The network for 'hippo signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hippo signaling

The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.

NameDescriptionProbabilityFunc Analog Organism
savsalvador1.000
kibrakibra ortholog0.979
ftfat0.858
wtswarts0.834
dsdachsous0.707
MerMerlin0.674
ykiyorkie0.506
hpohippo0.496
Tao-1CG14217 gene product from transcript CG14217-RF0.480
CG5794CG5794 gene product from transcript CG5794-RB0.461
fjfour-jointed0.417
egreiger0.330
CG14614CG14614 gene product from transcript CG14614-RA0.311
cindrCIN85 and CD2AP orthologue0.303
PRL-1CG4993 gene product from transcript CG4993-RB0.288
maskmultiple ankyrin repeats single KH domain0.245
crbcrumbs0.215
exexpanded0.177
lqfRliquid facets-Related0.171
CG6191CG6191 gene product from transcript CG6191-RA0.159
scribscribbled0.147
SmrSmrter0.137
pathpathetic0.113
lunaCG33473 gene product from transcript CG33473-RB0.109
Upf1CG1559 gene product from transcript CG1559-RA0.100
CG10741CG10741 gene product from transcript CG10741-RB0.096
crmcramped0.095
kek5kekkon50.092
mnbminibrain0.077
rstroughest0.076
Ten-mTenascin major0.074
Atg9Autophagy-specific gene 90.069
Toll-6CG7250 gene product from transcript CG7250-RA0.068
CG8538CG8538 gene product from transcript CG8538-RB0.067
bursbursicon0.067
Axud1CG4272 gene product from transcript CG4272-RA0.066
lftlowfat0.065
lmdlame duck0.059
panpangolin0.057
nejnejire0.057
kirrekin of irre0.054
Sop2Suppressor of profilin 20.051
CG3021CG3021 gene product from transcript CG3021-RA0.050
nctnicastrin0.047
spensplit ends0.045
meltmelted0.045
rokRho-kinase0.044
picoCG11940 gene product from transcript CG11940-RA0.041
hppyhappyhour0.040
CG13114CG13114 gene product from transcript CG13114-RB0.039
CG31869CG31869 gene product from transcript CG31869-RA0.038
CG14059CG14059 gene product from transcript CG14059-RB0.037
Pp2B-14DProtein phosphatase 2B at 14D0.037
ptrproximal to raf0.035
X11LCG5675 gene product from transcript CG5675-RB0.034
Trc8CG2304 gene product from transcript CG2304-RB0.032
scuscully0.031
TpnC47DTroponin C at 47D0.030
rnorhinoceros0.030
obst-Aobstructor-A0.030
mib1mind bomb 10.030
Jon99CiiiJonah 99Ciii0.030
snssticks and stones0.029
CG9772CG9772 gene product from transcript CG9772-RB0.029
CG3837CG3837 gene product from transcript CG3837-RA0.028
CG30263CG30263 gene product from transcript CG30263-RB0.028
p53CG33336 gene product from transcript CG33336-RB0.028
IlkIntegrin linked kinase0.028
lmglemming0.028
hbshibris0.026
ecechinus0.026
caupcaupolican0.026
CG1806CG1806 gene product from transcript CG1806-RA0.025
edechinoid0.025
skpCCG11941 gene product from transcript CG11941-RA0.024
Vrp1Verprolin 10.024
JhI-1Juvenile hormone-inducible protein 10.024
Caf1-180CG12109 gene product from transcript CG12109-RB0.023
CG14317CG14317 gene product from transcript CG14317-RA0.023
dltdiscs lost0.022
Irk3Inwardly rectifying potassium channel 30.022
PdkPyruvate dehydrogenase kinase0.021
LLobe0.020
CG6800CG6800 gene product from transcript CG6800-RA0.020
CG17278CG17278 gene product from transcript CG17278-RA0.020
raptorCG4320 gene product from transcript CG4320-RA0.020
Toll-7CG8595 gene product from transcript CG8595-RA0.020
CG4674CG4674 gene product from transcript CG4674-RA0.019
bdgbedraggled0.019
Cpr72EaCuticular protein 72Ea0.018
dcodiscs overgrown0.017
wgnwengen0.017
agoarchipelago0.017
Caf1Chromatin assembly factor 1 subunit0.017
Gef26CG9491 gene product from transcript CG9491-RB0.017
CG32556CG32556 gene product from transcript CG32556-RB0.017
vps2CG14542 gene product from transcript CG14542-RA0.017
CG12268CG12268 gene product from transcript CG12268-RB0.016
cutletCG33122 gene product from transcript CG33122-RA0.016
RhoGAP71ECG32149 gene product from transcript CG32149-RD0.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YAP1Yes-associated protein 11.000
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)1.000
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)1.000
AMOTL1angiomotin like 11.000
STK3serine/threonine kinase 31.000
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.999
LATS1LATS, large tumor suppressor, homolog 1 (Drosophila)0.999
PTPN14protein tyrosine phosphatase, non-receptor type 140.998
AMOTangiomotin0.991
STK4serine/threonine kinase 40.986
RASSF5Ras association (RalGDS/AF-6) domain family member 50.973
SAV1salvador homolog 1 (Drosophila)0.959
AMOTL2angiomotin like 20.952
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.945
HIPK2homeodomain interacting protein kinase 20.783
STK38Lserine/threonine kinase 38 like0.761
MPDZmultiple PDZ domain protein0.757
SNAI1snail homolog 1 (Drosophila)0.741
MAP3K1mitogen-activated protein kinase kinase kinase 10.727
INADLInaD-like (Drosophila)0.695
ANKRD28ankyrin repeat domain 280.600
EZRezrin0.484
VCLvinculin0.437
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.423
TOX4TOX high mobility group box family member 40.408
JUBjub, ajuba homolog (Xenopus laevis)0.339
FBXW11F-box and WD repeat domain containing 110.324
FERMT2fermitin family member 20.310
CD44CD44 molecule (Indian blood group)0.306
WWTR1WW domain containing transcription regulator 10.265
ACTN1actinin, alpha 10.260
TJP2tight junction protein 2 (zona occludens 2)0.248
RASSF1Ras association (RalGDS/AF-6) domain family member 10.243
TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor)0.235
NEK6NIMA (never in mitosis gene a)-related kinase 60.225
RASSF3Ras association (RalGDS/AF-6) domain family member 30.214
SCHIP1schwannomin interacting protein 10.207
TBC1D10ATBC1 domain family, member 10A0.165
LRCH1leucine-rich repeats and calponin homology (CH) domain containing 10.156
TP53BP2tumor protein p53 binding protein, 20.132
RUNX1runt-related transcription factor 10.120
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.112
CSNK1Ecasein kinase 1, epsilon0.104
WWC1WW and C2 domain containing 10.099
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.094
PPP6Cprotein phosphatase 6, catalytic subunit0.089
HOXA9homeobox A90.078
MED28mediator complex subunit 280.077
TEAD3TEA domain family member 30.065
MAP2K3mitogen-activated protein kinase kinase 30.062
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.060
MTMR4myotubularin related protein 40.058
NFAT5nuclear factor of activated T-cells 5, tonicity-responsive0.056
PPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16A0.048
NF2neurofibromin 2 (merlin)0.046
PPP6R3protein phosphatase 6, regulatory subunit 30.045
CRLF3cytokine receptor-like factor 30.040
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.036
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.035
MSNmoesin0.030
MCCmutated in colorectal cancers0.027
TEAD4TEA domain family member 40.027
SFNstratifin0.026
FLNBfilamin B, beta0.026
LIMK2LIM domain kinase 20.026
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.025
CNN2calponin 20.025
KIAA1683KIAA16830.024
MPP5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)0.023
RHOCras homolog gene family, member C0.023
BTBD7BTB (POZ) domain containing 70.022
LRCH2leucine-rich repeats and calponin homology (CH) domain containing 20.022
LZTS2leucine zipper, putative tumor suppressor 20.022
TJP1tight junction protein 1 (zona occludens 1)0.022
DCAF7DDB1 and CUL4 associated factor 70.021
FHL3four and a half LIM domains 30.021
DOCK6dedicator of cytokinesis 60.021
LASP1LIM and SH3 protein 10.020
UBE2R2ubiquitin-conjugating enzyme E2R 20.020
DVL1dishevelled, dsh homolog 1 (Drosophila)0.020
WBP1WW domain binding protein 10.020
WT1Wilms tumor 10.019
DVL2dishevelled, dsh homolog 2 (Drosophila)0.018
IPO11importin 110.018
NR2F2nuclear receptor subfamily 2, group F, member 20.018
DSTdystonin0.018
SRCIN1SRC kinase signaling inhibitor 10.017
MYH9myosin, heavy chain 9, non-muscle0.017
RASSF2Ras association (RalGDS/AF-6) domain family member 20.016
PPP6R2protein phosphatase 6, regulatory subunit 20.016
C5orf55chromosome 5 open reading frame 550.015
ADRB2adrenergic, beta-2-, receptor, surface0.015
SNIP1Smad nuclear interacting protein 10.014
HOXA1homeobox A10.013
GORASP1golgi reassembly stacking protein 1, 65kDa0.013
TGFB2transforming growth factor, beta 20.013
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.012
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.012
PDCD7programmed cell death 70.012
CLIC4chloride intracellular channel 40.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Yap1yes-associated protein 11.000
Wwtr1WW domain containing transcription regulator 10.975
Tead1TEA domain family member 10.923
Stk4serine/threonine kinase 40.825
Trp53transformation related protein 530.770
Mdm2transformed mouse 3T3 cell double minute 20.553
Apcadenomatosis polyposis coli0.481
Shesrc homology 2 domain-containing transforming protein E0.412
Invsinversin0.405
Nf1neurofibromatosis 10.284
Wwc2WW, C2 and coiled-coil domain containing 20.247
Smad6MAD homolog 6 (Drosophila)0.244
Gli3GLI-Kruppel family member GLI30.240
NanogNanog homeobox0.239
Lats2large tumor suppressor 20.195
Efnb1ephrin B10.172
Bmpr1abone morphogenetic protein receptor, type 1A0.172
Fgfr3fibroblast growth factor receptor 30.150
Notch3Notch gene homolog 3 (Drosophila)0.147
Epas1endothelial PAS domain protein 10.146
Tead2TEA domain family member 20.145
Acvr1activin A receptor, type 10.140
Gata3GATA binding protein 30.132
Fgfr2fibroblast growth factor receptor 20.125
Tsc1tuberous sclerosis 10.125
Rassf5Ras association (RalGDS/AF-6) domain family member 50.119
Sav1salvador homolog 1 (Drosophila)0.119
Sox4SRY-box containing gene 40.094
Sox11SRY-box containing gene 110.092
Ptpn14protein tyrosine phosphatase, non-receptor type 140.088
Tbx2T-box 20.087
Kitlkit ligand0.075
Sox2SRY-box containing gene 20.069
Tead4TEA domain family member 40.068
Cpdcarboxypeptidase D0.058
Ptk7PTK7 protein tyrosine kinase 70.056
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.054
Zfhx3zinc finger homeobox 30.054
Irs1insulin receptor substrate 10.047
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.045
Grb10growth factor receptor bound protein 100.045
RybpRING1 and YY1 binding protein0.040
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.040
Meox2mesenchyme homeobox 20.040
Hhexhematopoietically expressed homeobox0.039
Rock2Rho-associated coiled-coil containing protein kinase 20.039
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.039
Nfibnuclear factor I/B0.036
Cyr61cysteine rich protein 610.035
Itgb1integrin beta 1 (fibronectin receptor beta)0.035
Ush1gUsher syndrome 1G homolog (human)0.033
Flt1FMS-like tyrosine kinase 10.033
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.032
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.032
Vegfavascular endothelial growth factor A0.031
Bmp4bone morphogenetic protein 40.028
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.027
Tead3TEA domain family member 30.027
Myo10myosin X0.027
Hes1hairy and enhancer of split 1 (Drosophila)0.027
Adam17a disintegrin and metallopeptidase domain 170.027
BrafBraf transforming gene0.026
Ptprgprotein tyrosine phosphatase, receptor type, G0.026
Tsc2tuberous sclerosis 20.026
Cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.024
Cux1cut-like homeobox 10.023
Jubajuba0.023
Ptpn21protein tyrosine phosphatase, non-receptor type 210.023
Isl1ISL1 transcription factor, LIM/homeodomain0.021
Tbx3T-box 30.021
Tgfbr1transforming growth factor, beta receptor I0.020
Npr3natriuretic peptide receptor 30.020
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.020
Pax3paired box gene 30.020
Pik3c2aphosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide0.019
Arhgap29Rho GTPase activating protein 290.019
Lrp5low density lipoprotein receptor-related protein 50.019
Ephb4Eph receptor B40.019
Espnespin0.019
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.019
Tgif2TGFB-induced factor homeobox 20.018
Smad3MAD homolog 3 (Drosophila)0.018
Efsembryonal Fyn-associated substrate0.018
Fgfr1fibroblast growth factor receptor 10.018
Shroom3shroom family member 30.018
Ikbkapinhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein0.018
Sox7SRY-box containing gene 70.018
Ptprbprotein tyrosine phosphatase, receptor type, B0.017
Amotl2angiomotin-like 20.017
Pkn2protein kinase N20.017
Igf2bp1insulin-like growth factor 2 mRNA binding protein 10.017
Bcl6bB-cell CLL/lymphoma 6, member B0.017
Pxdnperoxidasin homolog (Drosophila)0.017
XiapX-linked inhibitor of apoptosis0.016
Syde1synapse defective 1, Rho GTPase, homolog 1 (C. elegans)0.016
Nuak1NUAK family, SNF1-like kinase, 10.016
Pax6paired box gene 60.016
Celsr1cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)0.016
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.016
Csnk2a1casein kinase 2, alpha 1 polypeptide0.015
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism