The network for 'lysosome organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lysosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.

Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rab7Rab-protein 70.392
Rab2Rab-protein 20.079
Rab14Rab-protein 140.068
Rab6Rab-protein 60.050
locolocomotion defects0.043
RelRelish0.032
CG8974CG8974 gene product from transcript CG8974-RD0.025
RhebCG1081 gene product from transcript CG1081-RA0.020
CG12004CG12004 gene product from transcript CG12004-RC0.019
Vps33BVacuolar protein sorting 33B0.019
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.018
LmptLimpet0.016
M6CG7540 gene product from transcript CG7540-RA0.014
bchsblue cheese0.013
CG14980CG14980 gene product from transcript CG14980-RB0.013
CG15309CG15309 gene product from transcript CG15309-RA0.012
CG10277CG10277 gene product from transcript CG10277-RB0.011
hkhook0.011
PliPellino0.011
Rab1Rab-protein 10.011
shrbshrub0.011
alaristaless0.010
Pvf2PDGF- and VEGF-related factor 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
aplnrbapelin receptor b0.012
zgc:123177zgc:1231770.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MON1BMON1 homolog B (yeast)0.582
SNX6sorting nexin 60.496
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.413
VPS33Bvacuolar protein sorting 33 homolog B (yeast)0.228
GDI2GDP dissociation inhibitor 20.181
ITSN1intersectin 1 (SH3 domain protein)0.132
FNBP1formin binding protein 10.119
MAPK8mitogen-activated protein kinase 80.081
CTSAcathepsin A0.060
VPS41vacuolar protein sorting 41 homolog (S. cerevisiae)0.050
OCRLoculocerebrorenal syndrome of Lowe0.041
ATF2activating transcription factor 20.040
GOLGA7golgin A70.035
HEXBhexosaminidase B (beta polypeptide)0.035
EEA1early endosome antigen 10.034
AP1G1adaptor-related protein complex 1, gamma 1 subunit0.034
PLD3phospholipase D family, member 30.032
LAMP2lysosomal-associated membrane protein 20.031
GLB1galactosidase, beta 10.030
TPM4tropomyosin 40.030
SNX33sorting nexin 330.030
STX12syntaxin 120.028
C5orf54chromosome 5 open reading frame 540.026
REEP6receptor accessory protein 60.026
GM2AGM2 ganglioside activator0.025
GNSglucosamine (N-acetyl)-6-sulfatase0.025
MFSD1major facilitator superfamily domain containing 10.025
GRNgranulin0.025
LAMTOR3late endosomal/lysosomal adaptor, MAPK and MTOR activator 30.024
CDC34cell division cycle 34 homolog (S. cerevisiae)0.024
AKTIPAKT interacting protein0.023
ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C10.023
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.019
AMBRA1autophagy/beclin-1 regulator 10.017
ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)0.017
RAB5ARAB5A, member RAS oncogene family0.017
SYT11synaptotagmin XI0.016
CTTNcortactin0.016
HOOK3hook homolog 3 (Drosophila)0.016
SS18synovial sarcoma translocation, chromosome 180.016
STX7syntaxin 70.015
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.015
EIF1Beukaryotic translation initiation factor 1B0.015
IGF2Rinsulin-like growth factor 2 receptor0.015
CTSDcathepsin D0.015
MMGT1membrane magnesium transporter 10.015
WDR48WD repeat domain 480.014
DNM1dynamin 10.014
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.014
GGA3golgi-associated, gamma adaptin ear containing, ARF binding protein 30.014
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.014
RNF170ring finger protein 1700.013
RAB6ARAB6A, member RAS oncogene family0.013
P2RX4purinergic receptor P2X, ligand-gated ion channel, 40.013
RTN1reticulon 10.013
CALUcalumenin0.012
MAPKAPK3mitogen-activated protein kinase-activated protein kinase 30.012
SCAMP2secretory carrier membrane protein 20.012
ARF3ADP-ribosylation factor 30.012
ZDHHC24zinc finger, DHHC-type containing 240.012
SPHARS-phase response (cyclin related)0.012
KIAA1377KIAA13770.012
NEU1sialidase 1 (lysosomal sialidase)0.012
CLCN7chloride channel 70.011
PEX2peroxisomal biogenesis factor 20.011
HPS1Hermansky-Pudlak syndrome 10.011
POLD4polymerase (DNA-directed), delta 40.011
VPS33Avacuolar protein sorting 33 homolog A (S. cerevisiae)0.011
M6PRmannose-6-phosphate receptor (cation dependent)0.011
SGSHN-sulfoglucosamine sulfohydrolase0.011
SGK3serum/glucocorticoid regulated kinase family, member 30.011
SYNJ1synaptojanin 10.011
TM9SF2transmembrane 9 superfamily member 20.011
STAMBPSTAM binding protein0.011
ZFYVE1zinc finger, FYVE domain containing 10.011
C1orf85chromosome 1 open reading frame 850.011
ATRNattractin0.011
NPC2Niemann-Pick disease, type C20.011
RABEP1rabaptin, RAB GTPase binding effector protein 10.010
TM9SF4transmembrane 9 superfamily protein member 40.010
MR1major histocompatibility complex, class I-related0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hexbhexosaminidase B0.995
Hexahexosaminidase A0.991
Dpp7dipeptidylpeptidase 70.990
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.966
Lystlysosomal trafficking regulator0.942
0610031J06RikRIKEN cDNA 0610031J06 gene0.868
Npc1Niemann Pick type C10.859
Mitfmicrophthalmia-associated transcription factor0.836
Iduaiduronidase, alpha-L-0.493
Pldnpallidin0.419
Lamp1lysosomal-associated membrane protein 10.374
NagaN-acetyl galactosaminidase, alpha0.360
Rab27aRAB27A, member RAS oncogene family0.310
Mfsd1major facilitator superfamily domain containing 10.302
Kitkit oncogene0.291
Naglualpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)0.259
Ush1gUsher syndrome 1G homolog (human)0.235
anonagouti0.233
Gaaglucosidase, alpha, acid0.233
Pld3phospholipase D family, member 30.216
Gnsglucosamine (N-acetyl)-6-sulfatase0.216
Slc24a5solute carrier family 24, member 50.208
Gbaglucosidase, beta, acid0.194
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.183
Psapprosaposin0.182
Renbprenin binding protein0.175
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.174
Tpp1tripeptidyl peptidase I0.169
Asah1N-acylsphingosine amidohydrolase 10.167
Apoeapolipoprotein E0.161
Tpra1transmembrane protein, adipocyte asscociated 10.160
Adam17a disintegrin and metallopeptidase domain 170.146
Tcn2transcobalamin 20.142
Ctsacathepsin A0.140
Ctsdcathepsin D0.138
Wdr81WD repeat domain 810.132
Gopcgolgi associated PDZ and coiled-coil motif containing0.130
Myo5amyosin VA0.121
Man2b1mannosidase 2, alpha B10.117
Grngranulin0.109
Lamtor3late endosomal/lysosomal adaptor, MAPK and MTOR activator 30.106
Zbtb24zinc finger and BTB domain containing 240.102
Neu1neuraminidase 10.098
Ctszcathepsin Z0.096
Arsaarylsulfatase A0.087
Hps6Hermansky-Pudlak syndrome 60.084
Rbl2retinoblastoma-like 20.083
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.083
Gusbglucuronidase, beta0.077
Pik3r2phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)0.076
RoraRAR-related orphan receptor alpha0.075
Pik3c3phosphoinositide-3-kinase, class 30.075
Kitlkit ligand0.074
AW549877expressed sequence AW5498770.072
Atp6v0eATPase, H+ transporting, lysosomal V0 subunit E0.070
Sgpl1sphingosine phosphate lyase 10.070
Mcoln1mucolipin 10.068
Lgmnlegumain0.068
Snx14sorting nexin 140.067
Itgb5integrin beta 50.067
RragcRas-related GTP binding C0.067
Atp6v0bATPase, H+ transporting, lysosomal V0 subunit B0.067
Myo6myosin VI0.065
Siaesialic acid acetylesterase0.062
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.062
Pcdh15protocadherin 150.061
Dscr3Down syndrome critical region gene 30.061
Heatr7aHEAT repeat containing 7A0.060
Yipf3Yip1 domain family, member 30.059
Mertkc-mer proto-oncogene tyrosine kinase0.059
Cln3ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)0.059
Manbamannosidase, beta A, lysosomal0.058
Mapk9mitogen-activated protein kinase 90.057
Coro1bcoronin, actin binding protein 1B0.053
Lrpap1low density lipoprotein receptor-related protein associated protein 10.053
Uap1l1UDP-N-acteylglucosamine pyrophosphorylase 1-like 10.052
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.050
Mtmr1myotubularin related protein 10.050
Sirpasignal-regulatory protein alpha0.050
Ppt2palmitoyl-protein thioesterase 20.049
Arsbarylsulfatase B0.049
Lgals8lectin, galactose binding, soluble 80.049
P2rx4purinergic receptor P2X, ligand-gated ion channel 40.048
Hltfhelicase-like transcription factor0.046
Nucb1nucleobindin 10.045
Mpv17MpV17 mitochondrial inner membrane protein0.045
Glb1galactosidase, beta 10.044
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.043
Il10rbinterleukin 10 receptor, beta0.043
Itm2cintegral membrane protein 2C0.042
Stard3START domain containing 30.042
Pla2g15phospholipase A2, group XV0.042
Lipalysosomal acid lipase A0.042
Gm2aGM2 ganglioside activator protein0.041
Hs1bp3HCLS1 binding protein 30.041
Clcn7chloride channel 70.040
Man2b2mannosidase 2, alpha B20.039
Abcd1ATP-binding cassette, sub-family D (ALD), member 10.038
Bri3brain protein I30.037
Galnsgalactosamine (N-acetyl)-6-sulfate sulfatase0.037
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism