The network for 'stem cell fate determination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

stem cell fate determination

The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed.

NameDescriptionProbabilityFunc Analog Organism
stgstring0.670
E(spl)Enhancer of split0.530
mammastermind0.486
numbCG3779 gene product from transcript CG3779-RB0.275
HLHm7E(spl) region transcript m70.221
Su(H)Suppressor of Hairless0.196
CycECyclin E0.191
nctnicastrin0.179
m4E(spl) region transcript m40.178
neurneuralized0.112
wgwingless0.100
hhhedgehog0.097
NotumCG13076 gene product from transcript CG13076-RB0.083
gcmglial cells missing0.081
aopanterior open0.078
HLHmbetaE(spl) region transcript mbeta0.073
HLHmgammaE(spl) region transcript mgamma0.072
DDichaete0.069
edechinoid0.067
AntpAntennapedia0.066
bcdbicoid0.055
amosabsent MD neurons and olfactory sensilla0.054
senssenseless0.054
ptcpatched0.053
slislit0.048
spdosanpodo0.048
miminus0.046
hkbhuckebein0.046
bibbig brain0.045
HHairless0.042
HLHm5E(spl) region transcript m50.042
HLHmdeltaE(spl) region transcript mdelta0.038
TomTwin of m40.037
scscute0.036
rhorhomboid0.035
pnrpannier0.034
gtgiant0.034
malphaE(spl) region transcript malpha0.033
UbxUltrabithorax0.032
enengrailed0.031
oafout at first0.028
dapdacapo0.026
HLHm3E(spl) region transcript m30.026
nubnubbin0.026
tldtolloid0.025
ciccapicua0.025
dadaughterless0.025
m2E(spl) region transcript m20.025
exexpanded0.023
rapretina aberrant in pattern0.023
bratbrain tumor0.022
arrarrow0.021
kluklumpfuss0.021
ftzfushi tarazu0.021
prosprospero0.021
inscinscuteable0.021
pcxpecanex0.021
brkbrinker0.021
fredfriend of echinoid0.021
RbfRetinoblastoma-family protein0.021
PcPolycomb0.020
salmspalt major0.019
CycACyclin A0.019
fasfaint sausage0.019
pblpebble0.019
simsingle-minded0.018
alaristaless0.017
snasnail0.017
MybMyb oncogene-like0.017
miramiranda0.017
slp2sloppy paired 20.016
commcommissureless0.016
exexextra-extra0.016
foifear-of-intimacy0.015
mirrmirror0.015
scascabrous0.015
gsbgooseberry0.015
tintinman0.015
ponpartner of numb0.014
SerSerrate0.014
oskoskar0.014
aseasense0.013
ococelliless0.013
sinaseven in absentia0.013
pdm2POU domain protein 20.012
drmdrumstick0.012
enaenabled0.011
lbeladybird early0.011
eygeyegone0.011
Tre1trapped in endoderm-10.011
Sema-1aCG18405 gene product from transcript CG18405-RD0.011
nerfin-1nervous fingers 10.011
pbproboscipedia0.010
Ptp52FCG18243 gene product from transcript CG18243-RB0.010
araaraucan0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
K08F9.4Protein K08F9.40.011
C45G9.2Protein C45G9.20.011
CELE_T04A8.8Protein T04A8.80.011
wdr-5.1Protein WDR-5.10.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
eng2aengrailed 2a0.967
pax6apaired box gene 6a0.849
ascl1aachaete-scute complex-like 1a (Drosophila)0.734
eng2bengrailed 2b0.682
nkx2.2aNK2 transcription factor related 2a0.664
ascl1bachaete-scute complex-like 1b (Drosophila)0.587
foxn4forkhead box N40.573
dladeltaA0.401
dlbdeltaB0.364
vsx2visual system homeobox 20.336
olig2oligodendrocyte lineage transcription factor 20.231
sox3SRY-box containing gene 30.197
otpborthopedia homolog b0.191
neurod4neurogenic differentiation 40.190
lhx1aLIM homeobox 1a0.185
dbx1adeveloping brain homeobox 1a0.179
dlcdeltaC0.166
neurodneurogenic differentiation0.150
lmx1b.1LIM homeobox transcription factor 1, beta 10.149
lhx5LIM homeobox 50.149
nr2e1nuclear receptor subfamily 2, group E, member 10.144
scube2signal peptide, CUB domain, EGF-like 20.143
fgf8bfibroblast growth factor 8 b0.138
neurog1neurogenin 10.133
pou3f3bPOU class 3 homeobox 3b0.133
prlprolactin0.133
sox2SRY-box containing gene 20.131
gbx2gastrulation brain homeo box 20.131
otx2orthodenticle homolog 20.114
meis3myeloid ecotropic viral integration site 30.111
ptf1apancreas specific transcription factor, 1a0.107
inabinternexin neuronal intermediate filament protein, alpha b0.097
pou3f1POU class 3 homeobox 10.097
vsx1visual system homeobox 1 homolog, chx10-like0.095
plp1aproteolipid protein 1a0.090
dlddeltaD0.088
mnx1motor neuron and pancreas homeobox 10.088
ntn1anetrin 1a0.076
foxg1aforkhead box G1a0.074
gata2aGATA-binding protein 2a0.074
phox2apaired-like homeobox 2a0.072
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.070
cdh2cadherin 2, neuronal0.069
eya1eyes absent homolog 10.068
fgfr1bfibroblast growth factor receptor 1b0.067
sox19aSRY-box containing gene 19a0.067
pou3f2POU class 3 homeobox 20.065
nr2e3nuclear receptor subfamily 2, group E, member 30.065
tal1T-cell acute lymphocytic leukemia 10.064
pitx3paired-like homeodomain transcription factor 30.061
mbpmyelin basic protein0.060
rad21RAD21 homolog (S. pombe)0.058
klf2aKruppel-like factor 2a0.058
barhl2BarH-like 20.056
isl1islet10.053
jag1bjagged 1b0.049
pax3apaired box gene 3a0.048
gbx1gastrulation brain homeobox 10.048
olig3oligodendrocyte transcription factor 30.046
zic6zic family member 60.043
pou1f1POU domain, class 1, transcription factor 10.040
her6hairy-related 60.040
coblcordon-bleu homolog (mouse)0.038
irx7iroquois homeobox protein 70.038
insm1binsulinoma-associated 1b0.038
crabp2bcellular retinoic acid binding protein 2, b0.037
zic4zic family member 40.037
atoh7atonal homolog 70.037
sox10SRY-box containing gene 100.036
wnt9awingless-type MMTV integration site family, member 9A0.035
pax2bpaired box gene 2b0.033
nkx2.1bNK2 homeobox 1b0.032
atoh1batonal homolog 1b0.032
nanos3nanos homolog 30.031
pitx2paired-like homeodomain transcription factor 20.030
barx1BarH-like homeobox 10.030
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.029
tp53tumor protein p530.028
nkx2.2bNK2 transcription factor related 2b0.028
shhasonic hedgehog a0.028
zic1zic family member 1 (odd-paired homolog, Drosophila)0.027
pax2apaired box gene 2a0.027
meis2.2myeloid ecotropic viral integration site 2.20.027
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.027
six1bsine oculis homeobox homolog 1b0.027
irx4airoquois homeobox protein 4a0.026
her4.2hairy-related 4.20.026
lmx1b.2LIM homeobox transcription factor 1, beta 20.026
cxcr4bchemokine (C-X-C motif), receptor 4b0.025
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.025
sfrp5secreted frizzled-related protein 50.025
atoh1aatonal homolog 1a0.025
hgfahepatocyte growth factor a0.023
epha4beph receptor A4b0.022
hey1hairy/enhancer-of-split related with YRPW motif 10.022
fgf8afibroblast growth factor 8 a0.022
her2hairy-related 20.022
cfl2lcofilin 2, like0.022
hoxb2ahomeo box B2a0.022
irx1biroquois homeobox protein 1, b0.021
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.964
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.920
Phox2apaired-like homeobox 2a0.900
Nrg1neuregulin 10.884
Otx1orthodenticle homolog 1 (Drosophila)0.878
Otx2orthodenticle homolog 2 (Drosophila)0.797
Dll1delta-like 1 (Drosophila)0.795
En1engrailed 10.753
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.730
Hes1hairy and enhancer of split 1 (Drosophila)0.698
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.669
Msx2homeobox, msh-like 20.658
Jag1jagged 10.570
Shhsonic hedgehog0.557
Retret proto-oncogene0.474
Emx1empty spiracles homolog 1 (Drosophila)0.445
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.439
Neurog2neurogenin 20.403
Ptf1apancreas specific transcription factor, 1a0.398
Pax2paired box gene 20.380
Neurod1neurogenic differentiation 10.336
Lmx1bLIM homeobox transcription factor 1 beta0.311
Fgf8fibroblast growth factor 80.308
Cdk2cyclin-dependent kinase 20.270
BrafBraf transforming gene0.245
Chd7chromodomain helicase DNA binding protein 70.228
Zfp423zinc finger protein 4230.226
Ntf5neurotrophin 50.220
Pax6paired box gene 60.207
Fgf17fibroblast growth factor 170.201
Foxg1forkhead box G10.194
Dsg4desmoglein 40.192
En2engrailed 20.186
Dll4delta-like 4 (Drosophila)0.179
Psen2presenilin 20.171
Ptenphosphatase and tensin homolog0.153
Vti1avesicle transport through interaction with t-SNAREs homolog 1A (yeast)0.153
Neurod4neurogenic differentiation 40.141
Gbx2gastrulation brain homeobox 20.140
Egfl7EGF-like domain 70.138
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.136
Dstdystonin0.132
Foxc1forkhead box C10.121
Sox2SRY-box containing gene 20.110
Hoxa1homeobox A10.107
Dkk1dickkopf homolog 1 (Xenopus laevis)0.100
Efnb2ephrin B20.095
Lmx1aLIM homeobox transcription factor 1 alpha0.089
Isl1ISL1 transcription factor, LIM/homeodomain0.077
Lama5laminin, alpha 50.074
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.070
Gata3GATA binding protein 30.069
Hes3hairy and enhancer of split 3 (Drosophila)0.064
Egfrepidermal growth factor receptor0.062
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.060
Phox2bpaired-like homeobox 2b0.057
Hrhairless0.056
Hey2hairy/enhancer-of-split related with YRPW motif 20.055
Dmbx1diencephalon/mesencephalon homeobox 10.054
TcraT-cell receptor alpha chain0.053
Fgfr1fibroblast growth factor receptor 10.051
Wnt3wingless-related MMTV integration site 30.049
Mid1midline 10.048
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.046
Wnt1wingless-related MMTV integration site 10.044
Sema5bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B0.041
Sp6trans-acting transcription factor 60.040
Foxp3forkhead box P30.039
Cdkn1bcyclin-dependent kinase inhibitor 1B0.039
Foxo1forkhead box O10.038
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.038
Notch1Notch gene homolog 1 (Drosophila)0.037
Tbx10T-box 100.036
Sox11SRY-box containing gene 110.036
Egr3early growth response 30.035
Six2sine oculis-related homeobox 2 homolog (Drosophila)0.035
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.035
Wnt9awingless-type MMTV integration site 9A0.034
Gli2GLI-Kruppel family member GLI20.032
Fgf4fibroblast growth factor 40.032
Mixl1Mix1 homeobox-like 1 (Xenopus laevis)0.032
Bdnfbrain derived neurotrophic factor0.031
Htra3HtrA serine peptidase 30.031
Pitx3paired-like homeodomain transcription factor 30.031
Vti1bvesicle transport through interaction with t-SNAREs 1B homolog0.031
Sim2single-minded homolog 2 (Drosophila)0.030
Ikbkapinhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein0.030
Selpselectin, platelet0.029
Klk4kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)0.029
Ikzf1IKAROS family zinc finger 10.028
Btbd17BTB (POZ) domain containing 170.028
Six5sine oculis-related homeobox 5 homolog (Drosophila)0.027
Lhx5LIM homeobox protein 50.027
Hoxb13homeobox B130.027
Gdnfglial cell line derived neurotrophic factor0.027
Jag2jagged 20.027
Zic1zinc finger protein of the cerebellum 10.027
Sox3SRY-box containing gene 30.025
Ntf3neurotrophin 30.024
Ptk7PTK7 protein tyrosine kinase 70.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism