The network for 'transcription coupled nucleotide excision repair' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

transcription coupled nucleotide excision repair

The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ERCC6excision repair cross-complementing rodent repair deficiency, complementation group 60.957
XAB2XPA binding protein 20.784
POLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDa0.773
GTF2H1general transcription factor IIH, polypeptide 1, 62kDa0.261
THOC4THO complex 40.181
STRN4striatin, calmodulin binding protein 40.167
DHX16DEAH (Asp-Glu-Ala-His) box polypeptide 160.149
THOC5THO complex 50.114
DDX39BDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.113
ISY1ISY1 splicing factor homolog (S. cerevisiae)0.078
SARNPSAP domain containing ribonucleoprotein0.077
GTF2H2general transcription factor IIH, polypeptide 2, 44kDa0.074
DDX39ADEAD (Asp-Glu-Ala-Asp) box polypeptide 39A0.069
THOC1THO complex 10.068
CHTOPchromatin target of PRMT10.059
ERCC8excision repair cross-complementing rodent repair deficiency, complementation group 80.049
PPIEpeptidylprolyl isomerase E (cyclophilin E)0.026
THOC6THO complex 6 homolog (Drosophila)0.024
USP11ubiquitin specific peptidase 110.022
RBM8ARNA binding motif protein 8A0.019
TUBA1Btubulin, alpha 1b0.018
XPAxeroderma pigmentosum, complementation group A0.014
CTDP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 10.014
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.013
XPCxeroderma pigmentosum, complementation group C0.013
ZMYND8zinc finger, MYND-type containing 80.012
EIF4A3eukaryotic translation initiation factor 4A30.012
SUPT6Hsuppressor of Ty 6 homolog (S. cerevisiae)0.011
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Srsf9serine/arginine-rich splicing factor 90.674
Ssrp1structure specific recognition protein 10.444
Snrnp40small nuclear ribonucleoprotein 40 (U5)0.323
Ewsr1Ewing sarcoma breakpoint region 10.282
Rnps1ribonucleic acid binding protein S10.247
Srrtserrate RNA effector molecule homolog (Arabidopsis)0.247
Prmt1protein arginine N-methyltransferase 10.230
Anp32bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B0.201
Trim28tripartite motif-containing 280.177
Hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.157
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.154
RanRAN, member RAS oncogene family0.126
Eftud2elongation factor Tu GTP binding domain containing 20.115
Thoc4THO complex 40.114
Tdgthymine DNA glycosylase0.104
Ptmaprothymosin alpha0.093
Fblfibrillarin0.089
Gar1GAR1 ribonucleoprotein homolog (yeast)0.082
Pabpn1poly(A) binding protein, nuclear 10.079
Nup93nucleoporin 930.066
Impdh2inosine 5'-phosphate dehydrogenase 20.053
Acin1apoptotic chromatin condensation inducer 10.053
Banf1barrier to autointegration factor 10.052
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.051
Ppp4cprotein phosphatase 4, catalytic subunit0.047
Srsf2serine/arginine-rich splicing factor 20.047
Tuba1btubulin, alpha 1B0.043
1500001M20RikRIKEN cDNA 1500001M20 gene0.042
Rcc2regulator of chromosome condensation 20.041
Ranbp1RAN binding protein 10.040
Safbscaffold attachment factor B0.039
Cdk9cyclin-dependent kinase 9 (CDC2-related kinase)0.039
Sf3b3splicing factor 3b, subunit 30.038
U2af1U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 10.037
SetSET nuclear oncogene0.035
Eif3geukaryotic translation initiation factor 3, subunit G0.035
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.035
Cct2chaperonin containing Tcp1, subunit 2 (beta)0.034
Hnrnpmheterogeneous nuclear ribonucleoprotein M0.033
Refbp2RNA and export factor binding protein 20.032
A430005L14RikRIKEN cDNA A430005L14 gene0.032
Senp3SUMO/sentrin specific peptidase 30.032
Apex1apurinic/apyrimidinic endonuclease 10.031
Gtf2f1general transcription factor IIF, polypeptide 10.029
Eif4a3eukaryotic translation initiation factor 4A30.029
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.029
Lsm2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.029
Nup107nucleoporin 1070.027
Srsf4serine/arginine-rich splicing factor 40.027
Ddx54DEAD (Asp-Glu-Ala-Asp) box polypeptide 540.026
Nclnucleolin0.026
Puf60poly-U binding splicing factor 600.025
Ipo5importin 50.024
Dnmt1DNA methyltransferase (cytosine-5) 10.024
Rbm14RNA binding motif protein 140.023
Nup62nucleoporin 620.023
Tbcbtubulin folding cofactor B0.023
Cks1bCDC28 protein kinase 1b0.023
Cdk2ap1CDK2 (cyclin-dependent kinase 2)-associated protein 10.022
Cpsf1cleavage and polyadenylation specific factor 10.022
Ctpscytidine 5'-triphosphate synthase0.022
Nxt1NTF2-related export protein 10.021
Tubb5tubulin, beta 50.021
Ncbp1nuclear cap binding protein subunit 10.021
Prpf8pre-mRNA processing factor 80.021
Cdk4cyclin-dependent kinase 40.020
Hn1hematological and neurological expressed sequence 10.019
Cdca4cell division cycle associated 40.018
Dtymkdeoxythymidylate kinase0.018
Taf5lTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor0.018
Xab2XPA binding protein 20.018
2700094K13RikRIKEN cDNA 2700094K13 gene0.017
Enoph1enolase-phosphatase 10.017
Nop56NOP56 ribonucleoprotein homolog (yeast)0.017
Snrpasmall nuclear ribonucleoprotein polypeptide A0.017
U2af2U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 20.016
SltmSAFB-like, transcription modulator0.016
Qrich1glutamine-rich 10.016
Ppanpeter pan homolog (Drosophila)0.016
Odc1ornithine decarboxylase, structural 10.016
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.016
H2afyH2A histone family, member Y0.015
Ppp1r8protein phosphatase 1, regulatory (inhibitor) subunit 80.015
2310036O22RikRIKEN cDNA 2310036O22 gene0.015
Eif3ceukaryotic translation initiation factor 3, subunit C0.015
Brd2bromodomain containing 20.015
Rbm10RNA binding motif protein 100.015
Hnrnpdheterogeneous nuclear ribonucleoprotein D0.014
Cherpcalcium homeostasis endoplasmic reticulum protein0.014
Pprc1peroxisome proliferative activated receptor, gamma, coactivator-related 10.014
Noc4lnucleolar complex associated 4 homolog (S. cerevisiae)0.014
Cox4nbCOX4 neighbor0.014
Siva1SIVA1, apoptosis-inducing factor0.014
RbmxrtRNA binding motif protein, X chromosome retrogene0.014
Dhx16DEAH (Asp-Glu-Ala-His) box polypeptide 160.014
Fam192afamily with sequence similarity 192, member A0.014
Pa2g4proliferation-associated 2G40.014
Nxf1nuclear RNA export factor 1 homolog (S. cerevisiae)0.014
Gtf3c2general transcription factor IIIC, polypeptide 2, beta0.014
Pcbp1poly(rC) binding protein 10.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RTF1Rtf1p0.838
CTR9Ctr9p0.820
HPR1Hpr1p0.538
SPT5Spt5p0.333
SPT16Spt16p0.242
GBP2Gbp2p0.241
RPB3Rpb3p0.234
PAF1Paf1p0.194
LEO1Leo1p0.102
DST1Dst1p0.090
MEX67Mex67p0.082
SSL1Ssl1p0.073
RPO21Rpo21p0.072
THO2Tho2p0.067
THP2Thp2p0.063
SUB1Sub1p0.058
SUS1Sus1p0.051
NRD1Nrd1p0.049
HOR2Hor2p0.042
SPT6Spt6p0.040
CKA1Cka1p0.039
TFA1Tfa1p0.035
PSY4Psy4p0.034
MSS116Mss116p0.031
YLR264C-Ahypothetical protein0.029
MPT5Mpt5p0.029
CKB1Ckb1p0.028
SRD1Srd1p0.028
LEU2Leu2p0.027
DED1Ded1p0.026
IML1Iml1p0.026
MMS1Mms1p0.026
HRB1Hrb1p0.026
BRN1Brn1p0.025
HXT3Hxt3p0.024
TEX1Tex1p0.024
UME1Ume1p0.023
YLR162Whypothetical protein0.023
APN1Apn1p0.023
MOT2Mot2p0.023
ARP10Arp10p0.023
YOL038C-Ahypothetical protein0.023
TYE7Tye7p0.022
ECM30Ecm30p0.022
MER1Mer1p0.022
SWT1Swt1p0.021
URA3Ura3p0.021
SPT4Spt4p0.020
HST3Hst3p0.020
RAD7Rad7p0.020
MFT1Mft1p0.019
HDA2Hda2p0.019
CAB3Cab3p0.019
ARG8Arg8p0.019
HOHop0.018
YLR042Chypothetical protein0.018
YAR068Whypothetical protein0.018
SEM1Sem1p0.018
ATP6Atp6p0.018
OPI1Opi1p0.018
YIL151Chypothetical protein0.017
SPL2Spl2p0.017
CUP1-1Cup1-1p0.017
SWC7Swc7p0.017
YBR013Chypothetical protein0.017
THP3Thp3p0.016
YPR157Whypothetical protein0.016
YIR035Chypothetical protein0.016
YLR422Whypothetical protein0.016
RAD18Rad18p0.016
HMO1Hmo1p0.016
FMT1Fmt1p0.016
APL5Apl5p0.015
STO1Sto1p0.015
AUA1Aua1p0.015
HPF1Hpf1p0.015
GYL1Gyl1p0.015
OPT2Opt2p0.015
BSC1Bsc1p0.015
SPE3Spe3p0.015
ZPS1Zps1p0.015
SWD3Swd3p0.015
CPD1Cpd1p0.014
RXT3Rxt3p0.014
TFG1Tfg1p0.014
ALT2Alt2p0.014
BAT2Bat2p0.014
MF(ALPHA)2Mf(alpha)2p0.014
YKR075Chypothetical protein0.014
YOL013W-Ahypothetical protein0.014
CRP1Crp1p0.014
UPS3Ups3p0.014
YOL014Whypothetical protein0.014
PCL9Pcl9p0.014
YNL234Whypothetical protein0.013
ARO10Aro10p0.013
SCM4Scm4p0.013
CHA1Cha1p0.013
RPL41ARpl41ap0.013
YML003Whypothetical protein0.013