The network for 'cranial nerve development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cranial nerve development

The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.

NameDescriptionProbabilityFunc Analog Organism
E(spl)Enhancer of split0.986
HLHm7E(spl) region transcript m70.865
HLHmdeltaE(spl) region transcript mdelta0.792
acachaete0.566
HLHmgammaE(spl) region transcript mgamma0.555
m4E(spl) region transcript m40.390
ptcpatched0.355
atoatonal0.342
sdscalloped0.327
malphaE(spl) region transcript malpha0.325
m2E(spl) region transcript m20.283
PoxnPox neuro0.235
bnlbranchless0.230
eyaeyes absent0.226
HLHmbetaE(spl) region transcript mbeta0.191
scascabrous0.186
kluklumpfuss0.185
vvlventral veins lacking0.180
senssenseless0.170
witwishful thinking0.147
vgvestigial0.144
amosabsent MD neurons and olfactory sensilla0.141
HLHm3E(spl) region transcript m30.139
ssspineless0.135
scscute0.108
lzlozenge0.101
kuzkuzbanian0.096
rorough0.095
nubnubbin0.087
SerSerrate0.083
salmspalt major0.083
Lim1CG11354 gene product from transcript CG11354-RA0.079
rhorhomboid0.077
aseasense0.077
Fak56DFocal Adhesion Kinase0.074
nrv2nervana 20.074
htlheartless0.074
kek1kekkon-10.069
stysprouty0.068
TomTwin of m40.063
alaristaless0.062
roboroundabout0.062
dsfdissatisfaction0.061
Abd-BAbdominal B0.059
Spn77BaSerpin 77Ba0.057
Irk2Inwardly rectifying potassium channel 20.053
tantantalus0.051
TolloCG6890 gene product from transcript CG6890-RA0.049
wgnwengen0.049
l(2)k16918lethal (2) k169180.048
Wnt2Wnt oncogene analog 20.048
HLHm5E(spl) region transcript m50.047
eyeyeless0.046
dandistal antenna0.046
CG10200CG10200 gene product from transcript CG10200-RB0.044
reporeversed polarity0.044
naunautilus0.043
stjstraightjacket0.043
gppgrappa0.043
netCG11450 gene product from transcript CG11450-RB0.043
sevsevenless0.042
dppdecapentaplegic0.042
CkIIalphaCasein kinase II alpha subunit0.041
stumpsCG31317 gene product from transcript CG31317-RC0.041
hrghiiragi0.039
Toll-7CG8595 gene product from transcript CG8595-RA0.038
CG13627CG13627 gene product from transcript CG13627-RA0.038
enengrailed0.038
svshaven0.037
LanB2Laminin B20.036
CaMKIICalcium/calmodulin-dependent protein kinase II0.036
stanstarry night0.035
bibifid0.035
nocno ocelli0.035
Applbeta amyloid protein precursor-like0.034
trioCG18214 gene product from transcript CG18214-RA0.034
Cpr97EbCuticular protein 97Eb0.034
emcextra macrochaetae0.034
Irk3Inwardly rectifying potassium channel 30.033
rnrotund0.033
GripGlutamate receptor binding protein0.033
plxpollux0.032
pbproboscipedia0.032
tintinman0.032
tutlturtle0.032
Cp190Centrosomal protein 190kD0.032
seqsequoia0.032
Sox102FCG11153 gene product from transcript CG11153-RB0.032
B-H1BarH10.031
elBelbow B0.030
egeagle0.030
cv-2crossveinless 20.030
wbwing blister0.029
btlbreathless0.029
loqsloquacious0.028
Nedd4CG42279 gene product from transcript CG42279-RJ0.028
srstripe0.027
HmgcrHMG Coenzyme A reductase0.027
cpocouch potato0.027
fredfriend of echinoid0.027
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
pax2apaired box gene 2a0.980
sox10SRY-box containing gene 100.956
atoh1aatonal homolog 1a0.858
dladeltaA0.821
six3bsine oculis homeobox homolog 3b0.820
foxi1forkhead box I10.762
eya1eyes absent homolog 10.713
phox2apaired-like homeobox 2a0.698
tbx1T-box 10.667
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.629
cntn2contactin 20.608
atoh1batonal homolog 1b0.564
six4bsine oculis homeobox homolog 4b0.563
dlx4adistal-less homeobox gene 4a0.532
crestincrestin0.489
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.441
gata3GATA-binding protein 30.397
pitx2paired-like homeodomain transcription factor 20.374
tgfb3transforming growth factor, beta 30.373
dlx1adistal-less homeobox gene 1a0.368
ret1receptor tyrosine kinase0.361
emx3empty spiracles homeobox 30.356
smad1MAD homolog 1 (Drosophila)0.354
hmx3homeo box (H6 family) 30.353
hapln1ahyaluronan and proteoglycan link protein 1a0.345
hoxb4ahomeo box B4a0.338
hoxb3ahomeo box B3a0.331
nkx2.1aNK2 homeobox 1a0.327
twist1atwist1a0.326
tubb5tubulin, beta 50.325
foxd3forkhead box D30.324
neurodneurogenic differentiation0.324
gcm2glial cells missing homolog 2 (Drosophila)0.315
tgfb2transforming growth factor, beta 20.299
gli2aGLI-Kruppel family member GLI2a0.298
nrp1aneuropilin 1a0.285
tbx2bT-box 2b0.284
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.273
dlddeltaD0.269
sox21bSRY-box containing gene 21 b0.269
rx3retinal homeobox gene 30.261
ndr2nodal-related 20.253
kitbkit receptor b0.249
msxemuscle segment homeobox E0.244
dpysl2bdihydropyrimidinase-like 2b0.243
pou3f3bPOU class 3 homeobox 3b0.242
robo1roundabout homolog 10.231
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.229
restRE1-silencing transcription factor0.229
pax6bpaired box gene 6b0.227
nr2e1nuclear receptor subfamily 2, group E, member 10.227
foxa1forkhead box A10.226
six4asine oculis homeobox homolog 4a0.221
sox9aSRY-box containing gene 9a0.214
hoxa3ahomeo box A3a0.213
grem2gremlin 2, cysteine knot superfamily0.208
alcamaactivated leukocyte cell adhesion molecule a0.200
foxa2forkhead box A20.199
isl1islet10.189
ek1eph-like kinase 10.188
zic1zic family member 1 (odd-paired homolog, Drosophila)0.183
st8sia1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 10.183
nkx3.2NK3 homeobox 20.182
pcdh18bprotocadherin 18b0.182
nr2f5nuclear receptor subfamily 2, group F, member 50.180
fgf3fibroblast growth factor 30.180
tp63tumor protein p630.176
ptf1apancreas specific transcription factor, 1a0.174
hoxb1ahomeo box B1a0.173
efnb2aephrin B2a0.173
dlx2adistal-less homeobox gene 2a0.171
stmn2bstathmin-like 2b0.162
six3asine oculis homeobox homolog 3a0.161
phox2bpaired-like homeobox 2b0.160
ptpraprotein tyrosine phosphatase, receptor type, A0.157
notch2notch homolog 20.156
nrg1neuregulin 10.154
cdh4cadherin 4, retinal0.149
gpr126G protein-coupled receptor 1260.149
shhbsonic hedgehog b0.149
olig2oligodendrocyte lineage transcription factor 20.147
crabp2acellular retinoic acid binding protein 2, a0.147
foxc1aforkhead box C1a0.144
m17IL-6 subfamily cytokine M170.141
nadl1.1neural adhesion molecule L1.10.135
fgfr3fibroblast growth factor receptor 30.134
tal1T-cell acute lymphocytic leukemia 10.132
hoxa1ahomeo box A1a0.130
mecomMDS1 and EVI1 complex locus0.125
cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.125
nrp1bneuropilin 1b0.125
spry4sprouty (Drosophila) homolog 40.125
pax8paired box gene 80.123
wu:fv91b12wu:fv91b120.122
epha4beph receptor A4b0.122
nrp2aneuropilin 2a0.121
bhlhe22basic helix-loop-helix family, member e220.121
hoxb5bhomeo box B5b0.121
tcf21transcription factor 210.121
cntn1bcontactin 1b0.120
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1.000
EGFRepidermal growth factor receptor1.000
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)1.000
DTNAdystrobrevin, alpha0.996
POU5F1POU class 5 homeobox 10.996
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.995
GRB7growth factor receptor-bound protein 70.992
SUFUsuppressor of fused homolog (Drosophila)0.987
CHD8chromodomain helicase DNA binding protein 80.978
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.976
EP300E1A binding protein p3000.975
PPARAperoxisome proliferator-activated receptor alpha0.959
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.956
CHD7chromodomain helicase DNA binding protein 70.954
PTCH1patched 10.932
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.895
HOXA5homeobox A50.894
STK36serine/threonine kinase 360.849
GATA2GATA binding protein 20.847
GATA4GATA binding protein 40.831
HOXB5homeobox B50.823
SETD8SET domain containing (lysine methyltransferase) 80.805
NR4A1nuclear receptor subfamily 4, group A, member 10.791
SOX2SRY (sex determining region Y)-box 20.788
VEGFAvascular endothelial growth factor A0.758
MYOD1myogenic differentiation 10.738
SIX6SIX homeobox 60.723
PTK6PTK6 protein tyrosine kinase 60.717
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.701
INSRinsulin receptor0.696
HAND2heart and neural crest derivatives expressed 20.661
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.653
KLF4Kruppel-like factor 4 (gut)0.648
NGFnerve growth factor (beta polypeptide)0.579
AKAP2A kinase (PRKA) anchor protein 20.558
PLCG1phospholipase C, gamma 10.546
TNS3tensin 30.535
HOXB9homeobox B90.534
HOXD12homeobox D120.528
TMSB4Xthymosin beta 4, X-linked0.505
PDX1pancreatic and duodenal homeobox 10.495
HOXA3homeobox A30.483
IER2immediate early response 20.476
PAX6paired box 60.468
ZFYVE9zinc finger, FYVE domain containing 90.467
COL4A3BPcollagen, type IV, alpha 3 (Goodpasture antigen) binding protein0.466
FGF1fibroblast growth factor 1 (acidic)0.464
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.456
HOXA4homeobox A40.447
LPXNleupaxin0.444
HDAC6histone deacetylase 60.443
MDFIMyoD family inhibitor0.441
ARID2AT rich interactive domain 2 (ARID, RFX-like)0.440
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.415
POU4F2POU class 4 homeobox 20.411
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.400
FGBfibrinogen beta chain0.392
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.391
NEUROG1neurogenin 10.391
CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 30.383
RUNX1runt-related transcription factor 10.381
HOXD13homeobox D130.363
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.361
SH3BP4SH3-domain binding protein 40.361
HOXD9homeobox D90.340
FEVFEV (ETS oncogene family)0.340
HOXA9homeobox A90.338
TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta)0.332
SYKspleen tyrosine kinase0.331
ALX4ALX homeobox 40.322
HOXA11homeobox A110.321
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.321
HOXB6homeobox B60.298
C11orf73chromosome 11 open reading frame 730.292
FGF2fibroblast growth factor 2 (basic)0.288
TUBB3tubulin, beta 30.286
BBS10Bardet-Biedl syndrome 100.284
EPHB1EPH receptor B10.283
HOXB3homeobox B30.280
PRR13proline rich 130.279
ZIC1Zic family member 1 (odd-paired homolog, Drosophila)0.276
TAL1T-cell acute lymphocytic leukemia 10.273
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.265
CYLDcylindromatosis (turban tumor syndrome)0.257
DTNBdystrobrevin, beta0.243
HOXB4homeobox B40.239
POU4F3POU class 4 homeobox 30.238
KCTD1potassium channel tetramerisation domain containing 10.236
HOXD11homeobox D110.235
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.233
BARX1BARX homeobox 10.228
HOXC11homeobox C110.220
PITX2paired-like homeodomain 20.218
TMEM30Btransmembrane protein 30B0.217
EYA2eyes absent homolog 2 (Drosophila)0.213
NRP2neuropilin 20.205
FRS2fibroblast growth factor receptor substrate 20.200
CABLES1Cdk5 and Abl enzyme substrate 10.197
JUNjun proto-oncogene0.196
ECEL1endothelin converting enzyme-like 10.194
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Otx2orthodenticle homolog 2 (Drosophila)1.000
Msx1homeobox, msh-like 10.998
Eya1eyes absent 1 homolog (Drosophila)0.998
Hoxa1homeobox A10.997
Tbx1T-box 10.997
Shhsonic hedgehog0.992
Gli3GLI-Kruppel family member GLI30.986
Fgf8fibroblast growth factor 80.980
Dlx5distal-less homeobox 50.980
Pax3paired box gene 30.980
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.975
Foxc2forkhead box C20.969
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.966
Fgfr2fibroblast growth factor receptor 20.958
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.957
Hoxa2homeobox A20.954
Isl1ISL1 transcription factor, LIM/homeodomain0.951
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.949
Hand1heart and neural crest derivatives expressed transcript 10.948
Sox2SRY-box containing gene 20.942
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.936
Hand2heart and neural crest derivatives expressed transcript 20.934
Tcfap2atranscription factor AP-2, alpha0.924
Pax2paired box gene 20.923
Foxg1forkhead box G10.922
Phox2bpaired-like homeobox 2b0.919
Gdnfglial cell line derived neurotrophic factor0.891
Pax6paired box gene 60.879
Pitx2paired-like homeodomain transcription factor 20.878
Hoxb1homeobox B10.874
Sall3sal-like 3 (Drosophila)0.844
Chd7chromodomain helicase DNA binding protein 70.843
Hoxd3homeobox D30.828
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.822
Chrdchordin0.817
Ntf3neurotrophin 30.802
Msx2homeobox, msh-like 20.800
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.784
Efnb2ephrin B20.760
Lhx9LIM homeobox protein 90.757
Epha4Eph receptor A40.754
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.752
Neurog1neurogenin 10.735
Prrx1paired related homeobox 10.732
Bdnfbrain derived neurotrophic factor0.703
Lhx1LIM homeobox protein 10.703
Gbx2gastrulation brain homeobox 20.696
Nognoggin0.685
Ascl1achaete-scute complex homolog 1 (Drosophila)0.682
Hes5hairy and enhancer of split 5 (Drosophila)0.670
Tbx3T-box 30.664
Dlx6distal-less homeobox 60.664
Pbx1pre B-cell leukemia transcription factor 10.657
Fgf3fibroblast growth factor 30.644
Hmx1H6 homeobox 10.637
Sox10SRY-box containing gene 100.600
Dlx2distal-less homeobox 20.594
Smosmoothened homolog (Drosophila)0.577
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.573
NanogNanog homeobox0.565
Lmx1aLIM homeobox transcription factor 1 alpha0.549
Pou4f2POU domain, class 4, transcription factor 20.542
Ednraendothelin receptor type A0.526
Gata4GATA binding protein 40.525
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.524
Jag1jagged 10.518
Zic3zinc finger protein of the cerebellum 30.515
Emx2empty spiracles homolog 2 (Drosophila)0.506
Fgf10fibroblast growth factor 100.505
Neurog2neurogenin 20.492
Pou3f3POU domain, class 3, transcription factor 30.480
Rargretinoic acid receptor, gamma0.474
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.474
Tlx3T-cell leukemia, homeobox 30.473
Dccdeleted in colorectal carcinoma0.466
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.462
Fgfr1fibroblast growth factor receptor 10.452
Ebf3early B-cell factor 30.439
Efna2ephrin A20.432
Sall4sal-like 4 (Drosophila)0.413
Vangl2vang-like 2 (van gogh, Drosophila)0.401
Retret proto-oncogene0.400
Prox1prospero-related homeobox 10.393
Bmp7bone morphogenetic protein 70.377
Lmx1bLIM homeobox transcription factor 1 beta0.363
Lef1lymphoid enhancer binding factor 10.362
Zic2zinc finger protein of the cerebellum 20.362
Hmx3H6 homeobox 30.361
Nrg1neuregulin 10.354
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.354
Wnt6wingless-related MMTV integration site 60.347
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.340
Hoxb4homeobox B40.336
Pcdh12protocadherin 120.330
Sox3SRY-box containing gene 30.330
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.322
Kcnd2potassium voltage-gated channel, Shal-related family, member 20.319
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.319
Notch3Notch gene homolog 3 (Drosophila)0.318
Gfra3glial cell line derived neurotrophic factor family receptor alpha 30.315
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Egr1early growth response 10.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism