The network for 'regulation of immune effector process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of immune effector process

Any process that modulates the frequency, rate, or extent of an immune effector process.

NameDescriptionProbabilityFunc Analog Organism
Spn27ASerpin 27A0.848
ird5immune response deficient 50.722
SPESpatzle-Processing Enzyme0.720
PGRP-LCPeptidoglycan recognition protein LC0.715
Mpk2CG5475 gene product from transcript CG5475-RB0.702
Tak1TGF-beta activated kinase 10.667
grassGram-positive Specific Serine protease0.620
Myd88CG2078 gene product from transcript CG2078-RA0.594
MadMothers against dpp0.592
p38bCG7393 gene product from transcript CG7393-RA0.431
Toll-7CG8595 gene product from transcript CG8595-RA0.413
CG15917CG15917 gene product from transcript CG15917-RA0.393
Mekk1CG7717 gene product from transcript CG7717-RB0.335
Akt1CG4006 gene product from transcript CG4006-RA0.284
GNBP3Gram-negative bacteria binding protein 30.275
imdimmune deficiency0.271
EgfrEpidermal growth factor receptor0.270
Spn1Serine protease inhibitor 10.266
ird1immune response deficient 10.240
18w18 wheeler0.239
MED14Mediator complex subunit 140.232
DreddDeath related ced-3/Nedd2-like protein0.229
BG4CG12297 gene product from transcript CG12297-RA0.225
Traf4TNF-receptor-associated factor 40.223
CG14478CG14478 gene product from transcript CG14478-RA0.203
Spn28DSerpin 28D0.202
Tab2TAK1-associated binding protein 20.193
Pp2B-14DProtein phosphatase 2B at 14D0.184
pirkpoor Imd response upon knock-in0.180
cindrCIN85 and CD2AP orthologue0.167
Kr-h1Kruppel homolog 10.159
Atf-2Activating transcription factor-20.157
upd3unpaired 30.156
cdicenter divider0.156
DuoxDual oxidase0.150
laceCG4162 gene product from transcript CG4162-RA0.147
modSPmodular serine protease0.145
Sp7Serine protease 70.141
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.139
Traf6TNF-receptor-associated factor 60.132
PGRP-SAPeptidoglycan recognition protein SA0.126
CG18594CG18594 gene product from transcript CG18594-RA0.125
Sema-1bCG6446 gene product from transcript CG6446-RA0.125
PvrPDGF- and VEGF-receptor related0.124
B52CG10851 gene product from transcript CG10851-RB0.124
emcextra macrochaetae0.120
drkdownstream of receptor kinase0.119
GNBP1Gram-negative bacteria binding protein 10.117
CG16718CG16718 gene product from transcript CG16718-RA0.109
ImpIGF-II mRNA-binding protein0.107
CG1347CG1347 gene product from transcript CG1347-RB0.104
CG9184CG9184 gene product from transcript CG9184-RB0.098
StamSignal transducing adaptor molecule0.096
PGRP-SDCG7496 gene product from transcript CG7496-RA0.094
CG6664CG6664 gene product from transcript CG6664-RC0.093
CG1103CG1103 gene product from transcript CG1103-RA0.093
eaterCG6124 gene product from transcript CG6124-RB0.089
l(3)05822lethal (3) 058220.084
CG3004CG3004 gene product from transcript CG3004-RA0.082
PGRP-LFPeptidoglycan recognition protein LF0.080
Rbp6RNA-binding protein 60.080
amosabsent MD neurons and olfactory sensilla0.078
upd2unpaired 20.078
E(spl)Enhancer of split0.078
CG5794CG5794 gene product from transcript CG5794-RB0.077
EphrinCG1862 gene product from transcript CG1862-RA0.076
CG2924CG2924 gene product from transcript CG2924-RA0.074
numbCG3779 gene product from transcript CG3779-RB0.071
Atg13Autophagy-specific gene 130.070
l(3)mbnlethal (3) malignant blood neoplasm0.066
Nrx-IVNeurexin IV0.065
CG12766CG12766 gene product from transcript CG12766-RA0.064
tamoCG4057 gene product from transcript CG4057-RA0.064
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.152
gata4GATA-binding protein 40.115
nod1nucleotide-binding oligomerization domain containing 10.109
crip2cysteine-rich protein 20.100
LOC557072caspase recruitment domain-containing protein 11-like0.094
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.082
gata6GATA-binding protein 60.071
pglyrp6peptidoglycan recognition protein 60.063
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.058
meis1myeloid ecotropic viral integration 10.047
ripk2receptor-interacting serine-threonine kinase 20.045
tlr9toll-like receptor 90.041
irak4interleukin-1 receptor-associated kinase 40.039
pycardPYD and CARD domain containing0.037
nkx2.2aNK2 transcription factor related 2a0.033
shhasonic hedgehog a0.031
tlr3toll-like receptor 30.029
stc1lstanniocalcin 1, like0.028
lfnglunatic fringe homolog0.026
aldh1a2aldehyde dehydrogenase 1 family, member A20.026
ppargperoxisome proliferator activated receptor gamma0.025
gabarapaGABA(A) receptor-associated protein a0.024
dbx1adeveloping brain homeobox 1a0.024
mpxmyeloid-specific peroxidase0.024
alkanaplastic lymphoma kinase (Ki-1)0.022
crb2acrumbs homolog 2a0.022
cpoxcoproporphyrinogen oxidase0.021
nos2anitric oxide synthase 2a, inducible0.021
grnagranulin a0.021
fgfr3fibroblast growth factor receptor 30.021
myh11amyosin, heavy polypeptide 11, smooth muscle a0.020
ifng1-2interferon, gamma 1-20.020
fli1bfriend leukemia integration 1b0.020
trim25tripartite motif-containing 250.019
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.019
mmp9matrix metalloproteinase 90.019
LOC100000934hypothetical protein LOC1000009340.018
ahctf1AT hook containing transcription factor 10.018
gata1aGATA binding protein 1a0.018
fxr2fragile X mental retardation, autosomal homolog 20.017
osr1odd-skipped related 1 (Drosophila)0.017
snai1asnail homolog 1a (Drosophila)0.016
ticam1toll-like receptor adaptor molecule 10.015
caspacaspase a0.015
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.014
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.014
epas1bendothelial PAS domain protein 1b0.014
gfergrowth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)0.014
adora2aaadenosine A2a receptor a0.013
ifnphi1interferon phi 10.013
kcnh2lpotassium voltage-gated channel, subfamily H (eag-related), member 2 like0.013
aidaaxin interaction partner and dorsalization antagonist0.013
pglyrp5peptidoglycan recognition protein 50.013
relv-rel reticuloendotheliosis viral oncogene homolog0.013
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.013
LOC100534776toll-like receptor 7-like0.013
foxb1.2forkhead box B1.20.012
flt4fms-related tyrosine kinase 40.012
mxra8amatrix-remodelling associated 8a0.012
rbm22RNA binding motif protein 220.012
LOC555739serine/threonine-protein kinase LMTK1-like0.011
hhexhematopoietically expressed homeobox0.011
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.011
tmprss4btransmembrane protease, serine 4b0.011
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.011
jak1Janus kinase 10.011
ptk6aPTK6 protein tyrosine kinase 6a0.010
col7a1lcollagen type VII alpha 1-like0.010
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.984
TRAF6TNF receptor-associated factor 60.984
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.891
UBCubiquitin C0.890
MYD88myeloid differentiation primary response gene (88)0.885
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.847
IFIT2interferon-induced protein with tetratricopeptide repeats 20.830
IFIT3interferon-induced protein with tetratricopeptide repeats 30.830
MAP3K7mitogen-activated protein kinase kinase kinase 70.817
SHC1SHC (Src homology 2 domain containing) transforming protein 10.814
CASP8caspase 8, apoptosis-related cysteine peptidase0.812
ICAM1intercellular adhesion molecule 10.770
BIRC3baculoviral IAP repeat containing 30.768
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.765
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.763
SYKspleen tyrosine kinase0.762
HLA-Cmajor histocompatibility complex, class I, C0.761
HLA-Amajor histocompatibility complex, class I, A0.749
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.747
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.737
SP110SP110 nuclear body protein0.716
TNFAIP3tumor necrosis factor, alpha-induced protein 30.708
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.703
C1Scomplement component 1, s subcomponent0.684
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.682
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.680
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.676
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.667
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.666
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.644
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.620
CXCL2chemokine (C-X-C motif) ligand 20.598
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.594
IL2RGinterleukin 2 receptor, gamma0.585
IL4Rinterleukin 4 receptor0.571
CD84CD84 molecule0.566
IL8interleukin 80.555
SH2D1ASH2 domain containing 1A0.551
CCR5chemokine (C-C motif) receptor 50.551
CXCL10chemokine (C-X-C motif) ligand 100.549
SLAMF1signaling lymphocytic activation molecule family member 10.513
LIN9lin-9 homolog (C. elegans)0.508
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.494
IFI44Linterferon-induced protein 44-like0.493
IFI44interferon-induced protein 440.474
RNF11ring finger protein 110.457
TLR2toll-like receptor 20.450
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.445
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.444
CCL8chemokine (C-C motif) ligand 80.439
CCR1chemokine (C-C motif) receptor 10.426
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.426
IFIH1interferon induced with helicase C domain 10.423
SAMD9sterile alpha motif domain containing 90.421
HLA-Bmajor histocompatibility complex, class I, B0.413
TRAF1TNF receptor-associated factor 10.409
PMLpromyelocytic leukemia0.404
RIPK2receptor-interacting serine-threonine kinase 20.404
HLA-Fmajor histocompatibility complex, class I, F0.400
IL2RBinterleukin 2 receptor, beta0.392
KLRD1killer cell lectin-like receptor subfamily D, member 10.392
IGF1Rinsulin-like growth factor 1 receptor0.388
C1Rcomplement component 1, r subcomponent0.384
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.382
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.372
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.365
NLRC4NLR family, CARD domain containing 40.364
LTAlymphotoxin alpha (TNF superfamily, member 1)0.362
IFIT5interferon-induced protein with tetratricopeptide repeats 50.361
BIRC2baculoviral IAP repeat containing 20.357
RXRAretinoid X receptor, alpha0.357
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.357
MAVSmitochondrial antiviral signaling protein0.353
CXCL3chemokine (C-X-C motif) ligand 30.350
ESR1estrogen receptor 10.341
CYLDcylindromatosis (turban tumor syndrome)0.333
MICAMHC class I polypeptide-related sequence A0.329
RARAretinoic acid receptor, alpha0.326
CCR7chemokine (C-C motif) receptor 70.324
MED15mediator complex subunit 150.318
FASFas (TNF receptor superfamily, member 6)0.312
PTPN6protein tyrosine phosphatase, non-receptor type 60.311
OASL2'-5'-oligoadenylate synthetase-like0.304
ZNF746zinc finger protein 7460.303
C3complement component 30.302
SMURF1SMAD specific E3 ubiquitin protein ligase 10.299
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.293
IRAK2interleukin-1 receptor-associated kinase 20.291
FCN1ficolin (collagen/fibrinogen domain containing) 10.290
GRAP2GRB2-related adaptor protein 20.289
CCL4chemokine (C-C motif) ligand 40.285
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.280
KLRK1killer cell lectin-like receptor subfamily K, member 10.280
CXCL9chemokine (C-X-C motif) ligand 90.279
IL10RAinterleukin 10 receptor, alpha0.274
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.274
CD14CD14 molecule0.272
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.264
CCR2chemokine (C-C motif) receptor 20.263
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hckhemopoietic cell kinase0.177
Casp1caspase 10.096
Neurl3neuralized homolog 3 (Drosophila)0.084
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.079
Fggfibrinogen gamma chain0.075
Icam1intercellular adhesion molecule 10.068
Cd247Cd247 molecule0.058
Cd53Cd53 molecule0.055
RT1-EC2RT1 class Ib, locus EC20.055
Csf1colony stimulating factor 1 (macrophage)0.054
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.048
Ptafrplatelet-activating factor receptor0.048
Has2hyaluronan synthase 20.047
Pzppregnancy-zone protein0.046
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.044
Aif1allograft inflammatory factor 10.041
Tfectranscription factor EC0.040
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.037
Dnase1l3deoxyribonuclease 1-like 30.035
Phkg1phosphorylase kinase, gamma 10.035
Hrh2histamine receptor H 20.034
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.034
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.034
Cd86CD86 molecule0.034
Il1binterleukin 1 beta0.033
Apcsamyloid P component, serum0.032
Ptger2prostaglandin E receptor 2 (subtype EP2)0.032
Cxcr4chemokine (C-X-C motif) receptor 40.032
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.031
Cxcl10chemokine (C-X-C motif) ligand 100.031
Cybbcytochrome b-245, beta polypeptide0.030
Klrd1killer cell lectin-like receptor, subfamily D, member 10.030
Mmp12matrix metallopeptidase 120.030
Ifnginterferon gamma0.029
C1scomplement component 1, s subcomponent0.029
Ctsjcathepsin J0.028
Adora3adenosine A3 receptor0.028
Sellselectin L0.028
Ncr1natural cytotoxicity triggering receptor 10.028
Arhgap4Rho GTPase activating protein 40.027
Gzmkgranzyme K0.027
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.027
Hsph1heat shock 105/110 protein 10.027
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.026
Cfbcomplement factor B0.026
Klrc1killer cell lectin-like receptor subfamily C, member 10.026
Cd4Cd4 molecule0.025
Rhohras homolog gene family, member H0.025
Il2rginterleukin 2 receptor, gamma0.025
Igsf6immunoglobulin superfamily, member 60.025
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.025
Lyz2lysozyme 20.025
Tlr4toll-like receptor 40.024
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.024
Hspb1heat shock protein 10.024
Zcwpw1zinc finger, CW-type with PWWP domain 10.024
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.024
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.023
Plauplasminogen activator, urokinase0.023
Fgafibrinogen alpha chain0.023
Pde3aphosphodiesterase 3A, cGMP inhibited0.023
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.023
Nkg7natural killer cell group 7 sequence0.023
RT1-BaRT1 class II, locus Ba0.022
Havcr1hepatitis A virus cellular receptor 10.022
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.022
Tlr7toll-like receptor 70.021
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.021
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.021
Adcy10adenylate cyclase 10 (soluble)0.020
Casp12caspase 120.020
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.020
Cficomplement factor I0.020
RT1-DaRT1 class II, locus Da0.020
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.020
Calcrcalcitonin receptor0.020
Apobapolipoprotein B0.020
Gbp2guanylate binding protein 20.020
Srxn1sulfiredoxin 1 homolog (S. cerevisiae)0.020
Hbzhemoglobin, zeta0.019
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.019
Ctsl1cathepsin L10.018
Ccr5chemokine (C-C motif) receptor 50.018
Olr1867olfactory receptor 18670.018
Vcam1vascular cell adhesion molecule 10.018
Fth1ferritin, heavy polypeptide 10.018
Cd28Cd28 molecule0.018
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.017
RT1-S3RT1 class Ib, locus S30.017
C3ar1complement component 3a receptor 10.017
Mcpt3mast cell peptidase 30.017
Dock8dedicator of cytokinesis 80.017
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.017
Cd38CD38 molecule0.017
Prlhrprolactin releasing hormone receptor0.017
RT1-CE12RT1 class I, locus CE120.017
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism