The network for 'interleukin 1 mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interleukin 1 mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ZNF43zinc finger protein 430.993
ZNF253zinc finger protein 2530.958
IRAK2interleukin-1 receptor-associated kinase 20.940
MAPK14mitogen-activated protein kinase 140.939
ZNF273zinc finger protein 2730.910
ZNF675zinc finger protein 6750.892
MAPK1mitogen-activated protein kinase 10.874
IL1R1interleukin 1 receptor, type I0.819
IL1Binterleukin 1, beta0.757
TRAF6TNF receptor-associated factor 60.616
IRAK1interleukin-1 receptor-associated kinase 10.548
EGR1early growth response 10.538
ZNF254zinc finger protein 2540.329
IL1RNinterleukin 1 receptor antagonist0.324
ZNF708zinc finger protein 7080.290
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.273
IL1RAPinterleukin 1 receptor accessory protein0.264
EGR3early growth response 30.225
EGR2early growth response 20.179
ZNF85zinc finger protein 850.173
ZNF91zinc finger protein 910.172
MAP3K8mitogen-activated protein kinase kinase kinase 80.150
MYD88myeloid differentiation primary response gene (88)0.136
DUSP1dual specificity phosphatase 10.132
ZNF430zinc finger protein 4300.131
EP300E1A binding protein p3000.119
ZNF117zinc finger protein 1170.102
MAP2K1mitogen-activated protein kinase kinase 10.087
MAPK3mitogen-activated protein kinase 30.087
IL1R2interleukin 1 receptor, type II0.085
ZNF93zinc finger protein 930.077
COASYCoA synthase0.069
ZNF680zinc finger protein 6800.069
PTPRJprotein tyrosine phosphatase, receptor type, J0.051
PELI3pellino homolog 3 (Drosophila)0.051
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.042
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.040
DVL3dishevelled, dsh homolog 3 (Drosophila)0.038
DUSP3dual specificity phosphatase 30.037
IRAK3interleukin-1 receptor-associated kinase 30.037
TICAM2toll-like receptor adaptor molecule 20.035
ZNF682zinc finger protein 6820.035
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.032
DUSP6dual specificity phosphatase 60.030
ZNF107zinc finger protein 1070.029
SH3BP2SH3-domain binding protein 20.028
TNIP1TNFAIP3 interacting protein 10.028
TNFAIP3tumor necrosis factor, alpha-induced protein 30.025
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.020
RICTORRPTOR independent companion of MTOR, complex 20.019
ZC3H12Azinc finger CCCH-type containing 12A0.019
IL8interleukin 80.019
ZNF92zinc finger protein 920.019
ENO2enolase 2 (gamma, neuronal)0.018
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.018
RNF19Aring finger protein 19A0.017
EEF2Keukaryotic elongation factor-2 kinase0.016
SQSTM1sequestosome 10.015
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.015
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.015
IPO11importin 110.013
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.013
TLR2toll-like receptor 20.013
PEA15phosphoprotein enriched in astrocytes 150.012
C10orf116chromosome 10 open reading frame 1160.011
MDFIMyoD family inhibitor0.011
SPTBN4spectrin, beta, non-erythrocytic 40.011
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.011
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.011
PTPRRprotein tyrosine phosphatase, receptor type, R0.011
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.010
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.010
C19orf46chromosome 19 open reading frame 460.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Myd88myeloid differentiation primary response gene 880.994
Traf6TNF receptor-associated factor 60.951
Tnfaip3tumor necrosis factor, alpha-induced protein 30.893
Map3k7mitogen-activated protein kinase kinase kinase 70.811
Irak4interleukin-1 receptor-associated kinase 40.762
Irak3interleukin-1 receptor-associated kinase 30.755
Tlr4toll-like receptor 40.647
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.394
TifaTRAF-interacting protein with forkhead-associated domain0.299
Cd40CD40 antigen0.252
Ccl2chemokine (C-C motif) ligand 20.240
Birc3baculoviral IAP repeat-containing 30.209
Stat3signal transducer and activator of transcription 30.182
Map3k8mitogen-activated protein kinase kinase kinase 80.182
Ptgs2prostaglandin-endoperoxide synthase 20.171
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.167
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.159
Il6interleukin 60.115
Bcl3B-cell leukemia/lymphoma 30.084
Irak1interleukin-1 receptor-associated kinase 10.080
Mavsmitochondrial antiviral signaling protein0.076
Trafd1TRAF type zinc finger domain containing 10.075
Cd44CD44 antigen0.071
FosFBJ osteosarcoma oncogene0.068
Cxcl2chemokine (C-X-C motif) ligand 20.066
Capns1calpain, small subunit 10.065
Sqstm1sequestosome 10.064
Egr2early growth response 20.062
JunbJun-B oncogene0.060
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.056
Nab2Ngfi-A binding protein 20.054
Ticam1toll-like receptor adaptor molecule 10.049
Mapk1mitogen-activated protein kinase 10.048
Il4rainterleukin 4 receptor, alpha0.047
Map3k1mitogen-activated protein kinase kinase kinase 10.043
Kiss1KiSS-1 metastasis-suppressor0.041
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.040
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.040
Il1rapinterleukin 1 receptor accessory protein0.040
Cav1caveolin 1, caveolae protein0.039
Actn4actinin alpha 40.036
Cxcl1chemokine (C-X-C motif) ligand 10.036
Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.036
Traf3ip2TRAF3 interacting protein 20.034
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.032
Ikbkginhibitor of kappaB kinase gamma0.031
Mknk2MAP kinase-interacting serine/threonine kinase 20.030
Itchitchy, E3 ubiquitin protein ligase0.027
Ier2immediate early response 20.026
Nr4a1nuclear receptor subfamily 4, group A, member 10.024
Il1binterleukin 1 beta0.024
Ube2nubiquitin-conjugating enzyme E2N0.024
Il1r1interleukin 1 receptor, type I0.023
Ikbkeinhibitor of kappaB kinase epsilon0.022
Ripk2receptor (TNFRSF)-interacting serine-threonine kinase 20.022
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.021
Csf1colony stimulating factor 1 (macrophage)0.021
Map3k3mitogen-activated protein kinase kinase kinase 30.021
Irak2interleukin-1 receptor-associated kinase 20.020
Leprleptin receptor0.019
Pea15aphosphoprotein enriched in astrocytes 15A0.019
Traf2TNF receptor-associated factor 20.018
Rnf41ring finger protein 410.018
Tolliptoll interacting protein0.017
Traf3TNF receptor-associated factor 30.017
Gnb2guanine nucleotide binding protein (G protein), beta 20.016
Hspa1bheat shock protein 1B0.015
Peli2pellino 20.015
Fliiflightless I homolog (Drosophila)0.015
Tlr2toll-like receptor 20.014
Prkcdprotein kinase C, delta0.014
Dusp1dual specificity phosphatase 10.014
FasFas (TNF receptor superfamily member 6)0.014
Clec4eC-type lectin domain family 4, member e0.014
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.013
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.013
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.013
Casp4caspase 4, apoptosis-related cysteine peptidase0.013
Flot1flotillin 10.013
Il1ainterleukin 1 alpha0.012
Anapc2anaphase promoting complex subunit 20.012
Atf3activating transcription factor 30.012
Ltbrlymphotoxin B receptor0.012
JunJun oncogene0.012
Saa3serum amyloid A 30.012
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.012
Socs3suppressor of cytokine signaling 30.011
Ldlrlow density lipoprotein receptor0.011
SkilSKI-like0.011
Cxcl5chemokine (C-X-C motif) ligand 50.011
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.011
Clec4dC-type lectin domain family 4, member d0.011
Icam1intercellular adhesion molecule 10.011
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.010
Tnftumor necrosis factor0.010
Adam8a disintegrin and metallopeptidase domain 80.010
Prkceprotein kinase C, epsilon0.010
EcsitECSIT homolog (Drosophila)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
FosFBJ osteosarcoma oncogene0.851
Junbjun B proto-oncogene0.547
Btg2BTG family, member 20.403
Nr4a1nuclear receptor subfamily 4, group A, member 10.279
Egr2early growth response 20.256
Ier2immediate early response 20.243
Dusp1dual specificity phosphatase 10.170
Dusp6dual specificity phosphatase 60.057
Zfp36zinc finger protein 360.053
Nr4a3nuclear receptor subfamily 4, group A, member 30.042
Cyr61cysteine-rich, angiogenic inducer, 610.035
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.035
JunJun oncogene0.034
Socs3suppressor of cytokine signaling 30.030
Hes2hairy and enhancer of split 2 (Drosophila)0.030
Ccl20chemokine (C-C motif) ligand 200.028
Atf3activating transcription factor 30.027
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.026
Klf4Kruppel-like factor 4 (gut)0.025
Gucy1b3guanylate cyclase 1, soluble, beta 30.025
Nos2nitric oxide synthase 2, inducible0.024
Il1ainterleukin 1 alpha0.023
Cxcl2chemokine (C-X-C motif) ligand 20.022
Il1binterleukin 1 beta0.022
Fosl1fos-like antigen 10.021
Sellselectin L0.021
Acppacid phosphatase, prostate0.020
Mmp3matrix metallopeptidase 30.020
Hbegfheparin-binding EGF-like growth factor0.019
Adora2aadenosine A2a receptor0.019
Galnt5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)0.019
Il1rninterleukin 1 receptor antagonist0.019
Dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 360.018
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.018
Il10interleukin 100.017
Ptgs2prostaglandin-endoperoxide synthase 20.017
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.016
Rpn2ribophorin II0.016
Nr5a2nuclear receptor subfamily 5, group A, member 20.016
Map3k8mitogen-activated protein kinase kinase kinase 80.016
Ccl3chemokine (C-C motif) ligand 30.015
Il6interleukin 60.015
Ccr2chemokine (C-C motif) receptor 20.015
Mtch1mitochondrial carrier homolog 1 (C. elegans)0.014
FasFas (TNF receptor superfamily, member 6)0.014
Rhobras homolog gene family, member B0.014
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.013
Fgd4FYVE, RhoGEF and PH domain containing 40.013
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.013
Mlanamelan-A0.013
Dstykdual serine/threonine and tyrosine protein kinase0.013
Igsf6immunoglobulin superfamily, member 60.013
Rasa2RAS p21 protein activator 20.013
Trib1tribbles homolog 1 (Drosophila)0.012
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.012
Ednraendothelin receptor type A0.012
Selpselectin P0.012
C1galt1core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 10.012
Clcn5chloride channel 50.012
Dusp5dual specificity phosphatase 50.012
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.012
Foxa3forkhead box A30.011
Reg3gregenerating islet-derived 3 gamma0.011
Tmed7transmembrane emp24 protein transport domain containing 70.011
Tbl1xtransducin (beta)-like 1 X-linked0.011
Rapgef2Rap guanine nucleotide exchange factor (GEF) 20.010
Hand1heart and neural crest derivatives expressed 10.010
Sf3b1splicing factor 3b, subunit 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism