The network for 'response to pain' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to pain

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.

NameDescriptionProbabilityFunc Analog Organism
Nmdar2NMDA receptor 20.821
Nmdar1NMDA receptor 10.661
CG32792CG32792 gene product from transcript CG32792-RF0.471
CG33289CG33289 gene product from transcript CG33289-RA0.451
ppk11pickpocket 110.432
Octbeta2RCG33976 gene product from transcript CG33976-RA0.403
Gr32aGustatory receptor 32a0.360
5-HT7Serotonin receptor 70.241
Irk3Inwardly rectifying potassium channel 30.232
ppk25pickpocket 250.191
oa2octopamine receptor 20.186
neuroliginCG13772 gene product from transcript CG13772-RA0.168
TrpA1Transient receptor potential A10.151
nonAno on or off transient A0.145
rpkripped pocket0.144
eagether a go-go0.110
CG13568CG13568 gene product from transcript CG13568-RG0.108
Ef1alpha48DElongation factor 1alpha48D0.082
VGlutVesicular glutamate transporter0.081
Spn77BaSerpin 77Ba0.079
NachCG8178 gene product from transcript CG8178-RA0.078
Gr33aGustatory receptor 33a0.077
stnBstoned B0.072
Ork1Open rectifier K[+] channel 10.071
CG11317CG11317 gene product from transcript CG11317-RA0.070
ppk23pickpocket 230.061
Obp99dOdorant-binding protein 99d0.055
CG12187CG12187 gene product from transcript CG12187-RA0.055
Or67dOdorant receptor 67d0.055
Gr59cGustatory receptor 59c0.052
CG9897CG9897 gene product from transcript CG9897-RA0.052
slp1sloppy paired 10.050
Gr61aGustatory receptor 61a0.050
shakBshaking B0.048
eloFelongase F0.045
Gr39aGustatory receptor 39a0.044
lushCG8807 gene product from transcript CG8807-RA0.043
Gr64fGustatory receptor 64f0.042
GluRIIAGlutamate receptor IIA0.041
CG15322CG15322 gene product from transcript CG15322-RB0.040
GABA-B-R2metabotropic GABA-B receptor subtype 20.040
Gr64bGustatory receptor 64b0.039
Gr43aGustatory receptor 43a0.036
CheB42aChemosensory protein B 42a0.035
RicRas which interacts with Calmodulin0.035
Or83bOdorant receptor 83b0.034
CG14280CG14280 gene product from transcript CG14280-RA0.034
nanarrow abdomen0.032
Gr64cGustatory receptor 64c0.030
mAcR-60Cmuscarinic Acetylcholine Receptor 60C0.030
CG13862CG13862 gene product from transcript CG13862-RA0.029
CG13117CG13117 gene product from transcript CG13117-RA0.029
CG10251CG10251 gene product from transcript CG10251-RB0.029
Gyc-89DbGuanylyl cyclase at 89Db0.029
TehaoCG7121 gene product from transcript CG7121-RA0.028
Ilp3Insulin-like peptide 30.028
CG34388CG34388 gene product from transcript CG34388-RC0.028
CG15153CG15153 gene product from transcript CG15153-RA0.028
CG11585CG11585 gene product from transcript CG11585-RB0.028
nulloCG14426 gene product from transcript CG14426-RB0.027
CG3238CG3238 gene product from transcript CG3238-RA0.027
CG12001CG12001 gene product from transcript CG12001-RA0.026
Or7aOdorant receptor 7a0.026
CG12522CG12522 gene product from transcript CG12522-RA0.026
npfneuropeptide F0.026
ninaBneither inactivation nor afterpotential B0.026
Gr64aGustatory receptor 64a0.025
Gyc-89DaGuanylyl cyclase at 89Da0.025
ppk16pickpocket 160.024
SNCFSoxNeuro Co-Factor0.024
Gr36cGustatory receptor 36c0.024
CG14234CG14234 gene product from transcript CG14234-RA0.024
Tdc2Tyrosine decarboxylase 20.023
CG10481CG10481 gene product from transcript CG10481-RA0.023
Ir11aIonotropic receptor 11a0.022
Ir92aIonotropic receptor 92a0.022
CG9925CG9925 gene product from transcript CG9925-RA0.022
Syx4Syntaxin 40.022
Or45bOdorant receptor 45b0.022
haloCG7428 gene product from transcript CG7428-RA0.022
fd19Bforkhead domain 19B0.022
fd85Eforkhead domain 85E0.022
CG15082CG15082 gene product from transcript CG15082-RA0.022
TTLL3ATubulin tyrosine ligase-like 3A0.021
HDAC6CG6170 gene product from transcript CG6170-RA0.021
CG8486CG8486 gene product from transcript CG8486-RE0.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)1.000
Drd2dopamine receptor D20.914
Ryr2ryanodine receptor 2, cardiac0.864
Oprm1opioid receptor, mu 10.786
Dlg4discs, large homolog 4 (Drosophila)0.736
Nos1nitric oxide synthase 1, neuronal0.724
Pgrprogesterone receptor0.498
Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)0.483
Grid2glutamate receptor, ionotropic, delta 20.427
Npy1rneuropeptide Y receptor Y10.419
Sox10SRY-box containing gene 100.410
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.407
Npy2rneuropeptide Y receptor Y20.402
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.401
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.355
Akt1thymoma viral proto-oncogene 10.284
Dlg2discs, large homolog 2 (Drosophila)0.276
Leprleptin receptor0.238
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.238
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.235
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.212
Grik2glutamate receptor, ionotropic, kainate 2 (beta 2)0.211
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.206
Ppargperoxisome proliferator activated receptor gamma0.205
Plcb1phospholipase C, beta 10.202
Gabra2gamma-aminobutyric acid (GABA) A receptor, subunit alpha 20.199
Emx1empty spiracles homolog 1 (Drosophila)0.198
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.186
Sstr3somatostatin receptor 30.184
Sstr1somatostatin receptor 10.178
Pax1paired box gene 10.174
Kcns2K+ voltage-gated channel, subfamily S, 20.164
Ntsr1neurotensin receptor 10.161
Nf1neurofibromatosis 10.148
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.145
Galr1galanin receptor 10.135
Gdnfglial cell line derived neurotrophic factor0.130
Gnb2guanine nucleotide binding protein (G protein), beta 20.124
Doc2bdouble C2, beta0.123
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.117
Kcnj9potassium inwardly-rectifying channel, subfamily J, member 90.114
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.110
Prkccprotein kinase C, gamma0.109
Syt2synaptotagmin II0.108
Epha6Eph receptor A60.108
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.107
Rit2Ras-like without CAAX 20.106
Aff2AF4/FMR2 family, member 20.106
Oprk1opioid receptor, kappa 10.104
Smyd1SET and MYND domain containing 10.104
Nr2e1nuclear receptor subfamily 2, group E, member 10.102
Ccr2chemokine (C-C motif) receptor 20.101
Trp73transformation related protein 730.100
Ppyr1pancreatic polypeptide receptor 10.100
Cacna2d2calcium channel, voltage-dependent, alpha 2/delta subunit 20.099
Adora2aadenosine A2a receptor0.098
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.096
Thtyrosine hydroxylase0.096
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.092
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.090
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.087
Neto1neuropilin (NRP) and tolloid (TLL)-like 10.087
Gabrqgamma-aminobutyric acid (GABA) A receptor, subunit theta0.086
Ptpn5protein tyrosine phosphatase, non-receptor type 50.086
Cnr1cannabinoid receptor 1 (brain)0.086
Ighimmunoglobulin heavy chain complex0.086
Trpc4transient receptor potential cation channel, subfamily C, member 40.086
Gabrg3gamma-aminobutyric acid (GABA) A receptor, subunit gamma 30.084
Oprl1opioid receptor-like 10.083
Dab1disabled homolog 1 (Drosophila)0.082
Ehmt2euchromatic histone lysine N-methyltransferase 20.081
Csnk1g2casein kinase 1, gamma 20.080
Igf1rinsulin-like growth factor I receptor0.080
Atp1a3ATPase, Na+/K+ transporting, alpha 3 polypeptide0.080
Rasgrf2RAS protein-specific guanine nucleotide-releasing factor 20.078
Gnao1guanine nucleotide binding protein, alpha O0.077
Trpc7transient receptor potential cation channel, subfamily C, member 70.076
Neurod2neurogenic differentiation 20.075
Ank1ankyrin 1, erythroid0.074
Edn1endothelin 10.074
Cntn4contactin 40.074
Git1G protein-coupled receptor kinase-interactor 10.072
Magel2melanoma antigen, family L, 20.072
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.071
Dctn1dynactin 10.071
Ldb3LIM domain binding 30.070
Il16interleukin 160.069
Mmp16matrix metallopeptidase 160.067
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.067
Neurog3neurogenin 30.067
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.066
RoraRAR-related orphan receptor alpha0.065
Rnf112ring finger protein 1120.064
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.098
Chrna7cholinergic receptor, nicotinic, alpha 70.082
Insrrinsulin receptor-related receptor0.044
Magmyelin-associated glycoprotein0.043
Olr857olfactory receptor 8570.042
Glp1rglucagon-like peptide 1 receptor0.041
Csf1colony stimulating factor 1 (macrophage)0.039
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.038
Cckarcholecystokinin A receptor0.035
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.034
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.033
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.033
Gja6gap junction protein, alpha 60.031
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.026
Pax6paired box 60.026
Pipprolactin induced protein0.026
Hrh3histamine receptor H30.026
Prss1protease, serine, 1 (trypsin 1)0.025
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.025
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.024
Cgaglycoprotein hormones, alpha polypeptide0.024
Fshbfollicle stimulating hormone, beta polypeptide0.024
Lim2lens intrinsic membrane protein 20.024
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.023
Ccbp2chemokine binding protein 20.023
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.023
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.023
Dlg4discs, large homolog 4 (Drosophila)0.023
Scn8asodium channel, voltage gated, type VIII, alpha subunit0.023
Htr75-hydroxytryptamine (serotonin) receptor 70.023
Adra1aadrenergic, alpha-1A-, receptor0.023
Slc9a4solute carrier family 9 (sodium/hydrogen exchanger), member 40.022
Fam38bfamily with sequence similarity 38, member B0.022
Mmp13matrix metallopeptidase 130.022
Cckbrcholecystokinin B receptor0.022
Ptch1patched homolog 1 (Drosophila)0.021
Scn10asodium channel, voltage-gated, type X, alpha subunit0.021
Slc14a2solute carrier family 14 (urea transporter), member 20.021
Il12binterleukin 12B0.021
RGD1307722similar to hypothetical protein MGC207000.020
Kcng3potassium voltage-gated channel, subfamily G, member 30.020
Ednraendothelin receptor type A0.020
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.020
Dsppdentin sialophosphoprotein0.020
Rims1regulating synaptic membrane exocytosis 10.019
Gpr1G protein-coupled receptor 10.019
Madcam1mucosal vascular addressin cell adhesion molecule 10.019
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.019
Aqp2aquaporin 2 (collecting duct)0.019
Tmem88transmembrane protein 880.018
Nrg1neuregulin 10.018
Tff1trefoil factor 10.018
Cysscystatin S0.018
Olr226olfactory receptor 2260.018
Trpm8transient receptor potential cation channel, subfamily M, member 80.017
Sstr2somatostatin receptor 20.017
Pde3aphosphodiesterase 3A, cGMP inhibited0.017
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.016
Vom2r53vomeronasal 2 receptor, 530.016
Abp1amiloride binding protein 1 (amine oxidase, copper-containing)0.016
Grin2cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.016
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.016
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.015
Reg3bregenerating islet-derived 3 beta0.015
Il4interleukin 40.015
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.015
Dnase1deoxyribonuclease I0.015
Slc18a1solute carrier family 18 (vesicular monoamine), member 10.015
Grm6glutamate receptor, metabotropic 60.015
Gad2glutamate decarboxylase 20.014
Ncr1natural cytotoxicity triggering receptor 10.014
Nmbrneuromedin B receptor0.014
Olr287olfactory receptor 2870.014
Gpr150G protein-coupled receptor 1500.014
Ghsrgrowth hormone secretagogue receptor0.014
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.014
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.013
Arnt2aryl hydrocarbon receptor nuclear translocator 20.013
Cnga4cyclic nucleotide gated channel alpha 40.013
Sstr3somatostatin receptor 30.013
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.013
Aqp6aquaporin 6, kidney specific0.013
Adam3aADAM metallopeptidase domain 3A (cyritestin 1)0.013
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.013
Slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.012
Ctsjcathepsin J0.012
Sorcs3sortilin-related VPS10 domain containing receptor 30.012
Crhr2corticotropin releasing hormone receptor 20.012
Kcns2potassium voltage-gated channel, delayed-rectifier, subfamily S, member 20.012
RGD1564327similar to integrin alpha 80.012
Olr1398olfactory receptor 13980.012
Tas2r118taste receptor, type 2, member 1180.012
Cysltr2cysteinyl leukotriene receptor 20.012
Ghrhgrowth hormone releasing hormone0.012
Fgf7fibroblast growth factor 70.012
Leprleptin receptor0.012
Folh1folate hydrolase 10.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism