The network for 'epidermal cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epidermal cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.

NameDescriptionProbabilityFunc Analog Organism
wgwingless0.999
Rho1CG8416 gene product from transcript CG8416-RB0.993
dshdishevelled0.981
edechinoid0.965
E(spl)Enhancer of split0.958
hhhedgehog0.952
hthhomothorax0.927
fzfrizzled0.894
stgstring0.862
amosabsent MD neurons and olfactory sensilla0.854
otkoff-track0.831
trctricornered0.809
G-oalpha47AG protein oalpha 47A0.803
HLHmbetaE(spl) region transcript mbeta0.792
ininturned0.779
nubnubbin0.750
fforked0.745
HLHm7E(spl) region transcript m70.745
ftfat0.742
cicubitus interruptus0.699
kuzkuzbanian0.673
acachaete0.669
atoatonal0.666
Rac1CG2248 gene product from transcript CG2248-RA0.652
fngfringe0.598
Cdc42CG12530 gene product from transcript CG12530-RA0.598
dsdachsous0.583
SoxNSoxNeuro0.575
SerSerrate0.550
hephemipterous0.537
enengrailed0.533
gcmglial cells missing0.521
HLHmdeltaE(spl) region transcript mdelta0.495
zipzipper0.485
snsinged0.470
Abd-BAbdominal B0.461
TomTwin of m40.460
stanstarry night0.456
MoeMoesin0.455
Oatp74DOrganic anion transporting polypeptide 74D0.450
fwfurrowed0.431
HLHmgammaE(spl) region transcript mgamma0.430
RASSF8CG5053 gene product from transcript CG5053-RA0.426
kluklumpfuss0.425
fz2frizzled 20.422
aseasense0.415
lzlozenge0.400
eygeyegone0.381
HLHm5E(spl) region transcript m50.371
MadMothers against dpp0.370
vvlventral veins lacking0.364
VangVan Gogh0.354
tsltorso-like0.350
flwflapwing0.348
NNotch0.347
flrflare0.321
elavembryonic lethal abnormal vision0.320
TolloCG6890 gene product from transcript CG6890-RA0.315
CG32556CG32556 gene product from transcript CG32556-RB0.301
DDichaete0.288
coracoracle0.275
norpAno receptor potential A0.269
scscute0.253
sshslingshot0.249
chicchickadee0.247
msnmisshapen0.245
droshaCG8730 gene product from transcript CG8730-RA0.245
commcommissureless0.244
mewmultiple edematous wings0.238
araaraucan0.232
smosmoothened0.226
Ntf-2Nuclear transport factor-20.222
Nrx-IVNeurexin IV0.222
svshaven0.219
emcextra macrochaetae0.212
lqfRliquid facets-Related0.205
armarmadillo0.194
Mpk2CG5475 gene product from transcript CG5475-RB0.191
Rab23CG2108 gene product from transcript CG2108-RA0.190
aopanterior open0.189
mammastermind0.189
Cul-3Cullin-30.188
shashavenoid0.186
sdscalloped0.185
eyeyeless0.181
rheaCG6831 gene product from transcript CG6831-RA0.181
par-1CG8201 gene product from transcript CG8201-RA0.177
Akt1CG4006 gene product from transcript CG4006-RA0.177
HLHm3E(spl) region transcript m30.176
DadDaughters against dpp0.170
CG9510CG9510 gene product from transcript CG9510-RC0.169
Pka-C1cAMP-dependent protein kinase 10.166
CG3563CG3563 gene product from transcript CG3563-RA0.166
argosCG4531 gene product from transcript CG4531-RA0.164
RalaRas-related protein0.158
sanoserrano0.157
vgvestigial0.157
VhaM8.9CG8444 gene product from transcript CG8444-RA0.153
MerMerlin0.152
notnon-stop0.143
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.478
unc-73Protein UNC-730.209
let-60Protein LET-600.191
elt-6Protein ELT-60.167
pha-4Protein PHA-40.110
egl-46Protein EGL-460.074
hlh-2Protein HLH-20.064
cnd-1Protein CND-10.056
ten-1Protein TEN-10.043
mpk-1Protein MPK-10.035
dys-1Protein DYS-10.035
flt-1Protein FLT-10.026
goa-1Protein GOA-10.025
mig-2Protein MIG-20.023
trim-9Protein TRIM-90.022
hlh-1Protein HLH-10.021
CELE_F23C8.7Protein F23C8.70.019
nhr-67Protein NHR-670.018
ceh-20Protein CEH-200.017
atn-1Protein ATN-10.017
egl-26Protein EGL-260.016
sel-8Protein SEL-80.016
cas-1Protein CAS-10.016
C06G1.5Protein C06G1.50.015
hbl-1Protein HBL-10.015
zip-7Protein ZIP-70.014
T23F11.1Protein T23F11.10.014
egl-5Protein EGL-50.014
tag-343Protein TAG-3430.014
egl-27Protein EGL-270.013
mls-2Protein MLS-20.012
ceh-16Protein CEH-160.012
C24G6.2Protein C24G6.20.012
ptp-1Protein PTP-10.012
nhr-34Protein NHR-340.012
ref-2Protein REF-20.012
nhr-25Protein NHR-250.011
F11D5.1Protein F11D5.10.011
K07A3.3Protein K07A3.30.011
unc-53Protein UNC-530.011
ceh-13Protein CEH-130.010
elc-1Protein ELC-10.010
C25E10.12Protein C25E10.120.010
lin-7Protein LIN-70.010
hlh-14Protein HLH-140.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dladeltaA0.997
notch1anotch homolog 1a0.965
dlcdeltaC0.960
jag1bjagged 1b0.942
atoh1batonal homolog 1b0.933
gata3GATA-binding protein 30.916
neurog1neurogenin 10.914
dlx4adistal-less homeobox gene 4a0.900
krt4keratin 40.887
tp63tumor protein p630.878
dlx4bdistal-less homeobox gene 4b0.853
ascl1aachaete-scute complex-like 1a (Drosophila)0.837
pax2apaired box gene 2a0.826
eya1eyes absent homolog 10.818
fgf3fibroblast growth factor 30.797
gli1GLI-Kruppel family member 10.777
ptf1apancreas specific transcription factor, 1a0.768
tbx1T-box 10.761
socs1suppressor of cytokine signaling 10.755
bmp4bone morphogenetic protein 40.735
hoxb3ahomeo box B3a0.730
tfap2atranscription factor AP-2 alpha0.696
prox1prospero-related homeobox gene 10.692
dlbdeltaB0.667
fgfr4fibroblast growth factor receptor 40.659
dlddeltaD0.658
six4bsine oculis homeobox homolog 4b0.606
fgf8afibroblast growth factor 8 a0.602
gli2aGLI-Kruppel family member GLI2a0.599
foxc1aforkhead box C1a0.593
foxi1forkhead box I10.583
neurod4neurogenic differentiation 40.582
fzd8afrizzled homolog 8a0.565
epb41l5erythrocyte membrane protein band 4.1 like 50.526
hhiphedgehog interacting protein0.492
her6hairy-related 60.489
mab21l2mab-21-like 20.485
hnf1baHNF1 homeobox Ba0.480
otpborthopedia homolog b0.475
myo7aamyosin VIIAa0.457
pitx2paired-like homeodomain transcription factor 20.457
pitx3paired-like homeodomain transcription factor 30.446
sp5lSp5 transcription factor-like0.444
foxa1forkhead box A10.439
irx1biroquois homeobox protein 1, b0.412
myf5myogenic factor 50.407
notch3notch homolog 30.400
notch2notch homolog 20.387
ephb3aeph receptor B3a0.383
pax6bpaired box gene 6b0.359
dlx3bdistal-less homeobox gene 3b0.358
pax8paired box gene 80.355
grhl2bgrainyhead-like 2b (Drosophila)0.348
dlx6adistal-less homeobox gene 6a0.346
cdh1cadherin 1, epithelial0.344
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.336
lmx1b.2LIM homeobox transcription factor 1, beta 20.336
lhx5LIM homeobox 50.321
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.321
pax2bpaired box gene 2b0.316
prdm1aPR domain containing 1a, with ZNF domain0.299
hoxb1bhomeo box B1b0.293
lrrc6leucine rich repeat containing 60.290
hey1hairy/enhancer-of-split related with YRPW motif 10.282
sall1asal-like 1a (Drosophila)0.282
eve1even-skipped-like10.278
foxj1bforkhead box J1b0.277
hoxa3ahomeo box A3a0.268
runx3runt-related transcription factor 30.256
lmx1b.1LIM homeobox transcription factor 1, beta 10.254
synj1synaptojanin 10.250
atf3activating transcription factor 30.244
lamc1laminin, gamma 10.242
otx2orthodenticle homolog 20.241
ift88intraflagellar transport 88 homolog0.237
shhbsonic hedgehog b0.233
hnf1bbHNF1 homeobox Bb0.226
sox10SRY-box containing gene 100.219
nkd1naked cuticle homolog 1 (Drosophila)0.217
wnt1wingless-type MMTV integration site family, member 10.216
mibmind bomb0.215
notum3notum 30.202
sox2SRY-box containing gene 20.202
foxa2forkhead box A20.199
lhx1aLIM homeobox 1a0.199
irx4biroquois homeobox protein 4b0.198
dlx1adistal-less homeobox gene 1a0.196
epha4beph receptor A4b0.195
crabp2acellular retinoic acid binding protein 2, a0.191
crestincrestin0.188
fgfr1afibroblast growth factor receptor 1a0.188
zgc:101606zgc:1016060.187
fstafollistatin a0.172
sox9aSRY-box containing gene 9a0.169
mnx1motor neuron and pancreas homeobox 10.168
fgf10afibroblast growth factor 10a0.167
slit3slit (Drosophila) homolog 30.165
meis2.1myeloid ecotropic viral integration site 2.10.165
phox2apaired-like homeobox 2a0.165
nrarpanotch-regulated ankyrin repeat protein a0.163
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
KRT15keratin 150.996
HDAC1histone deacetylase 10.994
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.994
STK3serine/threonine kinase 30.985
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.985
NOTCH1notch 10.963
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.958
TJP1tight junction protein 1 (zona occludens 1)0.946
KRT6Bkeratin 6B0.944
TP63tumor protein p630.914
SPRR1Asmall proline-rich protein 1A0.845
JAG1jagged 10.838
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.837
CREBBPCREB binding protein0.829
SFNstratifin0.815
KRT5keratin 50.767
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.750
NOTCH3notch 30.748
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.747
NCOA1nuclear receptor coactivator 10.746
KRT8keratin 80.741
KRT14keratin 140.734
NCOR2nuclear receptor corepressor 20.711
NME2non-metastatic cells 2, protein (NM23B) expressed in0.702
MDM2Mdm2 p53 binding protein homolog (mouse)0.690
EGFRepidermal growth factor receptor0.638
IQGAP1IQ motif containing GTPase activating protein 10.633
HOXB5homeobox B50.607
TRIM29tripartite motif containing 290.602
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.599
KRT1keratin 10.593
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.590
KRT19keratin 190.590
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.561
NFE2L2nuclear factor (erythroid-derived 2)-like 20.551
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.545
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.525
KRT18keratin 180.506
ZNF746zinc finger protein 7460.506
KRT6Akeratin 6A0.497
BBS10Bardet-Biedl syndrome 100.482
SUFUsuppressor of fused homolog (Drosophila)0.432
GRB7growth factor receptor-bound protein 70.422
TMBIM6transmembrane BAX inhibitor motif containing 60.422
RXRAretinoid X receptor, alpha0.421
ANXA1annexin A10.416
BMPR1Abone morphogenetic protein receptor, type IA0.414
RARAretinoic acid receptor, alpha0.405
ABI2abl-interactor 20.383
SORBS2sorbin and SH3 domain containing 20.378
ARandrogen receptor0.364
SPRR1Bsmall proline-rich protein 1B0.364
KRT17keratin 170.354
KRT34keratin 340.348
CTSBcathepsin B0.340
FN1fibronectin 10.339
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.332
HOXB6homeobox B60.323
ESR1estrogen receptor 10.316
EZRezrin0.310
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.307
DSG2desmoglein 20.305
GJB3gap junction protein, beta 3, 31kDa0.305
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.303
KRT16keratin 160.300
FHL1four and a half LIM domains 10.294
DSPdesmoplakin0.294
KRT33Bkeratin 33B0.274
HOXA10homeobox A100.257
HNF4Ahepatocyte nuclear factor 4, alpha0.252
EP300E1A binding protein p3000.251
HRhairless homolog (mouse)0.248
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.245
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.243
LY6Dlymphocyte antigen 6 complex, locus D0.240
NCOR1nuclear receptor corepressor 10.240
KRT6Ckeratin 6C0.236
SMAD1SMAD family member 10.233
IVLinvolucrin0.232
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.222
NCOA6nuclear receptor coactivator 60.221
KLK10kallikrein-related peptidase 100.219
S100A10S100 calcium binding protein A100.218
SPINT1serine peptidase inhibitor, Kunitz type 10.215
SRSF4serine/arginine-rich splicing factor 40.213
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.212
CASP9caspase 9, apoptosis-related cysteine peptidase0.211
FZD1frizzled homolog 1 (Drosophila)0.207
SLURP1secreted LY6/PLAUR domain containing 10.202
EFNA5ephrin-A50.193
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.190
EFNA1ephrin-A10.190
ATP6V0CATPase, H+ transporting, lysosomal 16kDa, V0 subunit c0.190
STK38Lserine/threonine kinase 38 like0.186
USHBP1Usher syndrome 1C binding protein 10.181
DSG1desmoglein 10.181
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.180
KRT4keratin 40.177
NEDD4neural precursor cell expressed, developmentally down-regulated 40.177
NCOA3nuclear receptor coactivator 30.175
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism