The network for 'muscle organ development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

muscle organ development

The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.

NameDescriptionProbabilityFunc Analog Organism
MhcMyosin heavy chain0.991
howheld out wings0.986
snssticks and stones0.966
Rac1CG2248 gene product from transcript CG2248-RA0.962
cicubitus interruptus0.961
DadDaughters against dpp0.959
emcextra macrochaetae0.958
MadMothers against dpp0.954
Rho1CG8416 gene product from transcript CG8416-RB0.944
LanALaminin A0.934
Mef2Myocyte enhancer factor 20.924
Fmr1CG6203 gene product from transcript CG6203-RC0.924
EcREcdysone receptor0.921
SmD3Small ribonucleoprotein particle protein SmD30.882
S6kRPS6-p70-protein kinase0.877
eyaeyes absent0.846
LanB2Laminin B20.836
EgfrEpidermal growth factor receptor0.804
mbcmyoblast city0.777
shotshort stop0.767
gbbglass bottom boat0.616
Akt1CG4006 gene product from transcript CG4006-RA0.582
Rac2CG8556 gene product from transcript CG8556-RA0.578
bibbig brain0.567
HLH54FCG5005 gene product from transcript CG5005-RA0.554
Pi3K92ECG4141 gene product from transcript CG4141-RB0.547
wupAwings up A0.543
BicDBicaudal D0.523
gcmglial cells missing0.500
CG12424CG12424 gene product from transcript CG12424-RC0.486
Adf1Adh transcription factor 10.481
LanB1CG7123 gene product from transcript CG7123-RA0.477
Gyc76CGuanylyl cyclase at 76C0.473
rolsrolling pebbles0.459
Tsc1CG6147 gene product from transcript CG6147-RA0.441
emsempty spiracles0.427
CtBPC-terminal Binding Protein0.424
Mi-2CG8103 gene product from transcript CG8103-RA0.413
stcksteamer duck0.412
srpk79Dserine-arginine protein kinase at 79D0.403
S6kIIRPS6-protein kinase-II0.391
Zasp52Z band alternatively spliced PDZ-motif protein 520.390
PoxnPox neuro0.387
vvlventral veins lacking0.347
stumpsCG31317 gene product from transcript CG31317-RC0.344
Tm2Tropomyosin 20.331
JraJun-related antigen0.325
CG18292CG18292 gene product from transcript CG18292-RA0.322
Ras85DRas oncogene at 85D0.313
sosine oculis0.310
norpAno receptor potential A0.304
CaMKIICalcium/calmodulin-dependent protein kinase II0.298
Six4CG3871 gene product from transcript CG3871-RA0.298
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-27Protein UNC-270.842
act-4Protein ACT-40.718
epi-1Protein EPI-10.701
pha-4Protein PHA-40.630
unc-73Protein UNC-730.562
lev-11Protein LEV-110.533
egl-15Protein EGL-150.516
hlh-1Protein HLH-10.510
myo-1Protein MYO-10.492
zip-7Protein ZIP-70.422
myo-3Protein MYO-30.395
unc-112Protein UNC-1120.354
unc-54Protein UNC-540.345
unc-15Protein UNC-150.345
T21B6.3Protein T21B6.30.336
unc-42Protein UNC-420.311
lin-29Protein LIN-290.308
egl-36Protein EGL-360.240
pqn-62Protein PQN-620.230
irx-1Protein IRX-10.230
K03E5.2Protein K03E5.20.169
unc-79Protein UNC-790.167
C53C9.2Protein C53C9.20.163
ceh-18Protein CEH-180.158
egl-13Protein EGL-130.150
pat-10Protein PAT-100.147
bar-1Protein BAR-10.144
elt-6Protein ELT-60.144
unc-68Protein UNC-680.142
tnt-2Protein TNT-20.139
lam-2Protein LAM-20.125
egl-23Protein EGL-230.123
let-268Protein LET-2680.123
unc-52Protein UNC-520.123
syg-2Protein SYG-20.122
gei-18Protein GEI-180.121
sem-5Protein SEM-50.118
fkh-2Protein FKH-20.114
pde-4Protein PDE-40.108
let-23Protein LET-230.108
eya-1Protein EYA-10.107
cpna-1Protein CPNA-10.106
unc-98Protein UNC-980.102
F44B9.2Protein F44B9.20.101
lin-11Protein LIN-110.097
mml-1Protein MML-10.096
inx-13Protein INX-130.095
emb-9Protein EMB-90.094
mig-2Protein MIG-20.092
twk-18Protein TWK-180.089
mat-3Protein MAT-30.088
eat-16Protein EAT-160.083
glt-1Protein GLT-10.082
ifa-1Protein IFA-10.082
fox-1Protein FOX-10.080
egl-26Protein EGL-260.079
act-2Protein ACT-20.079
insc-1Protein INSC-10.078
unc-87Protein UNC-870.077
lsy-2Protein LSY-20.077
let-756Protein LET-7560.076
exp-2Protein EXP-20.075
CELE_B0513.5Protein B0513.50.074
daf-11Protein DAF-110.073
pat-2Protein PAT-20.071
T25F10.6Protein T25F10.60.070
attf-2Protein ATTF-20.068
R90.1Protein R90.10.067
lec-2Protein LEC-20.065
pcca-1Protein PCCA-10.064
K09A9.6Protein K09A9.60.063
egl-30Protein EGL-300.062
sma-6Protein SMA-60.062
mep-1Protein MEP-10.061
his-24Protein HIS-240.061
mnp-1Protein MNP-10.060
tbb-4Protein TBB-40.059
olrn-1Protein OLRN-10.058
CELE_C08B6.4Protein C08B6.40.057
pat-3Protein PAT-30.057
rol-3Protein ROL-30.057
bre-1Protein BRE-10.056
csq-1Protein CSQ-10.055
T09B4.5Protein T09B4.50.054
arrd-22Protein ARRD-220.054
ppfr-2Protein PPFR-20.054
nhr-67Protein NHR-670.052
sel-7Protein SEL-70.052
tbb-2Protein TBB-20.052
unc-43Protein UNC-430.052
egl-44Protein EGL-440.052
lin-12Protein LIN-120.051
pop-1Protein POP-10.050
ajm-1Protein AJM-10.050
F21C10.7Protein F21C10.70.050
pac-1Protein PAC-10.050
act-1Protein ACT-10.049
soc-2Protein SOC-20.047
cfim-2Protein CFIM-20.046
ain-1Protein AIN-10.045
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
myod1myogenic differentiation 10.995
aldh1a2aldehyde dehydrogenase 1 family, member A20.994
unc45bunc-45 homolog B (C. elegans)0.988
smyd1bSET and MYND domain containing 1b0.962
gli1GLI-Kruppel family member 10.940
myf5myogenic factor 50.935
smyhc1slow myosin heavy chain 10.895
tnnc1btroponin C type 1b (slow)0.892
lef1lymphocyte enhancer binding factor 10.878
actn3aactinin alpha 3a0.868
actn2actinin, alpha 20.867
wnt5bwingless-type MMTV integration site family, member 5b0.849
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.835
ttnatitin a0.828
hsp90a.1heat shock protein 90-alpha 10.784
mef2camyocyte enhancer factor 2ca0.779
lamc1laminin, gamma 10.760
alcamaactivated leukocyte cell adhesion molecule a0.743
pdlim7PDZ and LIM domain 70.729
myf6myogenic factor 60.726
myhz2myosin, heavy polypeptide 2, fast muscle specific0.721
bmp2bbone morphogenetic protein 2b0.710
smyhc2slow myosin heavy chain 20.698
mbnl2muscleblind-like 2 (Drosophila)0.687
ryr1bryanodine receptor 1b (skeletal)0.674
smosmoothened homolog (Drosophila)0.672
wnt11rwingless-type MMTV integration site family, member 11, related0.668
lama4laminin, alpha 40.662
lamb2laminin, beta 2 (laminin S)0.635
dag1dystroglycan 10.622
ndr2nodal-related 20.620
frem3Fras1 related extracellular matrix 30.610
gbx2gastrulation brain homeo box 20.602
rx3retinal homeobox gene 30.598
gli2aGLI-Kruppel family member GLI2a0.576
tnni1btroponin I, skeletal, slow b0.549
osr1odd-skipped related 1 (Drosophila)0.541
her7hairy and enhancer of split related-70.537
ptch1patched 10.536
fn1fibronectin 10.536
flhfloating head0.514
col2a1acollagen type II, alpha-1a0.512
fstl1bfollistatin-like 1b0.512
hspb1heat shock protein, alpha-crystallin-related, 10.505
tbx1T-box 10.490
tbx2bT-box 2b0.468
prrx1apaired related homeobox 1a0.464
dctdopachrome tautomerase0.455
ret1receptor tyrosine kinase0.443
olfm2olfactomedin 20.439
lhx1aLIM homeobox 1a0.433
sox9bSRY-box containing gene 9b0.432
fabp11afatty acid binding protein 11a0.426
fgfrl1bfibroblast growth factor receptor-like 1b0.423
eng2aengrailed 2a0.417
chst11carbohydrate (chondroitin 4) sulfotransferase 110.410
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.387
ryr1aryanodine receptor 1a (skeletal)0.365
snai1asnail homolog 1a (Drosophila)0.359
sox9aSRY-box containing gene 9a0.343
pcdh8protocadherin 80.338
col1a1acollagen, type I, alpha 1a0.332
gli3GLI-Kruppel family member GLI30.331
stac3SH3 and cysteine rich domain 30.331
flot2aflotillin 2a0.330
hand2heart and neural crest derivatives expressed transcript 20.321
snai1bsnail homolog 1b (Drosophila)0.321
foxc1aforkhead box C1a0.315
ryr3ryanodine receptor 30.315
jhdm1dajumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)0.312
satb2SATB homeobox 20.312
neo1neogenin 10.310
mitfamicrophthalmia-associated transcription factor a0.305
fstafollistatin a0.302
tnni2a.4troponin I, skeletal, fast 2a.40.300
dccdeleted in colorectal carcinoma0.299
pdlim3bPDZ and LIM domain 3b0.299
jam2ajunctional adhesion molecule 2a0.296
kbtbd10bkelch repeat and BTB (POZ) domain containing 10b0.292
gfi1.1growth factor independent 1.10.291
runx2brunt-related transcription factor 2b0.289
acta1aactin, alpha 1a, skeletal muscle0.289
dkk1bdickkopf 1b0.288
s1pr2sphingosine-1-phosphate receptor 20.287
efemp2EGF-containing fibulin-like extracellular matrix protein 20.283
tbx18T-box 180.280
phox2apaired-like homeobox 2a0.279
mespbmesoderm posterior b0.277
mef2cbmyocyte enhancer factor 2cb0.275
jam3bjunctional adhesion molecule 3b0.269
pax3apaired box gene 3a0.269
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.262
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FLNAfilamin A, alpha0.996
EP300E1A binding protein p3000.992
TRIM63tripartite motif containing 630.989
SMAD2SMAD family member 20.982
ESR1estrogen receptor 10.977
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.962
FGFR2fibroblast growth factor receptor 20.957
MYOD1myogenic differentiation 10.951
HIPK2homeodomain interacting protein kinase 20.911
RBBP4retinoblastoma binding protein 40.907
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.905
CREBBPCREB binding protein0.883
FGF1fibroblast growth factor 1 (acidic)0.881
JAG1jagged 10.875
FHL2four and a half LIM domains 20.845
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.842
SRFserum response factor (c-fos serum response element-binding transcription factor)0.837
GSK3Bglycogen synthase kinase 3 beta0.833
NCOR2nuclear receptor corepressor 20.833
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.828
SIN3ASIN3 homolog A, transcription regulator (yeast)0.824
EGFRepidermal growth factor receptor0.816
HDAC2histone deacetylase 20.815
PTRFpolymerase I and transcript release factor0.780
RBPMSRNA binding protein with multiple splicing0.778
SMAD3SMAD family member 30.717
FN1fibronectin 10.696
TNNI1troponin I type 1 (skeletal, slow)0.682
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.678
MYH9myosin, heavy chain 9, non-muscle0.656
EGR1early growth response 10.612
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.610
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.549
NOTCH1notch 10.522
TP53tumor protein p530.497
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.492
QKIquaking homolog, KH domain RNA binding (mouse)0.490
SIRT1sirtuin 10.489
ATF3activating transcription factor 30.475
ITSN1intersectin 1 (SH3 domain protein)0.459
JUNjun proto-oncogene0.417
SMYD1SET and MYND domain containing 10.417
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.414
TPM1tropomyosin 1 (alpha)0.409
TNNC1troponin C type 1 (slow)0.409
EPAS1endothelial PAS domain protein 10.408
CTGFconnective tissue growth factor0.402
ILKintegrin-linked kinase0.401
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.400
ARandrogen receptor0.388
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.385
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.361
MYL9myosin, light chain 9, regulatory0.353
NCOA3nuclear receptor coactivator 30.346
FYNFYN oncogene related to SRC, FGR, YES0.345
GRB2growth factor receptor-bound protein 20.344
CASP8caspase 8, apoptosis-related cysteine peptidase0.332
NCOA1nuclear receptor coactivator 10.319
SMURF2SMAD specific E3 ubiquitin protein ligase 20.311
COL4A1collagen, type IV, alpha 10.309
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.308
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.297
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.296
RB1retinoblastoma 10.290
CKMcreatine kinase, muscle0.267
TBX5T-box 50.254
TRRAPtransformation/transcription domain-associated protein0.248
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.245
IGF2insulin-like growth factor 2 (somatomedin A)0.244
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.234
INADLInaD-like (Drosophila)0.234
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.231
BMP2bone morphogenetic protein 20.230
NCOR1nuclear receptor corepressor 10.226
CAV1caveolin 1, caveolae protein, 22kDa0.223
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.221
JUNBjun B proto-oncogene0.211
PALLDpalladin, cytoskeletal associated protein0.210
TNNT2troponin T type 2 (cardiac)0.209
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.209
COL1A2collagen, type I, alpha 20.207
NR4A2nuclear receptor subfamily 4, group A, member 20.203
TPM2tropomyosin 2 (beta)0.201
RARAretinoic acid receptor, alpha0.196
YAP1Yes-associated protein 10.196
GATA4GATA binding protein 40.194
FGF2fibroblast growth factor 2 (basic)0.192
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.191
ERBB2IPerbb2 interacting protein0.188
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.185
SHC1SHC (Src homology 2 domain containing) transforming protein 10.182
IKIK cytokine, down-regulator of HLA II0.170
TCF4transcription factor 40.165
MYOGmyogenin (myogenic factor 4)0.164
NR4A3nuclear receptor subfamily 4, group A, member 30.163
NCK1NCK adaptor protein 10.162
TGFB2transforming growth factor, beta 20.162
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col3a1collagen, type III, alpha 10.182
Col1a1collagen, type I, alpha 10.177
Actc1actin, alpha, cardiac muscle 10.160
Nfibnuclear factor I/B0.153
Fgfr2fibroblast growth factor receptor 20.149
Myh7myosin, heavy chain 7, cardiac muscle, beta0.102
Egr1early growth response 10.100
Col15a1collagen, type XV, alpha 10.097
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.091
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.087
Acta2smooth muscle alpha-actin0.086
Tnni2troponin I type 2 (skeletal, fast)0.084
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.081
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.075
Col1a2collagen, type I, alpha 20.072
Csrp3cysteine and glycine-rich protein 30.068
Anxa5annexin A50.062
S100a9S100 calcium binding protein A90.061
Tgfbr2transforming growth factor, beta receptor II0.060
Olfml2bolfactomedin-like 2B0.059
Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.059
H2afzH2A histone family, member Z0.058
Psgb1pregnancy-specific beta 1-glycoprotein0.056
Chrngcholinergic receptor, nicotinic, gamma0.055
Fgf5fibroblast growth factor 50.055
S100a6S100 calcium binding protein A60.054
Cd63Cd63 molecule0.054
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.054
Loxl1lysyl oxidase-like 10.054
Col12a1collagen, type XII, alpha 10.050
Fgf7fibroblast growth factor 70.050
Tnni1troponin I type 1 (skeletal, slow)0.049
Dccdeleted in colorectal carcinoma0.049
Hspb2heat shock protein beta 20.047
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.046
Col4a2collagen, type IV, alpha 20.046
Ptafrplatelet-activating factor receptor0.046
Myf6myogenic factor 60.045
Egr2early growth response 20.044
Tnni3troponin I type 3 (cardiac)0.043
Casq2calsequestrin 2 (cardiac muscle)0.042
Mfap4microfibrillar-associated protein 40.042
Hand2heart and neural crest derivatives expressed 20.042
Adora2aadenosine A2a receptor0.041
S100a8S100 calcium binding protein A80.041
Ckmcreatine kinase, muscle0.040
Dchs1dachsous 1 (Drosophila)0.039
Ednraendothelin receptor type A0.039
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.039
Bmp6bone morphogenetic protein 60.039
Mapk4mitogen-activated protein kinase 40.038
Sod3superoxide dismutase 3, extracellular0.038
Igfbp5insulin-like growth factor binding protein 50.038
Pgam2phosphoglycerate mutase 2 (muscle)0.038
Zfp382zinc finger protein 3820.037
Pcnaproliferating cell nuclear antigen0.037
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.037
Cav1caveolin 1, caveolae protein0.037
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.037
Myh9myosin, heavy chain 9, non-muscle0.037
Scn5asodium channel, voltage-gated, type V, alpha subunit0.037
JunJun oncogene0.036
Syt9synaptotagmin IX0.036
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.036
FosFBJ osteosarcoma oncogene0.036
Klf4Kruppel-like factor 4 (gut)0.036
F2rl1coagulation factor II (thrombin) receptor-like 10.036
Robo1roundabout homolog 1 (Drosophila)0.034
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.034
Ap2s1adaptor-related protein complex 2, sigma 1 subunit0.034
Nos3nitric oxide synthase 3, endothelial cell0.034
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.033
Mmp2matrix metallopeptidase 20.033
Homer3homer homolog 3 (Drosophila)0.033
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.033
Klf6Kruppel-like factor 60.033
Lig3ligase III, DNA, ATP-dependent0.033
Col6a2collagen, type VI, alpha 20.032
Klk1lkallikrein 1-like peptidase0.032
Tcfe2atranscription factor E2a0.032
Flt1FMS-related tyrosine kinase 10.032
Efnb1ephrin B10.032
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.032
Accn2amiloride-sensitive cation channel 2, neuronal0.032
Plekhg2pleckstrin homology domain containing, family G (with RhoGef domain) member 20.032
Ncr1natural cytotoxicity triggering receptor 10.031
Col5a1collagen, type V, alpha 10.031
Grm5glutamate receptor, metabotropic 50.031
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.031
Pou6f1POU class 6 homeobox 10.031
Atp7bATPase, Cu++ transporting, beta polypeptide0.031
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.031
Insrinsulin receptor0.030
Xcl1chemokine (C motif) ligand 10.030
Nr4a3nuclear receptor subfamily 4, group A, member 30.030
Zfp706zinc finger protein 7060.030
Prrx1paired related homeobox 10.030
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism