The network for 'cellular iron ion homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular iron ion homeostasis

Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.

NameDescriptionProbabilityFunc Analog Organism
Fer1HCHFerritin 1 heavy chain homologue0.399
CatCatalase0.212
Fer2LCHFerritin 2 light chain homologue0.122
CG4858CG4858 gene product from transcript CG4858-RA0.098
Sap-rSaposin-related0.027
CG12140CG12140 gene product from transcript CG12140-RA0.021
CG15741CG15741 gene product from transcript CG15741-RA0.017
Pi3K59FPhosphotidylinositol 3 kinase 59F0.016
Tango7Transport and Golgi organization 70.016
Hexo1Hexosaminidase 10.015
CG9836CG9836 gene product from transcript CG9836-RA0.013
CG4658CG4658 gene product from transcript CG4658-RA0.013
Dgp-1CG5729 gene product from transcript CG5729-RA0.013
CG7686CG7686 gene product from transcript CG7686-RA0.012
CG6145CG6145 gene product from transcript CG6145-RE0.012
CG7231CG7231 gene product from transcript CG7231-RE0.012
Src42ASrc oncogene at 42A0.012
mblmuscleblind0.012
Atg4Autophagy-specific gene 40.011
ScpXSterol carrier protein X-related thiolase0.011
CG32549CG32549 gene product from transcript CG32549-RD0.010
CG12379CG12379 gene product from transcript CG12379-RB0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
T22C1.5Protein T22C1.50.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tfr1atransferrin receptor 1a0.429
slc4a1asolute carrier family 4, anion exchanger, member 1a0.370
hbae3hemoglobin alpha embryonic-30.218
uroduroporphyrinogen decarboxylase0.217
hbaa1hemoglobin alpha adult-10.164
ireb2iron-responsive element binding protein 20.099
lmo2LIM domain only 2 (rhombotin-like 1)0.065
hbbe2hemoglobin beta embryonic-20.062
cpoxcoproporphyrinogen oxidase0.059
aco1aconitase 1, soluble0.058
slc25a37solute carrier family 25, member 370.047
gata1aGATA binding protein 1a0.042
klfdKruppel-like factor d0.038
zgc:101847zgc:1018470.037
hmbsbhydroxymethylbilane synthase, b0.031
glulbglutamate-ammonia ligase (glutamine synthase) b0.031
prdx2peroxiredoxin 20.029
fevFEV (ETS oncogene family)0.029
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.025
slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.025
junbjun B proto-oncogene0.023
zgc:92745zgc:927450.021
si:xx-bac7cse.2si:xx-bac7cse.20.019
trim33tripartite motif-containing 330.019
gng13aguanine nucleotide binding protein (G protein), gamma 13a0.019
csf3rcolony stimulating factor 3 receptor (granulocyte)0.019
hbae1hemoglobin alpha embryonic-10.019
mycl1bv-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b0.016
jag1bjagged 1b0.014
gfi1.1growth factor independent 1.10.014
bcl2B-cell leukemia/lymphoma 20.014
egfl7EGF-like-domain, multiple 70.014
tmem184atransmembrane protein 184a0.013
grnbgranulin b0.013
cltcaclathrin, heavy polypeptide a (Hc)0.013
fechferrochelatase0.013
ptprbprotein tyrosine phosphatase, receptor type, b0.013
gna13bguanine nucleotide binding protein (G protein), alpha 13b0.013
ppoxprotoporphyrinogen oxidase0.012
sec24cSEC24 family, member C (S. cerevisiae)0.012
llgl2lethal giant larvae homolog 2 (Drosophila)0.011
gpiaglucose phosphate isomerase a0.011
csgalnact2chondroitin sulfate N-acetylgalactosaminyltransferase 20.011
rdh10bretinol dehydrogenase 10b0.010
piguphosphatidylinositol glycan anchor biosynthesis, class U0.010
zgc:73311zgc:733110.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FTH1ferritin, heavy polypeptide 10.734
FTLferritin, light polypeptide0.430
NAMPTnicotinamide phosphoribosyltransferase0.135
SH3BP4SH3-domain binding protein 40.128
MAXMYC associated factor X0.067
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.053
RANBP9RAN binding protein 90.027
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hbb-b1hemoglobin, beta adult major chain0.877
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.394
Tfrctransferrin receptor0.299
Slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.177
Gdf5growth differentiation factor 50.139
Vhlvon Hippel-Lindau tumor suppressor0.118
Steap3STEAP family member 30.115
Ftl1ferritin light chain 10.107
Klf1Kruppel-like factor 1 (erythroid)0.106
Ank1ankyrin 1, erythroid0.095
Egln1EGL nine homolog 1 (C. elegans)0.082
Slc4a1solute carrier family 4 (anion exchanger), member 10.078
Spna1spectrin alpha 10.072
Eporerythropoietin receptor0.071
Gdf6growth differentiation factor 60.057
Nr3c1nuclear receptor subfamily 3, group C, member 10.054
Fbxl5F-box and leucine-rich repeat protein 50.052
Cpceruloplasmin0.051
Ahraryl-hydrocarbon receptor0.046
Ctnnb1catenin (cadherin associated protein), beta 10.043
Rdh10retinol dehydrogenase 10 (all-trans)0.042
Hba-a2hemoglobin alpha, adult chain 20.041
Ostm1osteopetrosis associated transmembrane protein 10.038
Tbx15T-box 150.038
Hfehemochromatosis0.031
Foxh1forkhead box H10.030
Nfe2l2nuclear factor, erythroid derived 2, like 20.030
Hand2heart and neural crest derivatives expressed transcript 20.028
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.028
Nckap1lNCK associated protein 1 like0.025
Dctpp1dCTP pyrophosphatase 10.024
Sqstm1sequestosome 10.024
Bmp5bone morphogenetic protein 50.022
Ror2receptor tyrosine kinase-like orphan receptor 20.022
Slc31a1solute carrier family 31, member 10.021
Glagalactosidase, alpha0.020
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.019
Smosmoothened homolog (Drosophila)0.019
Hoxd13homeobox D130.018
Exoc6exocyst complex component 60.018
Slc39a4solute carrier family 39 (zinc transporter), member 40.018
Apcadenomatosis polyposis coli0.017
Usp33ubiquitin specific peptidase 330.016
Bmpr1abone morphogenetic protein receptor, type 1A0.016
Slc22a6solute carrier family 22 (organic anion transporter), member 60.016
Fcnaficolin A0.016
Itih4inter alpha-trypsin inhibitor, heavy chain 40.016
Hand1heart and neural crest derivatives expressed transcript 10.016
Itgb1integrin beta 1 (fibronectin receptor beta)0.016
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.015
Hmox1heme oxygenase (decycling) 10.015
Larp4bLa ribonucleoprotein domain family, member 4B0.015
Chukconserved helix-loop-helix ubiquitous kinase0.015
Ppardperoxisome proliferator activator receptor delta0.015
P4htmprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)0.014
Ftl2ferritin light chain 20.014
Sult5a1sulfotransferase family 5A, member 10.014
Tgfbr3transforming growth factor, beta receptor III0.014
Stat5bsignal transducer and activator of transcription 5B0.014
Cd5lCD5 antigen-like0.014
Bmp7bone morphogenetic protein 70.014
Sox9SRY-box containing gene 90.014
Foxc1forkhead box C10.014
Lhx1LIM homeobox protein 10.014
Gdf3growth differentiation factor 30.013
MaxMax protein0.013
Stat5asignal transducer and activator of transcription 5A0.013
Foxf1aforkhead box F1a0.013
Sacm1lSAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)0.013
Sox17SRY-box containing gene 170.013
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.013
Tmem30atransmembrane protein 30A0.013
Fmn1formin 10.013
Smad3MAD homolog 3 (Drosophila)0.013
RestRE1-silencing transcription factor0.013
Ctslcathepsin L0.013
Ptch1patched homolog 10.013
Arntaryl hydrocarbon receptor nuclear translocator0.012
Hnf4ahepatic nuclear factor 4, alpha0.012
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.012
Tmprss6transmembrane serine protease 60.012
Gsk3bglycogen synthase kinase 3 beta0.012
Ifrd2interferon-related developmental regulator 20.012
Pcsk6proprotein convertase subtilisin/kexin type 60.012
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.011
Fgfr3fibroblast growth factor receptor 30.011
Smn1survival motor neuron 10.011
Fgf15fibroblast growth factor 150.011
Hoxa13homeobox A130.011
Dlx4distal-less homeobox 40.011
Fbn1fibrillin 10.011
Tgfbr2transforming growth factor, beta receptor II0.011
Tgfatransforming growth factor alpha0.011
Psen1presenilin 10.011
Pecam1platelet/endothelial cell adhesion molecule 10.011
Igfbp3insulin-like growth factor binding protein 30.011
Pcsk4proprotein convertase subtilisin/kexin type 40.011
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.010
Ext1exostoses (multiple) 10.010
Batf3basic leucine zipper transcription factor, ATF-like 30.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Psma3proteasome (prosome, macropain) subunit, alpha type 30.033
Psmb1proteasome (prosome, macropain) subunit, beta type 10.022
Psma7proteasome (prosome, macropain) subunit, alpha type 70.016
Psma2proteasome (prosome, macropain) subunit, alpha type 20.014
Rpl6ribosomal protein L60.013
Pnrc2proline-rich nuclear receptor coactivator 20.012
LOC100366237prefoldin subunit 4-like0.011
Capza2capping protein (actin filament) muscle Z-line, alpha 20.011
Rpl35ribosomal protein L350.011
LOC100359498ribosomal protein L35a-like0.011
Rps27aribosomal protein S27a0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ARN1Arn1p0.991
AFT1Aft1p0.756
FET3Fet3p0.677
GRX3Grx3p0.620
SIT1Sit1p0.432
CCS1Ccs1p0.415
YFH1Yfh1p0.403
PEX11Pex11p0.383
TIS11Tis11p0.369
ENB1Enb1p0.345
ISU1Isu1p0.339
PHO86Pho86p0.308
GRX4Grx4p0.301
CCC2Ccc2p0.292
FTR1Ftr1p0.289
FRE6Fre6p0.241
POS5Pos5p0.202
DRE2Dre2p0.175
NFS1Nfs1p0.175
CFD1Cfd1p0.145
ISD11Isd11p0.137
YHB1Yhb1p0.126
SKS1Sks1p0.117
ISA1Isa1p0.116
NHX1Nhx1p0.112
UTR1Utr1p0.110
FRE1Fre1p0.105
YMR155Whypothetical protein0.090
FRA1Fra1p0.086
SMF1Smf1p0.085
PEX25Pex25p0.084
PHO89Pho89p0.083
LYS9Lys9p0.080
ZRT3Zrt3p0.078
DSD1Dsd1p0.074
SSQ1Ssq1p0.073
PET8Pet8p0.070
MIA40Mia40p0.070
GLG2Glg2p0.069
FIT2Fit2p0.060
LEU5Leu5p0.060
ERG8Erg8p0.060
YDL012Chypothetical protein0.060
VMA16Vma16p0.059
ODC2Odc2p0.059
SPC2Spc2p0.059
IRC21Irc21p0.058
MRS4Mrs4p0.055
YPL109Chypothetical protein0.055
ROX1Rox1p0.055
PMP2Pmp2p0.052
MAS1Mas1p0.052
AAT2Aat2p0.051
COX4Cox4p0.049
GDH2Gdh2p0.048
YBR071Whypothetical protein0.048
PCS60Pcs60p0.047
HSM3Hsm3p0.046
TIM8Tim8p0.045
SWI1Swi1p0.044
CUE4Cue4p0.044
SFA1Sfa1p0.044
CNB1Cnb1p0.044
VMR1Vmr1p0.044
VID24Vid24p0.041
ARR1Arr1p0.040
PRM4Prm4p0.040
CAB1Cab1p0.040
CTR2Ctr2p0.039
MRL1Mrl1p0.039
YLR264C-Ahypothetical protein0.038
TOK1Tok1p0.038
YPL191Chypothetical protein0.038
NMT1Nmt1p0.037
YNL295Whypothetical protein0.036
PNG1Png1p0.036
ERG2Erg2p0.035
SHM1Shm1p0.035
UBC1Ubc1p0.035
NEO1Neo1p0.034
YNR064Chypothetical protein0.034
SMM1Smm1p0.034
TIM44Tim44p0.034
PDR15Pdr15p0.034
TAT1Tat1p0.034
SDT1Sdt1p0.033
HAL1Hal1p0.032
DSS1Dss1p0.032
ERS1Ers1p0.032
SRD1Srd1p0.031
HYM1Hym1p0.031
MDE1Mde1p0.031
CEM1Cem1p0.031
LEU2Leu2p0.031
ERG12Erg12p0.031
YLR326Whypothetical protein0.031
ISA2Isa2p0.030
YOL038C-Ahypothetical protein0.030
RNH201Rnh201p0.030
OCH1Och1p0.030