The network for 'eye morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

eye morphogenesis

The process in which the anatomical structures of the eye are generated and organized.

NameDescriptionProbabilityFunc Analog Organism
E(spl)Enhancer of split0.998
HLHm7E(spl) region transcript m70.991
argosCG4531 gene product from transcript CG4531-RA0.986
spensplit ends0.985
snostrawberry notch0.983
phlpole hole0.980
Ras85DRas oncogene at 85D0.978
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.973
amosabsent MD neurons and olfactory sensilla0.972
Akt1CG4006 gene product from transcript CG4006-RA0.962
hipkhomeodomain interacting protein kinase0.962
Rac1CG2248 gene product from transcript CG2248-RA0.961
Rab11Rab-protein 110.960
cicubitus interruptus0.954
vvlventral veins lacking0.943
CG11347CG11347 gene product from transcript CG11347-RE0.939
sinaseven in absentia0.939
ChcClathrin heavy chain0.935
sosine oculis0.927
Tsc1CG6147 gene product from transcript CG6147-RA0.923
TomTwin of m40.922
gbbglass bottom boat0.921
S6kIIRPS6-protein kinase-II0.914
TBPHCG10327 gene product from transcript CG10327-RC0.908
Kap-alpha3karyopherin alpha30.906
emcextra macrochaetae0.899
Ten-mTenascin major0.898
stanstarry night0.888
drkdownstream of receptor kinase0.877
Sra-1specifically Rac1-associated protein 10.875
Mi-2CG8103 gene product from transcript CG8103-RA0.872
VangVan Gogh0.869
Fas2Fasciclin 20.851
Cdc42CG12530 gene product from transcript CG12530-RA0.838
trioCG18214 gene product from transcript CG18214-RA0.834
Pi3K92ECG4141 gene product from transcript CG4141-RB0.824
Arr2Arrestin 20.823
cutletCG33122 gene product from transcript CG33122-RA0.815
Snr1Snf5-related 10.814
eyaeyes absent0.799
zfh1Zn finger homeodomain 10.792
hydhyperplastic discs0.792
elavembryonic lethal abnormal vision0.779
HopHsp70/Hsp90 organizing protein homolog0.770
Su(Tpl)CG32217 gene product from transcript CG32217-RB0.769
Trf2TATA box binding protein-related factor 20.765
ik2IkappaB kinase-like 20.756
Fmr1CG6203 gene product from transcript CG6203-RC0.753
grimCG4345 gene product from transcript CG4345-RA0.752
ebiCG4063 gene product from transcript CG4063-RA0.746
Eb1CG3265 gene product from transcript CG3265-RF0.745
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdh2cadherin 2, neuronal1.000
ndr2nodal-related 20.998
shhasonic hedgehog a0.996
bmp4bone morphogenetic protein 40.996
pax6bpaired box gene 6b0.993
foxa2forkhead box A20.991
eya1eyes absent homolog 10.989
pax2apaired box gene 2a0.987
otx2orthodenticle homolog 20.985
gdf6agrowth differentiation factor 6a0.983
kif17kinesin family member 170.980
hnf1baHNF1 homeobox Ba0.979
ift88intraflagellar transport 88 homolog0.978
rx2retinal homeobox gene 20.973
six3bsine oculis homeobox homolog 3b0.971
epb41l5erythrocyte membrane protein band 4.1 like 50.971
bmp2bbone morphogenetic protein 2b0.970
crb2acrumbs homolog 2a0.967
bocbrother of CDO0.962
jag2jagged 20.958
tfap2atranscription factor AP-2 alpha0.950
otpborthopedia homolog b0.948
fstafollistatin a0.946
irx1airoquois homeobox protein 1, a0.940
wnt11wingless-type MMTV integration site family, member 110.939
mibmind bomb0.939
flhfloating head0.937
rx3retinal homeobox gene 30.936
gli1GLI-Kruppel family member 10.932
rx1retinal homeobox gene 10.931
lmx1b.1LIM homeobox transcription factor 1, beta 10.929
myod1myogenic differentiation 10.928
lhx2bLIM homeobox 2b0.917
bhlhe22basic helix-loop-helix family, member e220.915
crxcone-rod homeobox0.914
fgf3fibroblast growth factor 30.906
tbx2bT-box 2b0.892
sox9aSRY-box containing gene 9a0.892
notch3notch homolog 30.887
vax2ventral anterior homeobox 20.885
shhbsonic hedgehog b0.885
sox2SRY-box containing gene 20.878
neurodneurogenic differentiation0.875
wnt8bwingless-type MMTV integration site family, member 8b0.862
tal1T-cell acute lymphocytic leukemia 10.858
gbx2gastrulation brain homeo box 20.839
pcdh8protocadherin 80.831
bmp2abone morphogenetic protein 2a0.830
fgf8afibroblast growth factor 8 a0.828
nr2e1nuclear receptor subfamily 2, group E, member 10.828
mab21l2mab-21-like 20.820
tfe3btranscription factor binding to IGHM enhancer 3b0.818
atoh7atonal homolog 70.816
dctn1adynactin 1a0.806
tfebtranscription factor EB0.805
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.788
prdm1aPR domain containing 1a, with ZNF domain0.778
metmet proto-oncogene (hepatocyte growth factor receptor)0.775
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.771
cdoncell adhesion molecule-related/down-regulated by oncogenes0.765
otx5orthodenticle homolog 50.753
irx4biroquois homeobox protein 4b0.749
dlx3bdistal-less homeobox gene 3b0.741
aldh1a2aldehyde dehydrogenase 1 family, member A20.738
gli2aGLI-Kruppel family member GLI2a0.716
lrrc6leucine rich repeat containing 60.715
ptch1patched 10.713
vsx1visual system homeobox 1 homolog, chx10-like0.706
vcanaversican a0.700
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.693
foxi1forkhead box I10.690
traf4atnf receptor-associated factor 4a0.675
fezf2FEZ family zinc finger 20.666
pitx2paired-like homeodomain transcription factor 20.665
hoxb1bhomeo box B1b0.662
olfm2olfactomedin 20.649
sox3SRY-box containing gene 30.648
cdh6cadherin 60.648
foxg1aforkhead box G1a0.632
sox4aSRY-box containing gene 4a0.630
rxraaretinoid X receptor, alpha a0.627
runx1runt-related transcription factor 10.622
nr2e3nuclear receptor subfamily 2, group E, member 30.620
fgf10afibroblast growth factor 10a0.609
tbx1T-box 10.608
lamb1alaminin, beta 1a0.607
fgfr4fibroblast growth factor receptor 40.601
meis1myeloid ecotropic viral integration 10.592
wnt4awingless-type MMTV integration site family, member 4a0.587
pcdh18bprotocadherin 18b0.585
ptf1apancreas specific transcription factor, 1a0.582
tp53tumor protein p530.581
notch1anotch homolog 1a0.573
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.638
SIN3ASIN3 homolog A, transcription regulator (yeast)0.605
COL1A1collagen, type I, alpha 10.581
SP1Sp1 transcription factor0.500
CREBBPCREB binding protein0.447
BCORBCL6 corepressor0.412
BMI1BMI1 polycomb ring finger oncogene0.312
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.304
EGFRepidermal growth factor receptor0.274
PTPN11protein tyrosine phosphatase, non-receptor type 110.197
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.185
NCOR1nuclear receptor corepressor 10.167
INADLInaD-like (Drosophila)0.161
SMAD3SMAD family member 30.155
NRP1neuropilin 10.153
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.148
RUNX1runt-related transcription factor 10.147
COL3A1collagen, type III, alpha 10.145
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.136
BCL2L1BCL2-like 10.124
PBX1pre-B-cell leukemia homeobox 10.121
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.113
HDAC2histone deacetylase 20.112
PCGF2polycomb group ring finger 20.111
PIAS1protein inhibitor of activated STAT, 10.111
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.108
MCM7minichromosome maintenance complex component 70.105
YAP1Yes-associated protein 10.102
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.097
NOTCH3notch 30.097
TP53tumor protein p530.092
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.090
BBS2Bardet-Biedl syndrome 20.089
DDR2discoidin domain receptor tyrosine kinase 20.088
EP300E1A binding protein p3000.087
SMAD4SMAD family member 40.083
COL6A1collagen, type VI, alpha 10.083
HCFC1host cell factor C1 (VP16-accessory protein)0.080
COL1A2collagen, type I, alpha 20.079
APCadenomatous polyposis coli0.078
MDFIMyoD family inhibitor0.078
TP53BP2tumor protein p53 binding protein, 20.077
SMOsmoothened homolog (Drosophila)0.075
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.075
CSNK1Ecasein kinase 1, epsilon0.072
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.072
SUFUsuppressor of fused homolog (Drosophila)0.068
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.063
NOTCH1notch 10.060
PTCH1patched 10.060
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.059
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.056
CDK19cyclin-dependent kinase 190.056
RBBP4retinoblastoma binding protein 40.055
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.055
PMLpromyelocytic leukemia0.054
PVRL4poliovirus receptor-related 40.053
HIPK2homeodomain interacting protein kinase 20.053
C2orf65chromosome 2 open reading frame 650.052
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.052
STK3serine/threonine kinase 30.052
SOX11SRY (sex determining region Y)-box 110.052
ESR1estrogen receptor 10.049
MDM2Mdm2 p53 binding protein homolog (mouse)0.049
PPFIA1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 10.049
TAL1T-cell acute lymphocytic leukemia 10.047
CADM4cell adhesion molecule 40.044
FGFR1fibroblast growth factor receptor 10.043
COL11A1collagen, type XI, alpha 10.042
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.040
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.039
COL2A1collagen, type II, alpha 10.039
PAX2paired box 20.038
BBS7Bardet-Biedl syndrome 70.038
SETD8SET domain containing (lysine methyltransferase) 80.037
BBS9Bardet-Biedl syndrome 90.036
GRB7growth factor receptor-bound protein 70.035
COL5A1collagen, type V, alpha 10.035
PTPN1protein tyrosine phosphatase, non-receptor type 10.035
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.034
BADBCL2-associated agonist of cell death0.034
BBS4Bardet-Biedl syndrome 40.032
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.031
NKX2-1NK2 homeobox 10.029
RASSF5Ras association (RalGDS/AF-6) domain family member 50.029
PVRL3poliovirus receptor-related 30.029
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.028
SKILSKI-like oncogene0.028
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.028
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.028
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.028
BCL2L11BCL2-like 11 (apoptosis facilitator)0.027
MXRA5matrix-remodelling associated 50.027
RB1retinoblastoma 10.026
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.026
FGF1fibroblast growth factor 1 (acidic)0.026
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Postnperiostin, osteoblast specific factor0.266
Col1a2collagen, type I, alpha 20.235
Fgfr2fibroblast growth factor receptor 20.234
Col3a1collagen, type III, alpha 10.231
Col1a1collagen, type I, alpha 10.220
Colec12collectin sub-family member 120.211
Cltcclathrin, heavy chain (Hc)0.184
Cd48Cd48 molecule0.178
Col12a1collagen, type XII, alpha 10.170
Copb2coatomer protein complex, subunit beta 2 (beta prime)0.167
Adam17ADAM metallopeptidase domain 170.136
Col5a2collagen, type V, alpha 20.133
Anxa1annexin A10.131
Cdk2cyclin dependent kinase 20.123
Cgaglycoprotein hormones, alpha polypeptide0.119
Psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.119
Loxlysyl oxidase0.114
Chgbchromogranin B0.114
Gabrr1gamma-aminobutyric acid (GABA) receptor, rho 10.110
Prph2peripherin 20.108
Gucy2eguanylate cyclase 2E0.106
Rtn1reticulon 10.102
Mipmajor intrinsic protein of lens fiber0.101
RorbRAR-related orphan receptor B0.098
Calcrlcalcitonin receptor-like0.094
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.090
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.090
Gipc1GIPC PDZ domain containing family, member 10.090
Tcfe2atranscription factor E2a0.089
Tnctenascin C0.089
Col14a1collagen, type XIV, alpha 10.089
Rararetinoic acid receptor, alpha0.088
Glra2glycine receptor, alpha 20.085
Lphn2latrophilin 20.084
Dab2disabled homolog 2 (Drosophila)0.081
Ddr2discoidin domain receptor tyrosine kinase 20.080
Nraddneurotrophin receptor associated death domain0.079
Lim2lens intrinsic membrane protein 20.077
Nrlneural retina leucine zipper0.076
Cpne3copine III0.074
Cfhcomplement factor H0.072
Cpxm2carboxypeptidase X (M14 family), member 20.072
Cdc2l6cell division cycle 2-like 6 (CDK8-like)0.071
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.071
Esr2estrogen receptor 2 (ER beta)0.071
Rbp3retinol binding protein 3, interstitial0.070
Cald1caldesmon 10.070
Folr1folate receptor 1 (adult)0.068
Il6stinterleukin 6 signal transducer0.068
Gnat1guanine nucleotide binding protein (G protein), alpha transducing 10.067
Bnip2BCL2/adenovirus E1B interacting protein 20.067
Dnm1dynamin 10.065
Lrrc59leucine rich repeat containing 590.064
Syt6synaptotagmin VI0.064
Caprin1cell cycle associated protein 10.064
Casp7caspase 70.064
Fbn1fibrillin 10.063
Ap3m1adaptor-related protein complex 3, mu 1 subunit0.061
Slc34a1solute carrier family 34 (sodium phosphate), member 10.061
Slc17a6solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 60.061
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.059
Cxcr5chemokine (C-X-C motif) receptor 50.059
Ptprcprotein tyrosine phosphatase, receptor type, C0.059
Stk3serine/threonine kinase 3 (STE20 homolog, yeast)0.059
Tmem47transmembrane protein 470.059
Camk1gcalcium/calmodulin-dependent protein kinase IG0.059
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.059
Crygscrystallin, gamma S0.058
Megf10multiple EGF-like domains 100.058
Adrb1adrenergic, beta-1-, receptor0.058
Tgfbr2transforming growth factor, beta receptor II0.057
Drd4dopamine receptor D40.057
Loxl1lysyl oxidase-like 10.057
Prl4a1prolactin family 4, subfamily a, member 10.057
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.057
Map3k8mitogen-activated protein kinase kinase kinase 80.057
St18suppression of tumorigenicity 180.057
Ak2adenylate kinase 20.056
Drd1adopamine receptor D1A0.056
Casp3caspase 30.056
Hist1h1dhistone cluster 1, H1d0.056
Drd2dopamine receptor D20.056
C1scomplement component 1, s subcomponent0.055
Nefmneurofilament, medium polypeptide0.055
Mid1midline 10.055
Mycbp2MYC binding protein 20.054
Ctsccathepsin C0.054
Lbplipopolysaccharide binding protein0.054
Bmpr1abone morphogenetic protein receptor, type IA0.053
VgfVGF nerve growth factor inducible0.053
Shmt1serine hydroxymethyltransferase 1 (soluble)0.052
Slit3slit homolog 3 (Drosophila)0.052
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism