The network for 'epithelial cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelial cell development

The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

NameDescriptionProbabilityFunc Analog Organism
par-1CG8201 gene product from transcript CG8201-RA1.000
Stat92ESignal-transducer and activator of transcription protein at 92E1.000
ttktramtrack0.999
Rac1CG2248 gene product from transcript CG2248-RA0.999
bazbazooka0.998
sqhspaghetti squash0.998
shgshotgun0.998
dshdishevelled0.995
par-6CG5884 gene product from transcript CG5884-RA0.995
hpohippo0.991
domedomeless0.991
coscosta0.990
wgwingless0.990
alpha-Catalpha Catenin0.990
cicubitus interruptus0.989
RalaRas-related protein0.987
CortactinCG3637 gene product from transcript CG3637-RA0.985
NNotch0.984
crbcrumbs0.983
osoutstretched0.983
p53CG33336 gene product from transcript CG33336-RB0.982
babobaboon0.981
KrnKeren0.978
Su(var)2-10Suppressor of variegation 2-100.977
fngfringe0.974
phlpole hole0.972
jingCG9397 gene product from transcript CG9397-RI0.970
SerSerrate0.969
kibrakibra ortholog0.968
kelkelch0.967
mbcmyoblast city0.967
fzfrizzled0.965
ecdecdysoneless0.964
hhhedgehog0.958
CalpBCalpain-B0.958
emcextra macrochaetae0.957
kuzkuzbanian0.956
Pvf1PDGF- and VEGF-related factor 10.952
l(2)gllethal (2) giant larvae0.952
TrlTrithorax-like0.948
Rab5Rab-protein 50.944
Rho1CG8416 gene product from transcript CG8416-RB0.944
rlrolled0.941
dlg1discs large 10.936
Tm1Tropomyosin 10.935
araaraucan0.933
kugkugelei0.931
DadDaughters against dpp0.931
aopanterior open0.931
Pi3K92ECG4141 gene product from transcript CG4141-RB0.930
MrtfMyocardin-related transcription factor0.928
gbbglass bottom boat0.926
lkb1CG9374 gene product from transcript CG9374-RJ0.922
shnschnurri0.920
PvrPDGF- and VEGF-receptor related0.918
CycECyclin E0.918
rokRho-kinase0.913
ShcSHC-adaptor protein0.912
ndlnudel0.912
cindrCIN85 and CD2AP orthologue0.890
Lis-1Lissencephaly-10.889
Ced-12CG5336 gene product from transcript CG5336-RA0.889
Btk29ABtk family kinase at 29A0.884
chicchickadee0.882
EcREcdysone receptor0.881
sggshaggy0.880
uspultraspiracle0.876
BicDBicaudal D0.874
Doc2Dorsocross20.873
Dcr-2Dicer-20.873
CtBPC-terminal Binding Protein0.866
yuCG3249 gene product from transcript CG3249-RA0.859
slboslow border cells0.858
kniknirps0.854
LLobe0.850
mirrmirror0.849
mewmultiple edematous wings0.848
cpbcapping protein beta0.847
latlatheo0.844
nyonyobe0.839
EgfrEpidermal growth factor receptor0.830
diadiaphanous0.830
pydpolychaetoid0.828
Vm26AbVitelline membrane 26Ab0.828
CG8155CG8155 gene product from transcript CG8155-RA0.827
exexpanded0.824
brkbrinker0.818
kiskismet0.811
edechinoid0.807
toctoucan0.805
RhoGEF2CG9635 gene product from transcript CG9635-RF0.800
zipzipper0.800
RbfRetinoblastoma-family protein0.799
ik2IkappaB kinase-like 20.776
maelmaelstrom0.774
RhebCG1081 gene product from transcript CG1081-RA0.765
GugGrunge0.761
nudECG8104 gene product from transcript CG8104-RB0.760
shashavenoid0.759
bambag of marbles0.757
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dladeltaA0.976
kdrlkinase insert domain receptor like0.976
cxcr4achemokine (C-X-C motif) receptor 4a0.894
dlcdeltaC0.882
shhasonic hedgehog a0.868
cdh1cadherin 1, epithelial0.831
osr2odd-skipped related 2 (Drosophila)0.821
notch3notch homolog 30.785
pax2apaired box gene 2a0.760
foxa1forkhead box A10.711
dlbdeltaB0.687
lhx1aLIM homeobox 1a0.676
neurog1neurogenin 10.628
wt1awilms tumor 1a0.622
jag1bjagged 1b0.620
sox3SRY-box containing gene 30.594
isl1islet10.587
hnf1baHNF1 homeobox Ba0.543
sox9aSRY-box containing gene 9a0.539
bocbrother of CDO0.536
eya1eyes absent homolog 10.531
tp53tumor protein p530.530
gata2aGATA-binding protein 2a0.517
gli2aGLI-Kruppel family member GLI2a0.490
tal1T-cell acute lymphocytic leukemia 10.467
rag1recombination activating gene 10.465
cdh23cadherin-like 230.457
mecomMDS1 and EVI1 complex locus0.423
dll4delta-like 4 (Drosophila)0.413
pax8paired box gene 80.407
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.406
crygm4crystallin, gamma M40.376
cldnbclaudin b0.375
pdgfaaplatelet-derived growth factor alpha a0.374
cxcr4bchemokine (C-X-C motif), receptor 4b0.374
rag2recombination activating gene 20.363
fras1Fraser syndrome 10.357
gdf6agrowth differentiation factor 6a0.349
tp63tumor protein p630.344
wt1bwilms tumor 1b0.330
osr1odd-skipped related 1 (Drosophila)0.327
lmx1b.1LIM homeobox transcription factor 1, beta 10.325
tfap2atranscription factor AP-2 alpha0.322
fbn2bfibrillin 2b0.315
hoxb3ahomeo box B3a0.308
trpm7transient receptor potential cation channel, subfamily M, member 70.304
crygmxl2crystallin, gamma MX, like 20.293
sox19aSRY-box containing gene 19a0.288
pitx3paired-like homeodomain transcription factor 30.266
plcg1phospholipase C, gamma 10.251
fzd8afrizzled homolog 8a0.250
hoxc4ahomeo box C4a0.237
dag1dystroglycan 10.231
wnt2bbwingless-type MMTV integration site family, member 2Bb0.218
cx43.4connexin 43.40.214
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.209
notch1anotch homolog 1a0.205
hey1hairy/enhancer-of-split related with YRPW motif 10.198
her9hairy-related 90.197
emx3empty spiracles homeobox 30.195
LOC560602novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)0.195
appl1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.194
pax6bpaired box gene 6b0.181
foxa2forkhead box A20.177
nrarpanotch-regulated ankyrin repeat protein a0.168
nr2f5nuclear receptor subfamily 2, group F, member 50.164
prox1prospero-related homeobox gene 10.161
six4bsine oculis homeobox homolog 4b0.160
six2asine oculis-related homeobox 2a0.160
crygm6crystallin, gamma M60.159
spint1aserine peptidase inhibitor, Kunitz type 1 a0.158
ptgs2aprostaglandin-endoperoxide synthase 2a0.153
her6hairy-related 60.153
hoxb1bhomeo box B1b0.152
epcamepithelial cell adhesion molecule0.151
etv2ets variant gene 20.150
evx1even-skipped homeobox 10.149
sox1aSRY-box containing gene 1a0.147
ctrlchymotrypsin-like0.146
gli1GLI-Kruppel family member 10.145
akap12bA kinase (PRKA) anchor protein (gravin) 12b0.142
cx55.5connexin 55.50.137
unc45aunc-45 homolog A (C. elegans)0.136
slc2a9l1solute carrier family 2 (facilitated glucose transporter), member 9-like 10.136
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.136
foxd3forkhead box D30.135
ephb4beph receptor B4b0.135
tbx2bT-box 2b0.135
metmet proto-oncogene (hepatocyte growth factor receptor)0.130
crygm2fcrystallin, gamma M2f0.130
neurod4neurogenic differentiation 40.129
jag1ajagged 1a0.129
lef1lymphocyte enhancer binding factor 10.129
cdh2cadherin 2, neuronal0.126
ascl1aachaete-scute complex-like 1a (Drosophila)0.125
sarsseryl-tRNA synthetase0.125
bmp4bone morphogenetic protein 40.125
pou5f1POU domain, class 5, transcription factor 10.122
shhbsonic hedgehog b0.121
plce1phospholipase C, epsilon 10.121
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 10.993
EGFRepidermal growth factor receptor0.977
CAV1caveolin 1, caveolae protein, 22kDa0.972
MDM2Mdm2 p53 binding protein homolog (mouse)0.934
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.926
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.900
TJP1tight junction protein 1 (zona occludens 1)0.878
TAL1T-cell acute lymphocytic leukemia 10.830
MYH9myosin, heavy chain 9, non-muscle0.792
FLNAfilamin A, alpha0.790
BCAR1breast cancer anti-estrogen resistance 10.772
RB1retinoblastoma 10.746
PTPN1protein tyrosine phosphatase, non-receptor type 10.733
DNM2dynamin 20.732
ACTBactin, beta0.719
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.719
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.691
GRB2growth factor receptor-bound protein 20.679
FGF1fibroblast growth factor 1 (acidic)0.637
JAG1jagged 10.588
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.577
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.568
PTPN11protein tyrosine phosphatase, non-receptor type 110.517
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.466
CCNE1cyclin E10.457
CCND1cyclin D10.456
QKIquaking homolog, KH domain RNA binding (mouse)0.428
BMPR1Abone morphogenetic protein receptor, type IA0.403
LATlinker for activation of T cells0.399
PBX1pre-B-cell leukemia homeobox 10.385
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.361
CAB39calcium binding protein 390.350
EZRezrin0.329
UBQLN1ubiquilin 10.308
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.307
RHOAras homolog gene family, member A0.297
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.289
ENGendoglin0.268
TJP2tight junction protein 2 (zona occludens 2)0.257
CALCAcalcitonin-related polypeptide alpha0.254
SORBS2sorbin and SH3 domain containing 20.245
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.238
ADRB1adrenergic, beta-1-, receptor0.200
PECAM1platelet/endothelial cell adhesion molecule0.200
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.196
CD44CD44 molecule (Indian blood group)0.187
SCHIP1schwannomin interacting protein 10.180
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.170
TCF4transcription factor 40.170
DNM1dynamin 10.169
E2F1E2F transcription factor 10.168
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.167
UHRF2ubiquitin-like with PHD and ring finger domains 20.165
SOCS3suppressor of cytokine signaling 30.165
AXIN1axin 10.164
CDK2cyclin-dependent kinase 20.158
DTNAdystrobrevin, alpha0.155
ARandrogen receptor0.145
SOS2son of sevenless homolog 2 (Drosophila)0.138
BCRbreakpoint cluster region0.136
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.133
TRIP6thyroid hormone receptor interactor 60.132
FERMT2fermitin family member 20.131
ARID4BAT rich interactive domain 4B (RBP1-like)0.130
NOTCH1notch 10.123
WIPF1WAS/WASL interacting protein family, member 10.123
CTNND1catenin (cadherin-associated protein), delta 10.121
RETret proto-oncogene0.118
PPM1Fprotein phosphatase, Mg2+/Mn2+ dependent, 1F0.118
NKX3-1NK3 homeobox 10.117
SOS1son of sevenless homolog 1 (Drosophila)0.113
CTTNcortactin0.110
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.109
ACTN1actinin, alpha 10.108
HNF4Ahepatocyte nuclear factor 4, alpha0.107
CCND3cyclin D30.105
PSEN1presenilin 10.105
POU5F1POU class 5 homeobox 10.103
TBC1D10ATBC1 domain family, member 10A0.103
PIAS1protein inhibitor of activated STAT, 10.103
COL2A1collagen, type II, alpha 10.101
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.101
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.101
ADAM15ADAM metallopeptidase domain 150.100
HDAC1histone deacetylase 10.096
DAXXdeath-domain associated protein0.096
APCadenomatous polyposis coli0.093
PTENphosphatase and tensin homolog0.093
PLCG1phospholipase C, gamma 10.093
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.092
MAPK6mitogen-activated protein kinase 60.091
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.091
BMPR1Bbone morphogenetic protein receptor, type IB0.088
GAB1GRB2-associated binding protein 10.087
FOXA2forkhead box A20.081
ERBB2IPerbb2 interacting protein0.080
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 400.080
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.076
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.076
NOTCH3notch 30.076
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.999
Gli3GLI-Kruppel family member GLI30.999
Shhsonic hedgehog0.999
Sox9SRY-box containing gene 90.996
Sox2SRY-box containing gene 20.994
Ptpn11protein tyrosine phosphatase, non-receptor type 110.992
Msx1homeobox, msh-like 10.992
Bmp4bone morphogenetic protein 40.990
Ptenphosphatase and tensin homolog0.986
Gli2GLI-Kruppel family member GLI20.984
Arandrogen receptor0.982
Pbx1pre B-cell leukemia transcription factor 10.979
Tgfb2transforming growth factor, beta 20.974
Foxc1forkhead box C10.974
Nr5a1nuclear receptor subfamily 5, group A, member 10.968
Otx2orthodenticle homolog 2 (Drosophila)0.967
Hoxa2homeobox A20.961
Ror2receptor tyrosine kinase-like orphan receptor 20.957
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.947
Trp63transformation related protein 630.946
Tcfap2atranscription factor AP-2, alpha0.928
Ush1gUsher syndrome 1G homolog (human)0.922
Fgf8fibroblast growth factor 80.919
Ascl1achaete-scute complex homolog 1 (Drosophila)0.918
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.918
Dlx5distal-less homeobox 50.914
Foxd1forkhead box D10.909
Foxa2forkhead box A20.907
Pthlhparathyroid hormone-like peptide0.902
Pax3paired box gene 30.898
Hand1heart and neural crest derivatives expressed transcript 10.885
Msx2homeobox, msh-like 20.883
Hoxa5homeobox A50.863
Neurod1neurogenic differentiation 10.862
Dlx1distal-less homeobox 10.860
Hoxd13homeobox D130.854
Onecut1one cut domain, family member 10.854
Twist2twist homolog 2 (Drosophila)0.843
Fgf10fibroblast growth factor 100.839
Pou3f3POU domain, class 3, transcription factor 30.839
Alx4aristaless-like homeobox 40.833
Hand2heart and neural crest derivatives expressed transcript 20.823
Col4a2collagen, type IV, alpha 20.817
Hoxd11homeobox D110.816
Prrx1paired related homeobox 10.809
Grid1glutamate receptor, ionotropic, delta 10.803
Lhx1LIM homeobox protein 10.803
Dok1docking protein 10.803
Pax8paired box gene 80.797
Pax6paired box gene 60.793
Hey2hairy/enhancer-of-split related with YRPW motif 20.790
Kiss1KiSS-1 metastasis-suppressor0.781
Ahraryl-hydrocarbon receptor0.777
Tbx15T-box 150.774
Hoxd3homeobox D30.772
Hoxa13homeobox A130.771
Sall4sal-like 4 (Drosophila)0.768
Atoh7atonal homolog 7 (Drosophila)0.767
Bmp7bone morphogenetic protein 70.766
Cftrcystic fibrosis transmembrane conductance regulator homolog0.749
Zic3zinc finger protein of the cerebellum 30.744
Gata6GATA binding protein 60.743
Egfrepidermal growth factor receptor0.738
Sall1sal-like 1 (Drosophila)0.737
Rspo2R-spondin 2 homolog (Xenopus laevis)0.735
Hoxa10homeobox A100.732
Gata4GATA binding protein 40.728
Runx2runt related transcription factor 20.723
Tbx1T-box 10.719
Lhx5LIM homeobox protein 50.709
Pax9paired box gene 90.706
Nos3nitric oxide synthase 3, endothelial cell0.703
Dlx2distal-less homeobox 20.700
Hes1hairy and enhancer of split 1 (Drosophila)0.685
Arntlaryl hydrocarbon receptor nuclear translocator-like0.683
Rargretinoic acid receptor, gamma0.673
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.673
Stat3signal transducer and activator of transcription 30.673
Lhx3LIM homeobox protein 30.668
Dccdeleted in colorectal carcinoma0.664
Ptk2PTK2 protein tyrosine kinase 20.661
Ctnnb1catenin (cadherin associated protein), beta 10.655
Foxh1forkhead box H10.653
Notch2Notch gene homolog 2 (Drosophila)0.651
En1engrailed 10.648
Nognoggin0.639
Sfnstratifin0.635
Foxc2forkhead box C20.631
Amhanti-Mullerian hormone0.621
Hoxc5homeobox C50.618
Hoxb5homeobox B50.617
Gata5GATA binding protein 50.616
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.615
Bmp2bone morphogenetic protein 20.611
Wnt4wingless-related MMTV integration site 40.611
Arid4aAT rich interactive domain 4A (RBP1-like)0.609
Eya1eyes absent 1 homolog (Drosophila)0.608
Hoxb4homeobox B40.594
Klklotho0.589
Lef1lymphoid enhancer binding factor 10.586
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism