin 18b	0.393
dnmt4	DNA (cytosine-5-)-methyltransferase 4	0.337
ef1a	elongation factor 1-alpha	0.305
egr2b	early growth response 2b	0.296
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.290
stc1l	stanniocalcin 1, like	0.284
eomesa	eomesodermin homolog a	0.252
card9	caspase recruitment domain family, member 9	0.221	Mouse
tlr9	toll-like receptor 9	0.203
nod1	nucleotide-binding oligomerization domain containing 1	0.202
tlr21	toll-like receptor 21	0.197
ripk2	receptor-interacting serine-threonine kinase 2	0.193
tnfb	tumor necrosis factor b (TNF superfamily, member 2)	0.157	Mouse
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.153
coro1a	coronin, actin binding protein, 1A	0.147
mpx	myeloid-specific peroxidase	0.146
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.133
LOC100000934	hypothetical protein LOC100000934	0.119
sh3gl1b	SH3-domain GRB2-like 1b	0.110
irak4	interleukin-1 receptor-associated kinase 4	0.103
pdcd2	programmed cell death 2	0.092
tlr2	toll-like receptor 2	0.092	Mouse
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.087
gata1a	GATA binding protein 1a	0.086
LOC557072	caspase recruitment domain-containing protein 11-like	0.084
jak1	Janus kinase 1	0.080
si:ch211-212m21.5	si:ch211-212m21.5	0.080	Human
caspa	caspase a	0.073
tgfb3	transforming growth factor, beta 3	0.070
sdcbp	syndecan binding protein (syntenin)	0.069
ptena	phosphatase and tensin homolog A	0.069
vasa	vasa homolog	0.068
arl4ab	ADP-ribosylation factor-like 4ab	0.066
slc30a7	solute carrier family 30 (zinc transporter), member 7	0.062
stat1b	signal transducer and activator of transcription 1b	0.062
wu:fi38e01	wu:fi38e01	0.062
sema3fb	semaphorin 3fb	0.060
epas1b	endothelial PAS domain protein 1b	0.059
rnasel1	ribonuclease like 1	0.059
wasb	Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b	0.058
tp53	tumor protein p53	0.057
fxr2	fragile X mental retardation, autosomal homolog 2	0.055
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.053
c1qc	complement component 1, q subcomponent, C chain	0.053
copa	coatomer protein complex, subunit alpha	0.053
klf2b	Kruppel-like factor 2b	0.052
zgc:64115	zgc:64115	0.049
defbl3	defensin, beta-like 3	0.047
rhag	Rhesus blood group-associated glycoprotein	0.046
epor	erythropoietin receptor	0.045
nos2a	nitric oxide synthase 2a, inducible	0.042
LOC100151531	zinc finger protein Gfi-1b-like	0.042
isg15	ISG15 ubiquitin-like modifier	0.041
fgfr2	fibroblast growth factor receptor 2	0.040	Fly
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.040
runx1	runt-related transcription factor 1	0.039
ip6k2	inositol hexaphosphate kinase 2	0.038
LOC100332505	hypothetical protein LOC100332505	0.038
pax7a	paired box gene 7a	0.037
ifnphi1	interferon phi 1	0.037
LOC100535037	leukotriene B4 receptor 1-like	0.037
proc	protein C (inactivator of coagulation factors Va and VIIIa)	0.036
cry1a	cryptochrome 1a	0.035
dnmt6	DNA (cytosine-5-)-methyltransferase 6	0.033
itgb1a	integrin, beta 1a	0.032
serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.031
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.031
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.031
col12a1	collagen, type XII, alpha 1	0.030
vwf	von Willebrand factor	0.029
lcp1	lymphocyte cytosolic plastin 1	0.029
ptpn11a	protein tyrosine phosphatase, non-receptor type 11, a	0.029
xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5	0.029
c1qb	complement component 1, q subcomponent, B chain	0.028
pax5	paired box gene 5	0.028
acvr2a	activin receptor IIa	0.028
wnt8a	wingless-type MMTV integration site family, member 8a	0.028
entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.027
ca15a	carbonic anhydrase XV a	0.027
ahr1a	aryl hydrocarbon receptor 1a	0.026
nos2b	nitric oxide synthase 2b, inducible	0.025
foxl1	forkhead box L1	0.025
pycard	PYD and CARD domain containing	0.025	Human Mouse
pcsk2	proprotein convertase subtilisin/kexin type 2	0.024
tlr4bb	toll-like receptor 4b, duplicate b	0.024	Human Mouse
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.024
LOC100534776	toll-like receptor 7-like	0.024
mitfa	microphthalmia-associated transcription factor a	0.024
trim25	tripartite motif-containing 25	0.023
rorca	RAR-related orphan receptor C a	0.022
pth1a	parathyroid hormone 1a	0.022
fsta	follistatin a	0.022
tmem144b	transmembrane protein 144b	0.022
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.022	Mouse Fly
myog	myogenin	0.022
zp3b	zona pellucida glycoprotein 3b	0.021	Mouse
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.020
prrx1a	paired related homeobox 1a	0.020
zbtb4	zinc finger and BTB domain containing 4	0.020
illr1	immune-related, lectin-like receptor 1	0.020	Zebrafish
fcho2	FCH domain only 2	0.020
pea3	ETS-domain transcription factor pea3	0.020
zp3a.1	zona pellucida glycoprotein 3a.1	0.020	Human
zgc:66488	zgc:66488	0.020
cd247l	CD247 antigen like	0.020
LOC100330224	fatty acid binding protein 1b-like	0.019
pdx1	pancreatic and duodenal homeobox 1	0.019
st8sia1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	0.019
csad	cysteine sulfinic acid decarboxylase	0.018
ecrg4a	esophageal cancer related gene 4a	0.018
calcr	calcitonin receptor	0.018
foxp3a	forkhead box P3a	0.018	Mouse
rarga	retinoic acid receptor gamma a	0.018
efnb3b	ephrin B3b	0.018
si:ch211-14a17.7	si:ch211-14a17.7	0.018
ifng1-2	interferon, gamma 1-2	0.018
cyt1	type I cytokeratin, enveloping layer	0.018
gdf6a	growth differentiation factor 6a	0.018
slc2a1b	solute carrier family 2 (facilitated glucose transporter), member 1b	0.018
gclc	glutamate-cysteine ligase, catalytic subunit	0.017
matn4	matrilin 4	0.017
pias4a	protein inhibitor of activated STAT, 4a	0.017
utrn	utrophin	0.017
eif3hb	eukaryotic translation initiation factor 3, subunit H, b	0.017
mpll	myeloproliferative leukemia virus oncogene, like	0.017
tm9sf2	transmembrane 9 superfamily member 2	0.017
si:ch211-195h23.3	si:ch211-195h23.3	0.017
emx1	empty spiracles homeobox 1	0.017
ikbkg	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.017
copb2	coatomer protein complex, subunit beta 2	0.016
il8	interleukin 8	0.016
tbx21	T-box 21	0.016
zgc:56005	zgc:56005	0.016
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.016	Mouse
bmp2b	bone morphogenetic protein 2b	0.016
bhmt	betaine-homocysteine methyltransferase	0.016
tirap	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.016
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.016
cd209	CD209 molecule	0.016	Zebrafish
xylt1	xylosyltransferase 1	0.015
rrp12	ribosomal RNA processing 12 homolog (S. cerevisiae)	0.015
pou3f3b	POU class 3 homeobox 3b	0.015
litaf	lipopolysaccharide-induced TNF factor	0.015
rag2	recombination activating gene 2	0.015
rhcgl1	Rhesus blood group, C glycoprotein, like 1	0.015
bmper	BMP binding endothelial regulator	0.015
slc4a2b	solute carrier family 4, anion exchanger, member 2b	0.015
pdia5	protein disulfide isomerase family A, member 5	0.015
lox	lysyl oxidase	0.015
c3c	complement component c3c	0.015	Human
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.014
cdh1	cadherin 1, epithelial	0.014
fes	feline sarcoma oncogene	0.014
zgc:66455	zgc:66455	0.014
tlr18	toll-like receptor 18	0.014
calcrla	calcitonin receptor-like a	0.014
foxi3a	forkhead box I3a	0.014
ins	preproinsulin	0.014
ntla	no tail a	0.014
col7a1l	collagen type VII alpha 1-like	0.014
cd40lg	CD40 ligand	0.014
LOC100149056	pannexin-3-like	0.014
mycbp2	MYC binding protein 2	0.014
sb:cb429	sb:cb429	0.014
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.014
axin2	axin 2 (conductin, axil)	0.013
lipc	lipase, hepatic	0.013
foxi3b	forkhead box I3b	0.013
slc4a4b	solute carrier family 4, sodium bicarbonate cotransporter, member 4b	0.013
defbl1	defensin, beta-like 1	0.013
kitlga	kit ligand a	0.013
c1qa	complement component 1, q subcomponent, A chain	0.013
il22	interleukin 22	0.013
hlxb9la	homeo box HB9 like a	0.013
zgc:66449	zgc:66449	0.013
zp2.2	zona pellucida glycoprotein 2.2	0.013
zgc:171779	zgc:171779	0.013	Human
fgf4	fibroblast growth factor 4	0.013
raraa	retinoic acid receptor, alpha a	0.013	Human
otc	ornithine carbamoyltransferase	0.013
LOC562403	hypothetical LOC562403	0.013
si:dkeyp-34c12.1	si:dkeyp-34c12.1	0.012
ptger4b	prostaglandin E receptor 4 (subtype EP4) b	0.012
si:dkeyp-110g5.2	si:dkeyp-110g5.2	0.012	Human
irf6	interferon regulatory factor 6	0.012
zgc:153921	zgc:153921	0.012
irf11	interferon regulatory factor 11	0.012
fgfr3	fibroblast growth factor receptor 3	0.012	Fly
kpna3	karyopherin (importin) alpha 3	0.012
gfer	growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)	0.012
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.012
grn1	granulin 1	0.011
hspa4b	heat shock protein 4b	0.011
polr2d	polymerase (RNA) II (DNA directed) polypeptide D	0.011
zgc:110340	zgc:110340	0.011
nkd2	naked cuticle homolog 2 and naked 2a	0.011
cd40	CD40 antigen	0.011
LOC100537597	hypothetical protein LOC100537597	0.011
cdh10	cadherin 10, type 2 (T2-cadherin)	0.011
btr16	bloodthirsty-related gene family, member 16	0.011
ercc2	excision repair cross-complementing rodent repair deficiency, complementation group 2	0.011
nipblb	novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)	0.011
zgc:161979	zgc:161979	0.011
fn1b	fibronectin 1b	0.011
tlr20f	toll-like receptor 20f	0.011
tal1	T-cell acute lymphocytic leukemia 1	0.011
si:dkey-46g23.5	si:dkey-46g23.5	0.011
wu:fc23b05	wu:fc23b05	0.011
zgc:103710	zgc:103710	0.011
chia.2	chitinase, acidic.2	0.011
spns2	spinster homolog 2 (Drosophila)	0.011
duox	dual oxidase	0.011
lta4h	leukotriene A4 hydrolase	0.011
fn1	fibronectin 1	0.011
mmp9	matrix metalloproteinase 9	0.011
zgc:113293	zgc:113293	0.011
npy7r	neuropeptide Y receptor Y7	0.011
crfb7	cytokine receptor family member b7	0.011
g6pd	glucose-6-phosphate dehydrogenase	0.010
atp1b2a	ATPase, Na+/K+ transporting, beta 2a polypeptide	0.010
nr1h5	nuclear receptor subfamily 1, group H, member 5	0.010
ighm	immunoglobulin heavy constant mu and immunoglobulin heavy constant mu	0.010
ccr6a	chemokine (C-C motif) receptor 6a	0.010
bmpr2a	bone morphogenetic protein receptor, type II a (serine/threonine kinase)	0.010
her1	hairy-related 1	0.010