IMP: Integrative Multi-species Prediction

Danio rerio

74 genes annotated in zebrafish

g protein coupled receptor signaling pathway

A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "g protein coupled receptor signaling pathway"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "g protein coupled receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
si:dkey-228g21.4	si:dkey-228g21.4	0.901
plcg1	phospholipase C, gamma 1	0.883
chat	choline acetyltransferase	0.845
hrh1	histamine receptor H1	0.812
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.740
drd2b	dopamine receptor D2b	0.720	Human Mouse Rat Worm Fly
npy8br	neuropeptide Y receptor Y8b	0.706
oprk1	opioid receptor, kappa 1	0.698	Human Zebrafish Mouse Rat
adra2b	adrenergic, alpha-2B-, receptor	0.685
LOC569642	hypothetical protein LOC569642	0.681
opn4l	opsin 4, like	0.680
opn1lw1	opsin 1 (cone pigments), long-wave-sensitive, 1	0.680	Zebrafish
gnat1	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	0.676	Yeast Mouse Fly
rho	rhodopsin	0.645
mchr1b	melanin-concentrating hormone receptor 1b	0.611	Zebrafish Fly
opn1sw2	opsin 1 (cone pigments), short-wave-sensitive 2	0.606	Zebrafish
opn4a	opsin 4a (melanopsin)	0.593
kiss1	KiSS-1 metastasis-suppressor	0.593
mc4r	melanocortin 4 receptor	0.591
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.588
LOC559201	similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)	0.587
oprm1	opioid receptor, mu 1	0.576	Human Zebrafish Mouse Rat
ulk2	unc-51-like kinase 2 (C. elegans)	0.533
mao	monoamine oxidase	0.524
pink1	PTEN induced putative kinase 1	0.465
cadm2b	cell adhesion molecule 2b	0.448
mtnr1ba	melatonin receptor type 1B a	0.442
htr1aa	5-hydroxytryptamine (serotonin) receptor 1A a	0.441
si:ch211-124k10.1	si:ch211-124k10.1	0.438
gnrhr3	gonadotropin releasing hormone receptor 3	0.436
trpc1	transient receptor potential cation channel, subfamily C, member 1	0.431	Fly
avpl	arginine vasopressin-like	0.419
lin7a	lin-7 homolog A (C. elegans)	0.418
dbh	dopamine beta hydroxylase	0.399
tbx1	T-box 1	0.391
cyp19a1a	cytochrome P450, family 19, subfamily A, polypeptide 1a	0.391
tac1	tachykinin 1	0.388
pi4kb	phosphatidylinositol 4-kinase, catalytic, beta	0.386
esr2a	estrogen receptor 2a	0.371
vangl2	vang-like 2 (van gogh, Drosophila)	0.364
gcm2	glial cells missing homolog 2 (Drosophila)	0.359
ptprc	protein tyrosine phosphatase, receptor type, C	0.358
drd2a	dopamine receptor D2a	0.355	Human Mouse Rat Worm Fly
adra2c	adrenergic, alpha-2C-, receptor	0.352
LOC100331502	melanopsin-B-like	0.349
kcnn1	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	0.344
gnrhr4	gonadotropin releasing hormone receptor 4	0.336
ntf7	neurotrophin 7	0.333
osr1	odd-skipped related 1 (Drosophila)	0.330
lhx8a	LIM homeobox 8a	0.321
gucy2f	guanylate cyclase 2F, retinal	0.311
gnat2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	0.310	Mouse Fly
mc1r	melanocortin 1 receptor	0.310	Zebrafish Mouse
pmch	pro-melanin concentrating hormone	0.293
nbl1	neuroblastoma, suppression of tumorigenicity 1	0.289
kiss2	kisspeptin 2	0.282
adra2a	adrenergic, alpha-2A-, receptor	0.275
LOC555482	tachykinin receptor 3-like	0.271
cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.266
gna13a	guanine nucleotide binding protein (G protein), alpha 13a	0.256
ildr1b	immunoglobulin-like domain containing receptor 1b	0.256
opn1sw1	opsin 1 (cone pigments), short-wave-sensitive 1	0.251	Zebrafish
slc8a4b	solute carrier family 8 (sodium/calcium exchanger), member 4b	0.248
gc2	guanylyl cyclase 2	0.238
mchr1a	melanin-concentrating hormone receptor 1a	0.229
gna14	guanine nucleotide binding protein (G protein), alpha 14	0.229
arr3a	arrestin 3a, retinal (X-arrestin)	0.225	Fly
hdc	histidine decarboxylase	0.219
c1qtnf4	C1q and tumor necrosis factor related protein 4	0.218
LOC793448	protein-glutamine gamma-glutamyltransferase K-like	0.215
oxtl	oxytocin-like	0.215
cnga5	cyclic nucleotide gated channel alpha 5	0.213
pou1f1	POU domain, class 1, transcription factor 1	0.212
tshb	thyroid stimulating hormone, beta subunit	0.212
scn1lab	sodium channel, voltage-gated, type I like, alpha b	0.211
nlgn1	neuroligin 1	0.206
gnaq	guanine nucleotide binding protein (G protein), q polypeptide	0.206	Rat
adra2db	adrenergic, alpha-2D-, receptor b	0.204
gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.203	Yeast
itgb1a	integrin, beta 1a	0.202
gnai2l	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like	0.199	Mouse Fly
pdca	phosducin a	0.198
vdra	vitamin D receptor a	0.198
opn4x1	opsin 4x1	0.196	Zebrafish Fly
camk2g2	calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2	0.192
crb2b	crumbs homolog 2b	0.186
gnrh3	gonadotropin-releasing hormone 3	0.183
gnav1	guanine nucleotide binding protein (G protein) alpha v1	0.183
paqr7b	progestin and adipoQ receptor family member VII, b	0.181
LOC568691	opsin-3-like	0.179
pde6h	phosphodiesterase 6H, cGMP-specific, cone, gamma	0.176	Mouse
slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.173
insra	insulin receptor a	0.173	Human
arf1	ADP-ribosylation factor 1	0.167
tas2r202	taste receptor, type 2, member 202	0.166
ctsl1a	cathepsin L, 1 a	0.165
slc18a3b	solute carrier family 18 (vesicular acetylcholine), member 3b	0.164
wu:fc57f07	wu:fc57f07	0.163
fam84b	family with sequence similarity 84, member B	0.162
irbp	interphotoreceptor retinoid-binding protein	0.161
rxrbb	retinoid x receptor, beta b	0.160
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.160
flt1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.158
hspb1	heat shock protein, alpha-crystallin-related, 1	0.155
kiss1ra	KISS1 receptor a	0.154
atp2b3a	ATPase, Ca++ transporting, plasma membrane 3a	0.153
epas1b	endothelial PAS domain protein 1b	0.153
cacnb2b	calcium channel, voltage-dependent, beta 2b	0.152
calcr	calcitonin receptor	0.152
or115-10	odorant receptor, family F, subfamily 115, member 10	0.149
aqp7	aquaporin 7	0.148
gria4b	glutamate receptor, ionotropic, AMPA 4b	0.146
pomca	proopiomelanocortin a	0.146
runx2b	runt-related transcription factor 2b	0.146
ucn3l	urocortin 3, like	0.143
ryr2b	ryanodine receptor 2b (cardiac)	0.142
arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.141
mcamb	melanoma cell adhesion molecule b	0.139
LOC100005405	Gig2-like protein DreJ	0.136
chrnb3b	cholinergic receptor, nicotinic, beta polypeptide 3b	0.135
exorh	extra-ocular rhodopsin	0.134
kif5c	kinesin family member 5C	0.134
pcp4a	Purkinje cell protein 4a	0.134
es1	es1 protein	0.133
c3b	complement component c3b	0.132
calcrla	calcitonin receptor-like a	0.132	Zebrafish Mouse
igfbp6b	insulin-like growth factor binding protein 6b	0.132
klf4a	Kruppel-like transcription factor 4a	0.132
ldha	lactate dehydrogenase A4	0.132
lama1	laminin, alpha 1	0.132
zgc:56548	zgc:56548	0.130
gnal	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	0.128
sst1.1	somatostatin 1, tandem duplicate 1	0.128
cyp11b2	cytochrome P450, family 11, subfamily B, polypeptide 2	0.128
cnr2	cannabinoid receptor 2	0.127	Zebrafish Rat
zgc:92392	zgc:92392	0.125
LOC799612	prolactin 2	0.124
atp1b2a	ATPase, Na+/K+ transporting, beta 2a polypeptide	0.123
mc5rb	melanocortin 5b receptor	0.121
LOC100001008	prepro-urotensin II-related peptide	0.121
cldn2	claudin 2	0.119
npy8ar	neuropeptide Y receptor Y8a	0.117
fzd7b	frizzled homolog 7b	0.116
pcsk1nl	proprotein convertase subtilisin/kexin type 1 inhibitor, like	0.114
si:ch73-60e21.1	si:ch73-60e21.1	0.113
LOC100332193	growth hormone secretagogue receptor type 1-like	0.112
adrb3b	adrenergic receptor, beta 3b	0.112	Human Zebrafish Mouse Rat
spon1a	spondin 1a	0.110
LOC100332929	guanine nucleotide-binding protein subunit alpha-15-like	0.110
pygmb	phosphorylase, glycogen (muscle) b	0.110
sncgb	synuclein, gamma b (breast cancer-specific protein 1)	0.108
dkk1a	dickkopf 1a	0.108
zgc:73138	zgc:73138	0.108
slc12a10.1	solute carrier family 12 (sodium/potassium/chloride transporters), member 10.1	0.107
tbx20	T-box 20	0.106
vamp2	vesicle-associated membrane protein 2	0.106
nlgn4a	neuroligin 4a	0.104
ptger1a	prostaglandin E receptor 1, subtype EP1a	0.104
zgc:171629	zgc:171629	0.104
mep1a.2	meprin A, alpha.2	0.102
plp2	proteolipid protein 2	0.102
rtn4r	reticulon 4 receptor	0.101
dio2	deiodinase, iodothyronine, type II	0.100
slc25a25a	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a	0.099
tgm2b	transglutaminase 2b	0.099
fshb	follicle stimulating hormone, beta polypeptide	0.097	Mouse
mapk1	mitogen-activated protein kinase 1	0.096	Yeast
lcp1	lymphocyte cytosolic plastin 1	0.096
ucp3	uncoupling protein 3	0.095
gfra1b	gdnf family receptor alpha 1b	0.095
zgc:153063	zgc:153063	0.095
rcv1	recoverin	0.095
hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.095
gnaz	guanine nucleotide binding protein (G protein), alpha z polypeptide	0.094
valopa	vertebrate ancient long opsin a	0.092	Zebrafish
tph2	tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)	0.092
ppp3cb	protein phosphatase 3, catalytic subunit, beta isozyme	0.090
cga	glycoprotein hormones, alpha polypeptide	0.089
rag2	recombination activating gene 2	0.088
valopb	vertebrate ancient long opsin b	0.088	Zebrafish
crb3a	crumbs homolog 3a	0.087
rdh5	retinol dehydrogenase 5 (11-cis/9-cis)	0.087
lhb	luteinizing hormone, beta polypeptide	0.087
hrh3	histamine receptor H3	0.087
csgalnact2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.086
prl	prolactin	0.085
ncam1b	neural cell adhesion molecule 1b	0.084
itgb1b.1	integrin, beta 1b.1	0.083
alcamb	activated leukocyte cell adhesion molecule b	0.083
per2	period homolog 2 (Drosophila)	0.083
slc4a11	solute carrier family 4, sodium borate transporter, member 11	0.083
cx55.5	connexin 55.5	0.083
pdxdc1	pyridoxal-dependent decarboxylase domain containing 1	0.082
adra2da	adrenergic, alpha-2D-, receptor a	0.081
rab11bb	RAB11B, member RAS oncogene family, b	0.081
vipr2	vasoactive intestinal peptide receptor 2	0.080
ND1	NADH dehydrogenase subunit 1	0.080
cx52.6	connexin 52.6	0.080
nrg2a	neuregulin 2a	0.080
ghrhrl	growth hormone releasing hormone receptor, like	0.080
gna13b	guanine nucleotide binding protein (G protein), alpha 13b	0.080	Mouse
penka	proenkephalin a	0.080
bik	BCL2-interacting killer (apoptosis-inducing)	0.080
vps37a	vacuolar protein sorting 37A	0.079
LOC100333520	hypothetical protein LOC100333520	0.079
guca1c	guanylate cyclase activator 1C	0.079
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.079
alx4a	aristaless-like homeobox 4a	0.078
rhogb	ras homolog gene family, member Gb	0.078
trim33	tripartite motif-containing 33	0.078
ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.077
crhbp	corticotropin releasing hormone binding protein	0.077
siah2l	seven in absentia homolog 2 (Drosophila)-like	0.076
chrm2a	cholinergic receptor, muscarinic 2a	0.075
si:dkeyp-22b2.3	si:dkeyp-22b2.3	0.075
pbx1a	pre-B-cell leukemia transcription factor 1a	0.075
nptx2b	neuronal pentraxin 2b	0.075
necab2	N-terminal EF-hand calcium binding protein 2	0.075
tspan3b	tetraspanin 3b	0.075
cacnb2a	calcium channel, voltage-dependent, beta 2a	0.075
LOC100333916	myomegalin-like	0.074
cadm1a	cell adhesion molecule 1a	0.074
ptger2b	prostaglandin E receptor 2b (subtype EP2)	0.072
tnr	tenascin R (restrictin, janusin)	0.072
opn1mw1	opsin 1 (cone pigments), medium-wave-sensitive, 1	0.072	Zebrafish
kdr	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.071
lpin1	lipin 1	0.071
gna11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	0.071	Rat
zgc:171495	zgc:171495	0.071
guk1	guanylate kinase 1	0.071
arrdc2	arrestin domain containing 2	0.070
ttc39c	tetratricopeptide repeat domain 39C	0.070
slc1a2a	solute carrier family 1 (glial high affinity glutamate transporter), member 2a	0.070
dclk2	doublecortin-like kinase 2	0.070
drd2l	dopamine receptor D2 like	0.070	Worm Fly
ndr1	nodal-related 1	0.069
s100s	S100 calcium binding protein S	0.069
igfbp6a	insulin-like growth factor binding protein 6a	0.069
LOC100003535	prostaglandin E2 receptor subtype EP1-like protein	0.069
htr1ab	5-hydroxytryptamine (serotonin) receptor 1A b	0.069	Human Zebrafish Mouse Rat
LOC562316	klotho-like	0.068
hcrtr2	hypocretin (orexin) receptor 2	0.068
adora2aa	adenosine A2a receptor a	0.068	Human Mouse Rat
or115-15	odorant receptor, family F, subfamily 115, member 15	0.068
gnai1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.067	Yeast
clec14a	C-type lectin domain family 14, member A	0.067
mtp	microsomal triglyceride transfer protein	0.067
eno2	enolase 2	0.067
adrb2a	adrenergic receptor, beta 2a	0.067
paqr8	progestin and adipoQ receptor family member VIII	0.067
ruvbl2	RuvB-like 2 (E. coli)	0.067
gdnf	glial cell derived neurotrophic factor	0.066
ctsba	cathepsin B, a	0.066
prkca	protein kinase C, alpha	0.066
snai1a	snail homolog 1a (Drosophila)	0.065
mc3r	melanocortin 3 receptor	0.065	Human Zebrafish Rat
zgc:77051	zgc:77051	0.064
wu:fb71f10	wu:fb71f10	0.064
LOC100005504	Gig2-like protein DreL	0.064
sox7	SRY-box containing gene 7	0.064
aqp1a.1	aquaporin 1a, tandem duplicate 1	0.064
trpm6	transient receptor potential cation channel, subfamily M, member 6	0.064
tnfsf10l2	tumor necrosis factor (ligand) superfamily, member 10 like 2	0.064
csrp1a	cysteine and glycine-rich protein 1a	0.063
hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.063
vegfaa	vascular endothelial growth factor Aa	0.063
gna12	guanine nucleotide binding protein (G protein) alpha 12	0.063
si:dkey-37m8.9	si:dkey-37m8.9	0.063
LOC565594	similar to glycoprotein (predicted)	0.062
gh1	growth hormone 1	0.062
nhsl1b	NHS-like 1b	0.062
kctd12.1	potassium channel tetramerisation domain containing 12.1	0.061
LOC100006361	galanin-like	0.061
ptpra	protein tyrosine phosphatase, receptor type, A	0.061
ora6	olfactory receptor class A related 6	0.061
pyya	peptide YYa	0.060
adora2b	adenosine A2b receptor	0.060	Mouse Rat
si:dkey-24h22.4	si:dkey-24h22.4	0.060
nrl	neural retina leucine zipper	0.060
LOC100005454	Gig2-like protein DreK	0.060
gnas	GNAS complex locus	0.059
zgc:101761	zgc:101761	0.059	Rat
gc3	guanylyl cyclase 3	0.059
hrh2	histamine receptor H2	0.059
gsdf	gonadal somatic cell derived factor	0.059
LOC556160	guanine nucleotide-binding protein subunit alpha-14-like	0.059
ugt5a5	UDP glucuronosyltransferase 5 family, polypeptide A5	0.059
nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.059
cpn1	carboxypeptidase N, polypeptide 1	0.059
nr4a2b	nuclear receptor subfamily 4, group A, member 2b	0.058
hamp1	hepcidin antimicrobial peptide 1	0.058
zgc:112018	zgc:112018	0.058
snrk1	SNF related kinase 1	0.058
zgc:92765	zgc:92765	0.058
slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.057
ryr1b	ryanodine receptor 1b (skeletal)	0.057
aanat2	arylalkylamine N-acetyltransferase	0.057
rx1	retinal homeobox gene 1	0.057
celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.056
rpsa	ribosomal protein SA	0.056
sh3gl1b	SH3-domain GRB2-like 1b	0.056
stmn1b	stathmin 1b	0.056
insrb	insulin receptor b	0.056	Human
zgc:73336	zgc:73336	0.056
LOC559147	novel protein similar to vertebrate hairy and enhancer of split 2 (Drosophila) (HES2)	0.056
slc26a4	solute carrier family 26, member 4	0.055
gnrhr2	gonadotropin releasing hormone receptor 2	0.055
gngt1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	0.055
sb:eu2485	sb:eu2485	0.055
fgf20b	fibroblast growth factor 20b	0.054
kctd12.2	potassium channel tetramerisation domain containing 12.2	0.054
scn1ba	sodium channel, voltage-gated, type I, beta a	0.054
sb:cb134	sb:cb134	0.054
LOC100003514	protein kinase C alpha type-like	0.054
sc:d0374	sc:d0374	0.053
LOC798577	NT-3 growth factor receptor-like	0.053
cx35	connexin 35	0.053
LOC565781	somatostatin-2-like	0.053
drd4a	dopamine receptor D4a	0.053	Human Mouse Rat Worm Fly
dcst1	DC-STAMP domain containing 1	0.053
gnao1b	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b	0.052	Mouse Rat Worm Fly
s100z	S100 calcium binding protein Z	0.052
scn4aa	sodium channel, voltage-gated, type IV, alpha, a	0.052
si:dkey-222f8.3	si:dkey-222f8.3	0.052
zgc:101614	zgc:101614	0.052
taar1b	trace amine associated receptor 1b	0.052
nr5a1b	nuclear receptor subfamily 5, group A, member 1b	0.052
ptger4a	prostaglandin E receptor 4 (subtype EP4) a	0.052
adrb1	adrenergic receptor, beta 1	0.052	Human Zebrafish Mouse Rat
plxnd1	plexin D1	0.052
rs1	retinoschisis (X-linked, juvenile) 1	0.052	Mouse
itgav	integrin, alpha V	0.051
gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.051
ugt5e1	UDP glucuronosyltransferase 5 family, polypeptide E1	0.051
flr	fleer	0.051
uts1	urotensin 1	0.051
nsfb	N-ethylmaleimide-sensitive factor b	0.051
ldb2a	LIM-domain binding factor 2a	0.051
cldn5b	claudin 5b	0.051
ddb2	damage-specific DNA binding protein 2	0.051
b3gnt2b	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2b	0.051
cnn2	calponin 2	0.051
LOC100334776	phosphatase and actin regulator 1-like	0.050
fabp7b	fatty acid binding protein 7, brain, b	0.050
gria2b	glutamate receptor, ionotropic, AMPA 2b	0.050
rab3c	RAB3C, member RAS oncogene family	0.050
dfna5	deafness, autosomal dominant 5	0.050
crygs1	crystallin, gamma S1	0.049
nr1i2	nuclear receptor subfamily 1, group I, member 2	0.049
slc2a13	solute carrier family 2 (facilitated glucose transporter), member 13	0.049
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.049
cry1a	cryptochrome 1a	0.049	Mouse
hn1l	hematological and neurological expressed 1-like	0.049
si:ch211-14k19.8	si:ch211-14k19.8	0.049
smtlb	somatolactin beta	0.049
ptpn13	protein tyrosine phosphatase, non-receptor type 13	0.048
aqp10b	aquaporin 10b	0.048
zgc:153115	zgc:153115	0.048	Mouse
zgc:194112	zgc:194112	0.048
itgb1b	integrin, beta 1b	0.047
irf8	interferon regulatory factor 8	0.047
zdhhc2	zinc finger, DHHC-type containing 2	0.047
wu:fd99c08	wu:fd99c08	0.047
wu:fc18c07	wu:fc18c07	0.047
insl3	insulin-like 3 (Leydig cell)	0.047	Rat
clock	clock	0.047
avpr1b	arginine vasopressin receptor 1B	0.046
mc2r	melanocortin 2 receptor	0.046
tnfsf18	tumor necrosis factor (ligand) superfamily, member 18	0.046
cacnb4a	calcium channel, voltage-dependent, beta 4a subunit	0.046	Mouse
s1pr2	sphingosine-1-phosphate receptor 2	0.046
vip	vasoactive intestinal peptide	0.046
kirrela	kin of IRRE like a	0.046
optc	opticin	0.046
crfb17	cytokine receptor family member B17	0.046
cpe	carboxypeptidase E	0.046
nr2e3	nuclear receptor subfamily 2, group E, member 3	0.046
wls	wntless homolog (Drosophila)	0.045
ldb1a	LIM-domain binding factor 1a	0.045
tmem88a	transmembrane protein 88 a	0.045
ptger1b	prostaglandin E receptor 1, subtype EP1b	0.045
npc1	Niemann-Pick disease, type C1	0.045
maff	v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)	0.045
otpa	orthopedia homolog a	0.045
ptgs2b	prostaglandin-endoperoxide synthase 2b	0.044
ywhag1	3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1	0.044
prox2	prospero homeobox 2	0.044
nrg1	neuregulin 1	0.044
trpc5	transient receptor potential cation channel, subfamily C, member 5	0.044
lhcgr	luteinizing hormone/choriogonadotropin receptor	0.044
LOC557722	similar to transient receptor potential cation channel, subfamily M, member 5	0.043
gnao1a	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a	0.043	Yeast Mouse Worm Fly
cry3	cryptochrome 3	0.043
sagb	S-antigen; retina and pineal gland (arrestin) b	0.043	Fly
grk5	G protein-coupled receptor kinase 5	0.043
si:dkey-12o15.1	si:dkey-12o15.1	0.043
cldnj	claudin j	0.043
tmprss13b	transmembrane protease, serine 13b	0.043
ora5	olfactory receptor class A related 5	0.043
nf1b	neurofibromin 1b	0.042
lamb2	laminin, beta 2 (laminin S)	0.042
elfn1	extracellular leucine-rich repeat and fibronectin type III domain containing 1	0.042
ugt5g1	UDP glucuronosyltransferase 5 family, polypeptide G1	0.042
tectb	tectorin beta	0.042
si:ch211-235f6.2	si:ch211-235f6.2	0.042
ppardb	peroxisome proliferator-activated receptor delta b	0.042
igfbp1b	insulin-like growth factor binding protein 1b	0.042
npas2	neuronal PAS domain protein 2	0.041
frzb	frizzled-related protein	0.041
zgc:64042	zgc:64042	0.041
gnrhr1	gonadotropin releasing hormone receptor 1	0.041
s100t	S100 calcium binding protein T	0.041
hint2	histidine triad nucleotide binding protein 2	0.041
lta4h	leukotriene A4 hydrolase	0.041
ora1	olfactory receptor class A related 1	0.041
cx44.1	connexin 44.1	0.041
ahrrb	aryl-hydrocarbon receptor repressor b	0.041
adcyap1r1a	adenylate cyclase activating polypeptide 1 receptor 1a	0.041
bsdc1	BSD domain containing 1	0.041
pou4f1	POU domain, class 4, transcription factor 1	0.040
hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	0.040
elovl2	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	0.040
lepb	leptin b	0.040
slc9a8	solute carrier family 9 (sodium/hydrogen exchanger), member 8	0.040
nrp2a	neuropilin 2a	0.040
pkm2a	pyruvate kinase, muscle, a	0.040
crx	cone-rod homeobox	0.040
heatr5a	HEAT repeat containing 5a	0.040
tfap2b	transcription factor AP-2 beta	0.040
wu:fj98a08	wu:fj98a08	0.040
ncam2	neural cell adhesion molecule 2	0.040
drd1	dopamine receptor D1	0.040	Rat Worm Fly
igfbp1a	insulin-like growth factor binding protein 1a	0.040
ugt5f1	UDP glucuronosyltransferase 5 family, polypeptide F1	0.040
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.039
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.039
gpr173	G-protein coupled receptor 173	0.039	Mouse
slc6a4a	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A	0.039
panx2	pannexin 2	0.039
pou4f2	POU domain, class 4, transcription factor 2	0.039
crh	corticotropin releasing hormone	0.039
LOC100538306	hypothetical protein LOC100538306	0.039
cspg4	chondroitin sulfate proteoglycan 4	0.038
ugt5c2	UDP glucuronosyltransferase 5 family, polypeptide C2	0.038
b4galt5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	0.038
rps2	ribosomal protein S2	0.038
rundc3b	RUN domain containing 3b	0.038
cntn2	contactin 2	0.038	Mouse
LOC794630	retinol-binding protein 3-like	0.038
mbnl3	muscleblind-like 3 (Drosophila)	0.038
sb:cb930	sb:cb930	0.038
rgs8	regulator of G-protein signaling 8	0.038
lrrtm4l2	leucine rich repeat transmembrane neuronal 4 like 2	0.038
LOC560602	novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)	0.038
aqp1a.2	aquaporin 1a, tandem duplicate 2	0.038
metrnl	meteorin, glial cell differentiation regulator-like	0.038
cadm2a	cell adhesion molecule 2a	0.038
chrm5a	cholinergic receptor, muscarinic 5a	0.037
dlg1	discs, large (Drosophila) homolog 1	0.037
zgc:162630	zgc:162630	0.037
gnb3b	guanine nucleotide binding protein (G protein), beta polypeptide 3b	0.037	Yeast
igf1	insulin-like growth factor 1	0.037
insl5a	insulin-like 5a	0.037
vtg7	vitellogenin 7	0.037
pcdh1g3	protocadherin 1 gamma 3	0.037
guca1d	guanylate cyclase activator 1d	0.037
crygm2a	crystallin, gamma M2a	0.037
inha	inhibin, alpha	0.037
gpc6l	glypican 6, like	0.037
slco2b1	solute carrier organic anion transporter family, member 2B1	0.037
llgl2	lethal giant larvae homolog 2 (Drosophila)	0.036
inadl	InaD-like (Drosophila)	0.036	Fly
zgc:172284	zgc:172284	0.036
fstl5	follistatin-like 5 and follistatin-like 5	0.036
tie1	endothelium-specific receptor tyrosine kinase 1	0.036
pcdh1g1	protocadherin 1 gamma 1	0.036
etnk1	ethanolamine kinase 1	0.036
nr1d2b	nuclear receptor subfamily 1, group D, member 2b	0.036
si:ch211-209p5.2	si:ch211-209p5.2	0.036
LOC556082	calcium binding protein 7-like	0.036
crabp1a	cellular retinoic acid binding protein 1a	0.036
zgc:92689	zgc:92689	0.036
si:ch1073-268b21.1	si:ch1073-268b21.1	0.036
htr5al	5-hydroxytryptamine (serotonin) receptor 5A like	0.036
cyp19a1b	cytochrome P450, family 19, subfamily A, polypeptide 1b	0.036
unc5a	unc-5 homolog A (C. elegans)	0.036
st8sia7.1p	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1, pseudogene	0.036
fbxo45	F-box protein 45	0.035
vtg2	vitellogenin 2	0.035
htr1bd	5-hydroxytryptamine (serotonin) receptor 1bd	0.035	Human Zebrafish Mouse
pcdh15a	protocadherin 15a	0.035
cnn3a	calponin 3, acidic a	0.035
atp6v0cb	ATPase, H+ transporting, lysosomal, V0 subunit c, b	0.035
lycat	lysocardiolipin acyltransferase	0.035
si:dkey-3d4.3	si:dkey-3d4.3	0.035
bmp8a	bone morphogenetic protein 8a	0.035
ndel1b	nudE nuclear distribution gene E homolog like 1 (A. nidulans) B	0.035
pdyn	prodynorphin	0.035
zgc:63663	zgc:63663	0.035
ugt2b6	UDP glucuronosyltransferase 2 family, polypeptide B6	0.035
mep1b	meprin A, beta	0.035
calb2b	calbindin 2b, (calretinin)	0.035
rgs5a	regulator of G-protein signaling 5a	0.034	Rat
arl4ab	ADP-ribosylation factor-like 4ab	0.034
crygm3	crystallin, gamma M3	0.034
ildr2	immunoglobulin-like domain containing receptor 2	0.034
zgc:73359	zgc:73359	0.034
itpr3	inositol 1,4,5-triphosphate receptor, type 3	0.034	Rat Fly
spata2	spermatogenesis associated 2	0.034
cyp1d1	cytochrome P450, family 1, subfamily D, polypeptide 1	0.034
parapinopsinb	parapinopsin b	0.034
zgc:85866	zgc:85866	0.034
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.034
fshr	follicle stimulating hormone receptor	0.034
wu:fb80e01	wu:fb80e01	0.034
mapk10	mitogen-activated protein kinase 10	0.034
sox21b	SRY-box containing gene 21 b	0.034
ghrhra	growth hormone releasing hormone receptor a	0.034
adcyap1a	adenylate cyclase activating polypeptide 1a	0.034	Human Mouse
fam3c	family with sequence similarity 3, member C	0.034
slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.034
hoxc12b	homeo box C12b	0.034
gpr27	G protein-coupled receptor 27	0.033
stac3	SH3 and cysteine rich domain 3	0.033
ptmab	prothymosin, alpha b	0.033
cyp2aa11	cytochrome P450, family 2, subfamily AA, polypeptide 11	0.033
aqp9b	aquaporin 9b	0.033
taar14d	trace amine associated receptor 14d	0.033
aqp4	aquaporin 4	0.033
rhag	Rhesus blood group-associated glycoprotein	0.033
th	tyrosine hydroxylase	0.033
faslg	Fas ligand (TNF superfamily, member 6)	0.033
rspo1	R-spondin homolog (Xenopus laevis)	0.033
guca1b	guanylate cyclase activator 1B	0.033
LOC100536988	Gig2-like protein DreQ	0.033
vegfab	vascular endothelial growth factor Ab	0.033
zgc:77060	zgc:77060	0.033
LOC553366	hypothetical protein LOC553366	0.033
gch1	GTP cyclohydrolase 1	0.033
cplx4a	complexin 4a	0.033
slco1f1	solute carrier organic anion transporter family, member 1F1	0.033
pacsin1a	protein kinase C and casein kinase substrate in neurons 1a	0.033
itm2ca	integral membrane protein 2Ca	0.033
rag1	recombination activating gene 1	0.033
LOC100005108	novel protein similar to solute carrier family 26, member 5 (slc26a5)	0.033
a1cf	apobec1 complementation factor	0.033
pde6c	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	0.033
dmbx1b	diencephalon/mesencephalon homeobox 1b	0.033
lmo7a	LIM domain only 7a	0.032
lifrb	leukemia inhibitory factor receptor alpha b	0.032
grk7b	G protein-coupled receptor kinase 7b	0.032
dao.2	D-amino-acid oxidase 2	0.032
si:dkey-71l1.7	si:dkey-71l1.7	0.032
ptger4b	prostaglandin E receptor 4 (subtype EP4) b	0.032
npy7r	neuropeptide Y receptor Y7	0.032
crygm6	crystallin, gamma M6	0.032
polrmt	polymerase (RNA) mitochondrial (DNA directed)	0.032
stmn4	stathmin-like 4	0.032
comtb	catechol-O-methyltransferase b	0.032
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.032
efna5b	ephrin A5b	0.032
cyp24a1	cytochrome P450, family 24, subfamily A, polypeptide 1	0.032
lrtm2	leucine-rich repeats and transmembrane domains 2	0.032
ptger2a	prostaglandin E receptor 2a (subtype EP2)	0.032
kcnip3l	Kv channel interacting protein 3, calsenilin, like	0.031
zgc:109949	zgc:109949	0.031
cx52.7	connexin 52.7	0.031
fam43b	family with sequence similarity 43, member B	0.031
s1pr5a	sphingosine-1-phosphate receptor 5a	0.031
tg	thyroglobulin	0.031
ifng1-1	interferon, gamma 1-1	0.031
rdh8l	retinol dehydrogenase 8 like	0.031
mtnr1bb	melatonin receptor 1B b and melatonin receptor 1B	0.031
kcnj13	potassium inwardly-rectifying channel, subfamily J, member 13	0.031
wnt5b	wingless-type MMTV integration site family, member 5b	0.031
sfrp1b	secreted frizzled-related protein 1b	0.031
crfa31.2	IL-4RA-like protein 2	0.031
fbxo7	F-box protein 7	0.031
pcdh18b	protocadherin 18b	0.031
zgc:77409	zgc:77409	0.031
kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.030
hspg2	heparan sulfate proteoglycan 2	0.030
lhx9	LIM homeobox 9	0.030
bsk146	brain specific kinase 146	0.030
gmds	GDP-mannose 4,6-dehydratase	0.030
si:ch211-207c7.1	si:ch211-207c7.1	0.030
rplp2l	ribosomal protein, large P2, like	0.030
scrib	scribbled homolog (Drosophila)	0.030
sgk1	serum/glucocorticoid regulated kinase 1	0.030
taar12f	trace amine associated receptor 12f	0.030
rnf128a	ring finger protein 128a	0.030
erlin1	ER lipid raft associated 1	0.030
tlr18	toll-like receptor 18	0.030
ntrk2b	neurotrophic tyrosine kinase, receptor, type 2b	0.030
opn1mw3	opsin 1 (cone pigments), medium-wave-sensitive, 3	0.030	Zebrafish
mpp5b	membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b)	0.030
LOC560358	solute carrier family 2, facilitated glucose transporter member 11-like	0.030
cadm1b	cell adhesion molecule 1b	0.029
celsr3	cadherin, EGF LAG seven-pass G-type receptor 3	0.029
aqp10a	aquaporin 10a	0.029
zgc:152911	zgc:152911	0.029
ralgapa1	Ral GTPase activating protein, alpha subunit 1 (catalytic)	0.029
rbm19	RNA binding motif protein 19	0.029
sema3ab	semaphorin 3ab	0.029
tpt1	tumor protein, translationally-controlled 1	0.029
kif5aa	kinesin family member 5A, a	0.029
cat	catalase	0.029
pygma	phosphorylase, glycogen (muscle) A	0.029
kirrelb	kin of IRRE like b	0.029
zbtb12.2	zinc finger and BTB domain containing 12, tandem duplicate 2	0.029
kita	kit receptor a	0.029
opn1mw2	opsin 1 (cone pigments), medium-wave-sensitive, 2	0.029
scn2b	sodium channel, voltage-gated, type II, beta	0.029
ache	acetylcholinesterase	0.029
wu:fb59b08	wu:fb59b08	0.029
wu:fv91b12	wu:fv91b12	0.029
saga	S-antigen; retina and pineal gland (arrestin) a	0.028	Fly
rnf144ab	ring finger protein 144ab	0.028
si:dkey-19f21.3	si:dkey-19f21.3	0.028
LOC563363	cholesterol side-chain cleavage enzyme, mitochondrial-like	0.028
ppm1e	protein phosphatase 1E (PP2C domain containing)	0.028
zgc:92901	zgc:92901	0.028
sgpl1	sphingosine-1-phosphate lyase 1	0.028
lrrc24	leucine rich repeat containing 24	0.028
tph1a	tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a	0.028
rln3a	relaxin 3a	0.028
hcrt	hypocretin (orexin) neuropeptide precursor	0.028	Rat
gnb3a	guanine nucleotide binding protein (G protein), beta polypeptide 3a	0.028	Yeast
crb3b	crumbs homolog 3b	0.028
fgf6a	fibroblast growth factor 6a	0.028
LOC797331	novel protein similar to vertebrate solute carrier family 12, (potassium-chloride transporter) member 5 (SLC12A5)	0.028
glra3	glycine receptor, alpha 3	0.028
LOC100332245	cordon-bleu protein-like 1-like	0.028
c9	complement component 9	0.028
zgc:63670	zgc:63670	0.028
zgc:92872	zgc:92872	0.028
abcg2c	ATP-binding cassette, sub-family G (WHITE), member 2c	0.028
zgc:195195	zgc:195195	0.028
gpr146	G protein-coupled receptor 146	0.028
kcnq1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.028	Worm
zgc:123207	zgc:123207	0.028
slc1a7a	solute carrier family 1 (glutamate transporter), member 7a	0.028
oprd1a	opioid receptor, delta 1a	0.027
hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.027
mkrn1	makorin, ring finger protein, 1	0.027
LOC569045	novel protein similar to vertebrate WD repeat domain 44 (WDR44)	0.027
prok2	prokineticin 2	0.027
gpr158	G protein-coupled receptor 158	0.027
syt13	synaptotagmin XIII	0.027
cx52.9	connexin 52.9	0.027
pcdh2g3	protocadherin 2 gamma 3	0.027
s100b	S100 calcium binding protein, beta (neural)	0.027
vipr1	vasoactive intestinal peptide receptor 1	0.027
zgc:136903	zgc:136903	0.027
taar13c	trace amine associated receptor 13c	0.027
rbp4l	retinol binding protein 4, like	0.027
taar15	trace amine associated receptor 15	0.027	Zebrafish
nelfb	nasal embryonic LHRH factor b	0.027
si:ch211-191i18.3	si:ch211-191i18.3	0.027
thrb	thyroid hormone receptor beta	0.027
zfpm2b	zinc finger protein, multitype 2b	0.027
il1b	interleukin 1, beta and interleukin 1, beta	0.027
fstl1a	follistatin-like 1a	0.027
zgc:55813	zgc:55813	0.027
slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.027
nptnb	neuroplastin b	0.027
aqp3b	aquaporin 3b	0.027
brd4	bromodomain containing 4	0.027
synpo2la	synaptopodin 2-like a	0.027
kctd8	potassium channel tetramerisation domain containing 8	0.027	Mouse
ptn	pleiotrophin	0.027
mych	myelocytomatosis oncogene homolog	0.027
LOC100005283	Gig2-like protein DreE	0.026
gpr137bb	G protein-coupled receptor 137bb	0.026
fabp11a	fatty acid binding protein 11a	0.026
spock3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	0.026
myo18l2	myosin XVIII-like 2	0.026
zzef1	zinc finger, ZZ-type with EF hand domain 1	0.026
taar10	trace amine-associated receptor 10	0.026	Zebrafish Mouse
sprn2	shadow of prion protein 2	0.026
cx35.4	connexin 35.4	0.026
abcc1	ATP-binding cassette, sub-family C, member 1	0.026
pcdh2g5	protocadherin 2 gamma 5	0.026
zgc:112986	zgc:112986	0.026
rxrba	retinoid x receptor, beta a	0.026
camk2n2	calcium/calmodulin-dependent protein kinase II inhibitor 2	0.026
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.026
LOC572430	e3 ubiquitin-protein ligase HACE1-like	0.026
wu:fc24e06	wu:fc24e06	0.026
fstb	follistatin b	0.026
inhbab	inhibin, beta Ab	0.026
dusp5	dual specificity phosphatase 5	0.026
smtla	somatolactin alpha	0.026
ca8	carbonic anhydrase VIII	0.026
LOC793222	cAMP-dependent protein kinase inhibitor alpha-like	0.026
tm9sf1	transmembrane 9 superfamily member 1	0.026
gabrb2	gamma-aminobutyric acid (GABA) A receptor, beta 2	0.026
h2afy2	H2A histone family, member Y2	0.026
clk4a	CDC-like kinase 4a	0.026
atp2b3b	ATPase, Ca++ transporting, plasma membrane 3b	0.026
gpib	glucose phosphate isomerase b	0.026
pcdh1g2	protocadherin 1 gamma 2	0.025
zgc:63633	zgc:63633	0.025
nadl1.2	neural adhesion molecule L1.2	0.025
ccrl1a	chemokine (C-C motif) receptor-like 1a	0.025
dnm1l	dynamin 1-like	0.025
acaca	acetyl-Coenzyme A carboxylase alpha	0.025
si:dkey-204f11.66	si:dkey-204f11.66	0.025
crfb13	cytokine receptor family member b13	0.025
ugt5b2	UDP glucuronosyltransferase 5 family, polypeptide B2	0.025
pparaa	peroxisome proliferator-activated receptor alpha a	0.025
sept6	septin 6	0.025
zmynd11	zinc finger, MYND domain containing 11	0.025
si:dkey-72l14.9	si:dkey-72l14.9	0.025
zgc:66382	zgc:66382	0.025
zgc:66433	zgc:66433	0.025
im:7154036	im:7154036	0.025
LOC100333546	hypothetical protein LOC100333546	0.025
pcdh2g1	protocadherin 2 gamma 1	0.025
pppde2a	PPPDE peptidase domain containing 2a	0.025
ptpn9a	protein tyrosine phosphatase, non-receptor type 9, a	0.025
ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.025
zgc:172136	zgc:172136	0.025
trim3a	tripartite motif-containing 3a	0.024
guca1e	guanylate cyclase activator 1e	0.024
prkar1aa	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a	0.024
ugt1b1	UDP glucuronosyltransferase 1 family, polypeptide B1	0.024
LOC566622	hypothetical protein LOC566622	0.024
cxc64	CXC chemokine 64	0.024
fgf13b	fibroblast growth factor 13b	0.024
ncoa2	nuclear receptor coactivator 2	0.024
abca5	ATP-binding cassette, sub-family A (ABC1), member 5	0.024
adpgk2	ADP-dependent glucokinase 2	0.024
cldn12	claudin 12	0.024
slc1a3b	solute carrier family 1 (glial high affinity glutamate transporter), member 3b	0.024
xkrx	XK, Kell blood group complex subunit-related, X-linked	0.024
lrrc38	leucine rich repeat containing 38	0.024
ahrra	aryl-hydrocarbon receptor repressor a	0.024
insl5b	insulin-like 5b	0.024
LOC100535088	hypothetical protein LOC100535088	0.024
gnb1a	guanine nucleotide binding protein (G protein), beta polypeptide 1a	0.024
kbp	kif1-binding protein	0.024
cfl2l	cofilin 2, like	0.024
scn4ab	sodium channel, voltage-gated, type IV, alpha, b	0.024
foxc1a	forkhead box C1a	0.024
dmrt3a	doublesex and mab-3 related transcription factor 3a	0.024
aanat1	arylalkylamine N-acetyltransferase 1	0.024
zgc:165373	zgc:165373	0.024
camk4	calcium/calmodulin-dependent protein kinase IV	0.024
per1a	period homolog 1a (Drosophila)	0.024