The network for 'toll signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

toll signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
Jon99CiiiJonah 99Ciii0.770
Sp7Serine protease 70.720
SPESpatzle-Processing Enzyme0.561
Spn27ASerpin 27A0.515
CG17633CG17633 gene product from transcript CG17633-RA0.414
GNBP3Gram-negative bacteria binding protein 30.411
yip7yippee interacting protein 70.405
Spn28DSerpin 28D0.342
Jon65AiiiJonah 65Aiii0.306
PGRP-SAPeptidoglycan recognition protein SA0.300
CG18594CG18594 gene product from transcript CG18594-RA0.281
CG9527CG9527 gene product from transcript CG9527-RA0.270
CG10472CG10472 gene product from transcript CG10472-RA0.246
PGRP-SDCG7496 gene product from transcript CG7496-RA0.231
grassGram-positive Specific Serine protease0.216
CG3868CG3868 gene product from transcript CG3868-RA0.201
Jon25BiiJonah 25Bii0.184
Jon25BiiiJonah 25Biii0.184
Spn4Serine protease inhibitor 40.151
CG9631CG9631 gene product from transcript CG9631-RA0.149
Ag5r2Antigen 5-related 20.142
CG10680CG10680 gene product from transcript CG10680-RA0.136
CG18180CG18180 gene product from transcript CG18180-RA0.116
CG8343CG8343 gene product from transcript CG8343-RA0.114
l(3)mbnlethal (3) malignant blood neoplasm0.103
GNBP1Gram-negative bacteria binding protein 10.103
CG32185CG32185 gene product from transcript CG32185-RA0.096
Jon99FiJonah 99Fi0.089
Amy-dAmylase distal0.085
PGRP-LCPeptidoglycan recognition protein LC0.084
Jon65AiJonah 65Ai0.078
CG6361CG6361 gene product from transcript CG6361-RA0.073
CG3239CG3239 gene product from transcript CG3239-RB0.071
CG12057CG12057 gene product from transcript CG12057-RA0.066
CG12581CG12581 gene product from transcript CG12581-RA0.065
spheroideCG9675 gene product from transcript CG9675-RA0.063
CG31326CG31326 gene product from transcript CG31326-RA0.058
CG15917CG15917 gene product from transcript CG15917-RA0.057
CG11911CG11911 gene product from transcript CG11911-RA0.049
Rapgap1CG34374 gene product from transcript CG34374-RD0.047
CG6295CG6295 gene product from transcript CG6295-RA0.046
CG9372CG9372 gene product from transcript CG9372-RA0.045
CG13840CG13840 gene product from transcript CG13840-RB0.044
Ser7CG2045 gene product from transcript CG2045-RA0.038
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.037
CG8586CG8586 gene product from transcript CG8586-RA0.037
TepIIThiolester containing protein II0.035
CG13045CG13045 gene product from transcript CG13045-RA0.035
eaterCG6124 gene product from transcript CG6124-RB0.032
Cyp4ad1CG2110 gene product from transcript CG2110-RA0.032
CG14567CG14567 gene product from transcript CG14567-RA0.031
CG9649CG9649 gene product from transcript CG9649-RA0.031
tamoCG4057 gene product from transcript CG4057-RA0.031
Jon99CiJonah 99Ci0.030
Myd88CG2078 gene product from transcript CG2078-RA0.030
CG6839CG6839 gene product from transcript CG6839-RA0.028
CG12766CG12766 gene product from transcript CG12766-RA0.028
CG16749CG16749 gene product from transcript CG16749-RA0.027
Spn1Serine protease inhibitor 10.025
CG15829CG15829 gene product from transcript CG15829-RA0.025
spiritSerine Protease Immune Response Integrator0.025
CG11841CG11841 gene product from transcript CG11841-RA0.024
Prat2Phosphoribosylamidotransferase 20.024
Jon25BiJonah 25Bi0.024
CG31550CG31550 gene product from transcript CG31550-RB0.023
CG1809CG1809 gene product from transcript CG1809-RA0.023
Lip3CG8823 gene product from transcript CG8823-RA0.022
Jon65AiiJonah 65Aii0.022
pirkpoor Imd response upon knock-in0.022
CG8693CG8693 gene product from transcript CG8693-RA0.021
CG9673CG9673 gene product from transcript CG9673-RA0.021
PGRP-LBPeptidoglycan recognition protein LB0.021
CG11912CG11912 gene product from transcript CG11912-RA0.021
Jon66CiJonah 66Ci0.021
DuoxDual oxidase0.021
Jon44EJonah 44E0.020
modSPmodular serine protease0.020
Tsp68CTetraspanin 68C0.020
CG4199CG4199 gene product from transcript CG4199-RG0.019
nAcRbeta-21Cnicotinic acetylcholine receptor beta 21C0.019
CG14500CG14500 gene product from transcript CG14500-RA0.019
CG14614CG14614 gene product from transcript CG14614-RA0.018
CG8562CG8562 gene product from transcript CG8562-RA0.018
CG8299CG8299 gene product from transcript CG8299-RA0.018
CG16996CG16996 gene product from transcript CG16996-RA0.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IRAK1interleukin-1 receptor-associated kinase 10.632
PELP1proline, glutamate and leucine rich protein 10.599
USPL1ubiquitin specific peptidase like 10.461
ZNF496zinc finger protein 4960.302
RANGAP1Ran GTPase activating protein 10.228
ELK1ELK1, member of ETS oncogene family0.106
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.099
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.096
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.088
CHMP4Bchromatin modifying protein 4B0.075
RIPK2receptor-interacting serine-threonine kinase 20.065
DAXXdeath-domain associated protein0.063
TSG101tumor susceptibility gene 1010.054
PIAS2protein inhibitor of activated STAT, 20.045
TRAF6TNF receptor-associated factor 60.042
HIPK2homeodomain interacting protein kinase 20.037
MDM4Mdm4 p53 binding protein homolog (mouse)0.034
PIAS4protein inhibitor of activated STAT, 40.033
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.032
MDN1MDN1, midasin homolog (yeast)0.030
SH3GL2SH3-domain GRB2-like 20.026
MUL1mitochondrial E3 ubiquitin protein ligase 10.024
TLR4toll-like receptor 40.022
SAE1SUMO1 activating enzyme subunit 10.022
IRAK4interleukin-1 receptor-associated kinase 40.021
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.021
PTK2PTK2 protein tyrosine kinase 20.021
PTPN23protein tyrosine phosphatase, non-receptor type 230.020
ZMYM2zinc finger, MYM-type 20.019
IRAK3interleukin-1 receptor-associated kinase 30.019
NKTRnatural killer-tumor recognition sequence0.018
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.018
TLR2toll-like receptor 20.017
GRAP2GRB2-related adaptor protein 20.017
GGA3golgi-associated, gamma adaptin ear containing, ARF binding protein 30.016
TRAF3TNF receptor-associated factor 30.016
SF3B4splicing factor 3b, subunit 4, 49kDa0.016
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.016
MEN1multiple endocrine neoplasia I0.016
IRF7interferon regulatory factor 70.015
SP100SP100 nuclear antigen0.015
FNBP4formin binding protein 40.015
PDCD6programmed cell death 60.014
WRNWerner syndrome, RecQ helicase-like0.014
TRIM27tripartite motif containing 270.014
PELI1pellino homolog 1 (Drosophila)0.014
PYCARDPYD and CARD domain containing0.014
PYDC2pyrin domain containing 20.013
OFD1oral-facial-digital syndrome 10.013
MEF2Amyocyte enhancer factor 2A0.013
NLRC4NLR family, CARD domain containing 40.012
HGShepatocyte growth factor-regulated tyrosine kinase substrate0.012
USP9Xubiquitin specific peptidase 9, X-linked0.012
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.012
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.012
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.011
WDR33WD repeat domain 330.011
IKZF3IKAROS family zinc finger 3 (Aiolos)0.011
GNMTglycine N-methyltransferase0.011
PAN3PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)0.011
TDGthymine-DNA glycosylase0.011
SUMO4SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)0.011
PIAS3protein inhibitor of activated STAT, 30.011
MAP3K14mitogen-activated protein kinase kinase kinase 140.011
MBD1methyl-CpG binding domain protein 10.010
UBA1ubiquitin-like modifier activating enzyme 10.010
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.010
SAMHD1SAM domain and HD domain 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism