The network for 'sarcomere organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

sarcomere organization

The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

NameDescriptionProbabilityFunc Analog Organism
MhcMyosin heavy chain1.000
Zasp52Z band alternatively spliced PDZ-motif protein 520.997
Actnalpha actinin0.997
Mlc2Myosin light chain 20.993
Tm2Tropomyosin 20.989
Act88FActin 88F0.988
wupAwings up A0.969
Zasp66Z band alternatively spliced PDZ-motif protein 660.949
salssarcomere length short0.858
CG11299CG11299 gene product from transcript CG11299-RA0.816
twProtein O-mannosyltransferase 20.734
MicalMolecule interacting with CasL0.491
DAAMDishevelled Associated Activator of Morphogenesis0.439
Rya-r44FRyanodine receptor 44F0.395
Cf2Chorion factor 20.369
fliIflightless I0.360
coroCG9446 gene product from transcript CG9446-RC0.322
TER94CG2331 gene product from transcript CG2331-RA0.314
GpdhGlycerol 3 phosphate dehydrogenase0.243
Mlp84BMuscle LIM protein at 84B0.223
pigspickled eggs0.187
stmAstambha A0.159
ScgdeltaSarcoglycan delta0.112
CanB2Calcineurin B20.109
eIF-4EEukaryotic initiation factor 4E0.094
Su(z)12CG8013 gene product from transcript CG8013-RA0.092
CaMKIICalcium/calmodulin-dependent protein kinase II0.090
RhoGEF2CG9635 gene product from transcript CG9635-RF0.084
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.082
rtrotated abdomen0.079
snssticks and stones0.078
endoAendophilin A0.076
Gpo-1Glycerophosphate oxidase-10.075
CG9297CG9297 gene product from transcript CG9297-RB0.073
mubmushroom-body expressed0.071
e(y)3enhancer of yellow 30.068
howheld out wings0.068
VAChTCG32848 gene product from transcript CG32848-RA0.065
Tom34Translocase of outer membrane 340.061
BicDBicaudal D0.059
stnAstoned A0.057
Vrp1Verprolin 10.056
Cdc42CG12530 gene product from transcript CG12530-RA0.054
Act57BActin 57B0.048
Mef2Myocyte enhancer factor 20.047
ewgerect wing0.043
LamCLamin C0.041
GripGlutamate receptor binding protein0.039
Mlc1Myosin alkali light chain 10.038
Mp20Muscle protein 200.038
CG32528CG32528 gene product from transcript CG32528-RA0.037
Unc-89CG33519 gene product from transcript CG33519-RC0.037
LaspCG3849 gene product from transcript CG3849-RB0.036
Unc-76CG3981 gene product from transcript CG3981-RB0.034
dcodiscs overgrown0.033
wbwing blister0.031
gclgerm cell-less0.031
zfh1Zn finger homeodomain 10.030
nanarrow abdomen0.029
unc-13CG2999 gene product from transcript CG2999-RA0.029
blowblown fuse0.028
Act5CActin 5C0.028
Cg25CCollagen type IV0.028
CG13424CG13424 gene product from transcript CG13424-RA0.028
wechCG42396 gene product from transcript CG42396-RC0.027
LrtLeucine-rich tendon-specific protein0.026
PknProtein kinase related to protein kinase N0.025
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-15Protein UNC-151.000
stn-1Protein STN-10.903
T21B6.3Protein T21B6.30.896
myo-3Protein MYO-30.868
emb-9Protein EMB-90.856
ketn-1Protein KETN-10.825
unc-87Protein UNC-870.742
myo-1Protein MYO-10.709
C53C9.2Protein C53C9.20.685
F35A5.1Protein F35A5.10.652
zyx-1Protein ZYX-10.503
T12D8.9Protein T12D8.90.477
slo-1Protein SLO-10.427
unc-89Protein UNC-890.397
dyc-1Protein DYC-10.383
unc-27Protein UNC-270.326
unc-68Protein UNC-680.251
dys-1Protein DYS-10.247
twk-18Protein TWK-180.238
hsp-12.2Protein HSP-12.20.220
ost-1Protein OST-10.182
dyb-1Protein DYB-10.165
pat-10Protein PAT-100.159
lgc-34Protein LGC-340.138
insc-1Protein INSC-10.129
dig-1Protein DIG-10.121
pde-4Protein PDE-40.118
mlc-2Protein MLC-20.114
ncx-2Protein NCX-20.099
CELE_B0513.5Protein B0513.50.097
C29F5.1Protein C29F5.10.093
C54E4.2Protein C54E4.20.088
tnt-2Protein TNT-20.088
T23E7.2Protein T23E7.20.083
abu-8Protein ABU-80.073
lev-11Protein LEV-110.073
T22B11.4Protein T22B11.40.068
K09A9.6Protein K09A9.60.067
unc-52Protein UNC-520.046
unc-96Protein UNC-960.041
T28B11.1Protein T28B11.10.040
csq-1Protein CSQ-10.039
act-4Protein ACT-40.037
tni-3Protein TNI-30.033
tnc-2Protein TNC-20.032
T25F10.6Protein T25F10.60.032
pgp-14Protein PGP-140.028
CELE_Y45F10B.13Protein Y45F10B.130.028
F21C10.7Protein F21C10.70.028
pat-2Protein PAT-20.027
unc-22Protein UNC-220.026
sup-12Protein SUP-120.026
CELE_W02D7.5Protein W02D7.50.026
cpna-1Protein CPNA-10.023
cpna-2Protein CPNA-20.022
myo-2Protein MYO-20.022
immt-1Protein IMMT-10.021
mig-6Protein MIG-60.021
myo-5Protein MYO-50.020
CELE_C08B6.4Protein C08B6.40.020
rig-6Protein RIG-60.019
ptp-1Protein PTP-10.019
mup-2Protein MUP-20.018
CELE_Y39B6A.1Protein Y39B6A.10.018
nep-17Protein NEP-170.018
ZC247.2Protein ZC247.20.017
M02D8.1Protein M02D8.10.017
F40F4.6Protein F40F4.60.017
CELE_M03D4.4Protein M03D4.40.016
rhgf-2Protein RHGF-20.016
F46G11.4Protein F46G11.40.016
kin-2Protein KIN-20.016
cpn-3Protein CPN-30.016
F46H5.3Protein F46H5.30.015
R03H10.2Protein R03H10.20.015
let-2Protein LET-20.015
sorb-1Protein SORB-10.015
unc-41Protein UNC-410.015
col-34Protein COL-340.014
ifb-2Protein IFB-20.013
tni-4Protein TNI-40.013
F55B11.1Protein F55B11.10.013
syg-1Protein SYG-10.013
epi-1Protein EPI-10.013
hum-7Protein HUM-70.013
stn-2Protein STN-20.012
W06A7.2Protein W06A7.20.012
C46G7.2Protein C46G7.20.012
dim-1Protein DIM-10.012
R11G1.6Protein R11G1.60.012
W05F2.4Protein W05F2.40.012
lec-2Protein LEC-20.011
ZC21.3Protein ZC21.30.011
nhl-1Protein NHL-10.011
ceh-48Protein CEH-480.011
Y71G12B.11Protein Y71G12B.110.011
ceh-22Protein CEH-220.011
ajm-1Protein AJM-10.011
pcp-3Protein PCP-30.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mef2cbmyocyte enhancer factor 2cb0.991
smyd1bSET and MYND domain containing 1b0.987
tnnc1btroponin C type 1b (slow)0.987
unc45bunc-45 homolog B (C. elegans)0.939
ttnatitin a0.903
stac3SH3 and cysteine rich domain 30.887
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.828
hsp90a.1heat shock protein 90-alpha 10.797
xirp1xin actin-binding repeat containing 10.734
vmhcventricular myosin heavy chain0.728
tnni2a.4troponin I, skeletal, fast 2a.40.629
myl1myosin, light chain 1, alkali; skeletal, fast0.628
smyd1aSET and MYND domain containing 1a0.569
actn1actinin, alpha 10.550
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.547
tnni1btroponin I, skeletal, slow b0.484
ttnbtitin b0.465
gapdhglyceraldehyde-3-phosphate dehydrogenase0.444
dag1dystroglycan 10.437
mef2camyocyte enhancer factor 2ca0.435
smyhc1lslow myosin heavy chain 1, like0.418
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.412
tnni1altroponin I, skeletal, slow like0.404
tnnt3btroponin T3b, skeletal, fast0.378
actc1bactin, alpha, cardiac muscle 1b0.375
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.366
jam2ajunctional adhesion molecule 2a0.361
tnnc1atroponin C type 1a (slow)0.325
pdlim7PDZ and LIM domain 70.325
mylz2myosin, light polypeptide 2, skeletal muscle0.322
desmadesmin a0.317
actc1aactin, alpha, cardiac muscle 1a0.265
itgb1aintegrin, beta 1a0.254
actn2actinin, alpha 20.246
acta1aactin, alpha 1a, skeletal muscle0.226
tpm3tropomyosin 30.222
cav3caveolin 30.216
hspg2heparan sulfate proteoglycan 20.213
pabpc4poly(A) binding protein, cytoplasmic 4 (inducible form)0.192
anxa6annexin A60.191
fxr1fragile X mental retardation, autosomal homolog 10.190
actn3bactinin alpha 3b0.187
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.180
ilkintegrin linked kinase0.169
tpm4tropomyosin 40.161
smyhc2slow myosin heavy chain 20.143
myl10myosin, light chain 10, regulatory0.132
tmem38atransmembrane protein 38A0.128
ckmacreatine kinase, muscle a0.122
tnnc2troponin C type 2 (fast)0.120
nppanatriuretic peptide precursor A0.113
znf148zinc finger protein 1480.110
kbtbd10bkelch repeat and BTB (POZ) domain containing 10b0.108
tpm2tropomyosin 2 (beta)0.100
smyhc1slow myosin heavy chain 10.099
xirp2axin actin-binding repeat containing 2a0.094
atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.091
pomt2protein-O-mannosyltransferase 20.090
smyd2bSET and MYND domain containing 2b0.087
frem3Fras1 related extracellular matrix 30.086
mybpc3myosin binding protein C, cardiac0.086
tnni2b.1troponin I, skeletal, fast 2b.10.080
wnt11rwingless-type MMTV integration site family, member 11, related0.079
lama2laminin, alpha 20.074
actn3aactinin alpha 3a0.074
itgb1bintegrin, beta 1b0.072
casrlcalcium-sensing receptor, like0.067
vmhclventricular myosin heavy chain-like0.065
ndrg4N-myc downstream regulated gene 40.063
flncbfilamin C, gamma b (actin binding protein 280)0.063
aldoabaldolase a, fructose-bisphosphate, b0.063
itgb1b.2integrin, beta 1b.20.062
fabp3fatty acid binding protein 3, muscle and heart0.061
alpialkaline phosphatase, intestinal0.060
col15a1bcollagen, type XV, alpha 1b0.059
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.057
fabp2fatty acid binding protein 2, intestinal0.056
myhz2myosin, heavy polypeptide 2, fast muscle specific0.055
fgf10afibroblast growth factor 10a0.054
ldb3aLIM-domain binding factor 3a0.053
ryr1bryanodine receptor 1b (skeletal)0.053
pdlim5PDZ and LIM domain 50.053
txlnbataxilin beta a0.053
mapk4mitogen-activated protein kinase 40.053
anxa1aannexin A1a0.052
chrndcholinergic receptor, nicotinic, delta polypeptide0.051
acta1bactin, alpha 1b, skeletal muscle0.051
anxa2aannexin A2a0.050
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MYH9myosin, heavy chain 9, non-muscle0.902
ACTN1actinin, alpha 10.892
FLNAfilamin A, alpha0.891
TRIM63tripartite motif containing 630.880
ACTBactin, beta0.749
KRT15keratin 150.575
KRT6Bkeratin 6B0.471
TPM1tropomyosin 1 (alpha)0.465
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.234
TNNI1troponin I type 1 (skeletal, slow)0.211
HDAC1histone deacetylase 10.151
TBX5T-box 50.116
PDLIM7PDZ and LIM domain 7 (enigma)0.115
MYOZ1myozenin 10.108
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.085
SORBS2sorbin and SH3 domain containing 20.084
KRT8keratin 80.084
KRT19keratin 190.081
ACTN4actinin, alpha 40.078
CNN2calponin 20.054
TPM4tropomyosin 40.051
MYL9myosin, light chain 9, regulatory0.051
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.043
ACTA2actin, alpha 2, smooth muscle, aorta0.042
KRT33Bkeratin 33B0.033
MYOD1myogenic differentiation 10.033
KRT6Akeratin 6A0.033
TPM2tropomyosin 2 (beta)0.032
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.031
FNBP1Lformin binding protein 1-like0.030
ACTA1actin, alpha 1, skeletal muscle0.030
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.030
ILKintegrin-linked kinase0.027
MYOGmyogenin (myogenic factor 4)0.027
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.026
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.021
TJP1tight junction protein 1 (zona occludens 1)0.021
KRT81keratin 810.020
TCAPtitin-cap (telethonin)0.018
HAP1huntingtin-associated protein 10.018
GLIS2GLIS family zinc finger 20.018
MKL1megakaryoblastic leukemia (translocation) 10.018
KRT34keratin 340.018
CFL1cofilin 1 (non-muscle)0.016
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.016
CALD1caldesmon 10.015
SPTBN1spectrin, beta, non-erythrocytic 10.015
RUNX1runt-related transcription factor 10.015
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.015
KRT33Akeratin 33A0.015
BMPR1Bbone morphogenetic protein receptor, type IB0.015
BAG1BCL2-associated athanogene0.014
FN1fibronectin 10.014
MYL1myosin, light chain 1, alkali; skeletal, fast0.014
KRT16keratin 160.013
RFX1regulatory factor X, 1 (influences HLA class II expression)0.013
FLNBfilamin B, beta0.013
GATA4GATA binding protein 40.013
KRT5keratin 50.012
CAPN3calpain 3, (p94)0.012
DSTNdestrin (actin depolymerizing factor)0.012
TLN1talin 10.012
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.012
CCDC85Bcoiled-coil domain containing 85B0.011
HNF4Ahepatocyte nuclear factor 4, alpha0.011
ACTC1actin, alpha, cardiac muscle 10.011
IQGAP1IQ motif containing GTPase activating protein 10.011
KRT13keratin 130.011
ACTN3actinin, alpha 30.011
CORO1Ccoronin, actin binding protein, 1C0.011
TNNC1troponin C type 1 (slow)0.011
CNN1calponin 1, basic, smooth muscle0.010
WDR1WD repeat domain 10.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Actc1actin, alpha, cardiac muscle 10.996
Ldb3LIM domain binding 30.993
Actn2actinin alpha 20.985
Tnnt3troponin T3, skeletal, fast0.976
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.969
Hrchistidine rich calcium binding protein0.935
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.902
Dmddystrophin, muscular dystrophy0.859
Myl3myosin, light polypeptide 30.844
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.825
Cnn1calponin 10.803
Wdr1WD repeat domain 10.767
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.732
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.731
Acta1actin, alpha 1, skeletal muscle0.721
Tpm2tropomyosin 2, beta0.720
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.709
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.667
Hand2heart and neural crest derivatives expressed transcript 20.657
Actg2actin, gamma 2, smooth muscle, enteric0.657
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.634
Csrp3cysteine and glycine-rich protein 30.629
Mybpc3myosin binding protein C, cardiac0.614
Hspb2heat shock protein 20.613
Dtnadystrobrevin alpha0.592
Sox9SRY-box containing gene 90.560
Myom1myomesin 10.553
Myom2myomesin 20.528
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.504
Myl1myosin, light polypeptide 10.482
Lmnalamin A0.474
Gli2GLI-Kruppel family member GLI20.473
Xirp1xin actin-binding repeat containing 10.465
Tnnt2troponin T2, cardiac0.450
Ank1ankyrin 1, erythroid0.437
Tnnc1troponin C, cardiac/slow skeletal0.416
Nppanatriuretic peptide type A0.408
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.398
Pdlim3PDZ and LIM domain 30.390
Krt15keratin 150.374
Shhsonic hedgehog0.371
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.367
Cav3caveolin 30.362
Eya1eyes absent 1 homolog (Drosophila)0.360
Cnn2calponin 20.343
Prkceprotein kinase C, epsilon0.335
Acta2actin, alpha 2, smooth muscle, aorta0.317
Casq2calsequestrin 20.316
Tpm1tropomyosin 1, alpha0.315
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.310
Mef2cmyocyte enhancer factor 2C0.307
Hdac4histone deacetylase 40.301
Myl7myosin, light polypeptide 7, regulatory0.298
Myh9myosin, heavy polypeptide 9, non-muscle0.280
Popdc3popeye domain containing 30.273
Mybphmyosin binding protein H0.235
Flncfilamin C, gamma0.229
Hspb7heat shock protein family, member 7 (cardiovascular)0.227
Myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.226
Tnni1troponin I, skeletal, slow 10.226
Ilkintegrin linked kinase0.225
Nrapnebulin-related anchoring protein0.224
Itga5integrin alpha 5 (fibronectin receptor alpha)0.224
Msx1homeobox, msh-like 10.223
Actn1actinin, alpha 10.215
Krt18keratin 180.208
Ckmt2creatine kinase, mitochondrial 20.207
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.201
Tnni2troponin I, skeletal, fast 20.200
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.189
Pgam2phosphoglycerate mutase 20.184
Fbn2fibrillin 20.180
Srpk3serine/arginine-rich protein specific kinase 30.175
Krt19keratin 190.174
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.165
Pthlhparathyroid hormone-like peptide0.164
Tbx5T-box 50.164
Pitx1paired-like homeodomain transcription factor 10.162
Krt7keratin 70.160
Wnt11wingless-related MMTV integration site 110.159
Gscgoosecoid homeobox0.155
Isl1ISL1 transcription factor, LIM/homeodomain0.151
Prrx1paired related homeobox 10.148
Myl9myosin, light polypeptide 9, regulatory0.147
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.146
Tnnc2troponin C2, fast0.144
Gata6GATA binding protein 60.141
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.132
Cpeb3cytoplasmic polyadenylation element binding protein 30.126
Pax3paired box gene 30.122
Ppp3cbprotein phosphatase 3, catalytic subunit, beta isoform0.121
Hand1heart and neural crest derivatives expressed transcript 10.119
Tbx1T-box 10.110
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.109
Tnnt1troponin T1, skeletal, slow0.106
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Krt18keratin 180.277
Myh7myosin, heavy chain 7, cardiac muscle, beta0.154
Actbactin, beta0.137
Actc1actin, alpha, cardiac muscle 10.121
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.120
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.096
Myh9myosin, heavy chain 9, non-muscle0.078
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.074
Mybpc1myosin binding protein C, slow type0.038
Ckmcreatine kinase, muscle0.032
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.029
Myl3myosin, light chain 3, alkali; ventricular, skeletal, slow0.028
Myoz2myozenin 20.026
Cd82Cd82 molecule0.023
Hspb2heat shock protein beta 20.022
Nrapnebulin-related anchoring protein0.020
Krt8keratin 80.020
Krt19keratin 190.019
Tnni1troponin I type 1 (skeletal, slow)0.018
Actn2actinin alpha 20.016
Klk1lkallikrein 1-like peptidase0.016
Myh2myosin, heavy chain 2, skeletal muscle, adult0.016
S100a11S100 calcium binding protein A11 (calizzarin)0.015
Csrp3cysteine and glycine-rich protein 30.015
Tagln2transgelin 20.015
Wdr1WD repeat domain 10.013
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.013
Lgals7lectin, galactoside-binding, soluble, 70.013
Krt14keratin 140.013
Casq2calsequestrin 2 (cardiac muscle)0.012
Flnbfilamin, beta0.012
Lmnalamin A0.011
Obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism