IMP: Integrative Multi-species Prediction

Danio rerio

96 genes annotated in zebrafish

Multi-species View

negative regulation of signaling

GO:0023057

Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.

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Known genes in the process in zebrafishInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of signaling"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of signaling" (in gray)

Name	Description	Probability	Func Analog Organism
bmp2b	bone morphogenetic protein 2b	0.907	Human
tbx1	T-box 1	0.863
pea3	ETS-domain transcription factor pea3	0.777
gli1	GLI-Kruppel family member 1	0.713	Human
chd	chordin	0.674
per3	period homolog 3 (Drosophila)	0.637
sox10	SRY-box containing gene 10	0.598
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.590	Mouse
fn1	fibronectin 1	0.556
egr1	early growth response 1	0.540	Mouse Worm
bmp4	bone morphogenetic protein 4	0.523	Human
wnt4a	wingless-type MMTV integration site family, member 4a	0.507	Zebrafish Mouse
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.493
sox9a	SRY-box containing gene 9a	0.483	Mouse
runx2b	runt-related transcription factor 2b	0.473	Mouse
sema3aa	semaphorin 3aa	0.465
ndr2	nodal-related 2	0.463
shha	sonic hedgehog a	0.458	Mouse
wnt3	wingless-type MMTV integration site family, member 3	0.432	Zebrafish
wnt11r	wingless-type MMTV integration site family, member 11, related	0.416	Zebrafish Mouse
lef1	lymphocyte enhancer binding factor 1	0.416	Human Zebrafish
fzd7a	frizzled homolog 7a	0.414
snai1a	snail homolog 1a (Drosophila)	0.406	Human
pcdh18b	protocadherin 18b	0.405
gdf6a	growth differentiation factor 6a	0.404
hcrt	hypocretin (orexin) neuropeptide precursor	0.379	Rat
wnt10a	wingless-type MMTV integration site family, member 10a	0.371	Zebrafish
mt2	metallothionein 2	0.363
pomca	proopiomelanocortin a	0.348
tbx6	T-box gene 6	0.329
mapk3	mitogen-activated protein kinase 3	0.324	Yeast
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.315	Human
edn1	endothelin 1	0.301
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.299
cyp19a1b	cytochrome P450, family 19, subfamily A, polypeptide 1b	0.295
csnk1da	casein kinase 1, delta a	0.294
pcna	proliferating cell nuclear antigen	0.293
bcl2l1	bcl2-like 1	0.291
fgf3	fibroblast growth factor 3	0.288
znf703	zinc finger protein 703	0.288
otpa	orthopedia homolog a	0.277
robo3	roundabout homolog 3	0.272
zeb2a	zinc finger E-box binding homeobox 2a	0.271
etv5b	ets variant 5b	0.269
col2a1a	collagen type II, alpha-1a	0.266	Mouse
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.255
twist3	twist3	0.255
runx1	runt-related transcription factor 1	0.254
zgc:158603	zgc:158603	0.245
nrg1	neuregulin 1	0.245	Human
adipor2	adiponectin receptor 2	0.244
nf1a	neurofibromin 1a	0.239
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.232
yap1	Yes-associated protein 1	0.230	Mouse
spry4	sprouty (Drosophila) homolog 4	0.227
dlx6a	distal-less homeobox gene 6a	0.223
igf1rb	insulin-like growth factor 1b receptor	0.220	Human Mouse
spry2	sprouty homolog 2	0.220
mcl1a	myeloid cell leukemia sequence 1a	0.219	Human Zebrafish
twist1a	twist1a	0.217
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.216
sulf1	sulfatase 1	0.216	Human Mouse Fly
fgfr3	fibroblast growth factor receptor 3	0.212	Mouse
wnt5b	wingless-type MMTV integration site family, member 5b	0.211	Human Zebrafish Mouse
adra2b	adrenergic, alpha-2B-, receptor	0.208
lhx2b	LIM homeobox 2b	0.205
zbtb4	zinc finger and BTB domain containing 4	0.199
flh	floating head	0.199
mef2d	myocyte enhancer factor 2d	0.198
lama5	laminin, alpha 5	0.197
epb41l5	erythrocyte membrane protein band 4.1 like 5	0.197
fgf20a	fibroblast growth factor 20a	0.194
cmyb	transcription factor cmyb	0.191
frem3	Fras1 related extracellular matrix 3	0.191
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.187
boc	brother of CDO	0.183
bmp2a	bone morphogenetic protein 2a	0.183	Human
rerea	arginine-glutamic acid dipeptide (RE) repeats a	0.181
baxa	bcl2-associated X protein, a	0.180	Zebrafish Mouse
tnfrsfa	tumor necrosis factor receptor superfamily, member a	0.180
acvr1b	activin A receptor, type IB	0.178
hmgb2b	high-mobility group box 2b	0.177	Mouse
bmp1a	bone morphogenetic protein 1a	0.171
tp53bp2	tumor protein p53 binding protein, 2	0.169
frzb	frizzled-related protein	0.169	Human Zebrafish Mouse Rat
bmper	BMP binding endothelial regulator	0.168	Mouse
dlx1a	distal-less homeobox gene 1a	0.168	Mouse
zmynd11	zinc finger, MYND domain containing 11	0.168
sox11b	SRY-box containing gene 11b	0.168
brd4	bromodomain containing 4	0.167
rbb4	retinoblastoma binding protein 4	0.166
nkx2.2a	NK2 transcription factor related 2a	0.166
notch2	notch homolog 2	0.164
whsc1	Wolf-Hirschhorn syndrome candidate 1	0.164
gli2a	GLI-Kruppel family member GLI2a	0.163
zdhhc8b	zinc finger, DHHC-type containing 8b	0.163
lmo4a	LIM domain only 4a	0.163
shhb	sonic hedgehog b	0.161	Mouse
socs3a	suppressor of cytokine signaling 3a	0.161	Zebrafish Mouse
erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog	0.159	Fly
epha4a	eph receptor A4a	0.158
fas	Fas (TNF receptor superfamily, member 6)	0.157
id1	inhibitor of DNA binding 1	0.155
cbx2	chromobox homolog 2 (Drosophila Pc class)	0.155
pak2b	p21 (CDKN1A)-activated kinase 2b	0.154
met	met proto-oncogene (hepatocyte growth factor receptor)	0.154
pcdh18a	protocadherin 18a	0.153
avpl	arginine vasopressin-like	0.153	Rat
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.152
wnt9b	wingless-type MMTV integration site family, member 9B	0.151	Zebrafish
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.151	Human Zebrafish Mouse
col10a1	collagen, type X, alpha 1	0.151
gnrh2	gonadotropin-releasing hormone 2	0.150
nrg2a	neuregulin 2a	0.149
ihha	Indian hedgehog homolog a	0.149
bmp7a	bone morphogenetic protein 7a	0.148	Human Mouse
fzd5	frizzled homolog 5	0.145
clock	clock	0.144	Mouse
gpc4	glypican 4	0.144	Fly
dbh	dopamine beta hydroxylase	0.144
hmx1	H6 homeo box 1	0.144
crb2b	crumbs homolog 2b	0.143	Zebrafish
tcf12	transcription factor 12	0.141
dld	deltaD	0.140
smo	smoothened homolog (Drosophila)	0.140	Fly
dkk1b	dickkopf 1b	0.138
gria2b	glutamate receptor, ionotropic, AMPA 2b	0.137
clptm1	cleft lip and palate associated transmembrane protein 1	0.137
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.136	Human
rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.136
furina	furin (paired basic amino acid cleaving enzyme) a	0.136
igfbp1a	insulin-like growth factor binding protein 1a	0.135	Zebrafish
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.135	Rat
stil	TAL1 (SCL) interrupting locus	0.133
vdra	vitamin D receptor a	0.133
si:ch211-209p5.2	si:ch211-209p5.2	0.132
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.132
csad	cysteine sulfinic acid decarboxylase	0.131
nog2	noggin 2	0.131
wnt11	wingless-type MMTV integration site family, member 11	0.131
ptprk	protein tyrosine phosphatase, receptor type, K	0.128
trim71	tripartite motif-containing 71	0.128
dusp6	dual specificity phosphatase 6	0.128	Human Fly
snai2	snail homolog 2 (Drosophila)	0.128	Human Mouse
irf6	interferon regulatory factor 6	0.127
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.126	Zebrafish
nog3	noggin 3	0.126
kal1a	Kallmann syndrome 1a sequence	0.126
sid4	secreted immunoglobulin domain 4	0.126
crb3a	crumbs homolog 3a	0.125
tp63	tumor protein p63	0.124
barx1	BarH-like homeobox 1	0.124	Mouse
col4a5	collagen, type IV, alpha 5 (Alport syndrome)	0.124
fgfrl1b	fibroblast growth factor receptor-like 1b	0.124
btg1	B-cell translocation gene 1	0.123
dao.2	D-amino-acid oxidase 2	0.123
wnt3a	wingless-type MMTV integration site family, member 3A	0.123	Human Zebrafish
ctgf	connective tissue growth factor	0.122	Zebrafish
igf1ra	insulin-like growth factor 1a receptor	0.122	Human Mouse
rasgef1ba	RasGEF domain family, member 1Ba	0.122
ptch2	patched 2	0.122
ins	preproinsulin	0.121
oprd1b	opioid receptor, delta 1b	0.121
fibin	fin bud initiation factor	0.119
etv5a	ets variant 5a	0.119
crb3b	crumbs homolog 3b	0.118
pax6a	paired box gene 6a	0.118
rxrbb	retinoid x receptor, beta b	0.117
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.117
hoxb2a	homeo box B2a	0.116
tph1a	tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a	0.116
nod1	nucleotide-binding oligomerization domain containing 1	0.115
jag2	jagged 2	0.115	Fly
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.114	Zebrafish
mcl1b	myeloid cell leukemia sequence 1b	0.114	Human Zebrafish
hoxd4a	homeo box D4a	0.114
slc25a22	solute carrier family 25 (mitochondrial carrier: glutamate), member 22	0.113
fgfr1a	fibroblast growth factor receptor 1a	0.112
col11a2	collagen type XI alpha-2	0.112
mapk1	mitogen-activated protein kinase 1	0.112	Yeast
snai1b	snail homolog 1b (Drosophila)	0.111	Human
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.111
rarga	retinoic acid receptor gamma a	0.111	Zebrafish
dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.111
flot2a	flotillin 2a	0.111
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.111
rag1	recombination activating gene 1	0.111
ip6k2	inositol hexaphosphate kinase 2	0.111
aox3	aldehyde oxidase 3	0.110
lzts2a	leucine zipper, putative tumor suppressor 2a	0.110
irf2bp2b	interferon regulatory factor 2 binding protein 2b	0.109
dlc	deltaC	0.109	Rat
tyr	tyrosinase	0.109
tbx16	T-box gene 16	0.109
nkx2.5	NK2 transcription factor related 5	0.109
cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.108
ncam2	neural cell adhesion molecule 2	0.108
nrp1a	neuropilin 1a	0.107	Mouse
hoxa13b	homeo box A13b	0.107
epb4.1l4	erythrocyte protein band 4.1-like 4	0.107
hs6st2	heparan sulfate 6-O-sulfotransferase 2	0.107
rnf2	ring finger protein 2	0.107
ewsr1a	Ewing sarcoma breakpoint region 1a	0.107
bcl2	B-cell leukemia/lymphoma 2	0.106	Human Zebrafish Mouse
hand2	heart and neural crest derivatives expressed transcript 2	0.105
itgb1b.2	integrin, beta 1b.2	0.105	Mouse
irx3a	iroquois homeobox protein 3a	0.105
tll1	tolloid-like 1	0.104
notum3	notum 3	0.104
fzd7b	frizzled homolog 7b	0.103	Zebrafish
grem2	gremlin 2, cysteine knot superfamily	0.103	Zebrafish
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.103	Fly
jag1b	jagged 1b	0.103	Fly
crestin	crestin	0.103
nfe2l3	nuclear factor (erythroid-derived 2)-like 3	0.102
frem1a	Fras1 related extracellular matrix 1a	0.102
mapk6	mitogen-activated protein kinase 6	0.102
ctnnb1	catenin (cadherin-associated protein), beta 1	0.102	Zebrafish Mouse Fly
junb	jun B proto-oncogene	0.101
arl6	ADP-ribosylation factor-like 6	0.101
pax8	paired box gene 8	0.101
fzd10	frizzled homolog 10	0.101	Zebrafish
waca	WW domain containing adaptor with coiled-coil a	0.100
ptgs1	prostaglandin-endoperoxide synthase 1	0.099	Rat
slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.099
oxtl	oxytocin-like	0.098	Rat
zgc:91870	zgc:91870	0.098
oprk1	opioid receptor, kappa 1	0.097
extl3	exostoses (multiple)-like 3	0.097
sgk1	serum/glucocorticoid regulated kinase 1	0.097
uts1	urotensin 1	0.097
egr2b	early growth response 2b	0.097	Worm
sox9b	SRY-box containing gene 9b	0.097
mtmr8	myotubularin related protein 8	0.096
sim1a	single-minded homolog 1a (Drosophila)	0.095
bnc2	basonuclin 2	0.095
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.095
stox1	storkhead box 1	0.094
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.094
klf2a	Kruppel-like factor 2a	0.093
bc2	putative breast adenocarcinoma marker	0.093	Fly
appa	amyloid beta (A4) precursor protein a	0.093
tm4sf4	transmembrane 4 L six family member 4	0.093
lft1	lefty1	0.093	Mouse
otx1a	orthodenticle homolog 1a	0.093
dlx5a	distal-less homeobox gene 5a	0.092
wnt2	wingless-type MMTV integration site family member 2	0.092	Zebrafish
lims1	LIM and senescent cell antigen-like domains 1	0.091	Fly
ilk	integrin linked kinase	0.091
dedd1	death effector domain-containing 1	0.091
axin2	axin 2 (conductin, axil)	0.091	Human Zebrafish Rat Worm Fly
cx30.3	connexin 30.3	0.090
smad1	MAD homolog 1 (Drosophila)	0.090
rnd3a	Rho family GTPase 3a	0.089
tagln2	transgelin 2	0.089
lmna	lamin A	0.089	Mouse
ptpn11a	protein tyrosine phosphatase, non-receptor type 11, a	0.089	Mouse
tob1a	transducer of ERBB2, 1a	0.088	Mouse
csrp1a	cysteine and glycine-rich protein 1a	0.088
irx5a	iroquois homeobox protein 5a	0.088
brpf1	bromodomain and PHD finger containing, 1	0.088
auts2	autism susceptibility candidate 2	0.088
axin1	axin 1	0.088
mycb	myelocytomatosis oncogene b	0.087
smad2	MAD homolog 2 (Drosophila)	0.087
ahcy	S-adenosylhomocysteine hydrolase	0.087
rasl11b	RAS-like, family 11, member B	0.086
kdrl	kinase insert domain receptor like	0.086
cnr1	cannabinoid receptor 1	0.086
bnip3lb	BCL2/adenovirus E1B interacting protein 3-like b	0.086
rhoab	ras homolog gene family, member Ab	0.086
tgif1	TGFB-induced factor homeobox 1	0.086	Mouse
card9	caspase recruitment domain family, member 9	0.086
epha4b	eph receptor A4b	0.086
plcb3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.086
roraa	RAR-related orphan receptor A, paralog a	0.086	Human
dnmt4	DNA (cytosine-5-)-methyltransferase 4	0.086
cry1a	cryptochrome 1a	0.085	Mouse
plekhg4	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	0.085
ppp4cb	protein phosphatase 4 (formerly X), catalytic subunit b	0.085
sema3d	semaphorin 3d	0.085
nkd2	naked cuticle homolog 2 and naked 2a	0.085
ext1b	exostoses (multiple) 1b	0.085
tuba1	tubulin, alpha 1	0.084
nog1	noggin 1	0.084
pitpnb	phosphotidylinositol transfer protein, beta	0.084
zgc:195154	zgc:195154	0.083
prdm1a	PR domain containing 1a, with ZNF domain	0.083	Mouse
dla	deltaA	0.083
map2k4a	mitogen-activated protein kinase kinase 4a	0.083
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.083	Zebrafish
traf4a	tnf receptor-associated factor 4a	0.083
tsc22d3	TSC22 domain family, member 3	0.082
nadl1.1	neural adhesion molecule L1.1	0.082
il6r	interleukin 6 receptor	0.081
pknox1.2	pbx/knotted 1 homeobox 1.2	0.081
ube2g2	ubiquitin-conjugating enzyme E2G 2	0.081
ntn1b	netrin 1b	0.081
pcdh8	protocadherin 8	0.081
zgc:64114	zgc:64114	0.081	Human Mouse
dusp4	dual specificity phosphatase 4	0.081	Rat
tm9sf2	transmembrane 9 superfamily member 2	0.081
zgc:113210	zgc:113210	0.080
kbp	kif1-binding protein	0.079
nkx3.2	NK3 homeobox 2	0.079
znf503	zinc finger protein 503	0.079
nkx6.2	NK6 transcription factor related, locus 2	0.079
ncf1	neutrophil cytosolic factor 1	0.079
rab11fip4a	RAB11 family interacting protein 4 (class II) a	0.078
ahi1	Abelson helper integration site 1	0.078
col8a1a	collagen, type VIII, alpha 1a	0.078
stm	starmaker	0.078
ntla	no tail a	0.078
mxi1	max interacting protein	0.077
sh3gl1b	SH3-domain GRB2-like 1b	0.077
zgc:136773	zgc:136773	0.077
spag1	sperm associated antigen 1	0.077
ephb4b	eph receptor B4b	0.076
rab1a	RAB1A, member RAS oncogene family	0.076
maff	v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)	0.076
sdcbp	syndecan binding protein (syntenin)	0.076
itgb1b	integrin, beta 1b	0.075	Mouse
th2	tyrosine hydroxylase 2	0.075
kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.075	Fly
ext2	exostoses (multiple) 2	0.075
her12	hairy-related 12	0.075
scd	stearoyl-CoA desaturase (delta-9-desaturase)	0.075
trim13	tripartite motif-containing 13	0.074
dag1	dystroglycan 1	0.074	Human
gfra1a	gdnf family receptor alpha 1a	0.074
emp2	epithelial membrane protein 2	0.074
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.074	Human Mouse
efnb2a	ephrin B2a	0.074
slit3	slit (Drosophila) homolog 3	0.074	Human
rest	RE1-silencing transcription factor	0.073
arl4ab	ADP-ribosylation factor-like 4ab	0.073
dlb	deltaB	0.073	Rat
fzd2	frizzled homolog 2	0.073	Zebrafish
amotl2a	angiomotin like 2a	0.072
rhag	Rhesus blood group-associated glycoprotein	0.072
cd99l2	CD99 antigen-like 2	0.072
epyc	epiphycan	0.072
npy8br	neuropeptide Y receptor Y8b	0.072
faf2	Fas associated factor family member 2	0.072
gdnf	glial cell derived neurotrophic factor	0.072	Human
neo1	neogenin 1	0.071
pafah1b1b	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b	0.071	Mouse
brd2a	bromodomain-containing 2a	0.071
disp1	dispatched homolog 1 (Drosophila)	0.071
hspa4a	heat shock protein 4a	0.071
tbx20	T-box 20	0.071	Mouse
fgf8a	fibroblast growth factor 8 a	0.070
sox32	SRY-box containing gene 32	0.070	Mouse
apoeb	apolipoprotein Eb	0.070	Human
evx1	even-skipped homeobox 1	0.070
igf1	insulin-like growth factor 1	0.070
llgl2	lethal giant larvae homolog 2 (Drosophila)	0.070	Fly
rx3	retinal homeobox gene 3	0.070
junbl	jun B proto-oncogene, like	0.070
btg2	B-cell translocation gene 2	0.070
ntrk3b	neurotrophic tyrosine kinase, receptor, type 3b	0.070
lpp	LIM domain containing preferred translocation partner in lipoma	0.070
skib	nuclear oncoprotein skib	0.069	Human Mouse
gng5	guanine nucleotide binding protein (G protein), gamma 5	0.069
ednrb1	endothelin receptor B	0.069
bsk146	brain specific kinase 146	0.069
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.068	Human Zebrafish Mouse
vegfc	vascular endothelial growth factor c	0.068
pdgfrb2	platelet derived growth factor receptor beta 2	0.068
spns2	spinster homolog 2 (Drosophila)	0.068	Fly
cdkl1	cyclin-dependent kinase-like 1 (CDC2-related kinase)	0.068
tmpoa	thymopoietin a	0.067
si:ch211-173b8.2	si:ch211-173b8.2	0.067	Zebrafish
plcg1	phospholipase C, gamma 1	0.067	Fly
fmr1	fragile X mental retardation 1	0.067	Fly
ptpra	protein tyrosine phosphatase, receptor type, A	0.067	Worm
htra1a	HtrA serine peptidase 1a	0.067	Mouse
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.067
trim3a	tripartite motif-containing 3a	0.067
mib	mind bomb	0.067
wls	wntless homolog (Drosophila)	0.066
lin28a	lin-28 homolog A (C. elegans)	0.066
sod1	superoxide dismutase 1, soluble	0.066
rarab	retinoic acid receptor, alpha b	0.066	Zebrafish
prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.066	Mouse
six4.3	sine oculis homeobox homolog 4.3	0.066
mfn2	mitofusin 2	0.065
sox4b	SRY-box containing gene 4b	0.065
hoxb1b	homeo box B1b	0.065
ier5l	immediate early response 5-like	0.065
exosc9	exosome component 9	0.064
bmp6	bone morphogenetic protein 6	0.064
tmem88a	transmembrane protein 88 a	0.064
tgfb3	transforming growth factor, beta 3	0.064	Rat
phactr4b	phosphatase and actin regulator 4b	0.064
erbb3b	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b	0.064	Human Fly
gnrh3	gonadotropin-releasing hormone 3	0.064
klhl11	kelch-like 11 (Drosophila)	0.063
sst1.1	somatostatin 1, tandem duplicate 1	0.063
csnk1g2a	casein kinase 1, gamma 2a	0.063
zgc:66440	zgc:66440	0.063	Fly
olig4	oligodendrocyte transcription factor 4	0.063
myog	myogenin	0.063
dab1a	disabled homolog 1a (Drosophila)	0.063	Mouse
guca1c	guanylate cyclase activator 1C	0.063
akt2	v-akt murine thymoma viral oncogene homolog 2	0.063	Fly
t54l	T54 protein-like	0.063
otx5	orthodenticle homolog 5	0.063
fzd8b	frizzled homolog 8b	0.062	Zebrafish
im:7162646	im:7162646	0.062
fli1a	friend leukemia integration 1a	0.062
ldb2b	LIM-domain binding factor 2b	0.062
jun	jun proto-oncogene	0.062
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.062
epas1b	endothelial PAS domain protein 1b	0.062
slc4a4a	solute carrier family 4, member 4a	0.062
mapk12	mitogen-activated protein kinase 12	0.061
ulk2	unc-51-like kinase 2 (C. elegans)	0.061
mapk15	mitogen-activated protein kinase 15	0.061
mbtps1	membrane-bound transcription factor protease, site 1	0.061
si:dkeyp-104h9.6	si:dkeyp-104h9.6	0.061
otud7b	OTU domain containing 7B	0.061
gcm2	glial cells missing homolog 2 (Drosophila)	0.061
pbx4	pre-B-cell leukemia transcription factor 4	0.061
pth2	parathyroid hormone 2	0.061
vax1	ventral anterior homeobox 1	0.061
ehd2	EH-domain containing 2	0.061
wif1	wnt inhibitory factor 1	0.061
prkar1aa	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a	0.061
smad5	MAD homolog 5 (Drosophila)	0.060
tnfsf10l3	tumor necrosis factor (ligand) superfamily, member 10 like 3	0.060	Fly
fev	FEV (ETS oncogene family)	0.060
aplnrb	apelin receptor b	0.060
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.060
insrb	insulin receptor b	0.060
fabp11a	fatty acid binding protein 11a	0.060
ahsa1l	AHA1, activator of heat shock protein ATPase homolog 1, like	0.060
kdm5c	lysine (K)-specific demethylase 5C	0.060
si:dkeyp-68f6.1	si:dkeyp-68f6.1	0.060
sfrp1b	secreted frizzled-related protein 1b	0.059	Human Mouse Rat
ldb1a	LIM-domain binding factor 1a	0.059
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.059	Human Mouse
hif1ab	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b	0.059	Human Mouse
tgfb1a	transforming growth factor, beta 1a	0.059
foxi2	forkhead box I2	0.059
ube2d1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.059
scrib	scribbled homolog (Drosophila)	0.059
mef2a	myocyte enhancer factor 2a	0.059
sb:cb560	sb:cb560	0.058
rcn1	reticulocalbin 1, EF-hand calcium binding domain	0.058
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.058
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.058
mpp5a	membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)	0.058
mapk14a	mitogen-activated protein kinase 14a	0.058
dct	dopachrome tautomerase	0.058
LOC100000500	sclerostin-like	0.058
krml2.2	Kreisler (mouse) maf-related leucine zipper homolog 2.2	0.058
sp2	sp2 transcription factor	0.058
pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.058
angptl2	angiopoietin-like 2	0.058
cntn1a	contactin 1a	0.057
LOC557072	caspase recruitment domain-containing protein 11-like	0.057
prkcea	protein kinase C, epsilon a	0.057
otx1b	orthodenticle homolog 1b	0.057
hspd1	heat shock 60kD protein 1 (chaperonin)	0.057
plk2b	polo-like kinase 2b (Drosophila)	0.057
zgc:172136	zgc:172136	0.057
nadl1.2	neural adhesion molecule L1.2	0.057
tomm34	translocase of outer mitochondrial membrane 34	0.057
metrnl	meteorin, glial cell differentiation regulator-like	0.057
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.056
dlx2a	distal-less homeobox gene 2a	0.056
cadm1b	cell adhesion molecule 1b	0.056
fbxl14b	F-box and leucine-rich repeat protein 14b	0.056
mecp2	methyl CpG binding protein 2	0.056
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.056
prdx3	peroxiredoxin 3	0.056
uba2	ubiquitin-like modifier activating enzyme 2	0.056
csnk1db	casein kinase 1, delta b	0.056
mapkapk2a	mitogen-activated protein kinase-activated protein kinase 2a	0.055
tsga14	testis specific, 14	0.055
klf4a	Kruppel-like transcription factor 4a	0.055
gadd45ab	growth arrest and DNA-damage-inducible, alpha, b	0.055
vasa	vasa homolog	0.055
si:rp71-39b20.7	si:rp71-39b20.7	0.055
smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.055
zgc:123170	zgc:123170	0.054
zgc:162126	zgc:162126	0.054
cyp1b1	cytochrome P450, family 1, subfamily B, polypeptide 1	0.054
desma	desmin a	0.054
rnaset2	ribonuclease T2	0.054
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.054	Human Mouse Fly
vcana	versican a	0.054
slc17a6b	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b	0.054
gnat2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	0.054
gcga	glucagon a and glucagon a-like	0.054
notch1a	notch homolog 1a	0.053	Mouse
msi1	musashi homolog 1 (Drosophila)	0.053
inhbaa	inhibin, beta Aa	0.053
scrt1b	scratch homolog 1, zinc finger protein b (Drosophila)	0.053
smoc1	SPARC related modular calcium binding 1	0.053
ralgapa1	Ral GTPase activating protein, alpha subunit 1 (catalytic)	0.053
insra	insulin receptor a	0.053
lmo7a	LIM domain only 7a	0.053
zgc:114095	zgc:114095	0.053
lft2	lefty2	0.053	Mouse
zgc:55813	zgc:55813	0.053
nr5a1b	nuclear receptor subfamily 5, group A, member 1b	0.053
st8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.053
mych	myelocytomatosis oncogene homolog	0.053
cav3	caveolin 3	0.053	Mouse
phf17	PHD finger protein 17	0.053	Fly
stk35l	serine/threonine kinase 35, like	0.053
plagl2	pleiomorphic adenoma gene-like 2	0.053
zgc:85866	zgc:85866	0.053	Zebrafish
ar	androgen receptor	0.053
h2afv	H2A histone family, member V	0.052
rtn4rl2b	reticulon 4 receptor-like 2b	0.052
gmnn	geminin, DNA replication inhibitor	0.052	Fly
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.052	Fly
cpla2	cytosolic phospholipase a2	0.052
th	tyrosine hydroxylase	0.052
fn1b	fibronectin 1b	0.052
mdkb	midkine-related growth factor b	0.052
pcdh17	protocadherin 17	0.052
mao	monoamine oxidase	0.052
oprd1a	opioid receptor, delta 1a	0.051
myst2	MYST histone acetyltransferase 2	0.051
nlgn1	neuroligin 1	0.051
spaw	southpaw	0.051
pax9	paired box gene 9	0.051
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.051
kctd12.1	potassium channel tetramerisation domain containing 12.1	0.051
cdh1	cadherin 1, epithelial	0.051	Mouse
fabp10a	fatty acid binding protein 10a, liver basic	0.051
wu:fj62d01	wu:fj62d01	0.050
cdx4	caudal type homeo box transcription factor 4	0.050
pard3	par-3 partitioning defective 3 homolog (C. elegans)	0.050
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.050
prnprs1	prion protein, related sequence 1	0.050
arfgef1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.050
odc1	ornithine decarboxylase 1	0.050
thraa	thyroid hormone receptor alpha a	0.050	Zebrafish
pprc1	peroxisome proliferator-activated receptor gamma, coactivator-related 1	0.050
asb2b	ankyrin repeat and SOCS box-containing 2b	0.050
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.050
ube2i	ubiquitin-conjugating enzyme E2I	0.050	Fly
sestd1	SEC14 and spectrin domains 1	0.050
map2k7	mitogen-activated protein kinase kinase 7	0.050
rhogb	ras homolog gene family, member Gb	0.050
tuba8l	tubulin, alpha 8 like	0.050
snrpc	small nuclear ribonucleoprotein polypeptide C	0.050
ptger4a	prostaglandin E receptor 4 (subtype EP4) a	0.050
fgg	fibrinogen, gamma polypeptide	0.050
atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.050
chsy1	chondroitin sulfate synthase 1	0.050
arhgap29b	Rho GTPase activating protein 29b	0.049
map3k4	mitogen activated protein kinase kinase kinase 4	0.049
ef1	ETS-related factor1	0.049
atf3	activating transcription factor 3	0.049
zgc:110298	zgc:110298	0.049
sf3b1	splicing factor 3b, subunit 1	0.049
zgc:77052	zgc:77052	0.049
veph	ventricular zone expressed PH domain protein	0.049
ctbp2	C-terminal binding protein 2	0.049
psen1	presenilin 1	0.049	Mouse
wnt8b	wingless-type MMTV integration site family, member 8b	0.049	Zebrafish
lama1	laminin, alpha 1	0.049
ppp1cb	protein phosphatase 1, catalytic subunit, beta isoform	0.049
hoxa13a	homeo box A13a	0.049
prkci	protein kinase C, iota	0.048
b3gnt5a	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a	0.048
fezf2	FEZ family zinc finger 2	0.048
chst11	carbohydrate (chondroitin 4) sulfotransferase 11	0.048	Mouse
vipr2	vasoactive intestinal peptide receptor 2	0.048
mobkl1aa	MOB1, Mps One Binder kinase activator-like 1A (yeast), genome duplicate a	0.048
nkx6.1	NK6 transcription factor related, locus 1 (Drosophila)	0.048
rogdi	rogdi homolog (Drosophila)	0.048
mllt10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	0.048
lmnb1	lamin B1	0.047
col7a1l	collagen type VII alpha 1-like	0.047
ptges	prostaglandin E synthase	0.047
zgc:77262	zgc:77262	0.047
fzd3a	frizzled homolog 3a	0.047	Zebrafish Fly
cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.047
stat3	signal transduction and activation of transcription 3	0.047
celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.047
zgc:112986	zgc:112986	0.047
hhip	hedgehog interacting protein	0.047
mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.047
crb1	crumbs homolog 1 (Drosophila)	0.047	Zebrafish
spint1a	serine peptidase inhibitor, Kunitz type 1 a	0.047
cyp1a	cytochrome P450, family 1, subfamily A	0.047
ncor1	nuclear receptor co-repressor 1	0.047	Human Mouse
itgb1a	integrin, beta 1a	0.047	Mouse
trpv4	transient receptor potential cation channel, subfamily V, member 4	0.047
map1lc3a	microtubule-associated protein 1 light chain 3 alpha	0.047
gfra1b	gdnf family receptor alpha 1b	0.046
erbb3a	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a	0.046	Human Fly
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.046
ntrk2a	neurotrophic tyrosine kinase, receptor, type 2a	0.046
rltpr	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.046
zgc:65979	zgc:65979	0.046
nkx2.2b	NK2 transcription factor related 2b	0.046
ldb2a	LIM-domain binding factor 2a	0.046
smad9	MAD homolog 9 (Drosophila)	0.046
grnb	granulin b	0.046
aurka	aurora kinase A	0.046
celf1	cugbp, Elav-like family member 1	0.046
ripk2	receptor-interacting serine-threonine kinase 2	0.046
jak1	Janus kinase 1	0.046
twist1b	twist1b	0.046
cldn12	claudin 12	0.046
gli3	GLI-Kruppel family member GLI3	0.046
ctsl1a	cathepsin L, 1 a	0.045
zgc:92481	zgc:92481	0.045
rxrba	retinoid x receptor, beta a	0.045
pcdh19	protocadherin 19	0.045
figf	c-fos induced growth factor	0.045
pax7b	paired box gene 7b	0.045
cldn2	claudin 2	0.045
zgc:136878	zgc:136878	0.045
tardbp	TAR DNA binding protein	0.045
fkbp5	FK506 binding protein 5	0.045
pfdn2	prefoldin subunit 2	0.045
mif	macrophage migration inhibitory factor	0.045	Mouse
zgc:153953	zgc:153953	0.045
zfpm2b	zinc finger protein, multitype 2b	0.045
oprm1	opioid receptor, mu 1	0.045	Human
hmgb1a	high-mobility group box 1a	0.045
apln	apelin	0.044
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.044	Human
zgc:73134	zgc:73134	0.044
efna2	ephrin A2	0.044
pmp22b	peripheral myelin protein 22b	0.044
opn1lw1	opsin 1 (cone pigments), long-wave-sensitive, 1	0.044
rab2a	RAB2A, member RAS oncogene family	0.044
shroom4	shroom family member 4	0.044
prdm16	PR domain containing 16	0.044
si:ch211-241e15.2	si:ch211-241e15.2	0.044
LOC797832	similar to signal peptide, CUB domain, EGF-like 1	0.044
etfa	electron-transfer-flavoprotein, alpha polypeptide	0.044
im:7137555	im:7137555	0.044
maf	v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog	0.044
gsc	goosecoid	0.044	Mouse
ntn2	netrin 2	0.044
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.044
zic2b	zic family member 2 (odd-paired homolog, Drosophila) b	0.044
il17rd	interleukin 17 receptor D	0.044
zgc:63663	zgc:63663	0.043
slc4a2a	solute carrier family 4, anion exchanger, member 2a	0.043
sulf2l	sulfatase 2, like	0.043	Mouse Fly
unc45a	unc-45 homolog A (C. elegans)	0.043
itga5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.043
cldn5b	claudin 5b	0.043
hlxb9lb	homeo box HB9 like b	0.043
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.043
fgf20b	fibroblast growth factor 20b	0.043
ppp1r7	protein phosphatase 1, regulatory (inhibitor) subunit 7	0.043
ftsjd1	FtsJ methyltransferase domain containing 1	0.043
nf1b	neurofibromin 1b	0.043
ptena	phosphatase and tensin homolog A	0.043	Human Mouse
bin1	bridging integrator 1	0.043
gdf6b	growth differentiation factor 6b	0.043
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.042
atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.042
ptprja	protein tyrosine phosphatase, receptor type, J a	0.042
inka1a	induced in neural crest by AP2, 1a	0.042
spata2	spermatogenesis associated 2	0.042
fras1	Fraser syndrome 1	0.042
hspa5	heat shock protein 5	0.042	Mouse
apaf1	apoptotic protease activating factor 1	0.042
tpst1	tyrosylprotein sulfotransferase 1	0.042
snw1	SNW domain containing 1	0.042
hspb6	heat shock protein, alpha-crystallin-related, b6	0.042
lhx1a	LIM homeobox 1a	0.042
matn4	matrilin 4	0.042
tshz1	teashirt family zinc finger 1	0.042
ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.042
im:7139293	im:7139293	0.042
bmi1	B lymphoma Mo-MLV insertion region 1	0.042	Mouse
nhsl1b	NHS-like 1b	0.042
hoxa1a	homeo box A1a	0.042
hmgb1b	high-mobility group box 1b	0.042
wnt16	wingless-type MMTV integration site family, member 16	0.042
nr1d2a	nuclear receptor subfamily 1, group D, member 2a	0.042	Zebrafish
phlda2	pleckstrin homology-like domain, family A, member 2	0.042
myo6b	myosin VIb	0.042
polb	polymerase (DNA directed), beta	0.042
pxn	paxillin	0.042
uxs1	UDP-glucuronic acid decarboxylase 1	0.042
mc2r	melanocortin 2 receptor	0.042
zgc:77051	zgc:77051	0.041
cnot1	CCR4-NOT transcription complex, subunit 1	0.041	Human
svil	supervillin	0.041
furinb	furin (paired basic amino acid cleaving enzyme) b	0.041
grk7a	G-protein-coupled receptor kinase 7a	0.041
gata4	GATA-binding protein 4	0.041
zfyve26	zinc finger, FYVE domain containing 26	0.041
vsx2	visual system homeobox 2	0.041
wdr69	WD repeat domain 69	0.041
glceb	glucuronyl C5-epimerase b	0.041
dkk1a	dickkopf 1a	0.041
ryk	receptor-like tyrosine kinase	0.041
tgm2b	transglutaminase 2b	0.041
polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.041
six4b	sine oculis homeobox homolog 4b	0.041
plk3	polo-like kinase 3 (Drosophila)	0.041
tp53	tumor protein p53	0.041	Mouse
si:dkeyp-59a8.4	si:dkeyp-59a8.4	0.040
xiap	X-linked inhibitor of apoptosis	0.040
irf2bp2a	interferon regulatory factor 2 binding protein 2a	0.040
cry3	cryptochrome 3	0.040	Mouse
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.040
thbs1	thrombospondin 1	0.040	Human
im:7153552	im:7153552	0.040
otpb	orthopedia homolog b	0.040
arhgap29a	Rho GTPase activating protein 29a	0.040
lass2	LAG1 homolog, ceramide synthase 2 (S. cerevisiae)	0.040
xgb	x globin	0.040
LOC554173	abnormal spindles	0.040
ache	acetylcholinesterase	0.040
fgf6a	fibroblast growth factor 6a	0.040
igfbp1b	insulin-like growth factor binding protein 1b	0.039	Zebrafish
mcamb	melanoma cell adhesion molecule b	0.039
zgc:193613	zgc:193613	0.039
tuba8l4	tubulin, alpha 8 like 4	0.039
cldn15lb	claudin 15-like b	0.039
podxl	podocalyxin-like	0.039
hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.039
hdac4	histone deacetylase 4	0.039
tcf7l1b	transcription factor 7-like 1b (T-cell specific, HMG-box)	0.039	Zebrafish
appl2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.039
ptrfb	polymerase I and transcript release factor b	0.039
foxh1	forkhead box H1	0.039
gpt2	glutamic pyruvate transaminase (alanine aminotransferase) 2	0.039
spon2a	spondin 2a, extracellular matrix protein	0.039
zgc:55558	zgc:55558	0.039	Fly
arntl1a	aryl hydrocarbon receptor nuclear translocator-like 1a	0.039	Mouse
stc1l	stanniocalcin 1, like	0.039
nrg2b	neuregulin 2b	0.039
wnt7aa	wingless-type MMTV integration site family, member 7Aa	0.039	Zebrafish
sparc	secreted acidic cysteine rich glycoprotein	0.039
fzd8a	frizzled homolog 8a	0.039	Zebrafish
si:dkeyp-34c12.2	si:dkeyp-34c12.2	0.039
dopey1	dopey family member 1	0.039
arih1l	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 like	0.039
cldng	claudin g	0.039
plekhg5a	pleckstrin homology domain containing, family G (with RhoGef domain) member 5a	0.038
mga	MAX gene associated	0.038