The network for 'positive regulation of rac gtpase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of rac gtpase activity

Any process that activates or increases the activity of a GTPase of the Rac family.

NameDescriptionProbabilityFunc Analog Organism
mbcmyoblast city0.902
plexBplexin B0.458
pod1CG4532 gene product from transcript CG4532-RF0.452
AbiAbelson interacting protein0.411
SosSon of sevenless0.388
HemHEM-protein0.344
RhoGEF2CG9635 gene product from transcript CG9635-RF0.321
neuroliginCG13772 gene product from transcript CG13772-RA0.297
DabDisabled0.207
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.206
gekgenghis khan0.163
rokRho-kinase0.140
enaenabled0.122
CG11033CG11033 gene product from transcript CG11033-RB0.112
l(2)k16918lethal (2) k169180.106
EphEph receptor tyrosine kinase0.070
synjsynaptojanin0.066
CG31224CG31224 gene product from transcript CG31224-RA0.061
vavCG7893 gene product from transcript CG7893-RB0.059
dockdreadlocks0.053
bazbazooka0.050
RhoGAP68FCG6811 gene product from transcript CG6811-RA0.045
EphrinCG1862 gene product from transcript CG1862-RA0.044
alpha-Man-IIbCG4606 gene product from transcript CG4606-RA0.044
su(s)suppressor of sable0.040
diadiaphanous0.040
CG6734CG6734 gene product from transcript CG6734-RA0.038
Pi3K92ECG4141 gene product from transcript CG4141-RB0.036
stgstring0.036
bin3bicoid-interacting protein 30.035
phlpole hole0.033
LIMK1LIM-kinase10.031
Pak3CG14895 gene product from transcript CG14895-RA0.031
CG15099CG15099 gene product from transcript CG15099-RA0.029
drkdownstream of receptor kinase0.026
enokenoki mushroom0.025
Ank2Ankyrin 20.024
nwknervous wreck0.024
pcxpecanex0.022
Wnt5Wnt oncogene analog 50.021
staistathmin0.021
betaInt-nubeta[nu] integrin0.021
laplike-AP1800.019
XNPCG4548 gene product from transcript CG4548-RA0.019
RanBPMRan-binding protein M0.019
Flo-2flotillin 20.019
Mkp3Mitogen-activated protein kinase phosphatase 30.018
MtlMig-2-like0.017
CG10631CG10631 gene product from transcript CG10631-RA0.017
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.017
tomosynCG17762 gene product from transcript CG17762-RB0.016
fbl6CG13213 gene product from transcript CG13213-RB0.015
Hip14Huntingtin-interacting protein 140.014
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.014
CG11486CG11486 gene product from transcript CG11486-RG0.014
exexextra-extra0.014
DAAMDishevelled Associated Activator of Morphogenesis0.014
CG3632CG3632 gene product from transcript CG3632-RH0.013
lmdlame duck0.013
taytay bridge0.013
CG12734CG12734 gene product from transcript CG12734-RA0.013
htlheartless0.013
NakNumb-associated kinase0.013
Sra-1specifically Rac1-associated protein 10.013
CG7518CG7518 gene product from transcript CG7518-RD0.012
CG11138CG11138 gene product from transcript CG11138-RC0.012
CG9425CG9425 gene product from transcript CG9425-RB0.012
SCARCG4636 gene product from transcript CG4636-RA0.012
CG8155CG8155 gene product from transcript CG8155-RA0.012
Eps-15Epidermal growth factor receptor pathway substrate clone 150.011
CG12187CG12187 gene product from transcript CG12187-RA0.011
CG12207CG12207 gene product from transcript CG12207-RB0.011
RhebCG1081 gene product from transcript CG1081-RA0.011
CG14442CG14442 gene product from transcript CG14442-RB0.011
CG10188CG10188 gene product from transcript CG10188-RB0.011
CG3125CG3125 gene product from transcript CG3125-RA0.010
GrafCG8948 gene product from transcript CG8948-RB0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)1.000
CDC42cell division cycle 42 (GTP binding protein, 25kDa)1.000
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 41.000
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.999
S100A6S100 calcium binding protein A60.998
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.996
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.996
EGFRepidermal growth factor receptor0.995
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.992
S100BS100 calcium binding protein B0.986
SOS1son of sevenless homolog 1 (Drosophila)0.980
S100A8S100 calcium binding protein A80.976
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.969
PTK2PTK2 protein tyrosine kinase 20.959
DOCK1dedicator of cytokinesis 10.947
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.944
S100A11S100 calcium binding protein A110.942
SFNstratifin0.933
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.928
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.924
ABI1abl-interactor 10.917
S100A9S100 calcium binding protein A90.894
NCF2neutrophil cytosolic factor 20.883
BAIAP2BAI1-associated protein 20.844
GRB2growth factor receptor-bound protein 20.828
CCR5chemokine (C-C motif) receptor 50.816
TRAF5TNF receptor-associated factor 50.804
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.755
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.749
CALM1calmodulin 1 (phosphorylase kinase, delta)0.746
S100A1S100 calcium binding protein A10.711
RHOCras homolog gene family, member C0.694
BBS10Bardet-Biedl syndrome 100.690
VAV1vav 1 guanine nucleotide exchange factor0.677
PLCG1phospholipase C, gamma 10.658
SH3RF3SH3 domain containing ring finger 30.657
LATlinker for activation of T cells0.649
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.620
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.616
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.598
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.588
CCL4chemokine (C-C motif) ligand 40.574
GRB7growth factor receptor-bound protein 70.564
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.538
S100A4S100 calcium binding protein A40.538
SH3KBP1SH3-domain kinase binding protein 10.521
SH3BP2SH3-domain binding protein 20.500
CNKSR2connector enhancer of kinase suppressor of Ras 20.466
NCKAP1NCK-associated protein 10.447
IQGAP1IQ motif containing GTPase activating protein 10.446
SHC1SHC (Src homology 2 domain containing) transforming protein 10.439
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.425
RHOAras homolog gene family, member A0.416
EMP3epithelial membrane protein 30.407
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.392
SH3RF1SH3 domain containing ring finger 10.384
LY6G6Flymphocyte antigen 6 complex, locus G6F0.383
MTORmechanistic target of rapamycin (serine/threonine kinase)0.378
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.368
RASSF5Ras association (RalGDS/AF-6) domain family member 50.364
NCK1NCK adaptor protein 10.343
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.326
LGALS1lectin, galactoside-binding, soluble, 10.319
RALBP1ralA binding protein 10.319
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.319
NAV1neuron navigator 10.255
ANXA2annexin A20.251
WIPF1WAS/WASL interacting protein family, member 10.243
S100A10S100 calcium binding protein A100.240
DPP4dipeptidyl-peptidase 40.239
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.232
MARK2MAP/microtubule affinity-regulating kinase 20.227
CXCL9chemokine (C-X-C motif) ligand 90.223
CHN2chimerin (chimaerin) 20.214
CAPGcapping protein (actin filament), gelsolin-like0.209
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.208
TNFtumor necrosis factor0.207
BCAR1breast cancer anti-estrogen resistance 10.203
CCL2chemokine (C-C motif) ligand 20.201
GSK3Bglycogen synthase kinase 3 beta0.193
SH2D1ASH2 domain containing 1A0.190
EFNA1ephrin-A10.190
ZNF746zinc finger protein 7460.187
GAS7growth arrest-specific 70.181
TRAF3TNF receptor-associated factor 30.178
RHOUras homolog gene family, member U0.173
CCL3chemokine (C-C motif) ligand 30.154
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.146
KIAA1377KIAA13770.143
EFNA5ephrin-A50.136
VAV3vav 3 guanine nucleotide exchange factor0.134
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.134
IL1Binterleukin 1, beta0.130
CCL8chemokine (C-C motif) ligand 80.127
ARHGAP15Rho GTPase activating protein 150.126
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.122
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.120
PVRL3poliovirus receptor-related 30.118
ZMYND11zinc finger, MYND-type containing 110.117
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.110
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grb2growth factor receptor bound protein 21.000
Itsn1intersectin 1 (SH3 domain protein 1A)1.000
Vav1vav 1 oncogene0.997
Git1G protein-coupled receptor kinase-interactor 10.980
Dlg4discs, large homolog 4 (Drosophila)0.972
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.943
CblCasitas B-lineage lymphoma0.942
Rac1RAS-related C3 botulinum substrate 10.887
Dnm1dynamin 10.885
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.819
Prkcdprotein kinase C, delta0.745
Bcrbreakpoint cluster region0.739
Anxa2annexin A20.698
Shc1src homology 2 domain-containing transforming protein C10.683
Efnb2ephrin B20.655
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.648
BrafBraf transforming gene0.620
Nf1neurofibromatosis 10.457
Ncf1neutrophil cytosolic factor 10.451
Pxnpaxillin0.440
Hey2hairy/enhancer-of-split related with YRPW motif 20.439
Elmo1engulfment and cell motility 1, ced-12 homolog (C. elegans)0.401
Efna1ephrin A10.393
Tgfb1transforming growth factor, beta 10.365
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.352
Lrrk2leucine-rich repeat kinase 20.348
Nckap1lNCK associated protein 1 like0.334
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.272
Inpp5dinositol polyphosphate-5-phosphatase D0.221
Frs2fibroblast growth factor receptor substrate 20.220
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.206
Apcadenomatosis polyposis coli0.204
Cxcr4chemokine (C-X-C motif) receptor 40.197
Axin1axin 10.183
Traf6TNF receptor-associated factor 60.178
Cep55centrosomal protein 550.177
Atp8b2ATPase, class I, type 8B, member 20.171
Prkceprotein kinase C, epsilon0.147
Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)0.146
Dock2dedicator of cyto-kinesis 20.144
Vav2vav 2 oncogene0.138
Arhgap21Rho GTPase activating protein 210.137
Ptk2PTK2 protein tyrosine kinase 20.131
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.127
Ptpn11protein tyrosine phosphatase, non-receptor type 110.126
Abractive BCR-related gene0.121
BtkBruton agammaglobulinemia tyrosine kinase0.121
Psen1presenilin 10.107
Zfyve16zinc finger, FYVE domain containing 160.105
Necap2NECAP endocytosis associated 20.103
Itga3integrin alpha 30.100
Sh3bgrl3SH3 domain binding glutamic acid-rich protein-like 30.097
Sh3kbp1SH3-domain kinase binding protein 10.096
Rasgrp1RAS guanyl releasing protein 10.095
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.095
Elmo2engulfment and cell motility 2, ced-12 homolog (C. elegans)0.094
Eps15epidermal growth factor receptor pathway substrate 150.094
Dlg2discs, large homolog 2 (Drosophila)0.093
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.091
Ptk2bPTK2 protein tyrosine kinase 2 beta0.088
Cd37CD37 antigen0.085
Irf5interferon regulatory factor 50.084
Pdcd6ipprogrammed cell death 6 interacting protein0.083
Ptpraprotein tyrosine phosphatase, receptor type, A0.083
S100a6S100 calcium binding protein A6 (calcyclin)0.083
Ptpreprotein tyrosine phosphatase, receptor type, E0.081
Sirpasignal-regulatory protein alpha0.080
Srgap2SLIT-ROBO Rho GTPase activating protein 20.074
Crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.072
Ptpn6protein tyrosine phosphatase, non-receptor type 60.072
Kitkit oncogene0.071
Ctnnb1catenin (cadherin associated protein), beta 10.068
Itga4integrin alpha 40.068
Rassf5Ras association (RalGDS/AF-6) domain family member 50.068
Epb4.1l2erythrocyte protein band 4.1-like 20.067
Prkcbprotein kinase C, beta0.067
Htthuntingtin0.065
Dckdeoxycytidine kinase0.065
SrcRous sarcoma oncogene0.063
Selplgselectin, platelet (p-selectin) ligand0.061
Itchitchy, E3 ubiquitin protein ligase0.061
Ccnb2cyclin B20.060
Ncoa3nuclear receptor coactivator 30.058
Usp12ubiquitin specific peptidase 120.057
Arf3ADP-ribosylation factor 30.056
Rad21RAD21 homolog (S. pombe)0.056
Smad3MAD homolog 3 (Drosophila)0.056
Coro1ccoronin, actin binding protein 1C0.055
Fbxo11F-box protein 110.053
Plp2proteolipid protein 20.053
Dlgap1discs, large (Drosophila) homolog-associated protein 10.053
Apaf1apoptotic peptidase activating factor 10.051
Gsk3aglycogen synthase kinase 3 alpha0.051
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.051
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.049
Plcb1phospholipase C, beta 10.046
Arhgap30Rho GTPase activating protein 300.045
4732456N10RikRIKEN cDNA 4732456N10 gene0.044
Plaurplasminogen activator, urokinase receptor0.044
BlnkB-cell linker0.043
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
S100a4S100 calcium-binding protein A40.170
Anxa2annexin A20.146
Cdc34cell division cycle 34 homolog (S. cerevisiae)0.114
Dlg3discs, large homolog 3 (Drosophila)0.062
Capn2calpain 20.053
S100a11S100 calcium binding protein A11 (calizzarin)0.035
Bap1BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)0.026
Eif2c2eukaryotic translation initiation factor 2C, 20.026
Fmnl1formin-like 10.025
Snx4sorting nexin 40.022
Wdfy1WD repeat and FYVE domain containing 10.022
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.020
Becn1beclin 1, autophagy related0.019
Anxa1annexin A10.018
Lcp2lymphocyte cytosolic protein 20.016
S100a6S100 calcium binding protein A60.015
Bin2bridging integrator 20.015
Mlf2myeloid leukemia factor 20.014
Mbtps1membrane-bound transcription factor peptidase, site 10.014
Shank2SH3 and multiple ankyrin repeat domains 20.013
Zmym4zinc finger, MYM-type 40.013
Lgals3lectin, galactoside-binding, soluble, 30.012
Zfp91zinc finger protein 910.012
Tmprss2transmembrane protease, serine 20.011
Rnf10ring finger protein 100.011
RGD1563106similar to novel protein0.011
Dlgap4discs, large homolog-associated protein 4 (Drosophila)0.011
Matkmegakaryocyte-associated tyrosine kinase0.010
Prr13proline rich 130.010
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism