The network for 'negative regulation of biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

NameDescriptionProbabilityFunc Analog Organism
CTCFCG8591 gene product from transcript CG8591-RA0.999
MadMothers against dpp0.995
TrlTrithorax-like0.994
Sir2CG5216 gene product from transcript CG5216-RA0.991
dsxdoublesex0.989
bratbrain tumor0.983
NNotch0.982
Snr1Snf5-related 10.978
CtBPC-terminal Binding Protein0.976
ScmSex comb on midleg0.976
mammastermind0.975
Fmr1CG6203 gene product from transcript CG6203-RC0.975
cicubitus interruptus0.974
hephemipterous0.966
atoatonal0.966
E2f2E2F transcription factor 20.964
osoutstretched0.961
ash1absent, small, or homeotic discs 10.961
escextra sexcombs0.959
pr-set7CG3307 gene product from transcript CG3307-RC0.958
gppgrappa0.958
foxoforkhead box, sub-group O0.954
Top2Topoisomerase 20.952
E(spl)Enhancer of split0.947
IswiImitation SWI0.946
eygeyegone0.945
UbxUltrabithorax0.940
shnschnurri0.938
grogroucho0.933
HLHm7E(spl) region transcript m70.932
ssspineless0.931
smt3CG4494 gene product from transcript CG4494-RA0.926
araaraucan0.923
spensplit ends0.918
SceSex combs extra0.917
piwiCG6122 gene product from transcript CG6122-RA0.914
dpndeadpan0.906
Nf-YCNuclear factor Y-box C0.903
PtenCG5671 gene product from transcript CG5671-RB0.900
Rpd3CG7471 gene product from transcript CG7471-RA0.897
PclPolycomblike0.896
Su(var)205Suppressor of variegation 2050.893
nubnubbin0.892
tlltailless0.887
ThorCG8846 gene product from transcript CG8846-RA0.886
phylphyllopod0.881
salmspalt major0.864
gsbgooseberry0.862
hephhephaestus0.861
tantantalus0.853
D1D1 chromosomal protein0.852
Su(var)2-10Suppressor of variegation 2-100.850
edechinoid0.840
lwrlesswright0.839
Pka-C1cAMP-dependent protein kinase 10.838
Pp1-87BProtein phosphatase 1 at 87B0.831
pbproboscipedia0.830
crolcrooked legs0.830
fufused0.830
CycBCyclin B0.822
BEAF-32Boundary element-associated factor of 32kD0.821
abd-Aabdominal A0.819
PcPolycomb0.819
mrnmarionette0.817
Kr-h1Kruppel homolog 10.811
ykiyorkie0.805
SRPKCG8174 gene product from transcript CG8174-RA0.797
Taf1TBP-associated factor 10.792
MED26Mediator complex subunit 260.792
slp1sloppy paired 10.787
Su(var)3-7Suppressor of variegation 3-70.781
emsempty spiracles0.780
RbfRetinoblastoma-family protein0.772
mirrmirror0.769
E(var)3-9Enhancer of variegation 3-90.769
HGTXCG13475 gene product from transcript CG13475-RB0.767
Doc2Dorsocross20.757
Sep2Septin-20.753
Trf2TATA box binding protein-related factor 20.752
Socs36ESuppressor of cytokine signaling at 36E0.748
toytwin of eyeless0.746
Ets97DEts at 97D0.739
CG9986CG9986 gene product from transcript CG9986-RA0.737
gtgiant0.737
barrbarren0.736
crmcramped0.733
OptixCG18455 gene product from transcript CG18455-RA0.732
nmonemo0.732
PliPellino0.731
invinvected0.730
bab2CG9102 gene product from transcript CG9102-RA0.730
dcodiscs overgrown0.722
wgwingless0.722
scascabrous0.721
alaristaless0.716
e(y)3enhancer of yellow 30.713
howheld out wings0.710
Cdk9Cyclin-dependent kinase 90.706
saxsaxophone0.704
simsingle-minded0.702
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.986
elt-6Protein ELT-60.705
his-1Protein HIS-10.639
pha-4Protein PHA-40.610
his-16Protein HIS-160.606
his-5Protein HIS-50.439
hcp-3Protein HCP-30.412
nhr-67Protein NHR-670.401
eya-1Protein EYA-10.388
mes-4Protein MES-40.382
ten-1Protein TEN-10.374
zip-7Protein ZIP-70.361
hbl-1Protein HBL-10.338
lin-53Protein LIN-530.326
mab-5Protein MAB-50.318
his-45Protein HIS-450.316
unc-62Protein UNC-620.314
egl-46Protein EGL-460.312
his-46Protein HIS-460.309
eor-1Protein EOR-10.308
his-31Protein HIS-310.281
lin-35Protein LIN-350.278
egl-13Protein EGL-130.277
nhr-2Protein NHR-20.265
vab-3Protein VAB-30.256
his-64Protein HIS-640.250
flt-1Protein FLT-10.239
gpb-2Protein GPB-20.235
his-61Protein HIS-610.231
let-502Protein LET-5020.220
glp-1Protein GLP-10.215
his-4Protein HIS-40.209
wrm-1Protein WRM-10.201
his-42Protein HIS-420.200
mom-2Protein MOM-20.191
lsy-22Protein LSY-220.186
rsp-1Protein RSP-10.183
pry-1Protein PRY-10.170
his-52Protein HIS-520.164
tbx-8Protein TBX-80.158
cdt-2Protein CDT-20.156
unc-73Protein UNC-730.154
his-24Protein HIS-240.149
atn-1Protein ATN-10.147
CELE_F17C11.10Protein F17C11.100.147
nhr-6Protein NHR-60.146
CELE_C24H12.5Protein C24H12.50.145
ztf-2Protein ZTF-20.134
plk-3Protein PLK-30.132
hlh-2Protein HLH-20.132
plc-1Protein PLC-10.130
saeg-1Protein SAEG-10.130
nhr-25Protein NHR-250.129
peb-1Protein PEB-10.128
ceh-32Protein CEH-320.127
pdr-1Protein PDR-10.121
his-48Protein HIS-480.121
npp-4Protein NPP-40.119
mnp-1Protein MNP-10.119
his-29Protein HIS-290.118
CELE_T26A8.4Protein T26A8.40.115
puf-3Protein PUF-30.114
rgs-7Protein RGS-70.114
num-1Protein NUM-10.114
crm-1Protein CRM-10.112
rnr-1Protein RNR-10.108
fbf-2Protein FBF-20.108
egl-27Protein EGL-270.108
deb-1Protein DEB-10.107
F39B2.1Protein F39B2.10.106
ran-1Protein RAN-10.106
his-62Protein HIS-620.104
klp-16Protein KLP-160.103
mcm-4Protein MCM-40.103
mat-3Protein MAT-30.103
eftu-2Protein EFTU-20.102
daf-1Protein DAF-10.102
daf-14Protein DAF-140.101
unc-52Protein UNC-520.100
mig-38Protein MIG-380.100
kle-2Protein KLE-20.100
snr-2Protein SNR-20.099
mix-1Protein MIX-10.098
drap-1Protein DRAP-10.096
cec-5Protein CEC-50.096
mls-2Protein MLS-20.096
tam-1Protein TAM-10.095
vps-33.2Protein VPS-33.20.095
ceh-20Protein CEH-200.095
mcm-7Protein MCM-70.095
ulp-2Protein ULP-20.095
egl-5Protein EGL-50.094
ceh-27Protein CEH-270.092
his-14Protein HIS-140.092
bed-3Protein BED-30.092
hlh-1Protein HLH-10.091
ceh-36Protein CEH-360.089
lin-13Protein LIN-130.089
mcm-5Protein MCM-50.085
attf-2Protein ATTF-20.085
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
notch1anotch homolog 1a0.894
jag2jagged 20.866
fgf3fibroblast growth factor 30.841
sox9bSRY-box containing gene 9b0.831
dlx2adistal-less homeobox gene 2a0.765
pcnaproliferating cell nuclear antigen0.718
ndr2nodal-related 20.689
mecomMDS1 and EVI1 complex locus0.670
egr1early growth response 10.667
mab21l2mab-21-like 20.640
prox1prospero-related homeobox gene 10.612
tfap2atranscription factor AP-2 alpha0.588
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.573
foxi1forkhead box I10.571
otpborthopedia homolog b0.565
emx3empty spiracles homeobox 30.539
hnf1baHNF1 homeobox Ba0.538
pbx1apre-B-cell leukemia transcription factor 1a0.531
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.484
tbx1T-box 10.482
prdm1aPR domain containing 1a, with ZNF domain0.481
tbx2aT-box gene 2a0.469
dlx3bdistal-less homeobox gene 3b0.462
dlx5adistal-less homeobox gene 5a0.459
nova2neuro-oncological ventral antigen 20.453
ccnd1cyclin D10.441
fstafollistatin a0.439
gro1groucho 10.401
bmp2bbone morphogenetic protein 2b0.389
snai1bsnail homolog 1b (Drosophila)0.380
tp53tumor protein p530.370
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.368
tal1T-cell acute lymphocytic leukemia 10.361
fli1afriend leukemia integration 1a0.354
lhx1aLIM homeobox 1a0.349
pax8paired box gene 80.335
bocbrother of CDO0.326
gata6GATA-binding protein 60.325
chdchordin0.321
foxa3forkhead box A30.314
whsc1Wolf-Hirschhorn syndrome candidate 10.308
gdf11growth differentiation factor 110.304
gata5GATA-binding protein 50.290
dlcdeltaC0.277
arxaristaless related homeobox0.266
rx2retinal homeobox gene 20.264
tac1tachykinin 10.261
sox3SRY-box containing gene 30.257
znf503zinc finger protein 5030.255
hand2heart and neural crest derivatives expressed transcript 20.244
cry1acryptochrome 1a0.239
evx1even-skipped homeobox 10.239
spry4sprouty (Drosophila) homolog 40.237
tyrtyrosinase0.235
dnmt7DNA (cytosine-5-)-methyltransferase 70.230
msxemuscle segment homeobox E0.229
gli1GLI-Kruppel family member 10.227
spawsouthpaw0.226
ikzf1IKAROS family zinc finger 1 (Ikaros)0.225
dusp6dual specificity phosphatase 60.223
inspreproinsulin0.223
sox19aSRY-box containing gene 19a0.222
pitx2paired-like homeodomain transcription factor 20.218
pou3f2POU class 3 homeobox 20.218
pcdh18bprotocadherin 18b0.215
gcm2glial cells missing homolog 2 (Drosophila)0.215
cdx4caudal type homeo box transcription factor 40.214
aldh1a2aldehyde dehydrogenase 1 family, member A20.207
nkx2.5NK2 transcription factor related 50.206
sox11bSRY-box containing gene 11b0.204
ascl1aachaete-scute complex-like 1a (Drosophila)0.203
klf4Kruppel-like factor 40.198
esr1estrogen receptor 10.195
tll1tolloid-like 10.194
six2asine oculis-related homeobox 2a0.189
sesn1sestrin 10.185
hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.183
esr2aestrogen receptor 2a0.182
jag1bjagged 1b0.176
plekhg4pleckstrin homology domain containing, family G (with RhoGef domain) member 40.172
emx1empty spiracles homeobox 10.172
ezh2enhancer of zeste homolog 2 (Drosophila)0.164
otx1borthodenticle homolog 1b0.163
her7hairy and enhancer of split related-70.162
insm1binsulinoma-associated 1b0.161
sox1aSRY-box containing gene 1a0.156
hoxd4ahomeo box D4a0.156
osr2odd-skipped related 2 (Drosophila)0.156
nr2f5nuclear receptor subfamily 2, group F, member 50.154
hnrnpkheterogeneous nuclear ribonucleoprotein K0.152
nclnucleolin0.150
pax3apaired box gene 3a0.149
tfebtranscription factor EB0.147
vsx2visual system homeobox 20.147
vcanaversican a0.146
has2hyaluronan synthase 20.144
foxi3aforkhead box I3a0.143
traf4atnf receptor-associated factor 4a0.143
alcamaactivated leukocyte cell adhesion molecule a0.142
wnt2bbwingless-type MMTV integration site family, member 2Bb0.141
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
JunJun oncogene0.911
Junbjun B proto-oncogene0.731
Tcfe2atranscription factor E2a0.589
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.574
FosFBJ osteosarcoma oncogene0.458
Pcnaproliferating cell nuclear antigen0.447
DbpD site of albumin promoter (albumin D-box) binding protein0.427
Smad7SMAD family member 70.421
Klf4Kruppel-like factor 4 (gut)0.415
Lhx5LIM homeobox 50.402
Dusp1dual specificity phosphatase 10.391
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.373
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.371
Nfibnuclear factor I/B0.360
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.357
Nr2f2nuclear receptor subfamily 2, group F, member 20.351
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.350
Nfyanuclear transcription factor-Y alpha0.346
Tgfbr2transforming growth factor, beta receptor II0.334
Cntn4contactin 40.331
Phf12PHD finger protein 120.330
Id1inhibitor of DNA binding 10.330
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.327
Metmet proto-oncogene0.322
RorbRAR-related orphan receptor B0.322
Lbrlamin B receptor0.320
RestRE1-silencing transcription factor0.318
Ier2immediate early response 20.315
Ldhalactate dehydrogenase A0.315
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.306
Gfi1growth factor independent 1 transcription repressor0.300
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.299
Mycmyelocytomatosis oncogene0.287
Nedd4neural precursor cell expressed, developmentally down-regulated 40.277
Cxxc5CXXC finger 50.274
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.270
S100a8S100 calcium binding protein A80.263
Cd40lgCD40 ligand0.258
Nrg1neuregulin 10.255
Shox2short stature homeobox 20.251
Pde4bphosphodiesterase 4B, cAMP specific0.251
Tp53tumor protein p530.251
Pgam1phosphoglycerate mutase 1 (brain)0.250
Eif4heukaryotic translation initiation factor 4H0.250
Fgfr2fibroblast growth factor receptor 20.246
Trim28tripartite motif-containing 280.243
Barhl2BarH-like homeobox 20.241
Hes1hairy and enhancer of split 1 (Drosophila)0.237
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.235
Rararetinoic acid receptor, alpha0.231
Ptpn1protein tyrosine phosphatase, non-receptor type 10.231
Rxraretinoid X receptor alpha0.229
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.227
Ccnd1cyclin D10.226
Kcnt1potassium channel, subfamily T, member 10.226
Nfianuclear factor I/A0.226
Bcl2B-cell CLL/lymphoma 20.224
Cxcl2chemokine (C-X-C motif) ligand 20.222
Mgpmatrix Gla protein0.222
Dlg1discs, large homolog 1 (Drosophila)0.215
Ccl4chemokine (C-C motif) ligand 40.215
Pou3f2POU class 3 homeobox 20.214
Errfi1ERBB receptor feedback inhibitor 10.213
Lzts2leucine zipper, putative tumor suppressor 20.212
Alx1ALX homeobox 10.212
Hoxc4homeo box C40.212
Casp2caspase 20.209
Fgfr1Fibroblast growth factor receptor 10.208
Socs3suppressor of cytokine signaling 30.208
Iappislet amyloid polypeptide0.208
Nr1d2nuclear receptor subfamily 1, group D, member 20.207
Dusp6dual specificity phosphatase 60.207
Prss3protease, serine, 30.207
Klf6Kruppel-like factor 60.206
Rhobras homolog gene family, member B0.205
Map3k3mitogen activated protein kinase kinase kinase 30.203
Ptmaprothymosin alpha0.201
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.200
S100a9S100 calcium binding protein A90.197
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.196
Klf2Kruppel-like factor 2 (lung)0.195
Grin2dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.192
Kdm6blysine (K)-specific demethylase 6B0.191
RGD1565591similar to Ski protein0.191
Usf2upstream transcription factor 2, c-fos interacting0.190
Grk1G protein-coupled receptor kinase 10.190
Nek9NIMA (never in mitosis gene a)- related kinase 90.189
Sp1Sp1 transcription factor0.184
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.183
Gjb3gap junction protein, beta 30.181
Nr4a1nuclear receptor subfamily 4, group A, member 10.180
Vax2ventral anterior homeobox 20.177
Mipmajor intrinsic protein of lens fiber0.176
Neurog1neurogenin 10.176
Kctd13potassium channel tetramerisation domain containing 130.176
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.175
Il1r1interleukin 1 receptor, type I0.175
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.173
Egr4early growth response 40.172
Runx1runt-related transcription factor 10.172
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RPD3Rpd3p0.999
HHT1Hht1p0.997
SIR4Sir4p0.992
RAP1Rap1p0.991
SIN3Sin3p0.989
CYC8Cyc8p0.985
HHF1Hhf1p0.983
SIR2Sir2p0.977
RXT2Rxt2p0.961
HDA1Hda1p0.957
SNF1Snf1p0.951
SUM1Sum1p0.950
RLF2Rlf2p0.949
PHO23Pho23p0.927
DCP2Dcp2p0.909
SIN4Sin4p0.902
ORC2Orc2p0.894
ASF1Asf1p0.889
HOG1Hog1p0.888
PGD1Pgd1p0.879
RGR1Rgr1p0.871
GLC7Glc7p0.857
RIM101Rim101p0.834
PAP2Pap2p0.829
SAS2Sas2p0.824
SET1Set1p0.819
GCN5Gcn5p0.811
RPN4Rpn4p0.809
RLM1Rlm1p0.802
RCO1Rco1p0.800
SPT16Spt16p0.793
CTI6Cti6p0.787
RIF1Rif1p0.784
ORC5Orc5p0.782
SLX5Slx5p0.779
ADR1Adr1p0.779
SDS3Sds3p0.763
MRC1Mrc1p0.762
UME1Ume1p0.746
YTA7Yta7p0.745
RTF1Rtf1p0.741
ORC3Orc3p0.740
CSE2Cse2p0.736
UBP10Ubp10p0.735
HAT1Hat1p0.734
SSN8Ssn8p0.733
HMO1Hmo1p0.724
MED2Med2p0.722
SGV1Sgv1p0.720
MOT1Mot1p0.719
ROX3Rox3p0.718
RSC2Rsc2p0.708
SSN3Ssn3p0.703
AFT1Aft1p0.702
HTB1Htb1p0.681
SNT1Snt1p0.674
HIR1Hir1p0.662
MED7Med7p0.658
NRG1Nrg1p0.654
CDC6Cdc6p0.641
DHH1Dhh1p0.637
GIS1Gis1p0.636
ITC1Itc1p0.627
RTT106Rtt106p0.625
HTZ1Htz1p0.619
SSD1Ssd1p0.619
HST1Hst1p0.618
UBP8Ubp8p0.608
GAL11Gal11p0.605
ISW1Isw1p0.603
FKH2Fkh2p0.602
NUT1Nut1p0.601
DOA1Doa1p0.600
CDC28Cdc28p0.595
PAT1Pat1p0.595
HHF2Hhf2p0.589
SCH9Sch9p0.589
MED1Med1p0.589
RSC8Rsc8p0.587
TIF4632Tif4632p0.579
SWI4Swi4p0.576
HHO1Hho1p0.568
SIR3Sir3p0.566
VPS36Vps36p0.562
HDA2Hda2p0.558
RPA135Rpa135p0.554
UME6Ume6p0.545
CTK1Ctk1p0.541
RAD9Rad9p0.532
CDC45Cdc45p0.532
SCP160Scp160p0.523
SRP1Srp1p0.521
HCM1Hcm1p0.520
HHT2Hht2p0.519
SWD1Swd1p0.513
CMK2Cmk2p0.513
CTF18Ctf18p0.512
ISW2Isw2p0.512
MCM7Mcm7p0.510
NHP6ANhp6ap0.499