The network for 'eye photoreceptor cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

eye photoreceptor cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.

NameDescriptionProbabilityFunc Analog Organism
E(spl)Enhancer of split0.999
amosabsent MD neurons and olfactory sensilla0.990
S6kIIRPS6-protein kinase-II0.985
RalaRas-related protein0.979
HLHm7E(spl) region transcript m70.956
Kap-alpha3karyopherin alpha30.954
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.944
trioCG18214 gene product from transcript CG18214-RA0.940
VangVan Gogh0.923
spensplit ends0.901
Ras85DRas oncogene at 85D0.898
Fas2Fasciclin 20.895
EgfrEpidermal growth factor receptor0.887
Gap1GTPase-activating protein 10.884
argosCG4531 gene product from transcript CG4531-RA0.866
vvlventral veins lacking0.864
CblCG7037 gene product from transcript CG7037-RB0.860
HLHmdeltaE(spl) region transcript mdelta0.847
hydhyperplastic discs0.842
TomTwin of m40.839
eyaeyes absent0.837
numbCG3779 gene product from transcript CG3779-RB0.826
WASpCG1520 gene product from transcript CG1520-RA0.819
HLHm5E(spl) region transcript m50.812
sinaseven in absentia0.795
ctpcut up0.762
eyseyes shut0.737
Tsc1CG6147 gene product from transcript CG6147-RA0.727
HLHmbetaE(spl) region transcript mbeta0.720
dcodiscs overgrown0.705
PtenCG5671 gene product from transcript CG5671-RB0.679
cdicenter divider0.665
m4E(spl) region transcript m40.655
drkdownstream of receptor kinase0.639
MrtfMyocardin-related transcription factor0.625
Cdc42CG12530 gene product from transcript CG12530-RA0.624
bibbig brain0.601
ImpIGF-II mRNA-binding protein0.600
Rh5Rhodopsin 50.597
hipkhomeodomain interacting protein kinase0.574
NFATNFAT homolog0.562
piepineapple eye0.560
ksrkinase suppressor of ras0.547
lqfRliquid facets-Related0.538
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
otx2orthodenticle homolog 20.990
pax2apaired box gene 2a0.989
hnf1baHNF1 homeobox Ba0.989
ift88intraflagellar transport 88 homolog0.980
kif17kinesin family member 170.974
pax6bpaired box gene 6b0.948
tfap2atranscription factor AP-2 alpha0.908
shhasonic hedgehog a0.902
crxcone-rod homeobox0.894
rx3retinal homeobox gene 30.871
tbx2bT-box 2b0.845
epb41l5erythrocyte membrane protein band 4.1 like 50.818
neurodneurogenic differentiation0.800
cdh2cadherin 2, neuronal0.794
flhfloating head0.789
foxi1forkhead box I10.765
gbx2gastrulation brain homeo box 20.719
dctn1adynactin 1a0.657
dccdeleted in colorectal carcinoma0.630
rxraaretinoid X receptor, alpha a0.614
neurog1neurogenin 10.609
six3asine oculis homeobox homolog 3a0.589
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.566
her1hairy-related 10.562
otx5orthodenticle homolog 50.553
ndr2nodal-related 20.541
nr2e3nuclear receptor subfamily 2, group E, member 30.532
otx1borthodenticle homolog 1b0.522
meis2.1myeloid ecotropic viral integration site 2.10.497
six3bsine oculis homeobox homolog 3b0.492
nr2e1nuclear receptor subfamily 2, group E, member 10.483
bmp4bone morphogenetic protein 40.458
jag2jagged 20.430
crb2acrumbs homolog 2a0.425
cc2d2acoiled-coil and C2 domain containing 2A0.381
bmp2bbone morphogenetic protein 2b0.379
tbx2aT-box gene 2a0.373
rx1retinal homeobox gene 10.357
mespamesoderm posterior a0.352
ahctf1AT hook containing transcription factor 10.343
ventventral expressed homeobox0.322
atoh7atonal homolog 70.318
fezf2FEZ family zinc finger 20.299
ahi1Abelson helper integration site 10.294
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.290
sox32SRY-box containing gene 320.270
sox10SRY-box containing gene 100.269
dnmt8DNA (cytosine-5-)-methyltransferase 80.261
her5hairy-related 50.254
ptf1apancreas specific transcription factor, 1a0.254
dlx3bdistal-less homeobox gene 3b0.240
rx2retinal homeobox gene 20.224
irx3airoquois homeobox protein 3a0.214
lhx3LIM homeobox 30.207
pdzd7aPDZ domain containing 7a0.199
pcdh8protocadherin 80.180
foxg1aforkhead box G1a0.178
her7hairy and enhancer of split related-70.175
irx7iroquois homeobox protein 70.175
dnmt6DNA (cytosine-5-)-methyltransferase 60.174
gli1GLI-Kruppel family member 10.174
irx1airoquois homeobox protein 1, a0.170
raraaretinoic acid receptor, alpha a0.166
ocrloculocerebrorenal syndrome of Lowe0.166
lrrc6leucine rich repeat containing 60.165
vsx2visual system homeobox 20.163
gngt2aguanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a0.163
gbx1gastrulation brain homeobox 10.162
sox9aSRY-box containing gene 9a0.152
metmet proto-oncogene (hepatocyte growth factor receptor)0.152
traf3ip1TNF receptor-associated factor 3 interacting protein 10.146
fgf8afibroblast growth factor 8 a0.143
gpr98G protein-coupled receptor 980.136
cdh6cadherin 60.134
ctbp2C-terminal binding protein 20.126
cacnb2bcalcium channel, voltage-dependent, beta 2b0.126
pdlim3aPDZ and LIM domain 3a0.125
rlbp1aretinaldehyde binding protein 1a0.123
pnxposterior neuron-specific homeobox0.122
otpborthopedia homolog b0.120
lrrc50leucine rich repeat containing 500.120
irbpinterphotoreceptor retinoid-binding protein0.119
gfi1.2growth factor independent 1.20.116
pcdh17protocadherin 170.114
foxa2forkhead box A20.112
voxventral homeobox0.112
rarabretinoic acid receptor, alpha b0.111
foxd5forkhead box D50.111
bhlhe22basic helix-loop-helix family, member e220.110
eya1eyes absent homolog 10.109
rxrabretinoid x receptor, alpha b0.109
bmperBMP binding endothelial regulator0.108
fstafollistatin a0.105
pax6apaired box gene 6a0.105
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.989
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.752
C2orf65chromosome 2 open reading frame 650.653
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.464
MED12mediator complex subunit 120.451
PDCD6IPprogrammed cell death 6 interacting protein0.447
DYNLT3dynein, light chain, Tctex-type 30.444
NRP1neuropilin 10.386
PCM1pericentriolar material 10.384
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.353
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.334
BBS1Bardet-Biedl syndrome 10.314
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.289
SIN3ASIN3 homolog A, transcription regulator (yeast)0.287
PPFIA1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 10.277
MED20mediator complex subunit 200.272
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.251
CADM4cell adhesion molecule 40.233
CSNK1Ecasein kinase 1, epsilon0.232
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.229
SOS1son of sevenless homolog 1 (Drosophila)0.225
CDK9cyclin-dependent kinase 90.210
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.206
BBS4Bardet-Biedl syndrome 40.198
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.189
NCOR1nuclear receptor corepressor 10.183
MED29mediator complex subunit 290.167
APCadenomatous polyposis coli0.160
SEC31ASEC31 homolog A (S. cerevisiae)0.152
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.133
HDAC3histone deacetylase 30.129
RXRAretinoid X receptor, alpha0.126
BBS2Bardet-Biedl syndrome 20.122
NKX2-1NK2 homeobox 10.120
MCCmutated in colorectal cancers0.118
EGFRepidermal growth factor receptor0.110
NTF4neurotrophin 40.103
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.101
MYBBP1AMYB binding protein (P160) 1a0.099
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.097
HDAC1histone deacetylase 10.090
INADLInaD-like (Drosophila)0.090
MAPTmicrotubule-associated protein tau0.090
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.080
CD2APCD2-associated protein0.077
BLNKB-cell linker0.077
SGK3serum/glucocorticoid regulated kinase family, member 30.073
SPC24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.072
SKA1spindle and kinetochore associated complex subunit 10.071
BCL3B-cell CLL/lymphoma 30.070
SPRY2sprouty homolog 2 (Drosophila)0.069
SH3GL2SH3-domain GRB2-like 20.067
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.067
WDR18WD repeat domain 180.064
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.063
METmet proto-oncogene (hepatocyte growth factor receptor)0.060
CDH5cadherin 5, type 2 (vascular endothelium)0.059
RAP1GAPRAP1 GTPase activating protein0.059
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.058
PIAS1protein inhibitor of activated STAT, 10.058
SEC23ASec23 homolog A (S. cerevisiae)0.058
TBL3transducin (beta)-like 30.057
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.057
SH3KBP1SH3-domain kinase binding protein 10.056
BBS9Bardet-Biedl syndrome 90.056
MED16mediator complex subunit 160.054
HDAC4histone deacetylase 40.054
HIVEP1human immunodeficiency virus type I enhancer binding protein 10.053
FAM83Dfamily with sequence similarity 83, member D0.053
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.052
TSC2tuberous sclerosis 20.050
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.049
BICD1bicaudal D homolog 1 (Drosophila)0.049
CD2CD2 molecule0.047
NEDD9neural precursor cell expressed, developmentally down-regulated 90.047
FAM110Afamily with sequence similarity 110, member A0.047
TUBA1Ctubulin, alpha 1c0.046
CDC25Bcell division cycle 25 homolog B (S. pombe)0.046
SHC2SHC (Src homology 2 domain containing) transforming protein 20.045
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.044
CBY1chibby homolog 1 (Drosophila)0.044
SNAP25synaptosomal-associated protein, 25kDa0.044
SOX11SRY (sex determining region Y)-box 110.044
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.043
CDK19cyclin-dependent kinase 190.043
STAT5Asignal transducer and activator of transcription 5A0.043
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.042
DTX1deltex homolog 1 (Drosophila)0.042
EXOC7exocyst complex component 70.042
LARP1La ribonucleoprotein domain family, member 10.041
RBBP7retinoblastoma binding protein 70.041
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.040
YAP1Yes-associated protein 10.038
SNX18sorting nexin 180.038
MED13mediator complex subunit 130.038
MDFIMyoD family inhibitor0.038
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.037
PAX2paired box 20.037
DEPDC1DEP domain containing 10.036
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.036
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pax2paired box gene 21.000
Pax6paired box gene 60.999
Otx2orthodenticle homolog 2 (Drosophila)0.999
Isl1ISL1 transcription factor, LIM/homeodomain0.999
Gli3GLI-Kruppel family member GLI30.999
Atoh7atonal homolog 7 (Drosophila)0.998
Crb2crumbs homolog 2 (Drosophila)0.997
Tcfap2atranscription factor AP-2, alpha0.995
Fgfr2fibroblast growth factor receptor 20.994
Crxcone-rod homeobox containing gene0.994
Prph2peripherin 20.992
Sox2SRY-box containing gene 20.983
Pax3paired box gene 30.979
Fgf8fibroblast growth factor 80.969
Pitx2paired-like homeodomain transcription factor 20.960
Dlx5distal-less homeobox 50.958
Emx1empty spiracles homolog 1 (Drosophila)0.954
Foxc1forkhead box C10.945
Stat5asignal transducer and activator of transcription 5A0.931
Ift88intraflagellar transport 88 homolog (Chlamydomonas)0.919
Stat5bsignal transducer and activator of transcription 5B0.916
Leprleptin receptor0.896
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.895
Pou4f2POU domain, class 4, transcription factor 20.895
Gbx2gastrulation brain homeobox 20.894
Hoxa1homeobox A10.886
Ptpn11protein tyrosine phosphatase, non-receptor type 110.884
Foxc2forkhead box C20.877
Bcl2B-cell leukemia/lymphoma 20.869
Bbs2Bardet-Biedl syndrome 2 (human)0.864
Ror2receptor tyrosine kinase-like orphan receptor 20.860
Eya1eyes absent 1 homolog (Drosophila)0.859
Lhx1LIM homeobox protein 10.845
Fgfr1fibroblast growth factor receptor 10.833
Nr2e1nuclear receptor subfamily 2, group E, member 10.828
Nos3nitric oxide synthase 3, endothelial cell0.826
Emx2empty spiracles homolog 2 (Drosophila)0.820
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.802
Cd2apCD2-associated protein0.791
Hand1heart and neural crest derivatives expressed transcript 10.788
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.783
Hand2heart and neural crest derivatives expressed transcript 20.781
Otx1orthodenticle homolog 1 (Drosophila)0.772
Zeb1zinc finger E-box binding homeobox 10.752
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.704
Nf1neurofibromatosis 10.696
Neurod1neurogenic differentiation 10.694
Neurog2neurogenin 20.694
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.678
Pcm1pericentriolar material 10.678
Itgb1integrin beta 1 (fibronectin receptor beta)0.675
Chd7chromodomain helicase DNA binding protein 70.672
Retret proto-oncogene0.670
Pde6gphosphodiesterase 6G, cGMP-specific, rod, gamma0.661
Ntf3neurotrophin 30.660
Bmp4bone morphogenetic protein 40.656
Irf9interferon regulatory factor 90.653
Ush1gUsher syndrome 1G homolog (human)0.650
Tbx3T-box 30.649
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.629
Sox9SRY-box containing gene 90.627
Gata3GATA binding protein 30.619
Ptenphosphatase and tensin homolog0.612
Flt4FMS-like tyrosine kinase 40.581
Trpm1transient receptor potential cation channel, subfamily M, member 10.572
En2engrailed 20.566
Arl6ADP-ribosylation factor-like 60.564
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.557
Sult4a1sulfotransferase family 4A, member 10.542
Unc5cunc-5 homolog C (C. elegans)0.536
Sox4SRY-box containing gene 40.534
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.531
Ntn1netrin 10.531
Tgfb1transforming growth factor, beta 10.530
Wnt1wingless-related MMTV integration site 10.527
Gucy2dguanylate cyclase 2d0.523
Ndel1nuclear distribution gene E-like homolog 1 (A. nidulans)0.520
Pkd1polycystic kidney disease 1 homolog0.518
Dclk1doublecortin-like kinase 10.499
Rxraretinoid X receptor alpha0.474
Pax8paired box gene 80.450
Kitkit oncogene0.443
Flt1FMS-like tyrosine kinase 10.415
Lmx1aLIM homeobox transcription factor 1 alpha0.412
Ctnnb1catenin (cadherin associated protein), beta 10.410
Ascl1achaete-scute complex homolog 1 (Drosophila)0.409
Raxretina and anterior neural fold homeobox0.408
En1engrailed 10.406
Alx4aristaless-like homeobox 40.402
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.396
Myd88myeloid differentiation primary response gene 880.394
Tbx5T-box 50.393
Fliiflightless I homolog (Drosophila)0.389
Hbegfheparin-binding EGF-like growth factor0.387
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism