The network for 'proteoglycan metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

proteoglycan metabolic process

The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

NameDescriptionProbabilityFunc Analog Organism
Yp3Yolk protein 30.779
Ext2CG8433 gene product from transcript CG8433-RA0.322
CG7916CG7916 gene product from transcript CG7916-RA0.305
raspCG11495 gene product from transcript CG11495-RA0.282
CG14837CG14837 gene product from transcript CG14837-RC0.196
LvpHLarval visceral protein H0.172
rtettetracycline resistance0.128
CG6283CG6283 gene product from transcript CG6283-RA0.081
cicubitus interruptus0.061
EloAElongin A0.055
CG5390CG5390 gene product from transcript CG5390-RA0.054
sogshort gastrulation0.051
Jon65AivJonah 65Aiv0.046
CG1887CG1887 gene product from transcript CG1887-RD0.043
CG3194CG3194 gene product from transcript CG3194-RB0.042
Jon25BiiJonah 25Bii0.040
l(2)notlethal (2) neighbor of tid0.038
CG12883CG12883 gene product from transcript CG12883-RA0.034
Cyp4d21CG6730 gene product from transcript CG6730-RA0.033
ImpE1Ecdysone-inducible gene E10.026
Jon99CiJonah 99Ci0.025
CG14119CG14119 gene product from transcript CG14119-RA0.022
CG8690CG8690 gene product from transcript CG8690-RA0.021
CG12746CG12746 gene product from transcript CG12746-RD0.021
CG3631CG3631 gene product from transcript CG3631-RD0.021
CG17159CG17159 gene product from transcript CG17159-RF0.020
CG17163CG17163 gene product from transcript CG17163-RA0.020
CG13160CG13160 gene product from transcript CG13160-RA0.019
CG14820CG14820 gene product from transcript CG14820-RA0.019
Irk2Inwardly rectifying potassium channel 20.018
CG10361CG10361 gene product from transcript CG10361-RA0.018
CG15534CG15534 gene product from transcript CG15534-RA0.017
Bre1CG10542 gene product from transcript CG10542-RA0.016
CG14196CG14196 gene product from transcript CG14196-RA0.016
DmsR-2Dromyosuppressin receptor 20.016
CG5335CG5335 gene product from transcript CG5335-RA0.016
CG6462CG6462 gene product from transcript CG6462-RA0.015
CG15533CG15533 gene product from transcript CG15533-RA0.015
CG10911CG10911 gene product from transcript CG10911-RA0.015
CG4377CG4377 gene product from transcript CG4377-RA0.014
CG12483CG12483 gene product from transcript CG12483-RA0.014
CG18616CG18616 gene product from transcript CG18616-RA0.014
CG12374CG12374 gene product from transcript CG12374-RA0.014
CG6277CG6277 gene product from transcript CG6277-RA0.014
CG11103CG11103 gene product from transcript CG11103-RB0.013
botvbrother of tout-velu0.013
CG7638CG7638 gene product from transcript CG7638-RA0.013
CG10555CG10555 gene product from transcript CG10555-RA0.013
Pgant35APolypeptide N-acetylgalactosaminyltransferase 35A0.013
CG10824CG10824 gene product from transcript CG10824-RA0.013
Cp38Chorion protein 380.013
NotumCG13076 gene product from transcript CG13076-RB0.012
CG9672CG9672 gene product from transcript CG9672-RA0.012
Spn77BbSerpin 77Bb0.012
CG11192CG11192 gene product from transcript CG11192-RB0.012
CG34221CG34221 gene product from transcript CG34221-RB0.012
CG10086CG10086 gene product from transcript CG10086-RA0.012
CG8093CG8093 gene product from transcript CG8093-RA0.012
CG6996CG6996 gene product from transcript CG6996-RB0.012
CG15353CG15353 gene product from transcript CG15353-RA0.011
CG4025CG4025 gene product from transcript CG4025-RA0.011
CG5567CG5567 gene product from transcript CG5567-RA0.011
CG6178CG6178 gene product from transcript CG6178-RA0.011
Cyp18a1Cytochrome P450-18a10.010
CG5945CG5945 gene product from transcript CG5945-RA0.010
CG4293CG4293 gene product from transcript CG4293-RD0.010
CG7213CG7213 gene product from transcript CG7213-RA0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
xylt1xylosyltransferase 10.928
sec24dSEC24 family, member D (S. cerevisiae)0.874
uxs1UDP-glucuronic acid decarboxylase 10.801
hs6st1aheparan sulfate 6-O-sulfotransferase 1a0.789
hs6st2heparan sulfate 6-O-sulfotransferase 20.721
ptch2patched 20.474
tcf7transcription factor 7 (T-cell specific, HMG-box)0.437
col5a1procollagen, type V, alpha 10.427
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.397
col1a2collagen, type I, alpha 20.350
col1a1acollagen, type I, alpha 1a0.328
fam20bfamily with sequence similarity 20, member B (H. sapiens)0.309
col5a2lcollagen, type V, alpha 2-like0.238
ext2exostoses (multiple) 20.218
sulf1sulfatase 10.189
sox9aSRY-box containing gene 9a0.177
jag1bjagged 1b0.172
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.158
col11a2collagen type XI alpha-20.158
ptpraprotein tyrosine phosphatase, receptor type, A0.128
extl3exostoses (multiple)-like 30.122
slc35b2solute carrier family 35, member B20.113
hs6st1bheparan sulfate 6-O-sulfotransferase 1b0.111
bmp1abone morphogenetic protein 1a0.094
hs6st3heparan sulfate 6-O-sulfotransferase 30.091
chd7chromodomain helicase DNA binding protein 70.090
col27a1acollagen, type XXVII, alpha 1a0.071
wnt5bwingless-type MMTV integration site family, member 5b0.068
nkd1naked cuticle homolog 1 (Drosophila)0.057
sec13SEC13 homolog (S. cerevisiae)0.055
col10a1collagen, type X, alpha 10.054
hapln1ahyaluronan and proteoglycan link protein 1a0.054
rereaarginine-glutamic acid dipeptide (RE) repeats a0.053
foxi1forkhead box I10.052
smosmoothened homolog (Drosophila)0.049
dcaf7ddb1 and cul4 associated factor 70.046
col1a1bcollagen, type I, alpha 1b0.043
sdc2syndecan 20.042
ext1bexostoses (multiple) 1b0.041
sec23aSec23 homolog A (S. cerevisiae)0.040
serpinf1serine (or cysteine) peptidase inhibitor, clade F, member 10.039
rcn1reticulocalbin 1, EF-hand calcium binding domain0.039
enpp1ectonucleotide pyrophosphatase/phosphodiesterase 10.037
usp9ubiquitin specific peptidase 90.035
gle1GLE1 RNA export mediator homolog (yeast)0.035
hs2st1aheparan sulfate 2-O-sulfotransferase 1a0.033
b3gat3beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) and beta3-glucuronyltransferase0.032
thbs1thrombospondin 10.031
csnk1a1casein kinase 1, alpha 10.030
sufusuppressor of fused homolog (Drosophila)0.029
pdlim7PDZ and LIM domain 70.029
sparcsecreted acidic cysteine rich glycoprotein0.029
LOC556849ectonucleoside triphosphate diphosphohydrolase 5-like0.028
furinafurin (paired basic amino acid cleaving enzyme) a0.027
atp7aATPase, Cu++ transporting, alpha polypeptide0.027
fibinfin bud initiation factor0.024
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.022
emilin1belastin microfibril interfacer 1b0.021
bambibBMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b0.020
spry2sprouty homolog 20.020
barx1BarH-like homeobox 10.020
ephb4beph receptor B4b0.019
dusp6dual specificity phosphatase 60.018
wnt3awingless-type MMTV integration site family, member 3A0.018
tjp1tight junction protein 1 (zona occludens 1)0.018
col6a2collagen, type VI, alpha 20.017
matn4matrilin 40.017
piguphosphatidylinositol glycan anchor biosynthesis, class U0.017
wnt9awingless-type MMTV integration site family, member 9A0.017
pdia5protein disulfide isomerase family A, member 50.016
ihhaIndian hedgehog homolog a0.016
pkd2polycystic kidney disease 20.016
brd2abromodomain-containing 2a0.016
col11a1bcollagen type XI alpha-1b and collagen, type XI, alpha 1b0.015
LOC568379von Willebrand factor A domain-containing protein 1-like0.015
col6a3collagen, type VI, alpha 30.015
robo1roundabout homolog 10.015
col8a1acollagen, type VIII, alpha 1a0.015
gdf9growth differentiation factor 90.015
ecrg4aesophageal cancer related gene 4a0.015
lmo4aLIM domain only 4a0.014
cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.014
pmp22aperipheral myelin protein 22a0.014
ywhaqatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a0.014
vaspvasodilator-stimulated phosphoprotein0.014
olfml3bolfactomedin-like 3b0.014
disp1dispatched homolog 1 (Drosophila)0.014
col2a1acollagen type II, alpha-1a0.014
fgf20afibroblast growth factor 20a0.014
postnperiostin, osteoblast specific factor0.014
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.993
BMPR1Abone morphogenetic protein receptor, type IA0.970
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.799
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.777
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.742
IGF2Rinsulin-like growth factor 2 receptor0.497
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.481
CTNNBIP1catenin, beta interacting protein 10.468
JUPjunction plakoglobin0.456
ITGB1BP3integrin beta 1 binding protein 30.408
GLIS2GLIS family zinc finger 20.325
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.158
COMPcartilage oligomeric matrix protein0.138
CNTFciliary neurotrophic factor0.138
PSEN1presenilin 10.110
COL6A1collagen, type VI, alpha 10.102
HIC1hypermethylated in cancer 10.089
ZNF431zinc finger protein 4310.081
COL14A1collagen, type XIV, alpha 10.078
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 20.076
PKP4plakophilin 40.073
APCadenomatous polyposis coli0.072
FSTL1follistatin-like 10.070
MXRA5matrix-remodelling associated 50.070
PRELPproline/arginine-rich end leucine-rich repeat protein0.069
MXRA8matrix-remodelling associated 80.066
BMP1bone morphogenetic protein 10.065
THY1Thy-1 cell surface antigen0.062
TCF4transcription factor 40.060
COL5A1collagen, type V, alpha 10.056
GPR124G protein-coupled receptor 1240.045
LRRC15leucine rich repeat containing 150.042
IGF2insulin-like growth factor 2 (somatomedin A)0.042
SOAT1sterol O-acyltransferase 10.041
MAN1B1mannosidase, alpha, class 1B, member 10.041
IGFBP5insulin-like growth factor binding protein 50.040
SCARB2scavenger receptor class B, member 20.039
TMEM127transmembrane protein 1270.039
PTK7PTK7 protein tyrosine kinase 70.039
FAF1Fas (TNFRSF6) associated factor 10.038
PTPRJprotein tyrosine phosphatase, receptor type, J0.037
APOBapolipoprotein B (including Ag(x) antigen)0.037
WISP1WNT1 inducible signaling pathway protein 10.036
RGS4regulator of G-protein signaling 40.036
TNIKTRAF2 and NCK interacting kinase0.036
FBLN1fibulin 10.035
EDNRAendothelin receptor type A0.035
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.035
HMGXB3HMG box domain containing 30.035
COPZ2coatomer protein complex, subunit zeta 20.034
OLFML3olfactomedin-like 30.034
MFAP2microfibrillar-associated protein 20.034
WNT6wingless-type MMTV integration site family, member 60.033
CTNND1catenin (cadherin-associated protein), delta 10.032
HEXBhexosaminidase B (beta polypeptide)0.032
WDYHV1WDYHV motif containing 10.032
PCOLCEprocollagen C-endopeptidase enhancer0.031
SFRP4secreted frizzled-related protein 40.030
PKD1polycystic kidney disease 1 (autosomal dominant)0.030
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.029
LTBP2latent transforming growth factor beta binding protein 20.029
COL1A2collagen, type I, alpha 20.029
LAMP1lysosomal-associated membrane protein 10.029
BTRCbeta-transducin repeat containing0.029
ISLRimmunoglobulin superfamily containing leucine-rich repeat0.029
LEF1lymphoid enhancer-binding factor 10.029
KLF10Kruppel-like factor 100.029
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.028
SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 10.027
MFAP5microfibrillar associated protein 50.027
NOVnephroblastoma overexpressed gene0.027
TGOLN2trans-golgi network protein 20.027
UNC5Bunc-5 homolog B (C. elegans)0.026
TWIST1twist homolog 1 (Drosophila)0.026
HMGCL3-hydroxymethyl-3-methylglutaryl-CoA lyase0.026
TGFB2transforming growth factor, beta 20.026
FNDC3Bfibronectin type III domain containing 3B0.024
OLFML2Bolfactomedin-like 2B0.024
FNDC1fibronectin type III domain containing 10.024
NGFRnerve growth factor receptor0.024
COL13A1collagen, type XIII, alpha 10.023
CDH3cadherin 3, type 1, P-cadherin (placental)0.023
COL11A1collagen, type XI, alpha 10.023
DIO2deiodinase, iodothyronine, type II0.023
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.022
SPOCK1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 10.022
DPY19L4dpy-19-like 4 (C. elegans)0.022
TMEM119transmembrane protein 1190.021
ITGBL1integrin, beta-like 1 (with EGF-like repeat domains)0.021
P2RX2purinergic receptor P2X, ligand-gated ion channel, 20.021
OSTM1osteopetrosis associated transmembrane protein 10.021
SFRP2secreted frizzled-related protein 20.020
PIGKphosphatidylinositol glycan anchor biosynthesis, class K0.020
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.997
Fgfr2fibroblast growth factor receptor 20.988
Fgfr3fibroblast growth factor receptor 30.980
Col3a1collagen, type III, alpha 10.974
Gli3GLI-Kruppel family member GLI30.968
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.959
Col2a1collagen, type II, alpha 10.958
Col5a2collagen, type V, alpha 20.954
Col1a2collagen, type I, alpha 20.941
Tgfb2transforming growth factor, beta 20.848
Sox9SRY-box containing gene 90.846
Postnperiostin, osteoblast specific factor0.843
Foxc1forkhead box C10.729
H2-Aahistocompatibility 2, class II antigen A, alpha0.692
Pthlhparathyroid hormone-like peptide0.643
Islrimmunoglobulin superfamily containing leucine-rich repeat0.550
Gdf1growth differentiation factor 10.530
Col6a2collagen, type VI, alpha 20.522
Ror2receptor tyrosine kinase-like orphan receptor 20.473
Bmpr1abone morphogenetic protein receptor, type 1A0.470
Amhr2anti-Mullerian hormone type 2 receptor0.457
Ptenphosphatase and tensin homolog0.445
Shhsonic hedgehog0.442
Smpd3sphingomyelin phosphodiesterase 3, neutral0.427
Fbn1fibrillin 10.406
IhhIndian hedgehog0.360
H2-DMahistocompatibility 2, class II, locus DMa0.325
Apcadenomatosis polyposis coli0.302
H2-Eb1histocompatibility 2, class II antigen E beta0.286
Runx2runt related transcription factor 20.285
Kif3akinesin family member 3A0.276
Fn1fibronectin 10.259
Sulf1sulfatase 10.253
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.243
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.231
Tnctenascin C0.228
Hand1heart and neural crest derivatives expressed transcript 10.222
Fstl1follistatin-like 10.208
Meox2mesenchyme homeobox 20.204
Colec12collectin sub-family member 120.196
Sulf2sulfatase 20.190
Col6a3collagen, type VI, alpha 30.185
Col11a1collagen, type XI, alpha 10.184
H2-Ab1histocompatibility 2, class II antigen A, beta 10.183
Gdf3growth differentiation factor 30.182
Ctnnb1catenin (cadherin associated protein), beta 10.180
Col6a1collagen, type VI, alpha 10.169
Zic3zinc finger protein of the cerebellum 30.150
Mrc1mannose receptor, C type 10.149
Dag1dystroglycan 10.148
Smad4MAD homolog 4 (Drosophila)0.143
Ceacam16carcinoembryonic antigen-related cell adhesion molecule 160.143
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.136
Col8a1collagen, type VIII, alpha 10.128
Capn6calpain 60.124
Sparcsecreted acidic cysteine rich glycoprotein0.121
Ccdc80coiled-coil domain containing 800.121
1700080E11RikRIKEN cDNA 1700080E11 gene0.118
Col12a1collagen, type XII, alpha 10.115
Hspg2perlecan (heparan sulfate proteoglycan 2)0.113
Acvr1activin A receptor, type 10.107
Thbs2thrombospondin 20.104
Ext1exostoses (multiple) 10.102
Fndc1fibronectin type III domain containing 10.101
Grb10growth factor receptor bound protein 100.096
Smad1MAD homolog 1 (Drosophila)0.091
Egfrepidermal growth factor receptor0.090
Fgf8fibroblast growth factor 80.088
Matn4matrilin 40.087
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.086
Igf1insulin-like growth factor 10.084
Tff1trefoil factor 10.084
Treml1triggering receptor expressed on myeloid cells-like 10.084
Pth1rparathyroid hormone 1 receptor0.083
Slc45a2solute carrier family 45, member 20.083
Ctrb1chymotrypsinogen B10.081
Col16a1collagen, type XVI, alpha 10.081
Scara3scavenger receptor class A, member 30.080
Wnt9bwingless-type MMTV integration site 9B0.078
Ctskcathepsin K0.078
Colqcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase0.078
Twist2twist homolog 2 (Drosophila)0.078
Adamts2a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20.074
Gsg1germ cell-specific gene 10.073
Arandrogen receptor0.072
Fgf23fibroblast growth factor 230.071
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.070
Wisp1WNT1 inducible signaling pathway protein 10.070
Foxf2forkhead box F20.070
Lmnalamin A0.069
2210010C04RikRIKEN cDNA 2210010C04 gene0.069
Krt4keratin 40.068
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fn1fibronectin 10.033
Col5a2collagen, type V, alpha 20.020
Loxlysyl oxidase0.016
Fabp4fatty acid binding protein 4, adipocyte0.015
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.015
Cpne8copine VIII0.013
C1scomplement component 1, s subcomponent0.012
Tpothyroid peroxidase0.012
Aebp1AE binding protein 10.012
Slc22a1solute carrier family 22 (organic cation transporter), member 10.011
Mgpmatrix Gla protein0.011
Ctskcathepsin K0.011
Lect1leukocyte cell derived chemotaxin 10.011
Tas2r118taste receptor, type 2, member 1180.011
Galnt10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)0.011
Xpnpep2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound0.011
Mrc1mannose receptor, C type 10.011
C7complement component 70.010
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.010
Crybb1crystallin, beta B10.010
Slc23a1solute carrier family 23 (nucleobase transporters), member 10.010
Hnf4ahepatocyte nuclear factor 4, alpha0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism