The network for 'cellular response to sterol depletion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to sterol depletion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

NameDescriptionProbabilityFunc Analog Organism
desat1CG5887 gene product from transcript CG5887-RA0.066
Dcp-1Death caspase-10.065
BG4CG12297 gene product from transcript CG12297-RA0.060
CG6751CG6751 gene product from transcript CG6751-RA0.056
HmgDHigh mobility group protein D0.051
imdimmune deficiency0.045
RbfRetinoblastoma-family protein0.043
Lk6CG17342 gene product from transcript CG17342-RA0.043
Eip63EEcdysone-induced protein 63E0.041
NcNedd2-like caspase0.039
Eps-15Epidermal growth factor receptor pathway substrate clone 150.038
CG6854CG6854 gene product from transcript CG6854-RC0.038
PezCG9493 gene product from transcript CG9493-RA0.038
pUf68poly U binding factor 68kD0.037
opa1-likeoptic atrophy 1-like0.035
CG8443CG8443 gene product from transcript CG8443-RA0.035
Letm1CG4589 gene product from transcript CG4589-RB0.032
cpacapping protein alpha0.031
CG5854CG5854 gene product from transcript CG5854-RA0.031
dupdouble parked0.026
MESR6Misexpression suppressor of ras 60.025
Top2Topoisomerase 20.024
RalaRas-related protein0.023
Top1Topoisomerase 10.021
pex16peroxin 160.021
p53CG33336 gene product from transcript CG33336-RB0.021
Tom34Translocase of outer membrane 340.020
Ptp61FProtein tyrosine phosphatase 61F0.019
CG32418CG32418 gene product from transcript CG32418-RA0.019
CragCalmodulin-binding protein related to a Rab3 GDP/GTP exchange protein0.019
ird5immune response deficient 50.019
CG4287CG4287 gene product from transcript CG4287-RB0.017
CG5726CG5726 gene product from transcript CG5726-RA0.017
DlicDynein light intermediate chain0.017
DNApol-alpha60DNA polymerase alpha 60kD0.017
Lsd-2Lipid storage droplet-20.016
Unc-76CG3981 gene product from transcript CG3981-RB0.015
Kap3Kinesin associated protein 30.014
CG5931CG5931 gene product from transcript CG5931-RA0.014
HoHeme oxygenase0.014
D1D1 chromosomal protein0.014
Mpk2CG5475 gene product from transcript CG5475-RB0.014
Deaf1Deformed epidermal autoregulatory factor-10.014
swshort wing0.013
X11LCG5675 gene product from transcript CG5675-RB0.013
GstS1Glutathione S transferase S10.013
PcafCG4107 gene product from transcript CG4107-RA0.013
Toll-7CG8595 gene product from transcript CG8595-RA0.013
Pabp2CG2163 gene product from transcript CG2163-RA0.012
Atg7Autophagy-specific gene 70.012
l(1)G0469lethal (1) G04690.012
CG5794CG5794 gene product from transcript CG5794-RB0.012
pex1peroxin 10.012
Nup153Nucleoporin 1530.012
l(2)03659lethal (2) 036590.012
MarfMitochondrial assembly regulatory factor0.011
Hrb87FHeterogeneous nuclear ribonucleoprotein at 87F0.011
Hsc70-3Heat shock protein cognate 30.011
Uch-L3Ubiquitin C-terminal hydrolase0.011
Gs1Glutamine synthetase 10.011
Sgt1CG9617 gene product from transcript CG9617-RA0.011
Usp7ubiquitin-specific protease 70.010
p38bCG7393 gene product from transcript CG7393-RA0.010
Sh3betaCG8582 gene product from transcript CG8582-RD0.010
PapssPAPS synthetase0.010
CG17746CG17746 gene product from transcript CG17746-RA0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.118
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 10.043
SC4MOLsterol-C4-methyl oxidase-like0.026
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.025
IDI1isopentenyl-diphosphate delta isomerase 10.021
CUL1cullin 10.017
CCDC6coiled-coil domain containing 60.014
MMS22LMMS22-like, DNA repair protein0.013
FDFT1farnesyl-diphosphate farnesyltransferase 10.011
SREBF2sterol regulatory element binding transcription factor 20.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lmnb1lamin B10.489
Lmnb2lamin B20.444
Itgb1integrin beta 1 (fibronectin receptor beta)0.387
Trp53transformation related protein 530.222
Fgfr3fibroblast growth factor receptor 30.143
Fbn1fibrillin 10.126
Akt1thymoma viral proto-oncogene 10.118
Sh3pxd2bSH3 and PX domains 2B0.096
Smn1survival motor neuron 10.085
Gja1gap junction protein, alpha 10.077
Gtf2ird1general transcription factor II I repeat domain-containing 10.065
2310046A06RikRIKEN cDNA 2310046A06 gene0.050
Egfrepidermal growth factor receptor0.038
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.037
Plk1polo-like kinase 1 (Drosophila)0.034
Fubp3far upstream element (FUSE) binding protein 30.034
Ptpn11protein tyrosine phosphatase, non-receptor type 110.034
Scd1stearoyl-Coenzyme A desaturase 10.032
Ptenphosphatase and tensin homolog0.032
Ppargperoxisome proliferator activated receptor gamma0.028
Ptk2PTK2 protein tyrosine kinase 20.027
Dmddystrophin, muscular dystrophy0.026
Col1a1collagen, type I, alpha 10.025
Vegfavascular endothelial growth factor A0.023
Cnbpcellular nucleic acid binding protein0.023
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.021
Ankprogressive ankylosis0.020
2610044O15RikRIKEN cDNA 2610044O15 gene0.020
IkIK cytokine0.020
Nsa2NSA2 ribosome biogenesis homolog (S. cerevisiae)0.019
Mfn2mitofusin 20.019
Prkceprotein kinase C, epsilon0.018
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.018
Rcc1regulator of chromosome condensation 10.017
Supv3l1suppressor of var1, 3-like 1 (S. cerevisiae)0.017
Smad4MAD homolog 4 (Drosophila)0.017
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.017
Paicsphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase0.016
Bscl2Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)0.015
Zfand1zinc finger, AN1-type domain 10.015
E2f1E2F transcription factor 10.015
Dram2VDNA-damage regulated autophagy modulator 20.015
Ckap4cytoskeleton-associated protein 40.015
Dynlt3dynein light chain Tctex-type 30.014
Cav1caveolin 1, caveolae protein0.014
Kif2ckinesin family member 2C0.013
Zbtb45zinc finger and BTB domain containing 450.013
Lmnalamin A0.013
Dhcr2424-dehydrocholesterol reductase0.013
Aurkaaurora kinase A0.013
Myh9myosin, heavy polypeptide 9, non-muscle0.012
Ube2cubiquitin-conjugating enzyme E2C0.012
Ighmbp2immunoglobulin mu binding protein 20.012
Cyp51cytochrome P450, family 510.012
Camsap1calmodulin regulated spectrin-associated protein 10.011
Igbp1immunoglobulin (CD79A) binding protein 10.011
Chaf1bchromatin assembly factor 1, subunit B (p60)0.011
Apoeapolipoprotein E0.011
Vhlvon Hippel-Lindau tumor suppressor0.010
Tagln2transgelin 20.010
Casp3caspase 30.010
Lsslanosterol synthase0.010
Tnfrsf12atumor necrosis factor receptor superfamily, member 12a0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism