The network for 'skeletal muscle tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skeletal muscle tissue development

The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.

NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.857
snssticks and stones0.565
EcREcdysone receptor0.421
EgfrEpidermal growth factor receptor0.269
stumpsCG31317 gene product from transcript CG31317-RC0.234
BicDBicaudal D0.226
Akt1CG4006 gene product from transcript CG4006-RA0.220
Rya-r44FRyanodine receptor 44F0.215
InRInsulin-like receptor0.193
S6kRPS6-p70-protein kinase0.177
nabCG33545 gene product from transcript CG33545-RC0.160
MadMothers against dpp0.118
lbeladybird early0.109
rolsrolling pebbles0.108
stcksteamer duck0.103
Eip75BEcdysone-induced protein 75B0.096
eveeven skipped0.094
HGTXCG13475 gene product from transcript CG13475-RB0.091
ImpIGF-II mRNA-binding protein0.088
LanB1CG7123 gene product from transcript CG7123-RA0.081
Mlc2Myosin light chain 20.079
RicRas which interacts with Calmodulin0.079
DlicDynein light intermediate chain0.068
G-oalpha47AG protein oalpha 47A0.063
Pp2B-14DProtein phosphatase 2B at 14D0.061
Pi3K92ECG4141 gene product from transcript CG4141-RB0.059
norpAno receptor potential A0.056
wbwing blister0.055
Fas2Fasciclin 20.050
Vrp1Verprolin 10.050
pdm2POU domain protein 20.049
LanB2Laminin B20.047
MhcMyosin heavy chain0.044
ash2absent, small, or homeotic discs 20.041
Tm2Tropomyosin 20.039
Cg25CCollagen type IV0.037
GripGlutamate receptor binding protein0.036
Pkc98EProtein C kinase 98E0.036
Act87EActin 87E0.036
slmbsupernumerary limbs0.036
raspCG11495 gene product from transcript CG11495-RA0.035
CG7145CG7145 gene product from transcript CG7145-RD0.033
Arp66BActin-related protein 66B0.031
RhebCG1081 gene product from transcript CG1081-RA0.031
jebjelly belly0.030
CG9007CG9007 gene product from transcript CG9007-RA0.030
Mef2Myocyte enhancer factor 20.029
foxoforkhead box, sub-group O0.029
tomosynCG17762 gene product from transcript CG17762-RB0.029
Actnalpha actinin0.027
pigspickled eggs0.027
dcodiscs overgrown0.026
lblladybird late0.026
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
actn3aactinin alpha 3a0.997
myod1myogenic differentiation 10.993
unc45bunc-45 homolog B (C. elegans)0.951
smyd1bSET and MYND domain containing 1b0.928
lama2laminin, alpha 20.925
dag1dystroglycan 10.924
tnni1altroponin I, skeletal, slow like0.844
myhz2myosin, heavy polypeptide 2, fast muscle specific0.837
actn2actinin, alpha 20.832
smyhc2slow myosin heavy chain 20.794
smyhc1slow myosin heavy chain 10.757
prdm16PR domain containing 160.743
atp1a2aATPase, Na+/K+ transporting, alpha 2a polypeptide0.710
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.691
lamb2laminin, beta 2 (laminin S)0.686
jhdm1dajumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)0.678
foxd3forkhead box D30.648
s1pr2sphingosine-1-phosphate receptor 20.630
gli1GLI-Kruppel family member 10.630
mbnl2muscleblind-like 2 (Drosophila)0.625
pdlim7PDZ and LIM domain 70.618
smyd1aSET and MYND domain containing 1a0.610
lama4laminin, alpha 40.605
myf5myogenic factor 50.559
phox2apaired-like homeobox 2a0.553
ndr2nodal-related 20.542
lbx2ladybird homeobox homolog 2 (Drosophila)0.524
myf6myogenic factor 60.512
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.504
bocbrother of CDO0.502
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.501
chsy1chondroitin sulfate synthase 10.495
lama5laminin, alpha 50.485
apobec2aapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a0.482
rargaretinoic acid receptor gamma a0.465
ryr1aryanodine receptor 1a (skeletal)0.465
rx3retinal homeobox gene 30.445
gdf6bgrowth differentiation factor 6b0.422
junjun proto-oncogene0.420
disp1dispatched homolog 1 (Drosophila)0.419
ret1receptor tyrosine kinase0.414
efnb2aephrin B2a0.410
tp73tumor protein p730.410
gli3GLI-Kruppel family member GLI30.409
tnnc1btroponin C type 1b (slow)0.406
tnni2a.4troponin I, skeletal, fast 2a.40.397
tbx1T-box 10.387
sox9aSRY-box containing gene 9a0.369
ryr1bryanodine receptor 1b (skeletal)0.368
tbx24T-box 240.361
mef2dmyocyte enhancer factor 2d0.353
hspg2heparan sulfate proteoglycan 20.331
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.318
hoxa9ahomeo box A9a0.317
jam3bjunctional adhesion molecule 3b0.315
mef2camyocyte enhancer factor 2ca0.314
prdm1aPR domain containing 1a, with ZNF domain0.299
ambra1autophagy/beclin-1 regulator 10.288
barx1BarH-like homeobox 10.287
mylz2myosin, light polypeptide 2, skeletal muscle0.285
bmp2bbone morphogenetic protein 2b0.271
actn1actinin, alpha 10.268
brd4bromodomain containing 40.262
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.258
xirp1xin actin-binding repeat containing 10.257
admpanti-dorsalizing morphogenic protein0.257
plagl2pleiomorphic adenoma gene-like 20.253
scxascleraxis homolog A (mouse)0.253
foxi1forkhead box I10.250
gpr126G protein-coupled receptor 1260.246
chrna6cholinergic receptor, nicotinic, alpha 60.246
gbx2gastrulation brain homeo box 20.236
chrndcholinergic receptor, nicotinic, delta polypeptide0.229
dlx5adistal-less homeobox gene 5a0.228
dmrt2adoublesex and mab-3 related transcription factor 2a0.225
tead3aTEA domain family member 3 a0.222
pcdh10bprotocadherin 10b0.220
ptch2patched 20.219
efnb3bephrin B3b0.217
vgll2bvestigial like 2b0.215
xirp2axin actin-binding repeat containing 2a0.211
dkk1bdickkopf 1b0.208
pdlim3bPDZ and LIM domain 3b0.206
cdh2cadherin 2, neuronal0.206
olig1oligodendrocyte lineage transcription factor 10.204
pax9paired box gene 90.201
pax8paired box gene 80.200
csnk1a1casein kinase 1, alpha 10.199
smosmoothened homolog (Drosophila)0.194
popdc2popeye domain containing 20.193
eya1eyes absent homolog 10.188
mmp15bmatrix metallopeptidase 15b0.188
hsp90a.1heat shock protein 90-alpha 10.186
thtyrosine hydroxylase0.183
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SRFserum response factor (c-fos serum response element-binding transcription factor)0.752
ESR1estrogen receptor 10.578
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.577
FHL2four and a half LIM domains 20.575
JAG1jagged 10.502
JUNjun proto-oncogene0.460
FLNAfilamin A, alpha0.414
HDAC4histone deacetylase 40.246
EGFRepidermal growth factor receptor0.212
CAV1caveolin 1, caveolae protein, 22kDa0.200
IGF2insulin-like growth factor 2 (somatomedin A)0.192
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.161
ARandrogen receptor0.158
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.154
SMAD3SMAD family member 30.153
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.150
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.148
FN1fibronectin 10.131
MEF2Cmyocyte enhancer factor 2C0.128
RBPMSRNA binding protein with multiple splicing0.127
FBLN1fibulin 10.127
POU5F1POU class 5 homeobox 10.121
PAX3paired box 30.117
SMAD2SMAD family member 20.112
NCOR2nuclear receptor corepressor 20.101
APPamyloid beta (A4) precursor protein0.099
SIN3ASIN3 homolog A, transcription regulator (yeast)0.099
NOTCH1notch 10.087
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.084
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.068
ATF3activating transcription factor 30.068
MYOD1myogenic differentiation 10.067
EP300E1A binding protein p3000.060
SPTBN1spectrin, beta, non-erythrocytic 10.058
JUNBjun B proto-oncogene0.058
BCL6B-cell CLL/lymphoma 60.053
FSTL1follistatin-like 10.051
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.049
TCF4transcription factor 40.048
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.048
MEF2Amyocyte enhancer factor 2A0.046
GSK3Bglycogen synthase kinase 3 beta0.045
BMPR1Abone morphogenetic protein receptor, type IA0.045
TRIM63tripartite motif containing 630.043
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.041
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.040
DBPD site of albumin promoter (albumin D-box) binding protein0.040
SP1Sp1 transcription factor0.039
PARVAparvin, alpha0.038
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.038
FOSFBJ murine osteosarcoma viral oncogene homolog0.038
EGR3early growth response 30.038
TNNI1troponin I type 1 (skeletal, slow)0.036
NOTCH3notch 30.036
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.036
SIRT1sirtuin 10.036
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.035
COL6A1collagen, type VI, alpha 10.035
LOXlysyl oxidase0.035
NFIL3nuclear factor, interleukin 3 regulated0.035
CASP8caspase 8, apoptosis-related cysteine peptidase0.035
NR4A2nuclear receptor subfamily 4, group A, member 20.034
EGR1early growth response 10.034
NR4A3nuclear receptor subfamily 4, group A, member 30.034
FYNFYN oncogene related to SRC, FGR, YES0.033
BCL2L1BCL2-like 10.032
ACTA2actin, alpha 2, smooth muscle, aorta0.032
MAPTmicrotubule-associated protein tau0.032
SMURF2SMAD specific E3 ubiquitin protein ligase 20.032
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.032
COL1A1collagen, type I, alpha 10.032
FBN1fibrillin 10.032
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.031
CREBBPCREB binding protein0.031
PTENphosphatase and tensin homolog0.030
LAMB1laminin, beta 10.030
JUNDjun D proto-oncogene0.029
ESR2estrogen receptor 2 (ER beta)0.029
SMAD4SMAD family member 40.028
RB1retinoblastoma 10.028
EGR2early growth response 20.028
SMAD9SMAD family member 90.028
FADDFas (TNFRSF6)-associated via death domain0.028
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.028
PSEN1presenilin 10.028
MDM2Mdm2 p53 binding protein homolog (mouse)0.027
NCOA3nuclear receptor coactivator 30.024
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.024
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.024
LRP6low density lipoprotein receptor-related protein 60.024
INO80BINO80 complex subunit B0.024
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.023
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.023
COL4A6collagen, type IV, alpha 60.023
DTNAdystrobrevin, alpha0.022
DUSP1dual specificity phosphatase 10.022
TESK1testis-specific kinase 10.021
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Egr2early growth response 20.285
Egr1early growth response 10.268
Tnni2troponin I type 2 (skeletal, fast)0.222
Myl1myosin, light chain 10.193
Vipr2vasoactive intestinal peptide receptor 20.191
Actc1actin, alpha, cardiac muscle 10.179
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.136
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.131
Tgfbr2transforming growth factor, beta receptor II0.124
FosFBJ osteosarcoma oncogene0.116
Tnni1troponin I type 1 (skeletal, slow)0.105
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.100
Fgfr2fibroblast growth factor receptor 20.098
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.097
Dusp6dual specificity phosphatase 60.097
Mybphmyosin binding protein H0.097
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.096
Purbpurine rich element binding protein B0.091
S100a8S100 calcium binding protein A80.091
Runx1runt-related transcription factor 10.088
S100a9S100 calcium binding protein A90.084
Nr4a2nuclear receptor subfamily 4, group A, member 20.076
Nos3nitric oxide synthase 3, endothelial cell0.072
Fgf7fibroblast growth factor 70.071
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.069
JunJun oncogene0.066
Flt1FMS-related tyrosine kinase 10.061
Ednraendothelin receptor type A0.061
Prrx1paired related homeobox 10.060
Nos2nitric oxide synthase 2, inducible0.058
Myh7myosin, heavy chain 7, cardiac muscle, beta0.054
Col3a1collagen, type III, alpha 10.053
Casq2calsequestrin 2 (cardiac muscle)0.053
Adam10ADAM metallopeptidase domain 100.051
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.050
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.050
Edn1endothelin 10.049
Clic4chloride intracellular channel 40.049
Irs1insulin receptor substrate 10.048
Pecam1platelet/endothelial cell adhesion molecule 10.048
Mybpc2myosin binding protein C, fast-type0.048
Lig3ligase III, DNA, ATP-dependent0.048
Hand2heart and neural crest derivatives expressed 20.047
Junbjun B proto-oncogene0.047
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.047
Acacbacetyl-Coenzyme A carboxylase beta0.047
GperG protein-coupled estrogen receptor 10.046
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.046
Smad6SMAD family member 60.046
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.045
Neurl2neuralized homolog 2 (Drosophila)0.044
Myh8myosin, heavy chain 8, skeletal muscle, perinatal0.044
Tnnc2troponin C type 2 (fast)0.042
Miamelanoma inhibitory activity0.040
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.040
Sirpasignal-regulatory protein alpha0.040
Csrp3cysteine and glycine-rich protein 30.039
Tnnt3troponin T type 3 (skeletal, fast)0.039
Hbegfheparin-binding EGF-like growth factor0.039
Pla1aphospholipase A1 member A0.038
Il1binterleukin 1 beta0.038
Cd4Cd4 molecule0.038
Nr4a3nuclear receptor subfamily 4, group A, member 30.036
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.036
Fxyd1FXYD domain-containing ion transport regulator 10.035
Nr2f2nuclear receptor subfamily 2, group F, member 20.035
Myo9amyosin IXA0.035
Cmklr1chemokine-like receptor 10.034
Agtr1aangiotensin II receptor, type 1a0.034
Epn2epsin 20.033
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.033
Strnstriatin, calmodulin binding protein0.033
Dchs1dachsous 1 (Drosophila)0.033
Pate4prostate and testis expressed 40.033
Smpxsmall muscle protein, X-linked0.032
Itpr2inositol 1,4,5-triphosphate receptor, type 20.032
Myh2myosin, heavy chain 2, skeletal muscle, adult0.032
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.032
Ckmcreatine kinase, muscle0.032
Lrp1low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)0.031
Insrinsulin receptor0.031
Mapk3mitogen activated protein kinase 30.031
Zfp382zinc finger protein 3820.031
Dpysl3dihydropyrimidinase-like 30.031
Kremen1kringle containing transmembrane protein 10.031
Mbpmyelin basic protein0.030
Anxa2annexin A20.030
Pcsk5proprotein convertase subtilisin/kexin type 50.030
Prg2proteoglycan 2, bone marrow0.030
Cacng1calcium channel, voltage-dependent, gamma subunit 10.029
Ahraryl hydrocarbon receptor0.029
Chrngcholinergic receptor, nicotinic, gamma0.029
Mylk2myosin light chain kinase 20.029
Col4a2collagen, type IV, alpha 20.028
Cav3caveolin 30.028
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism