The network for 'positive regulation of i kappab kinase nf kappab signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of i kappab kinase nf kappab signaling

Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

NameDescriptionProbabilityFunc Analog Organism
TlToll0.537
panpangolin0.219
Vap-33-1CG5014 gene product from transcript CG5014-RB0.206
RelRelish0.167
Toll-7CG8595 gene product from transcript CG8595-RA0.160
PcafCG4107 gene product from transcript CG4107-RA0.146
Toll-6CG7250 gene product from transcript CG7250-RA0.143
spzspatzle0.106
18w18 wheeler0.090
pumpumilio0.068
p24-1p24-related-10.064
baibaiser0.058
ftz-f1ftz transcription factor 10.055
CG10414CG10414 gene product from transcript CG10414-RA0.054
Cf2Chorion factor 20.054
keykenny0.053
Btk29ABtk family kinase at 29A0.052
Tak1TGF-beta activated kinase 10.048
Myd88CG2078 gene product from transcript CG2078-RA0.048
cactcactus0.047
miltmilton0.046
CatCatalase0.046
chicchickadee0.043
CG10650CG10650 gene product from transcript CG10650-RA0.043
krzkurtz0.043
Rab11Rab-protein 110.041
par-1CG8201 gene product from transcript CG8201-RA0.040
l(2)k16918lethal (2) k169180.039
PliPellino0.038
parkparkin0.038
ttan0.037
Su(H)Suppressor of Hairless0.036
weeCG4488 gene product from transcript CG4488-RA0.036
PaxPaxillin0.034
HcfHost cell factor0.033
sqhspaghetti squash0.033
Fmr1CG6203 gene product from transcript CG6203-RC0.033
Rac2CG8556 gene product from transcript CG8556-RA0.032
Gycalpha99BGuanylyl cyclase alpha-subunit at 99B0.032
grngrain0.032
TolloCG6890 gene product from transcript CG6890-RA0.031
jarjaguar0.031
Nipped-BCG17704 gene product from transcript CG17704-RI0.031
CHIPCG5203 gene product from transcript CG5203-RA0.031
sloslowpoke0.030
hephemipterous0.029
tamoCG4057 gene product from transcript CG4057-RA0.029
alphaTryalphaTrypsin0.029
norpAno receptor potential A0.029
elavembryonic lethal abnormal vision0.029
SoxNSoxNeuro0.029
CG14614CG14614 gene product from transcript CG14614-RA0.028
unc79CG5237 gene product from transcript CG5237-RB0.028
Akt1CG4006 gene product from transcript CG4006-RA0.028
mnbminibrain0.028
plexAplexin A0.027
lmglemming0.027
decaydeath executioner caspase related to Apopain/Yama0.027
Pp2B-14DProtein phosphatase 2B at 14D0.027
liclicorne0.027
RanGapRan GTPase activating protein0.026
Nup160Nucleoporin 1600.026
slowslowdown0.026
GgaCG3002 gene product from transcript CG3002-RB0.026
Apc2Adenomatous polyposis coli tumor suppressor homolog 20.026
ebiCG4063 gene product from transcript CG4063-RA0.025
sbbscribbler0.025
ranCG1404 gene product from transcript CG1404-RB0.025
EloAElongin A0.025
CG32711CG32711 gene product from transcript CG32711-RA0.025
M6CG7540 gene product from transcript CG7540-RA0.025
nanarrow abdomen0.025
Tre1trapped in endoderm-10.024
l(2)05510lethal (2) 055100.024
fzyfizzy0.024
CamCalmodulin0.024
bskbasket0.023
Dip3Dorsal interacting protein 30.023
CG17108CG17108 gene product from transcript CG17108-RA0.023
MESR6Misexpression suppressor of ras 60.023
nopono poles0.022
p53CG33336 gene product from transcript CG33336-RB0.022
Ube3aUbiquitin protein ligase E3A0.022
pigspickled eggs0.022
HtrA2CG8464 gene product from transcript CG8464-RA0.022
CycDCyclin D0.022
BG4CG12297 gene product from transcript CG12297-RA0.022
ArkApaf-1-related-killer0.021
DripCG9023 gene product from transcript CG9023-RA0.021
ari-1ariadne0.020
Usp7ubiquitin-specific protease 70.020
trioCG18214 gene product from transcript CG18214-RA0.020
CG17746CG17746 gene product from transcript CG17746-RA0.020
DuoxDual oxidase0.020
ContContactin0.020
CG13323CG13323 gene product from transcript CG13323-RA0.020
cln3CG5582 gene product from transcript CG5582-RA0.019
CG15784CG15784 gene product from transcript CG15784-RA0.019
ird5immune response deficient 50.019
Trap1CG3152 gene product from transcript CG3152-RA0.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tlr3toll-like receptor 30.524
tnfatumor necrosis factor a (TNF superfamily, member 2)0.503
cd63Cd63 antigen0.344
il8interleukin 80.340
adipor2adiponectin receptor 20.322
tfr1atransferrin receptor 1a0.312
tlr9toll-like receptor 90.291
adipoqladiponectin, C1Q and collagen domain containing, like0.282
LOC557072caspase recruitment domain-containing protein 11-like0.277
cahzcarbonic anhydrase0.271
caspacaspase a0.269
drldraculin0.266
klfdKruppel-like factor d0.237
LOC100003514protein kinase C alpha type-like0.223
itm2bbintegral membrane protein 2Bb0.218
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.218
il6rinterleukin 6 receptor0.208
blvrbbiliverdin reductase B (flavin reductase (NADPH))0.195
adipor1badiponectin receptor 1b0.194
zgc:64115zgc:641150.183
adipoql2adiponectin, C1Q and collagen domain containing, like 20.168
coro1acoronin, actin binding protein, 1A0.162
il6stinterleukin 6 signal transducer0.156
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.156
cav1caveolin 10.146
hmbsbhydroxymethylbilane synthase, b0.145
nod1nucleotide-binding oligomerization domain containing 10.142
si:dkey-114g7.4si:dkey-114g7.40.142
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.138
adipor1aadiponectin receptor 1a0.136
b2mbeta-2-microglobulin0.126
relv-rel reticuloendotheliosis viral oncogene homolog0.123
bmp7bbone morphogenetic protein 7b0.121
unc5cunc-5 homolog C (C. elegans)0.118
prkczprotein kinase C, zeta0.117
nt5c2l15'-nucleotidase, cytosolic II, like 10.115
elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.112
slc4a1bsolute carrier family 4, anion exchanger, member 1b0.109
hbaa1hemoglobin alpha adult-10.107
alas2aminolevulinate, delta-, synthetase 20.105
sirt1sirtuin (silent mating type information regulation 2 homolog) 10.104
LOC100000934hypothetical protein LOC1000009340.104
foxo3bforkhead box O3b0.101
hdrhematopoietic death receptor0.099
vegfaavascular endothelial growth factor Aa0.098
sdcbpsyndecan binding protein (syntenin)0.095
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.095
il1binterleukin 1, beta and interleukin 1, beta0.095
lats1LATS, large tumor suppressor, homolog 1 (Drosophila)0.094
eporerythropoietin receptor0.094
hcrthypocretin (orexin) neuropeptide precursor0.092
rbm22RNA binding motif protein 220.089
irak4interleukin-1 receptor-associated kinase 40.089
slc4a1asolute carrier family 4, anion exchanger, member 1a0.088
wu:fc23b05wu:fc23b050.087
lndc1ly6/neurotoxin domain containing 10.086
hspa4aheat shock protein 4a0.084
zgc:92027zgc:920270.084
tnfbtumor necrosis factor b (TNF superfamily, member 2)0.082
card9caspase recruitment domain family, member 90.081
mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.078
pcsk7proprotein convertase subtilisin/kexin type 70.077
mpxmyeloid-specific peroxidase0.076
acsl3aacyl-CoA synthetase long-chain family member 3a0.075
slc7a6solute carrier family 7 (cationic amino acid transporter, y+ system), member 60.072
tlr8btoll-like receptor 8b0.072
acp5bacid phosphatase 5b, tartrate resistant0.071
adrb2aadrenergic receptor, beta 2a0.070
si:ch211-9d9.3si:ch211-9d9.30.068
tlr18toll-like receptor 180.068
tgm2btransglutaminase 2b0.068
ppoxprotoporphyrinogen oxidase0.067
ecscrendothelial cell-specific chemotaxis regulator0.067
tmem93transmembrane protein 930.066
si:dkeyp-94b4.2si:dkeyp-94b4.20.066
arf2ADP-ribosylation factor 20.066
slc9a8solute carrier family 9 (sodium/hydrogen exchanger), member 80.065
k31k31 gene0.065
msi1musashi homolog 1 (Drosophila)0.065
vcanbversican b0.065
hapln1ahyaluronan and proteoglycan link protein 1a0.065
tmed2transmembrane emp24 domain trafficking protein 20.065
LOC100332039ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like0.064
anxa2bannexin A2b0.063
LOC100004946transient receptor potential cation channel subfamily M member 4-like0.062
hspb11heat shock protein, alpha-crystallin-related, b110.062
stard3START domain containing 30.062
LOC566020Gig2-like protein DreO0.062
ube2nbubiquitin-conjugating enzyme E2Nb0.061
traf6TNF receptor-associated factor 60.061
sema3fbsemaphorin 3fb0.061
slco1c1solute carrier organic anion transporter family, member 1C10.061
rhdRh blood group, D antigen0.060
elovl4aelongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4a0.058
sepp1bselenoprotein P, plasma, 1b0.057
hif1aahypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a0.057
si:dkey-8l13.4si:dkey-8l13.40.056
chmp4bchromatin modifying protein 4B0.055
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.055
trpv6transient receptor potential cation channel, subfamily V, member 60.055
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 11.000
BIRC3baculoviral IAP repeat containing 31.000
XIAPX-linked inhibitor of apoptosis1.000
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma1.000
TRAF6TNF receptor-associated factor 61.000
TRAF1TNF receptor-associated factor 11.000
TRAF2TNF receptor-associated factor 21.000
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
RIPK2receptor-interacting serine-threonine kinase 21.000
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta1.000
TRAF3TNF receptor-associated factor 31.000
UBCubiquitin C0.999
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.999
BIRC2baculoviral IAP repeat containing 20.999
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.999
FASFas (TNF receptor superfamily, member 6)0.998
SQSTM1sequestosome 10.998
S100A6S100 calcium binding protein A60.998
MYD88myeloid differentiation primary response gene (88)0.996
TNFAIP3tumor necrosis factor, alpha-induced protein 30.995
MAP3K7mitogen-activated protein kinase kinase kinase 70.995
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.995
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.990
TRADDTNFRSF1A-associated via death domain0.989
CFLARCASP8 and FADD-like apoptosis regulator0.988
MDM2Mdm2 p53 binding protein homolog (mouse)0.987
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.984
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.981
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.981
CHUKconserved helix-loop-helix ubiquitous kinase0.981
MAP3K3mitogen-activated protein kinase kinase kinase 30.980
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.974
TNFtumor necrosis factor0.952
PMLpromyelocytic leukemia0.945
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.939
CAV1caveolin 1, caveolae protein, 22kDa0.937
FADDFas (TNFRSF6)-associated via death domain0.937
IL1R1interleukin 1 receptor, type I0.937
SMAD3SMAD family member 30.936
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.936
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.935
FLNAfilamin A, alpha0.931
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.928
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.920
TRIM39tripartite motif containing 390.909
S100BS100 calcium binding protein B0.893
CASP3caspase 3, apoptosis-related cysteine peptidase0.893
IL1Binterleukin 1, beta0.879
CASP10caspase 10, apoptosis-related cysteine peptidase0.878
CD40CD40 molecule, TNF receptor superfamily member 50.874
TICAM2toll-like receptor adaptor molecule 20.871
ANXA1annexin A10.825
ANXA2annexin A20.825
CASP7caspase 7, apoptosis-related cysteine peptidase0.824
S100A11S100 calcium binding protein A110.819
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.810
S100A16S100 calcium binding protein A160.797
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.796
TRIM21tripartite motif containing 210.795
MAP3K14mitogen-activated protein kinase kinase kinase 140.770
NCF1neutrophil cytosolic factor 10.770
CCL2chemokine (C-C motif) ligand 20.765
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.750
TANKTRAF family member-associated NFKB activator0.750
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.736
CASP9caspase 9, apoptosis-related cysteine peptidase0.730
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.718
GBP1guanylate binding protein 1, interferon-inducible0.715
IL8interleukin 80.679
TRAF5TNF receptor-associated factor 50.677
S100A1S100 calcium binding protein A10.675
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.670
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.669
TLR4toll-like receptor 40.669
S100A14S100 calcium binding protein A140.669
PSEN1presenilin 10.641
ZC3H12Azinc finger CCCH-type containing 12A0.632
IRF1interferon regulatory factor 10.620
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.618
ACTN4actinin, alpha 40.597
CXCL9chemokine (C-X-C motif) ligand 90.585
S100A4S100 calcium binding protein A40.580
PIAS4protein inhibitor of activated STAT, 40.571
MED15mediator complex subunit 150.557
CYLDcylindromatosis (turban tumor syndrome)0.552
EZRezrin0.546
PTK2BPTK2B protein tyrosine kinase 2 beta0.531
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.530
MAP3K8mitogen-activated protein kinase kinase kinase 80.526
UBE2L6ubiquitin-conjugating enzyme E2L 60.523
TLR2toll-like receptor 20.510
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.501
DAXXdeath-domain associated protein0.500
LTAlymphotoxin alpha (TNF superfamily, member 1)0.497
CD14CD14 molecule0.482
CCR5chemokine (C-C motif) receptor 50.479
ACVR1Bactivin A receptor, type IB0.447
APOL3apolipoprotein L, 30.445
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.440
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.433
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.595
Il1ainterleukin 1 alpha0.365
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.230
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.202
Timp1TIMP metallopeptidase inhibitor 10.139
Ccl2chemokine (C-C motif) ligand 20.131
Il6interleukin 60.119
Stat3signal transducer and activator of transcription 30.119
Parp14poly (ADP-ribose) polymerase family, member 140.089
Lgals5lectin, galactose binding, soluble 50.085
Myd88myeloid differentiation primary response gene 880.080
LOC686326similar to Interferon-alpha/beta receptor beta chain precursor (IFN-alpha-REC) (Type I interferon receptor) (IFN-R) (Interferon alpha/beta receptor-2)0.073
Lrp10low-density lipoprotein receptor-related protein 100.070
Dtx3ldeltex 3-like (Drosophila)0.070
Ccnd3cyclin D30.065
Icam1intercellular adhesion molecule 10.060
Hist1h1ahistone cluster 1, H1a0.056
Stat6signal transducer and activator of transcription 60.055
Vcam1vascular cell adhesion molecule 10.055
Syngr2synaptogyrin 20.052
Usf2upstream transcription factor 2, c-fos interacting0.051
Ccl4chemokine (C-C motif) ligand 40.049
Ccl3chemokine (C-C motif) ligand 30.047
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.046
Tnftumor necrosis factor (TNF superfamily, member 2)0.041
Mgat1mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase0.039
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.039
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.035
Svs3aseminal vesicle secretory protein 3A0.034
Casp12caspase 120.033
Arl11ADP-ribosylation factor-like 110.032
Arf5ADP-ribosylation factor 50.031
Cxcl13chemokine (C-X-C motif) ligand 130.030
Cxcl10chemokine (C-X-C motif) ligand 100.030
Neurl3neuralized homolog 3 (Drosophila)0.029
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.029
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.028
Gatad1GATA zinc finger domain containing 10.028
Cdk4cyclin-dependent kinase 40.027
Apol3apolipoprotein L, 30.027
Cxcl2chemokine (C-X-C motif) ligand 20.027
Litaflipopolysaccharide-induced TNF factor0.026
Ubtfupstream binding transcription factor, RNA polymerase I0.026
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.025
Shisa5shisa homolog 5 (Xenopus laevis)0.023
Gna12guanine nucleotide binding protein (G protein) alpha 120.022
Ptprcprotein tyrosine phosphatase, receptor type, C0.022
Mmp12matrix metallopeptidase 120.022
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.019
Oaz2ornithine decarboxylase antizyme 20.019
LOC100362108poly (ADP-ribose) polymerase family, member 100.018
Apba3amyloid beta (A4) precursor protein-binding, family A, member 30.018
Vdac1voltage-dependent anion channel 10.018
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.017
Hckhemopoietic cell kinase0.017
Tcf4transcription factor 40.016
Selpselectin P0.016
Epha2Eph receptor A20.016
Myh9myosin, heavy chain 9, non-muscle0.016
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.015
Map2k1mitogen activated protein kinase kinase 10.015
Mx1myxovirus (influenza virus) resistance 10.015
Hspb1heat shock protein 10.015
Cd14CD14 molecule0.015
Slc39a1solute carrier family 39 (zinc transporter), member 10.015
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.015
Il2rbinterleukin 2 receptor, beta0.015
Ptafrplatelet-activating factor receptor0.015
Casp1caspase 10.014
Il18interleukin 180.014
Mca32mast cell antigen 320.014
Fgfr1Fibroblast growth factor receptor 10.014
Vat1vesicle amine transport protein 1 homolog (T californica)0.014
Mpripmyosin phosphatase Rho interacting protein0.013
Il1rl2interleukin 1 receptor-like 20.013
Cfhcomplement factor H0.013
Nptnneuroplastin0.013
Cd40CD40 molecule, TNF receptor superfamily member 50.013
Zfp36l1zinc finger protein 36, C3H type-like 10.013
Tfpi2tissue factor pathway inhibitor 20.012
Cd4Cd4 molecule0.012
Rab1bRAB1B, member RAS oncogene family0.012
Gcnt1glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)0.012
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.012
Rab20RAB20, member RAS oncogene family0.012
Eef2eukaryotic translation elongation factor 20.012
Cd83CD83 molecule0.012
Socs3suppressor of cytokine signaling 30.011
BokBCL2-related ovarian killer0.011
Orai1ORAI calcium release-activated calcium modulator 10.011
RGD1305793similar to hypothetical protein FLJ201540.011
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.011
Gltpglycolipid transfer protein0.011
Calcbcalcitonin-related polypeptide, beta0.011
Ifitm1interferon induced transmembrane protein 10.011
Il1binterleukin 1 beta0.011
Gas7growth arrest specific 70.010
Hn1hematological and neurological expressed 10.010
Akt2v-akt murine thymoma viral oncogene homolog 20.010
Thbdthrombomodulin0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism