The network for 'positive regulation of catalytic activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

NameDescriptionProbabilityFunc Analog Organism
Stat92ESignal-transducer and activator of transcription protein at 92E0.787
Rac1CG2248 gene product from transcript CG2248-RA0.786
Ras85DRas oncogene at 85D0.527
mbcmyoblast city0.465
Pi3K92ECG4141 gene product from transcript CG4141-RB0.464
Pk61CProtein kinase 61C0.448
Fmr1CG6203 gene product from transcript CG6203-RC0.436
phlpole hole0.421
PknProtein kinase related to protein kinase N0.420
trioCG18214 gene product from transcript CG18214-RA0.419
pucpuckered0.413
G-oalpha47AG protein oalpha 47A0.410
Src42ASrc oncogene at 42A0.400
bskbasket0.400
p120ctnAdherens junction protein p1200.393
CycECyclin E0.393
rokRho-kinase0.385
eIF-4EEukaryotic initiation factor 4E0.383
NNotch0.351
PtenCG5671 gene product from transcript CG5671-RB0.343
cnocanoe0.339
Rho1CG8416 gene product from transcript CG8416-RB0.335
Akt1CG4006 gene product from transcript CG4006-RA0.320
kibrakibra ortholog0.318
rheaCG6831 gene product from transcript CG6831-RA0.317
Socs36ESuppressor of cytokine signaling at 36E0.311
flwflapwing0.310
kaykayak0.308
prosprospero0.298
MerMerlin0.298
Cip4CG15015 gene product from transcript CG15015-RA0.294
HLHm7E(spl) region transcript m70.273
dmdiminutive0.269
FhosCG42610 gene product from transcript CG42610-RC0.257
Tak1TGF-beta activated kinase 10.252
EcREcdysone receptor0.252
JraJun-related antigen0.249
PakPAK-kinase0.248
X11LCG5675 gene product from transcript CG5675-RB0.243
nwknervous wreck0.241
HLHmdeltaE(spl) region transcript mdelta0.238
wgwingless0.238
chicchickadee0.235
bazbazooka0.232
gclgerm cell-less0.232
tefutelomere fusion0.228
smosmoothened0.227
par-1CG8201 gene product from transcript CG8201-RA0.226
pydpolychaetoid0.209
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.200
PliPellino0.199
cindrCIN85 and CD2AP orthologue0.199
maskmultiple ankyrin repeats single KH domain0.198
CycGCyclin G0.197
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.191
CG8155CG8155 gene product from transcript CG8155-RA0.185
DabDisabled0.182
RhebCG1081 gene product from transcript CG1081-RA0.179
mbtmushroom bodies tiny0.178
ykiyorkie0.175
ShawShaker cognate w0.173
cenG1Acentaurin gamma 1A0.170
cbscentrosomin's beautiful sister0.169
putpunt0.167
LanB2Laminin B20.163
panpangolin0.161
fz2frizzled 20.161
dncdunce0.159
twstwins0.158
wupAwings up A0.154
scbscab0.152
dapdacapo0.151
Dhc64CDynein heavy chain 64C0.147
mus209mutagen-sensitive 2090.146
msnmisshapen0.145
Smg1CG32743 gene product from transcript CG32743-RA0.139
drkdownstream of receptor kinase0.138
Tm1Tropomyosin 10.137
HphHIF prolyl hydroxylase0.136
Mkp3Mitogen-activated protein kinase phosphatase 30.134
jarjaguar0.134
CG5146CG5146 gene product from transcript CG5146-RA0.134
WASpCG1520 gene product from transcript CG1520-RA0.133
RASSF8CG5053 gene product from transcript CG5053-RA0.133
sogshort gastrulation0.133
CakiCalcium/calmodulin-dependent protein kinase0.133
rutrutabaga0.132
wtswarts0.130
sharkSrc homology 2, ankyrin repeat, tyrosine kinase0.129
UbxUltrabithorax0.126
Ada2bCG9638 gene product from transcript CG9638-RA0.126
eastenhanced adult sensory threshold0.125
l(3)82FdCG32464 gene product from transcript CG32464-RR0.124
Myo31DFMyosin 31DF0.123
nmonemo0.121
mysmyospheroid0.121
AGO2Argonaute 20.120
SmoxSmad on X0.120
Cks30ACyclin-dependent kinase subunit 30A0.119
Bap60Brahma associated protein 60kD0.119
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
plk-1Protein PLK-10.486
sur-2Protein SUR-20.363
egl-18Protein EGL-180.315
K10D6.4Protein K10D6.40.271
patr-1Protein PATR-10.265
mpk-1Protein MPK-10.238
lin-13Protein LIN-130.235
zoo-1Protein ZOO-10.216
rig-6Protein RIG-60.214
ess-2Protein ESS-20.214
let-60Protein LET-600.199
nhr-6Protein NHR-60.186
C11E4.6Protein C11E4.60.177
mei-1Protein MEI-10.166
sad-1Protein SAD-10.164
sas-4Protein SAS-40.163
sem-5Protein SEM-50.155
ina-1Protein INA-10.154
lam-2Protein LAM-20.143
nhr-34Protein NHR-340.134
sma-6Protein SMA-60.133
pig-1Protein PIG-10.131
cks-1Protein CKS-10.131
rps-2Protein RPS-20.130
cyc-1Protein CYC-10.128
lin-36Protein LIN-360.124
D1043.1Protein D1043.10.121
svh-2Protein SVH-20.119
unc-26Protein UNC-260.115
hsp-1Protein HSP-10.114
hgrs-1Protein HGRS-10.112
gei-4Protein GEI-40.110
abl-1Protein ABL-10.110
rsa-1Protein RSA-10.110
rhgf-2Protein RHGF-20.108
egl-15Protein EGL-150.107
pkc-3Protein PKC-30.106
dars-1Protein DARS-10.104
par-5Protein PAR-50.103
C27H2.2Protein C27H2.20.103
lag-1Protein LAG-10.102
gei-17Protein GEI-170.102
CELE_F14E5.2Protein F14E5.20.101
bar-1Protein BAR-10.100
F28B3.1Protein F28B3.10.098
soc-2Protein SOC-20.092
hda-2Protein HDA-20.092
csn-1Protein CSN-10.092
stam-1Protein STAM-10.092
tpxl-1Protein TPXL-10.092
ergo-1Protein ERGO-10.089
mig-38Protein MIG-380.087
snf-1Protein SNF-10.086
pry-1Protein PRY-10.086
ect-2Protein ECT-20.085
aha-1Protein AHA-10.084
unc-71Protein UNC-710.081
daf-19Protein DAF-190.081
rpm-1Protein RPM-10.080
egl-8Protein EGL-80.080
mcm-2Protein MCM-20.079
sli-1Protein SLI-10.078
lin-53Protein LIN-530.078
cdk-1Protein CDK-10.077
unc-84Protein UNC-840.077
CELE_Y60A3A.9Protein Y60A3A.90.076
srgp-1Protein SRGP-10.076
C27F2.8Protein C27F2.80.075
goa-1Protein GOA-10.075
ZK858.6Protein ZK858.60.075
npp-15Protein NPP-150.075
aak-2Protein AAK-20.075
daf-21Protein DAF-210.075
unc-41Protein UNC-410.073
unc-76Protein UNC-760.073
Y110A7A.4Protein Y110A7A.40.073
ceh-32Protein CEH-320.072
gei-8Protein GEI-80.072
inx-3Protein INX-30.072
duo-3Protein DUO-30.072
ubq-1Protein UBQ-10.072
nfyc-1Protein NFYC-10.071
unc-40Protein UNC-400.069
F56D2.6Protein F56D2.60.068
ttx-1Protein TTX-10.067
rpn-1Protein RPN-10.067
par-3Protein PAR-30.067
unc-11Protein UNC-110.066
eor-2Protein EOR-20.065
csn-4Protein CSN-40.065
let-502Protein LET-5020.065
pek-1Protein PEK-10.064
unc-85Protein UNC-850.064
Y119C1A.1Protein Y119C1A.10.064
unc-73Protein UNC-730.064
cdc-48.2Protein CDC-48.20.064
hsr-9Protein HSR-90.063
obr-3Protein OBR-30.063
nck-1Protein NCK-10.063
acs-13Protein ACS-130.063
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wnt2bbwingless-type MMTV integration site family, member 2Bb0.278
tpm4tropomyosin 40.237
tlr3toll-like receptor 30.222
bidaBH3 interacting domain death agonist0.173
crb2acrumbs homolog 2a0.154
ascl1aachaete-scute complex-like 1a (Drosophila)0.151
rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.149
pkd2polycystic kidney disease 20.125
foxi1forkhead box I10.123
cx43connexin 430.120
otpaorthopedia homolog a0.084
dag1dystroglycan 10.084
sox11bSRY-box containing gene 11b0.082
dnmt5DNA (cytosine-5-)-methyltransferase 50.073
msi1musashi homolog 1 (Drosophila)0.072
yrkYes-related kinase0.072
cnn2calponin 20.071
axin2axin 2 (conductin, axil)0.070
crhcorticotropin releasing hormone0.069
fgfr3fibroblast growth factor receptor 30.069
foxn4forkhead box N40.069
id3inhibitor of DNA binding 30.066
sox19aSRY-box containing gene 19a0.064
rtcd1RNA terminal phosphate cyclase domain 10.062
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.061
map3k4mitogen activated protein kinase kinase kinase 40.060
dlddeltaD0.060
tgfb3transforming growth factor, beta 30.059
psen1presenilin 10.058
pycardPYD and CARD domain containing0.056
mycamyelocytomatosis oncogene a0.053
shhasonic hedgehog a0.053
gro1groucho 10.052
wnt1wingless-type MMTV integration site family, member 10.051
mpzmyelin protein zero0.051
adrb2aadrenergic receptor, beta 2a0.049
lef1lymphocyte enhancer binding factor 10.049
id1inhibitor of DNA binding 10.048
si:ch211-212m21.5si:ch211-212m21.50.048
im:7162646im:71626460.048
egr2bearly growth response 2b0.047
sec23aSec23 homolog A (S. cerevisiae)0.046
cmybtranscription factor cmyb0.045
disp1dispatched homolog 1 (Drosophila)0.045
notch3notch homolog 30.045
adipor1badiponectin receptor 1b0.045
epb41l5erythrocyte membrane protein band 4.1 like 50.044
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.043
her15.1hairy and enhancer of split-related 15.10.043
crip2cysteine-rich protein 20.043
pvrl1bpoliovirus receptor-related 1b0.042
hmgb2ahigh-mobility group box 2a0.041
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.041
baxabcl2-associated X protein, a0.040
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.040
ca8carbonic anhydrase VIII0.040
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.039
whsc1Wolf-Hirschhorn syndrome candidate 10.038
podxlpodocalyxin-like0.037
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.037
pth2parathyroid hormone 20.036
pak2ap21 (CDKN1A)-activated kinase 2a0.036
fbln4fibulin 40.036
sall4sal-like 4 (Drosophila)0.036
hhiphedgehog interacting protein0.036
trpm7transient receptor potential cation channel, subfamily M, member 70.035
eif4eeukaryotic translation initiation factor 4e0.034
esrraestrogen-related receptor alpha0.034
ghragrowth hormone receptor a0.034
junjun proto-oncogene0.034
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.033
rhoabras homolog gene family, member Ab0.033
fstl1bfollistatin-like 1b0.033
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.033
zbtb4zinc finger and BTB domain containing 40.033
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.032
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.032
or102-1odorant receptor, family C, subfamily 102, member 10.032
nf1bneurofibromin 1b0.032
stc1lstanniocalcin 1, like0.031
traf4atnf receptor-associated factor 4a0.031
furinbfurin (paired basic amino acid cleaving enzyme) b0.031
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.031
nf1aneurofibromin 1a0.031
thtyrosine hydroxylase0.030
card9caspase recruitment domain family, member 90.030
LOC795916mucolipin-1-like0.030
card14caspase recruitment domain family, member 140.030
bdnfbrain-derived neurotrophic factor0.030
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.030
gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 10.029
rnd3aRho family GTPase 3a0.029
mmp2matrix metalloproteinase 20.029
mycbp2MYC binding protein 20.029
il8interleukin 80.029
adra2badrenergic, alpha-2B-, receptor0.028
cfl2lcofilin 2, like0.028
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.028
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.028
dzip1DAZ interacting protein 10.027
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.553
Nedd4neural precursor cell expressed, developmentally down-regulated 40.389
Cd38CD38 molecule0.384
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.375
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.371
Grm5glutamate receptor, metabotropic 50.365
Myo1bmyosin Ib0.356
Agtr1aangiotensin II receptor, type 1a0.338
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.316
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.304
Mpeg1macrophage expressed 10.300
Epas1endothelial PAS domain protein 10.299
Jak2Janus kinase 20.296
Cd4Cd4 molecule0.290
Fkbp1aFK506 binding protein 1a0.283
Homer3homer homolog 3 (Drosophila)0.271
Tacr1tachykinin receptor 10.269
Utrnutrophin0.265
Flt1FMS-related tyrosine kinase 10.256
Calcrlcalcitonin receptor-like0.254
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.253
HrasHarvey rat sarcoma virus oncogene0.250
S100a8S100 calcium binding protein A80.248
Adora2aadenosine A2a receptor0.244
Folh1folate hydrolase 10.243
Nrp2neuropilin 20.240
Mchr1melanin-concentrating hormone receptor 10.235
Copb2coatomer protein complex, subunit beta 2 (beta prime)0.234
Robo1roundabout homolog 1 (Drosophila)0.231
Junbjun B proto-oncogene0.228
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.226
Fgfr2fibroblast growth factor receptor 20.225
Clic4chloride intracellular channel 40.223
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.222
Wt1Wilms tumor 10.222
Trhrthyrotropin releasing hormone receptor0.220
Edn1endothelin 10.211
Sox17SRY (sex determining region Y)-box 170.211
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.209
Il1r1interleukin 1 receptor, type I0.207
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.204
Sirpasignal-regulatory protein alpha0.204
Rgs8regulator of G-protein signaling 80.202
Mmp8matrix metallopeptidase 80.198
Sellselectin L0.198
Oprk1opioid receptor, kappa 10.196
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.195
Grb2growth factor receptor bound protein 20.195
Tgfbr2transforming growth factor, beta receptor II0.193
Il8rainterleukin 8 receptor, alpha0.193
Cfpcomplement factor properdin0.193
Pde5aphosphodiesterase 5A, cGMP-specific0.190
Htr75-hydroxytryptamine (serotonin) receptor 70.189
Inpp5dinositol polyphosphate-5-phosphatase D0.187
Testintestin gene0.187
Prl7a4prolactin family 7, subfamily a, member 40.186
Ccnd1cyclin D10.186
Syt4synaptotagmin IV0.186
Mapk1mitogen activated protein kinase 10.186
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.185
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.182
Ripk3receptor-interacting serine-threonine kinase 30.180
Agxtalanine-glyoxylate aminotransferase0.178
KitlgKIT ligand0.178
Hsp90b1heat shock protein 90, beta, member 10.176
Arhgap25Rho GTPase activating protein 250.171
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.170
Rgs9regulator of G-protein signaling 90.168
Hpcahippocalcin0.167
Smad7SMAD family member 70.163
Phc1polyhomeotic homolog 1 (Drosophila)0.163
Syt8synaptotagmin VIII0.162
Notch3Notch homolog 3 (Drosophila)0.162
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.160
Ccr5chemokine (C-C motif) receptor 50.159
Albalbumin0.158
Arpc1bactin related protein 2/3 complex, subunit 1B0.157
Clpscolipase, pancreatic0.156
Nrg1neuregulin 10.154
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.154
RGD1304644similar to RIKEN cDNA 2310046K010.154
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.153
Snap23synaptosomal-associated protein 230.153
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.152
Adam10ADAM metallopeptidase domain 100.151
Gng7guanine nucleotide binding protein (G protein), gamma 70.151
Galnt5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)0.150
Slc7a1solute carrier family 7 (cationic amino acid transporter, y+ system), member 10.150
Fn1fibronectin 10.149
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.148
Stx2syntaxin 20.148
Prb1proline-rich protein BstNI subfamily 10.147
Klf6Kruppel-like factor 60.146
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.145
Gja1gap junction protein, alpha 10.145
Gpr6G protein-coupled receptor 60.144
Prkcdprotein kinase C, delta0.144
Pspparotid secretory protein0.143
Ciitaclass II, major histocompatibility complex, transactivator0.143
Cskc-src tyrosine kinase0.142
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC12Cdc12p0.619
SSK2Ssk2p0.347
ROM2Rom2p0.347
RAS2Ras2p0.346
PBS2Pbs2p0.346
SDS22Sds22p0.325
SLT2Slt2p0.304
MKK1Mkk1p0.302
REG1Reg1p0.276
DIA2Dia2p0.276
HSL1Hsl1p0.266
NBP2Nbp2p0.247
RPP1BRpp1bp0.228
MYO5Myo5p0.217
CDC48Cdc48p0.212
SUI3Sui3p0.188
CDC24Cdc24p0.184
STE11Ste11p0.184
ATG21Atg21p0.175
CRN1Crn1p0.173
SHS1Shs1p0.171
YME1Yme1p0.166
STI1Sti1p0.156
GYL1Gyl1p0.148
DNM1Dnm1p0.145
NTH1Nth1p0.143
CYM1Cym1p0.142
SPA2Spa2p0.135
RAD52Rad52p0.131
SSA4Ssa4p0.126
RPG1Rpg1p0.123
MSO1Mso1p0.121
SNF4Snf4p0.120
RHO1Rho1p0.119
SSK1Ssk1p0.118
SIP1Sip1p0.114
VID28Vid28p0.114
TSA2Tsa2p0.112
FAR1Far1p0.112
VPS4Vps4p0.110
ARF1Arf1p0.110
HSP10Hsp10p0.108
BEM2Bem2p0.108
CHS1Chs1p0.106
GPH1Gph1p0.103
BEM3Bem3p0.102
CDC10Cdc10p0.100
GCD6Gcd6p0.099
BCK1Bck1p0.099
CMK1Cmk1p0.099
BNI4Bni4p0.097
HSV2Hsv2p0.096
BIK1Bik1p0.096
TSC11Tsc11p0.096
SSK22Ssk22p0.094
PKC1Pkc1p0.094
SHP1Shp1p0.093
SRO7Sro7p0.092
CYK3Cyk3p0.091
FAB1Fab1p0.091
GDI1Gdi1p0.088
NAP1Nap1p0.087
SEC1Sec1p0.087
PTP2Ptp2p0.085
URA6Ura6p0.085
CDC53Cdc53p0.084
COT1Cot1p0.084
NET1Net1p0.083
RIM21Rim21p0.082
YLR257Whypothetical protein0.081
AKL1Akl1p0.081
SSE1Sse1p0.081
GAL83Gal83p0.081
HSP60Hsp60p0.081
MYO2Myo2p0.079
CDC23Cdc23p0.076
CHS6Chs6p0.076
KEM1Kem1p0.075
MSG5Msg5p0.075
TUS1Tus1p0.075
MSH2Msh2p0.074
RPT3Rpt3p0.074
INP53Inp53p0.073
PSP2Psp2p0.072
SEC27Sec27p0.071
MTC4Mtc4p0.071
UFO1Ufo1p0.070
CLN3Cln3p0.070
YPT53Ypt53p0.069
CCS1Ccs1p0.069
VPS13Vps13p0.068
AHP1Ahp1p0.068
MEX67Mex67p0.068
STE5Ste5p0.068
ATG13Atg13p0.067
SHE4She4p0.066
RGA2Rga2p0.066
TPS1Tps1p0.066
SEC53Sec53p0.066
YMR196Whypothetical protein0.066