The network for 'germ line stem cell maintenance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

germ line stem cell maintenance

Any process by which an organism or tissue maintains a population of germ-line stem cells.

NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.999
bambag of marbles0.999
piwiCG6122 gene product from transcript CG6122-RA0.988
zpgzero population growth0.987
bratbrain tumor0.975
Pabp2CG2163 gene product from transcript CG2163-RA0.923
Ras85DRas oncogene at 85D0.910
stetstem cell tumor0.866
gbbglass bottom boat0.853
EgfrEpidermal growth factor receptor0.849
HopHsp70/Hsp90 organizing protein homolog0.846
dallydivision abnormally delayed0.732
InRInsulin-like receptor0.723
htshu li tai shao0.575
CG8443CG8443 gene product from transcript CG8443-RA0.528
Gef26CG9491 gene product from transcript CG9491-RB0.522
bgcnbenign gonial cell neoplasm0.513
DadDaughters against dpp0.461
emcextra macrochaetae0.422
Su(var)3-3Suppressor of variegation 3-30.419
Zfrp8Zinc finger protein RP-80.411
CG9576CG9576 gene product from transcript CG9576-RA0.371
RanBPMRan-binding protein M0.362
Su(H)Suppressor of Hairless0.337
Dsor1Downstream of raf10.275
SnooSno oncogene0.238
CG11347CG11347 gene product from transcript CG11347-RE0.212
Fmr1CG6203 gene product from transcript CG6203-RC0.200
A2bp1Ataxin-2 binding protein 10.192
twinCG31137 gene product from transcript CG31137-RB0.192
PtenCG5671 gene product from transcript CG5671-RB0.191
LaspCG3849 gene product from transcript CG3849-RB0.181
inx2innexin 20.179
argosCG4531 gene product from transcript CG4531-RA0.164
PargPoly(ADP-ribose) glycohydrolase0.153
dosdaughter of sevenless0.149
RhebCG1081 gene product from transcript CG1081-RA0.148
fs(1)Ybfemale sterile (1) Yb0.144
Sin3ACG8815 gene product from transcript CG8815-RC0.141
Taf1TBP-associated factor 10.133
ovoCG6824 gene product from transcript CG6824-RE0.124
kibrakibra ortholog0.111
Gap1GTPase-activating protein 10.107
aopanterior open0.099
cicubitus interruptus0.091
fz2frizzled 20.087
Nup153Nucleoporin 1530.087
CG9139CG9139 gene product from transcript CG9139-RA0.085
Nop60BNucleolar protein at 60B0.084
Pi3K92ECG4141 gene product from transcript CG4141-RB0.083
swshort wing0.082
BicDBicaudal D0.082
AcslAcyl-CoA synthetase long-chain0.081
Rbp9RNA-binding protein 90.081
CSN4COP9 complex homolog subunit 40.080
Syt4Synaptotagmin 40.080
CG3342CG3342 gene product from transcript CG3342-RA0.076
Wnt4Wnt oncogene analog 40.075
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
itgb1b.2integrin, beta 1b.20.887
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.644
bmp2bbone morphogenetic protein 2b0.572
bmp4bone morphogenetic protein 40.561
itgb1bintegrin, beta 1b0.387
itgb1aintegrin, beta 1a0.342
fbn2bfibrillin 2b0.330
jag1bjagged 1b0.328
wnt5bwingless-type MMTV integration site family, member 5b0.299
jag2jagged 20.298
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.297
mibmind bomb0.296
tp63tumor protein p630.294
itgb1b.1integrin, beta 1b.10.266
mycamyelocytomatosis oncogene a0.262
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.250
acvr1lactivin A receptor, type I like0.241
mmp14bmatrix metalloproteinase 14b (membrane-inserted)0.234
notch1anotch homolog 1a0.231
ripk2receptor-interacting serine-threonine kinase 20.219
foxi1forkhead box I10.202
tbx2bT-box 2b0.200
LOC570775protein argonaute-1-like0.193
hnf1bbHNF1 homeobox Bb0.183
lmo4aLIM domain only 4a0.177
sox19aSRY-box containing gene 19a0.158
cdh1cadherin 1, epithelial0.156
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.155
pcdh18aprotocadherin 18a0.152
ctnnb1catenin (cadherin-associated protein), beta 10.151
scn8aasodium channel, voltage-gated, type VIII, alpha a0.150
tbpl2TATA box binding protein like 20.145
hlxb9lbhomeo box HB9 like b0.143
spry4sprouty (Drosophila) homolog 40.140
ptger2aprostaglandin E receptor 2a (subtype EP2)0.136
bnc2basonuclin 20.136
mmp2matrix metalloproteinase 20.135
pcdh8protocadherin 80.132
sox19bSRY-box containing gene 19b0.131
msnamoesin a0.125
nrg1neuregulin 10.122
rargaretinoic acid receptor gamma a0.120
eif2c4eukaryotic translation initiation factor 2C, 40.119
tbpTATA box binding protein0.118
mapk12mitogen-activated protein kinase 120.117
igf2ainsulin-like growth factor 2a0.111
foxj1bforkhead box J1b0.108
id1inhibitor of DNA binding 10.106
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.101
bnc1basonuclin 10.101
edn1endothelin 10.100
igfbp6binsulin-like growth factor binding protein 6b0.098
zmat2zinc finger, matrin type 20.096
wnt11rwingless-type MMTV integration site family, member 11, related0.095
evx1even-skipped homeobox 10.094
mapk3mitogen-activated protein kinase 30.090
wnt3awingless-type MMTV integration site family, member 3A0.090
lhx1aLIM homeobox 1a0.089
gli1GLI-Kruppel family member 10.089
mapk7mitogen-activated protein kinase 70.088
cdh2cadherin 2, neuronal0.087
alcamaactivated leukocyte cell adhesion molecule a0.086
ccm2cerebral cavernous malformation 20.086
axin1axin 10.085
igfbp6ainsulin-like growth factor binding protein 6a0.084
cx43connexin 430.083
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.082
pitx2paired-like homeodomain transcription factor 20.082
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.080
eya1eyes absent homolog 10.080
nrarpanotch-regulated ankyrin repeat protein a0.080
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.079
hmgb3ahigh-mobility group box 3a0.079
pitx1paired-like homeodomain transcription factor 10.078
gata2aGATA-binding protein 2a0.077
laptm4alysosomal-associated protein transmembrane 4 alpha0.077
arrb2barrestin, beta 2b0.076
inka1ainduced in neural crest by AP2, 1a0.076
restRE1-silencing transcription factor0.076
tgfb1atransforming growth factor, beta 1a0.075
tgfb3transforming growth factor, beta 30.074
sdc2syndecan 20.074
tmem2transmembrane protein 20.074
smtnlsmoothelin, like0.073
dzip1DAZ interacting protein 10.072
id3inhibitor of DNA binding 30.072
tnnt2atroponin T2a, cardiac0.071
ptprkprotein tyrosine phosphatase, receptor type, K0.071
cdc42cell division cycle 420.071
fgfrl1afibroblast growth factor receptor-like 1a0.071
fanclFanconi anemia, complementation group L0.071
itgavintegrin, alpha V0.071
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Notch1Notch gene homolog 1 (Drosophila)0.978
Dll1delta-like 1 (Drosophila)0.887
Psen1presenilin 10.592
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.502
Ctnnb1catenin (cadherin associated protein), beta 10.463
Fgfr2fibroblast growth factor receptor 20.420
Foxc1forkhead box C10.404
Shhsonic hedgehog0.387
Ptpn11protein tyrosine phosphatase, non-receptor type 110.369
Jag1jagged 10.288
Chd7chromodomain helicase DNA binding protein 70.261
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.232
Isl1ISL1 transcription factor, LIM/homeodomain0.199
Smad4MAD homolog 4 (Drosophila)0.180
Fgfr1fibroblast growth factor receptor 10.164
Bmp4bone morphogenetic protein 40.150
Fgf8fibroblast growth factor 80.106
Foxh1forkhead box H10.102
Sox2SRY-box containing gene 20.092
Foxp3forkhead box P30.088
Nr3c1nuclear receptor subfamily 3, group C, member 10.083
Notch2Notch gene homolog 2 (Drosophila)0.083
Pax3paired box gene 30.083
Pitx2paired-like homeodomain transcription factor 20.080
Stat5bsignal transducer and activator of transcription 5B0.077
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.077
Hoxd13homeobox D130.075
Smad1MAD homolog 1 (Drosophila)0.074
Otx2orthodenticle homolog 2 (Drosophila)0.073
Apcadenomatosis polyposis coli0.071
Cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.070
Tcfap2atranscription factor AP-2, alpha0.069
Smad3MAD homolog 3 (Drosophila)0.065
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.061
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.059
Alx4aristaless-like homeobox 40.058
Bmp7bone morphogenetic protein 70.057
Msx2homeobox, msh-like 20.054
Dll4delta-like 4 (Drosophila)0.053
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.052
Ptenphosphatase and tensin homolog0.051
Rargretinoic acid receptor, gamma0.047
Gli3GLI-Kruppel family member GLI30.044
Acvr1activin A receptor, type 10.042
Stat5asignal transducer and activator of transcription 5A0.041
Tgfb2transforming growth factor, beta 20.040
Hand2heart and neural crest derivatives expressed transcript 20.039
Nos3nitric oxide synthase 3, endothelial cell0.038
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.037
Vangl2vang-like 2 (van gogh, Drosophila)0.036
Trp53transformation related protein 530.036
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.035
Sox9SRY-box containing gene 90.034
Tgfbr2transforming growth factor, beta receptor II0.034
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.034
Nrg1neuregulin 10.033
Hnrpdlheterogeneous nuclear ribonucleoprotein D-like0.033
Adam17a disintegrin and metallopeptidase domain 170.032
Retret proto-oncogene0.032
Ntf3neurotrophin 30.031
Hand1heart and neural crest derivatives expressed transcript 10.030
Map3k7mitogen-activated protein kinase kinase kinase 70.029
Jag2jagged 20.029
Phox2apaired-like homeobox 2a0.028
Tbx1T-box 10.028
Bcl2B-cell leukemia/lymphoma 20.027
Rb1retinoblastoma 10.026
CrebbpCREB binding protein0.025
Hoxa1homeobox A10.025
Itgb1integrin beta 1 (fibronectin receptor beta)0.024
Vegfavascular endothelial growth factor A0.024
Gata3GATA binding protein 30.023
Zic3zinc finger protein of the cerebellum 30.023
Eya1eyes absent 1 homolog (Drosophila)0.022
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.022
Hes1hairy and enhancer of split 1 (Drosophila)0.022
Snai1snail homolog 1 (Drosophila)0.022
Ptch1patched homolog 10.021
Ptgs2prostaglandin-endoperoxide synthase 20.021
Axin1axin 10.019
Hif1ahypoxia inducible factor 1, alpha subunit0.019
Lama5laminin, alpha 50.019
Meox2mesenchyme homeobox 20.018
Hey2hairy/enhancer-of-split related with YRPW motif 20.018
Pax6paired box gene 60.017
Efnb2ephrin B20.016
Il4rainterleukin 4 receptor, alpha0.016
Ece1endothelin converting enzyme 10.016
Hnrnpa1heterogeneous nuclear ribonucleoprotein A10.016
Hmgb1high mobility group box 10.016
Cpeb3cytoplasmic polyadenylation element binding protein 30.016
Tln1talin 10.015
Fgf15fibroblast growth factor 150.015
Foxn1forkhead box N10.015
Tgfbr3transforming growth factor, beta receptor III0.014
Tbx10T-box 100.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism