The network for 'keratinization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms


The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.

NameDescriptionProbabilityFunc Analog Organism
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
KRT15keratin 151.000
TP63tumor protein p631.000
KRT17keratin 171.000
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)1.000
CDH1cadherin 1, type 1, E-cadherin (epithelial)1.000
KRT6Bkeratin 6B1.000
KRT19keratin 191.000
JUPjunction plakoglobin1.000
KRT14keratin 141.000
KRT18keratin 181.000
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
KRT5keratin 51.000
DSG2desmoglein 20.999
CTNND1catenin (cadherin-associated protein), delta 10.997
TRIM29tripartite motif containing 290.996
PKP3plakophilin 30.994
KRT6Akeratin 6A0.992
CDH3cadherin 3, type 1, P-cadherin (placental)0.992
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.992
SPRR1Asmall proline-rich protein 1A0.990
KRT8keratin 80.989
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.980
C19orf50chromosome 19 open reading frame 500.977
KRT16keratin 160.973
DSG3desmoglein 30.968
PKP2plakophilin 20.968
EGFRepidermal growth factor receptor0.966
SPRR1Bsmall proline-rich protein 1B0.953
GJB3gap junction protein, beta 3, 31kDa0.947
KRT6Ckeratin 6C0.933
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.914
SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 50.897
KLK10kallikrein-related peptidase 100.886
KRT4keratin 40.885
PPP2R2Bprotein phosphatase 2, regulatory subunit B, beta0.876
KRT34keratin 340.870
KRT1keratin 10.865
FGFBP1fibroblast growth factor binding protein 10.863
KRT2keratin 20.842
DSG1desmoglein 10.821
KRT81keratin 810.777
DSC3desmocollin 30.742
KRT9keratin 90.721
ALOX12arachidonate 12-lipoxygenase0.712
KRT75keratin 750.712
GPR87G protein-coupled receptor 870.701
S100A2S100 calcium binding protein A20.685
LY6Dlymphocyte antigen 6 complex, locus D0.673
LYPD3LY6/PLAUR domain containing 30.659
TNK2tyrosine kinase, non-receptor, 20.629
LAD1ladinin 10.624
KLK7kallikrein-related peptidase 70.624
KRT13keratin 130.576
GJB5gap junction protein, beta 5, 31.1kDa0.572
PTPRJprotein tyrosine phosphatase, receptor type, J0.547
COL17A1collagen, type XVII, alpha 10.542
SPRR3small proline-rich protein 30.534
CLCA2chloride channel accessory 20.480
KRT33Bkeratin 33B0.475
ITGB4integrin, beta 40.470
PSEN1presenilin 10.459
SERPINB13serpin peptidase inhibitor, clade B (ovalbumin), member 130.450
RNF31ring finger protein 310.391
PI3peptidase inhibitor 3, skin-derived0.375
SLURP1secreted LY6/PLAUR domain containing 10.362
TNS4tensin 40.341
S100A7S100 calcium binding protein A70.331
RHCGRh family, C glycoprotein0.325
S100A14S100 calcium binding protein A140.322
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.313
KLK11kallikrein-related peptidase 110.305
LY6G6Clymphocyte antigen 6 complex, locus G6C0.296
WASLWiskott-Aldrich syndrome-like0.292
SERPINB4serpin peptidase inhibitor, clade B (ovalbumin), member 40.291
SERPINB3serpin peptidase inhibitor, clade B (ovalbumin), member 30.289
GABRPgamma-aminobutyric acid (GABA) A receptor, pi0.286
BNC1basonuclin 10.252
KRT23keratin 23 (histone deacetylase inducible)0.246
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.232
KRT33Akeratin 33A0.221
TGFAtransforming growth factor, alpha0.215
GLIS2GLIS family zinc finger 20.212
KRT31keratin 310.205
ERRFI1ERBB receptor feedback inhibitor 10.203
SERPINB7serpin peptidase inhibitor, clade B (ovalbumin), member 70.189
KLK5kallikrein-related peptidase 50.188
CTNNBIP1catenin, beta interacting protein 10.182
C1orf116chromosome 1 open reading frame 1160.181
KRT7keratin 70.175
CCDC85Bcoiled-coil domain containing 85B0.169
FAT2FAT tumor suppressor homolog 2 (Drosophila)0.156
SPINK5serine peptidase inhibitor, Kazal type 50.150
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.148
IL1F5interleukin 1 family, member 5 (delta)0.148
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.972
Krt14keratin 140.902
Krt5keratin 50.810
Krt8keratin 80.800
Krt17keratin 170.728
Psapl1prosaposin-like 10.691
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.582
Krt6akeratin 6A0.505
Krt27keratin 270.365
Krt33bkeratin 33B0.347
Krt19keratin 190.345
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.338
Dlx3distal-less homeobox 30.334
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.326
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.304
Trp63transformation related protein 630.249
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.247
Krt71keratin 710.233
Sprr1asmall proline-rich protein 1A0.229
Pkp1plakophilin 10.219
Foxn1forkhead box N10.209
Krtap8-1keratin associated protein 8-10.207
Krt35keratin 350.182
Krt7keratin 70.175
Egfrepidermal growth factor receptor0.162
Lrrk2leucine-rich repeat kinase 20.160
Krt18keratin 180.133
Cldn3claudin 30.132
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.130
Lgals7lectin, galactose binding, soluble 70.129
Mt4metallothionein 40.125
S100a14S100 calcium binding protein A140.105
Krtap3-1keratin associated protein 3-10.105
Pthlhparathyroid hormone-like peptide0.101
Krt86keratin 860.098
Tgm3transglutaminase 3, E polypeptide0.093
Syt8synaptotagmin VIII0.092
Tcfap2ctranscription factor AP-2, gamma0.087
Clic3chloride intracellular channel 30.078
5430421N21RikRIKEN cDNA 5430421N21 gene0.078
Wnt10awingless related MMTV integration site 10a0.077
Calm4calmodulin 40.073
Gjb4gap junction protein, beta 40.071
Krt36keratin 360.065
Cldn4claudin 40.062
Rnf31ring finger protein 310.057
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.057
Msx2homeobox, msh-like 20.056
Rdh8retinol dehydrogenase 80.054
Trim29tripartite motif-containing 290.052
Krt31keratin 310.052
Krtap5-1keratin associated protein 5-10.051
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.050
Cldn7claudin 70.049
Serpinb5serine (or cysteine) peptidase inhibitor, clade B, member 50.046
Tff1trefoil factor 10.045
Padi3peptidyl arginine deiminase, type III0.044
Pkp3plakophilin 30.043
Padi4peptidyl arginine deiminase, type IV0.041
Dsg4desmoglein 40.041
Krt85keratin 850.041
Krt75keratin 750.040
Krt72-pskeratin 72, pseudogene0.039
Fam83ffamily with sequence similarity 83, member F0.038
Krt34keratin 340.038
Klk6kallikrein related-peptidase 60.038
Slurp1secreted Ly6/Plaur domain containing 10.038
Ptk7PTK7 protein tyrosine kinase 70.038
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.037
Krt13keratin 130.037
Trpm1transient receptor potential cation channel, subfamily M, member 10.036
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.035
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.034
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.033
S100a3S100 calcium binding protein A30.033
Krt6bkeratin 6B0.032
Lama5laminin, alpha 50.032
Eya2eyes absent 2 homolog (Drosophila)0.032
Il1f5interleukin 1 family, member 5 (delta)0.032
Wfdc2WAP four-disulfide core domain 20.029
Nppcnatriuretic peptide type C0.029
Sprr2fsmall proline-rich protein 2F0.029
Wnt4wingless-related MMTV integration site 40.029
Krtap6-2keratin associated protein 6-20.029
Phlda2pleckstrin homology-like domain, family A, member 20.028
Krt32keratin 320.027
Fgfbp1fibroblast growth factor binding protein 10.027
Myh9myosin, heavy polypeptide 9, non-muscle0.026
Krt25keratin 250.026
Cdcp1CUB domain containing protein 10.025
Asprv1aspartic peptidase, retroviral-like 10.025
Fam83gfamily with sequence similarity 83, member G0.025
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism