The network for 'activation of innate immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of innate immune response

Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.

NameDescriptionProbabilityFunc Analog Organism
PGRP-LCPeptidoglycan recognition protein LC0.996
grassGram-positive Specific Serine protease0.978
SPESpatzle-Processing Enzyme0.951
DptBDiptericin B0.905
PGRP-SAPeptidoglycan recognition protein SA0.848
Spn27ASerpin 27A0.823
modSPmodular serine protease0.814
18w18 wheeler0.698
DreddDeath related ced-3/Nedd2-like protein0.689
IM1Immune induced molecule 10.663
PGRP-SDCG7496 gene product from transcript CG7496-RA0.644
CG15065CG15065 gene product from transcript CG15065-RA0.640
Toll-6CG7250 gene product from transcript CG7250-RA0.584
Toll-7CG8595 gene product from transcript CG8595-RA0.579
PGRP-LBPeptidoglycan recognition protein LB0.568
GNBP1Gram-negative bacteria binding protein 10.464
imdimmune deficiency0.461
DuoxDual oxidase0.384
IM2Immune induced molecule 20.375
IM10Immune induced molecule 100.358
Myd88CG2078 gene product from transcript CG2078-RA0.358
CG15067CG15067 gene product from transcript CG15067-RA0.358
pirkpoor Imd response upon knock-in0.358
GNBP3Gram-negative bacteria binding protein 30.332
IrcImmune-regulated catalase0.323
IM4Immune induced molecule 40.315
CG5791CG5791 gene product from transcript CG5791-RA0.313
CG18594CG18594 gene product from transcript CG18594-RA0.309
CG18067CG18067 gene product from transcript CG18067-RA0.299
CG32185CG32185 gene product from transcript CG32185-RA0.276
IM23Immune induced molecule 230.263
Nrx-IVNeurexin IV0.254
PGRP-SB1CG9681 gene product from transcript CG9681-RA0.243
HcfHost cell factor0.216
ird5immune response deficient 50.210
eaterCG6124 gene product from transcript CG6124-RB0.205
Spn1Serine protease inhibitor 10.203
Sp7Serine protease 70.191
CG16836CG16836 gene product from transcript CG16836-RA0.187
PGRP-LFPeptidoglycan recognition protein LF0.174
TimpTissue inhibitor of metalloproteases0.158
spiritSerine Protease Immune Response Integrator0.140
Gadd45CG11086 gene product from transcript CG11086-RA0.139
plexBplexin B0.137
CG15917CG15917 gene product from transcript CG15917-RA0.127
Tsp42EcTetraspanin 42Ec0.123
Spn88EbSerpin 88Eb0.120
TepIIIThiolester containing protein III0.117
CG5778CG5778 gene product from transcript CG5778-RB0.115
BG4CG12297 gene product from transcript CG12297-RA0.113
CG16713CG16713 gene product from transcript CG16713-RA0.096
CG13422CG13422 gene product from transcript CG13422-RA0.094
Mmp1Matrix metalloproteinase 10.094
upd2unpaired 20.093
PRL-1CG4993 gene product from transcript CG4993-RB0.089
p38bCG7393 gene product from transcript CG7393-RA0.089
CG16718CG16718 gene product from transcript CG16718-RA0.088
Vap-33-1CG5014 gene product from transcript CG5014-RB0.087
CG9184CG9184 gene product from transcript CG9184-RB0.085
l(3)mbnlethal (3) malignant blood neoplasm0.080
Nhe3Na[+]/H[+] hydrogen exchanger 30.076
spheroideCG9675 gene product from transcript CG9675-RA0.076
CG15152CG15152 gene product from transcript CG15152-RA0.073
CG6038CG6038 gene product from transcript CG6038-RA0.071
rtrotated abdomen0.070
CG10650CG10650 gene product from transcript CG10650-RA0.068
CecCCecropin C0.065
Akt1CG4006 gene product from transcript CG4006-RA0.064
CG18480CG18480 gene product from transcript CG18480-RA0.064
CG12974CG12974 gene product from transcript CG12974-RA0.063
CG6361CG6361 gene product from transcript CG6361-RA0.063
CG5390CG5390 gene product from transcript CG5390-RA0.062
Sox14Sox box protein 140.062
CG13323CG13323 gene product from transcript CG13323-RA0.060
PGRP-SC2CG14745 gene product from transcript CG14745-RA0.060
AGO2Argonaute 20.060
bbgbig bang0.059
CG9917CG9917 gene product from transcript CG9917-RA0.055
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nod1nucleotide-binding oligomerization domain containing 10.836
tlr9toll-like receptor 90.358
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.259
tnfbtumor necrosis factor b (TNF superfamily, member 2)0.210
pdcd2programmed cell death 20.137
relv-rel reticuloendotheliosis viral oncogene homolog0.137
LOC100151531zinc finger protein Gfi-1b-like0.118
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.096
LOC557072caspase recruitment domain-containing protein 11-like0.094
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.063
LOC100000934hypothetical protein LOC1000009340.062
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.052
hspa9heat shock protein 90.052
ip6k2inositol hexaphosphate kinase 20.042
tlr18toll-like receptor 180.040
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.032
hdrhematopoietic death receptor0.031
rrp12ribosomal RNA processing 12 homolog (S. cerevisiae)0.030
epas1bendothelial PAS domain protein 1b0.026
ecscrendothelial cell-specific chemotaxis regulator0.026
rrm2bribonucleotide reductase M2 b0.025
LOC566708FL cytokine receptor-like0.025
fxr2fragile X mental retardation, autosomal homolog 20.023
LOC100534776toll-like receptor 7-like0.021
tlr2toll-like receptor 20.020
tiraptoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.020
rhagRhesus blood group-associated glycoprotein0.019
fam20bfamily with sequence similarity 20, member B (H. sapiens)0.019
ticam1toll-like receptor adaptor molecule 10.018
tlr20atoll-like receptor 20a0.017
nos2anitric oxide synthase 2a, inducible0.016
tufmTu translation elongation factor, mitochondrial0.015
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.015
rhogbras homolog gene family, member Gb0.014
cpoxcoproporphyrinogen oxidase0.013
tlr21toll-like receptor 210.013
foxi3aforkhead box I3a0.011
gipgastric inhibitory polypeptide0.011
tlr20ftoll-like receptor 20f0.011
vcanbversican b0.011
stc1lstanniocalcin 1, like0.011
fn1bfibronectin 1b0.010
tlr4bbtoll-like receptor 4b, duplicate b0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma1.000
IRAK1interleukin-1 receptor-associated kinase 11.000
BIRC3baculoviral IAP repeat containing 31.000
MYD88myeloid differentiation primary response gene (88)1.000
TRAF6TNF receptor-associated factor 61.000
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)1.000
IRAK2interleukin-1 receptor-associated kinase 20.999
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.999
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.997
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.997
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.995
TNFAIP3tumor necrosis factor, alpha-induced protein 30.993
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.984
TNIP2TNFAIP3 interacting protein 20.983
TLR4toll-like receptor 40.979
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.975
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.964
TRAF1TNF receptor-associated factor 10.954
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.924
RIPK2receptor-interacting serine-threonine kinase 20.914
S100A1S100 calcium binding protein A10.913
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.900
BIRC2baculoviral IAP repeat containing 20.893
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.874
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.864
TNIP1TNFAIP3 interacting protein 10.839
MAPK14mitogen-activated protein kinase 140.827
S100A16S100 calcium binding protein A160.821
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.813
SAMD9sterile alpha motif domain containing 90.808
NLRC4NLR family, CARD domain containing 40.805
TRAF3TNF receptor-associated factor 30.771
CYLDcylindromatosis (turban tumor syndrome)0.737
S100A14S100 calcium binding protein A140.708
IFIH1interferon induced with helicase C domain 10.688
TMEM173transmembrane protein 1730.686
MAP3K8mitogen-activated protein kinase kinase kinase 80.683
TRIM22tripartite motif containing 220.646
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.624
S100BS100 calcium binding protein B0.613
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.602
S100A6S100 calcium binding protein A60.590
LRRK2leucine-rich repeat kinase 20.566
ARRB1arrestin, beta 10.557
TRAF2TNF receptor-associated factor 20.463
TRIM21tripartite motif containing 210.460
BTN3A3butyrophilin, subfamily 3, member A30.452
BCL3B-cell CLL/lymphoma 30.425
MDM2Mdm2 p53 binding protein homolog (mouse)0.394
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.373
TLR2toll-like receptor 20.360
CTLA4cytotoxic T-lymphocyte-associated protein 40.355
AKT1v-akt murine thymoma viral oncogene homolog 10.352
SP100SP100 nuclear antigen0.348
IRF7interferon regulatory factor 70.347
MAP3K14mitogen-activated protein kinase kinase kinase 140.343
RARAretinoic acid receptor, alpha0.329
XIAPX-linked inhibitor of apoptosis0.326
KLRD1killer cell lectin-like receptor subfamily D, member 10.318
MAP3K5mitogen-activated protein kinase kinase kinase 50.318
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.308
BTN3A2butyrophilin, subfamily 3, member A20.307
NMIN-myc (and STAT) interactor0.282
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.275
IRAK4interleukin-1 receptor-associated kinase 40.261
MEFVMediterranean fever0.225
CCR2chemokine (C-C motif) receptor 20.225
ZNF263zinc finger protein 2630.209
TRIM5tripartite motif containing 50.208
MAVSmitochondrial antiviral signaling protein0.207
RXRAretinoid X receptor, alpha0.203
SP110SP110 nuclear body protein0.201
IFI44interferon-induced protein 440.190
BTN3A1butyrophilin, subfamily 3, member A10.187
PYDC2pyrin domain containing 20.187
PMLpromyelocytic leukemia0.187
CD80CD80 molecule0.183
TRIM38tripartite motif containing 380.182
GBP1guanylate binding protein 1, interferon-inducible0.181
PARP12poly (ADP-ribose) polymerase family, member 120.180
STRNstriatin, calmodulin binding protein0.176
EIF2C1eukaryotic translation initiation factor 2C, 10.172
PELI3pellino homolog 3 (Drosophila)0.172
DTX3Ldeltex 3-like (Drosophila)0.166
CASP4caspase 4, apoptosis-related cysteine peptidase0.162
STAT1signal transducer and activator of transcription 1, 91kDa0.157
SAMD9Lsterile alpha motif domain containing 9-like0.154
IRAK3interleukin-1 receptor-associated kinase 30.154
SBF1SET binding factor 10.149
AGERadvanced glycosylation end product-specific receptor0.149
TRIM25tripartite motif containing 250.148
CARD11caspase recruitment domain family, member 110.141
CTSScathepsin S0.140
CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)0.139
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.134
IGSF6immunoglobulin superfamily, member 60.129
CASP8caspase 8, apoptosis-related cysteine peptidase0.128
IL15interleukin 150.127
GBP3guanylate binding protein 30.126
SMSspermine synthase0.123
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Myd88myeloid differentiation primary response gene 881.000
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1051.000
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1001.000
Traf6TNF receptor-associated factor 61.000
Casp4caspase 4, apoptosis-related cysteine peptidase1.000
Tnfaip3tumor necrosis factor, alpha-induced protein 30.999
Map3k8mitogen-activated protein kinase kinase kinase 80.998
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.998
Tnftumor necrosis factor0.991
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.988
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.987
AxlAXL receptor tyrosine kinase0.986
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.985
Trim30atripartite motif-containing 30A0.978
Irf7interferon regulatory factor 70.977
Ikbkginhibitor of kappaB kinase gamma0.962
Casp1caspase 10.960
Klra9killer cell lectin-like receptor subfamily A, member 90.959
Unc93b1unc-93 homolog B1 (C. elegans)0.957
Gbp7guanylate binding protein 70.956
Gnrh1gonadotropin releasing hormone 10.954
Zbp1Z-DNA binding protein 10.952
Birc3baculoviral IAP repeat-containing 30.937
Cd180CD180 antigen0.936
Grb2growth factor receptor bound protein 20.935
Tlr4toll-like receptor 40.932
Chukconserved helix-loop-helix ubiquitous kinase0.929
Cd40CD40 antigen0.923
Parp14poly (ADP-ribose) polymerase family, member 140.922
Pyhin1pyrin and HIN domain family, member 10.919
Klrk1killer cell lectin-like receptor subfamily K, member 10.905
Irf9interferon regulatory factor 90.904
Mapk14mitogen-activated protein kinase 140.897
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.881
Map3k7mitogen-activated protein kinase kinase kinase 70.876
Cd33CD33 antigen0.867
Ifi44interferon-induced protein 440.847
Sykbspleen tyrosine kinase0.845
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.840
Emr4EGF-like module containing, mucin-like, hormone receptor-like sequence 40.837
Ptenphosphatase and tensin homolog0.822
Ticam1toll-like receptor adaptor molecule 10.822
Gbp3guanylate binding protein 30.821
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.818
Ldb3LIM domain binding 30.811
BC013712cDNA sequence BC0137120.798
Trim30dtripartite motif-containing 30D0.789
Ncr1natural cytotoxicity triggering receptor 10.778
Irak3interleukin-1 receptor-associated kinase 30.776
Rsad2radical S-adenosyl methionine domain containing 20.774
Mndalmyeloid nuclear differentiation antigen like0.731
Gbp5guanylate binding protein 50.718
Esr1estrogen receptor 1 (alpha)0.715
BC006779cDNA sequence BC0067790.707
Cd80CD80 antigen0.706
Tnfaip2tumor necrosis factor, alpha-induced protein 20.701
Traf3ip2TRAF3 interacting protein 20.693
Bcl3B-cell leukemia/lymphoma 30.687
Cd86CD86 antigen0.685
Oasl22'-5' oligoadenylate synthetase-like 20.681
Ifi203interferon activated gene 2030.675
Irgm1immunity-related GTPase family M member 10.673
Ikbkbinhibitor of kappaB kinase beta0.669
Cd14CD14 antigen0.658
Relreticuloendotheliosis oncogene0.649
Slamf8SLAM family member 80.648
Ltbrlymphotoxin B receptor0.635
Tyro3TYRO3 protein tyrosine kinase 30.632
Uba7ubiquitin-like modifier activating enzyme 70.631
Ighimmunoglobulin heavy chain complex0.628
Ccl4chemokine (C-C motif) ligand 40.625
Irg1immunoresponsive gene 10.620
Pilrb1paired immunoglobin-like type 2 receptor beta 10.613
Gab1growth factor receptor bound protein 2-associated protein 10.585
Stx11syntaxin 110.583
Clec4eC-type lectin domain family 4, member e0.581
Rtp4receptor transporter protein 40.558
Irf5interferon regulatory factor 50.555
Irgm2immunity-related GTPase family M member 20.550
Map3k14mitogen-activated protein kinase kinase kinase 140.540
Naip6NLR family, apoptosis inhibitory protein 60.536
Mndamyeloid cell nuclear differentiation antigen0.525
Ifit1interferon-induced protein with tetratricopeptide repeats 10.522
Reg1regenerating islet-derived 10.522
Nlrp3NLR family, pyrin domain containing 30.516
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.511
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.508
Gbp2guanylate binding protein 20.496
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.492
Il1rninterleukin 1 receptor antagonist0.481
Cd300ldCD300 molecule-like family member d0.478
Arrb1arrestin, beta 10.474
Tlr8toll-like receptor 80.473
Klra2killer cell lectin-like receptor, subfamily A, member 20.473
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.470
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.468
Csf1colony stimulating factor 1 (macrophage)0.464
Stat3signal transducer and activator of transcription 30.461
Traf2TNF receptor-associated factor 20.459
BtkBruton agammaglobulinemia tyrosine kinase0.458
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
DbpD site of albumin promoter (albumin D-box) binding protein0.432
Pcm1pericentriolar material 10.052
Fcgr1aFc fragment of IgG, high affinity Ia, receptor (CD64)0.048
Zfp36zinc finger protein 360.039
Il1binterleukin 1 beta0.032
Ccl4chemokine (C-C motif) ligand 40.029
Arl11ADP-ribosylation factor-like 110.017
Tlr4toll-like receptor 40.016
Tlr2toll-like receptor 20.015
Cd86CD86 molecule0.012
Slamf9SLAM family member 90.011
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.011
Lpllipoprotein lipase0.011
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.010
Hcls1hematopoietic cell specific Lyn substrate 10.010
Parp9poly (ADP-ribose) polymerase family, member 90.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism