IMP: Integrative Multi-species Prediction

The network for 'skeletal muscle tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skeletal muscle tissue development

The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.

Drosophila melanogaster

Name	Description	Probability
ci	cubitus interruptus	0.857
sns	sticks and stones	0.565
pan	pangolin	0.464
EcR	Ecdysone receptor	0.421
hth	homothorax	0.319
Egfr	Epidermal growth factor receptor	0.269
stumps	CG31317 gene product from transcript CG31317-RC	0.234
CadN	Cadherin-N	0.227
BicD	Bicaudal D	0.226
Akt1	CG4006 gene product from transcript CG4006-RA	0.220
Rya-r44F	Ryanodine receptor 44F	0.215
InR	Insulin-like receptor	0.193
Antp	Antennapedia	0.187
mys	myospheroid	0.182
wg	wingless	0.182
S6k	RPS6-p70-protein kinase	0.177
Gug	Grunge	0.163
nab	CG33545 gene product from transcript CG33545-RC	0.160
slou	slouch	0.149
shn	schnurri	0.145
Moe	Moesin	0.137
htl	heartless	0.122
Mad	Mothers against dpp	0.118
lbe	ladybird early	0.109
rols	rolling pebbles	0.108
up	upheld	0.105
stck	steamer duck	0.103
hbs	hibris	0.103
gsb	gooseberry	0.099
en	engrailed	0.098
Eip75B	Ecdysone-induced protein 75B	0.096
eve	even skipped	0.094
vg	vestigial	0.091
HGTX	CG13475 gene product from transcript CG13475-RB	0.091
Imp	IGF-II mRNA-binding protein	0.088
ex	expanded	0.084
LanB1	CG7123 gene product from transcript CG7123-RA	0.081
Mlc2	Myosin light chain 2	0.079
Ric	Ras which interacts with Calmodulin	0.079
trx	trithorax	0.076
smo	smoothened	0.076
kis	kismet	0.072
nau	nautilus	0.069
Dlic	Dynein light intermediate chain	0.068
prd	paired	0.067
egh	egghead	0.066
G-oalpha47A	G protein oalpha 47A	0.063
phyl	phyllopod	0.062
Ppn	Papilin	0.062
Pp2B-14D	Protein phosphatase 2B at 14D	0.061
Pi3K92E	CG4141 gene product from transcript CG4141-RB	0.059
norpA	no receptor potential A	0.056
H	Hairless	0.056
wb	wing blister	0.055
Fas2	Fasciclin 2	0.050
mael	maelstrom	0.050
Vrp1	Verprolin 1	0.050
pdm2	POU domain protein 2	0.049
LanB2	Laminin B2	0.047
dnc	dunce	0.045
if	inflated	0.045
Mhc	Myosin heavy chain	0.044
Ubx	Ultrabithorax	0.043
pnt	pointed	0.041
ash2	absent, small, or homeotic discs 2	0.041
slo	slowpoke	0.039
Tm2	Tropomyosin 2	0.039
dome	domeless	0.038
Cg25C	Collagen type IV	0.037
Grip	Glutamate receptor binding protein	0.036
Pkc98E	Protein C kinase 98E	0.036
Act87E	Actin 87E	0.036
slmb	supernumerary limbs	0.036
rasp	CG11495 gene product from transcript CG11495-RA	0.035
Cul-3	Cullin-3	0.035
CG7145	CG7145 gene product from transcript CG7145-RD	0.033
Ser	Serrate	0.033
sd	scalloped	0.032
gro	groucho	0.032
Arp66B	Actin-related protein 66B	0.031
Rheb	CG1081 gene product from transcript CG1081-RA	0.031
jeb	jelly belly	0.030
tsh	teashirt	0.030
kn	knot	0.030
CG9007	CG9007 gene product from transcript CG9007-RA	0.030
Nrg	Neuroglian	0.030
Mef2	Myocyte enhancer factor 2	0.029
foxo	forkhead box, sub-group O	0.029
tomosyn	CG17762 gene product from transcript CG17762-RB	0.029
sr	stripe	0.028
sty	sprouty	0.028
Atx2	Ataxin-2	0.028
simj	simjang	0.027
ap	apterous	0.027
mirr	mirror	0.027
Actn	alpha actinin	0.027
pigs	pickled eggs	0.027
dco	discs overgrown	0.026
inv	invected	0.026
lbl	ladybird late	0.026

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Caenorhabditis elegans

Name	Description	Probability	Func Analog Organism

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Danio rerio

Name	Description	Probability
actn3a	actinin alpha 3a	0.997
myod1	myogenic differentiation 1	0.993
unc45b	unc-45 homolog B (C. elegans)	0.951
smyd1b	SET and MYND domain containing 1b	0.928
dmd	dystrophin	0.927
lama2	laminin, alpha 2	0.925
dag1	dystroglycan 1	0.924
twist1b	twist1b	0.878
myog	myogenin	0.859
tnni1al	troponin I, skeletal, slow like	0.844
myhz2	myosin, heavy polypeptide 2, fast muscle specific	0.837
actn2	actinin, alpha 2	0.832
smyhc2	slow myosin heavy chain 2	0.794
smyhc1	slow myosin heavy chain 1	0.757
prdm16	PR domain containing 16	0.743
atp1a2a	ATPase, Na+/K+ transporting, alpha 2a polypeptide	0.710
erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog	0.691
lamb2	laminin, beta 2 (laminin S)	0.686
jhdm1da	jumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)	0.678
foxd3	forkhead box D3	0.648
s1pr2	sphingosine-1-phosphate receptor 2	0.630
gli1	GLI-Kruppel family member 1	0.630
mbnl2	muscleblind-like 2 (Drosophila)	0.625
pdlim7	PDZ and LIM domain 7	0.618
smyd1a	SET and MYND domain containing 1a	0.610
lama4	laminin, alpha 4	0.605
myf5	myogenic factor 5	0.559
phox2a	paired-like homeobox 2a	0.553
ndr2	nodal-related 2	0.542
lbx2	ladybird homeobox homolog 2 (Drosophila)	0.524
myf6	myogenic factor 6	0.512
slc12a2	solute carrier family 12 (potassium/chloride transporters), member 2	0.504
boc	brother of CDO	0.502
chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1	0.501
chsy1	chondroitin sulfate synthase 1	0.495
chd	chordin	0.487
lama5	laminin, alpha 5	0.485
apobec2a	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a	0.482
rarga	retinoic acid receptor gamma a	0.465
ryr1a	ryanodine receptor 1a (skeletal)	0.465
rx3	retinal homeobox gene 3	0.445
twist3	twist3	0.434
gdf6b	growth differentiation factor 6b	0.422
jun	jun proto-oncogene	0.420
disp1	dispatched homolog 1 (Drosophila)	0.419
ret1	receptor tyrosine kinase	0.414
efnb2a	ephrin B2a	0.410
tp73	tumor protein p73	0.410
gli3	GLI-Kruppel family member GLI3	0.409
wu:fv91b12	wu:fv91b12	0.408
tnnc1b	troponin C type 1b (slow)	0.406
tnni2a.4	troponin I, skeletal, fast 2a.4	0.397
tbx1	T-box 1	0.387
sox9a	SRY-box containing gene 9a	0.369
ryr1b	ryanodine receptor 1b (skeletal)	0.368
tbx24	T-box 24	0.361
mef2d	myocyte enhancer factor 2d	0.353
hspg2	heparan sulfate proteoglycan 2	0.331
myhz1.1	myosin, heavy polypeptide 1.1, skeletal muscle	0.318
hoxa9a	homeo box A9a	0.317
jam3b	junctional adhesion molecule 3b	0.315
mef2ca	myocyte enhancer factor 2ca	0.314
prdm1a	PR domain containing 1a, with ZNF domain	0.299
ambra1	autophagy/beclin-1 regulator 1	0.288
barx1	BarH-like homeobox 1	0.287
mylz2	myosin, light polypeptide 2, skeletal muscle	0.285
bmp2b	bone morphogenetic protein 2b	0.271
actn1	actinin, alpha 1	0.268
brd4	bromodomain containing 4	0.262
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.258
xirp1	xin actin-binding repeat containing 1	0.257
admp	anti-dorsalizing morphogenic protein	0.257
plagl2	pleiomorphic adenoma gene-like 2	0.253
scxa	scleraxis homolog A (mouse)	0.253
foxi1	forkhead box I1	0.250
gpr126	G protein-coupled receptor 126	0.246
chrna6	cholinergic receptor, nicotinic, alpha 6	0.246
gbx2	gastrulation brain homeo box 2	0.236
chrnd	cholinergic receptor, nicotinic, delta polypeptide	0.229
dlx5a	distal-less homeobox gene 5a	0.228
dmrt2a	doublesex and mab-3 related transcription factor 2a	0.225
tead3a	TEA domain family member 3 a	0.222
pcdh10b	protocadherin 10b	0.220
ptch2	patched 2	0.219
efnb3b	ephrin B3b	0.217
vgll2b	vestigial like 2b	0.215
xirp2a	xin actin-binding repeat containing 2a	0.211
dkk1b	dickkopf 1b	0.208
pdlim3b	PDZ and LIM domain 3b	0.206
cdh2	cadherin 2, neuronal	0.206
olig1	oligodendrocyte lineage transcription factor 1	0.204
pax9	paired box gene 9	0.201
pax8	paired box gene 8	0.200
csnk1a1	casein kinase 1, alpha 1	0.199
smo	smoothened homolog (Drosophila)	0.194
popdc2	popeye domain containing 2	0.193
eya1	eyes absent homolog 1	0.188
mmp15b	matrix metallopeptidase 15b	0.188
hsp90a.1	heat shock protein 90-alpha 1	0.186
th	tyrosine hydroxylase	0.183

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Homo sapiens

Name	Description	Probability
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.752
ESR1	estrogen receptor 1	0.578
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.577
FHL2	four and a half LIM domains 2	0.575
JAG1	jagged 1	0.502
JUN	jun proto-oncogene	0.460
FLNA	filamin A, alpha	0.414
HDAC4	histone deacetylase 4	0.246
EGFR	epidermal growth factor receptor	0.212
CAV1	caveolin 1, caveolae protein, 22kDa	0.200
IGF2	insulin-like growth factor 2 (somatomedin A)	0.192
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.161
AR	androgen receptor	0.158
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.154
SMAD3	SMAD family member 3	0.153
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.150
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.148
FN1	fibronectin 1	0.131
MEF2C	myocyte enhancer factor 2C	0.128
RBPMS	RNA binding protein with multiple splicing	0.127
FBLN1	fibulin 1	0.127
POU5F1	POU class 5 homeobox 1	0.121
PAX3	paired box 3	0.117
SMAD2	SMAD family member 2	0.112
NCOR2	nuclear receptor corepressor 2	0.101
APP	amyloid beta (A4) precursor protein	0.099
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.099
NOTCH1	notch 1	0.087
MYH7B	myosin, heavy chain 7B, cardiac muscle, beta	0.084
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.068
ATF3	activating transcription factor 3	0.068
MYOD1	myogenic differentiation 1	0.067
EP300	E1A binding protein p300	0.060
SPTBN1	spectrin, beta, non-erythrocytic 1	0.058
JUNB	jun B proto-oncogene	0.058
BCL6	B-cell CLL/lymphoma 6	0.053
FSTL1	follistatin-like 1	0.051
DMD	dystrophin	0.051
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.049
TCF4	transcription factor 4	0.048
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.048
MEF2A	myocyte enhancer factor 2A	0.046
TTN	titin	0.045
GSK3B	glycogen synthase kinase 3 beta	0.045
BMPR1A	bone morphogenetic protein receptor, type IA	0.045
TRIM63	tripartite motif containing 63	0.043
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.041
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.040
DBP	D site of albumin promoter (albumin D-box) binding protein	0.040
SP1	Sp1 transcription factor	0.039
PARVA	parvin, alpha	0.038
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.038
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.038
EGR3	early growth response 3	0.038
TNNI1	troponin I type 1 (skeletal, slow)	0.036
NOTCH3	notch 3	0.036
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.036
SIRT1	sirtuin 1	0.036
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.035
COL6A1	collagen, type VI, alpha 1	0.035
LOX	lysyl oxidase	0.035
NFIL3	nuclear factor, interleukin 3 regulated	0.035
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.035
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.034
EGR1	early growth response 1	0.034
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.034
FYN	FYN oncogene related to SRC, FGR, YES	0.033
BCL2L1	BCL2-like 1	0.032
ACTA2	actin, alpha 2, smooth muscle, aorta	0.032
MAPT	microtubule-associated protein tau	0.032
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.032
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.032
COL1A1	collagen, type I, alpha 1	0.032
FBN1	fibrillin 1	0.032
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.031
CREBBP	CREB binding protein	0.031
PTEN	phosphatase and tensin homolog	0.030
GSN	gelsolin	0.030
LAMB1	laminin, beta 1	0.030
JUND	jun D proto-oncogene	0.029
ESR2	estrogen receptor 2 (ER beta)	0.029
SMAD4	SMAD family member 4	0.028
RB1	retinoblastoma 1	0.028
EGR2	early growth response 2	0.028
SMAD9	SMAD family member 9	0.028
FADD	Fas (TNFRSF6)-associated via death domain	0.028
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.028
PSEN1	presenilin 1	0.028
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.027
NCOA3	nuclear receptor coactivator 3	0.024
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.024
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.024
LRP6	low density lipoprotein receptor-related protein 6	0.024
INO80B	INO80 complex subunit B	0.024
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.023
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.023
COL4A6	collagen, type IV, alpha 6	0.023
DTNA	dystrobrevin, alpha	0.022
DUSP1	dual specificity phosphatase 1	0.022
TESK1	testis-specific kinase 1	0.021

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Mus musculus

Name	Description	Probability	Func Analog Organism

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Rattus norvegicus

Name	Description	Probability
Egr2	early growth response 2	0.285
Egr1	early growth response 1	0.268
Tnni2	troponin I type 2 (skeletal, fast)	0.222
Myl1	myosin, light chain 1	0.193
Vipr2	vasoactive intestinal peptide receptor 2	0.191
Actc1	actin, alpha, cardiac muscle 1	0.179
Myh3	myosin, heavy chain 3, skeletal muscle, embryonic	0.136
Ampd1	adenosine monophosphate deaminase 1 (isoform M)	0.131
Tgfbr2	transforming growth factor, beta receptor II	0.124
Fos	FBJ osteosarcoma oncogene	0.116
Tnni1	troponin I type 1 (skeletal, slow)	0.105
Mylpf	myosin light chain, phosphorylatable, fast skeletal muscle	0.100
Fgfr2	fibroblast growth factor receptor 2	0.098
Casq1	calsequestrin 1 (fast-twitch, skeletal muscle)	0.097
Dusp6	dual specificity phosphatase 6	0.097
Mybph	myosin binding protein H	0.097
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.096
Purb	purine rich element binding protein B	0.091
S100a8	S100 calcium binding protein A8	0.091
Runx1	runt-related transcription factor 1	0.088
S100a9	S100 calcium binding protein A9	0.084
Nr4a2	nuclear receptor subfamily 4, group A, member 2	0.076
Nos3	nitric oxide synthase 3, endothelial cell	0.072
Fgf7	fibroblast growth factor 7	0.071
Gabra3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.069
Des	desmin	0.067
Jun	Jun oncogene	0.066
Flt1	FMS-related tyrosine kinase 1	0.061
Ednra	endothelin receptor type A	0.061
Prrx1	paired related homeobox 1	0.060
Nos2	nitric oxide synthase 2, inducible	0.058
Myh7	myosin, heavy chain 7, cardiac muscle, beta	0.054
Col3a1	collagen, type III, alpha 1	0.053
Casq2	calsequestrin 2 (cardiac muscle)	0.053
Myog	myogenin	0.053
Asph	aspartate-beta-hydroxylase	0.052
Adam10	ADAM metallopeptidase domain 10	0.051
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.050
Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	0.050
Edn1	endothelin 1	0.049
Clic4	chloride intracellular channel 4	0.049
Irs1	insulin receptor substrate 1	0.048
Pecam1	platelet/endothelial cell adhesion molecule 1	0.048
Mybpc2	myosin binding protein C, fast-type	0.048
Lig3	ligase III, DNA, ATP-dependent	0.048
Hand2	heart and neural crest derivatives expressed 2	0.047
Junb	jun B proto-oncogene	0.047
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.047
Acacb	acetyl-Coenzyme A carboxylase beta	0.047
Gper	G protein-coupled estrogen receptor 1	0.046
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.046
Smad6	SMAD family member 6	0.046
Dcn	decorin	0.046
Myh1	myosin, heavy polypeptide 1, skeletal muscle, adult	0.045
Neurl2	neuralized homolog 2 (Drosophila)	0.044
Myh8	myosin, heavy chain 8, skeletal muscle, perinatal	0.044
Tnnc2	troponin C type 2 (fast)	0.042
Ogn	osteoglycin	0.041
Mia	melanoma inhibitory activity	0.040
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.040
Sirpa	signal-regulatory protein alpha	0.040
Csrp3	cysteine and glycine-rich protein 3	0.039
Tnnt3	troponin T type 3 (skeletal, fast)	0.039
Hbegf	heparin-binding EGF-like growth factor	0.039
Pla1a	phospholipase A1 member A	0.038
Il1b	interleukin 1 beta	0.038
Cd4	Cd4 molecule	0.038
Nr4a3	nuclear receptor subfamily 4, group A, member 3	0.036
Serpine1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.036
Fxyd1	FXYD domain-containing ion transport regulator 1	0.035
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.035
Myo9a	myosin IXA	0.035
Cmklr1	chemokine-like receptor 1	0.034
Agtr1a	angiotensin II receptor, type 1a	0.034
Epn2	epsin 2	0.033
Pkia	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	0.033
Strn	striatin, calmodulin binding protein	0.033
Dchs1	dachsous 1 (Drosophila)	0.033
Pate4	prostate and testis expressed 4	0.033
Smpx	small muscle protein, X-linked	0.032
Itpr2	inositol 1,4,5-triphosphate receptor, type 2	0.032
Myh2	myosin, heavy chain 2, skeletal muscle, adult	0.032
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.032
Ckm	creatine kinase, muscle	0.032
Lrp1	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	0.031
Insr	insulin receptor	0.031
Mapk3	mitogen activated protein kinase 3	0.031
Zfp382	zinc finger protein 382	0.031
Dpysl3	dihydropyrimidinase-like 3	0.031
Kremen1	kringle containing transmembrane protein 1	0.031
Mbp	myelin basic protein	0.030
Anxa2	annexin A2	0.030
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.030
Prg2	proteoglycan 2, bone marrow	0.030
Cacng1	calcium channel, voltage-dependent, gamma subunit 1	0.029
Ahr	aryl hydrocarbon receptor	0.029
Chrng	cholinergic receptor, nicotinic, gamma	0.029
Mylk2	myosin light chain kinase 2	0.029
Col4a2	collagen, type IV, alpha 2	0.028
Cav3	caveolin 3	0.028

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Saccharomyces cerevisiae

Name	Description	Probability	Func Analog Organism