The network for 'pigmentation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms


The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.

NameDescriptionProbabilityFunc Analog Organism
SodSuperoxide dismutase0.540
drddrop dead0.530
nkdnaked cuticle0.441
DdcDopa decarboxylase0.378
ninaAneither inactivation nor afterpotential A0.363
Cnx99ACalnexin 99A0.354
abd-Aabdominal A0.354
cupCG11181 gene product from transcript CG11181-RB0.339
inaDinactivation no afterpotential D0.338
snostrawberry notch0.337
AP-47CG9388 gene product from transcript CG9388-RA0.309
SmoxSmad on X0.308
ph-dpolyhomeotic distal0.288
argosCG4531 gene product from transcript CG4531-RA0.280
ninaBneither inactivation nor afterpotential B0.252
l(2)37Cblethal (2) 37Cb0.224
CG5958CG5958 gene product from transcript CG5958-RA0.209
Gp150CG5820 gene product from transcript CG5820-RA0.204
Arr2Arrestin 20.203
Pka-C1cAMP-dependent protein kinase 10.199
LnkCG17367 gene product from transcript CG17367-RC0.191
MadMothers against dpp0.187
CG11786CG11786 gene product from transcript CG11786-RB0.186
CG32676CG32676 gene product from transcript CG32676-RA0.185
Cyp301a1CG8587 gene product from transcript CG8587-RA0.172
ash2absent, small, or homeotic discs 20.172
p53CG33336 gene product from transcript CG33336-RB0.171
lunaCG33473 gene product from transcript CG33473-RB0.159
VhaPPA1-1CG7007 gene product from transcript CG7007-RA0.155
CG3625CG3625 gene product from transcript CG3625-RC0.150
HcfHost cell factor0.150
CG9664CG9664 gene product from transcript CG9664-RB0.148
Mob2CG11711 gene product from transcript CG11711-RC0.148
PapssPAPS synthetase0.148
rictorrapamycin-insensitive companion of Tor0.148
CG3225CG3225 gene product from transcript CG3225-RA0.146
Vha26Vacuolar H[+]-ATPase 26kD E subunit0.138
Mpk2CG5475 gene product from transcript CG5475-RB0.136
OscillinCG6957 gene product from transcript CG6957-RA0.135
fredfriend of echinoid0.134
InRInsulin-like receptor0.132
p115CG1422 gene product from transcript CG1422-RA0.132
ninaEneither inactivation nor afterpotential E0.131
CG5009CG5009 gene product from transcript CG5009-RA0.130
ird5immune response deficient 50.126
ade2adenosine 20.126
Eip74EFEcdysone-induced protein 74EF0.124
mldmolting defective0.123
Trxr-1Thioredoxin reductase-10.121
Hnf4Hepatocyte nuclear factor 40.120
CG10550CG10550 gene product from transcript CG10550-RB0.120
Dhc64CDynein heavy chain 64C0.120
CG8301CG8301 gene product from transcript CG8301-RA0.120
sinaseven in absentia0.118
CspCysteine string protein0.113
ph-ppolyhomeotic proximal0.111
CG3164CG3164 gene product from transcript CG3164-RA0.109
nabCG33545 gene product from transcript CG33545-RC0.108
norpAno receptor potential A0.108
fasfaint sausage0.105
oddodd skipped0.105
C3GCG42328 gene product from transcript CG42328-RC0.104
CG5853CG5853 gene product from transcript CG5853-RA0.102
Hr38Hormone receptor-like in 380.101
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
osm-5Protein OSM-50.063
B0361.3Protein B0361.30.051
cki-1Protein CKI-10.047
pha-4Protein PHA-40.042
gpb-1Protein GPB-10.037
let-60Protein LET-600.037
tra-1Protein TRA-10.035
unc-62Protein UNC-620.035
cat-1Protein CAT-10.034
C52E12.1Protein C52E12.10.034
ins-2Protein INS-20.034
C34D10.2Protein C34D10.20.033
F23F1.4Protein F23F1.40.033
F20D12.2Protein F20D12.20.032
rho-1Protein RHO-10.032
nhr-6Protein NHR-60.031
bar-1Protein BAR-10.030
sma-6Protein SMA-60.030
sulp-2Protein SULP-20.029
che-13Protein CHE-130.029
bbs-1Protein BBS-10.029
ceh-13Protein CEH-130.028
daf-3Protein DAF-30.028
egl-46Protein EGL-460.027
ZC504.3Protein ZC504.30.027
F09E5.7Protein F09E5.70.027
ist-1Protein IST-10.027
rbg-2Protein RBG-20.027
arl-13Protein ARL-130.026
plc-1Protein PLC-10.026
soc-2Protein SOC-20.026
bli-1Protein BLI-10.026
kel-3Protein KEL-30.025
F47G3.3Protein F47G3.30.025
gon-2Protein GON-20.025
sec-24.1Protein SEC-24.10.024
cku-70Protein CKU-700.024
rskn-2Protein RSKN-20.024
alh-4Protein ALH-40.024
itr-1Protein ITR-10.024
ptr-11Protein PTR-110.024
pry-1Protein PRY-10.023
Y71F9AL.17Protein Y71F9AL.170.023
K10C2.1Protein K10C2.10.023
eor-2Protein EOR-20.023
vav-1Protein VAV-10.023
plc-3Protein PLC-30.022
cdh-7Protein CDH-70.022
ZK686.3Protein ZK686.30.022
pop-1Protein POP-10.022
F10D7.5Protein F10D7.50.022
cat-4Protein CAT-40.022
cyp-33A1Protein CYP-33A10.022
imp-2Protein IMP-20.022
W08E3.2Protein W08E3.20.021
tbx-8Protein TBX-80.021
rbg-1Protein RBG-10.021
mat-2Protein MAT-20.021
dos-2Protein DOS-20.021
daf-12Protein DAF-120.021
pap-1Protein PAP-10.021
T01H3.2Protein T01H3.20.021
daf-1Protein DAF-10.020
pde-4Protein PDE-40.020
hmg-4Protein HMG-40.020
pyr-1Protein PYR-10.020
dpy-8Protein DPY-80.020
F10C2.5Protein F10C2.50.020
rha-2Protein RHA-20.020
glo-4Protein GLO-40.020
egl-2Protein EGL-20.020
let-607Protein LET-6070.020
grd-1Protein GRD-10.020
mls-2Protein MLS-20.020
CELE_C44C10.4Protein C44C10.40.020
CELE_E01G4.6Protein E01G4.60.020
ZK632.11Protein ZK632.110.020
cogc-3Protein COGC-30.020
bbs-8Protein BBS-80.020
gst-7Protein GST-70.020
npp-21Protein NPP-210.019
elt-6Protein ELT-60.019
mpk-1Protein MPK-10.019
C52E4.5Protein C52E4.50.019
W04D2.6Protein W04D2.60.019
grd-2Protein GRD-20.019
sago-1Protein SAGO-10.019
CELE_Y75B8A.24Protein Y75B8A.240.019
ced-7Protein CED-70.019
afd-1Protein AFD-10.019
col-110Protein COL-1100.019
unc-42Protein UNC-420.019
F45D3.3Protein F45D3.30.019
atg-2Protein ATG-20.019
haf-3Protein HAF-30.019
ztf-22Protein ZTF-220.019
egl-36Protein EGL-360.019
T19C3.2Protein T19C3.20.019
cel-1Protein CEL-10.018
col-73Protein COL-730.018
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sox10SRY-box containing gene 101.000
kitakit receptor a1.000
mitfamicrophthalmia-associated transcription factor a1.000
slc45a2solute carrier family 45, member 21.000
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.999
pmelapremelanosome protein a0.998
slc24a5solute carrier family 24, member 50.997
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.996
sox2SRY-box containing gene 20.992
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.988
ltkleukocyte tyrosine kinase0.986
csf1racolony stimulating factor 1 receptor, a0.982
foxd3forkhead box D30.966
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.963
mibmind bomb0.948
gartphosphoribosylglycinamide formyltransferase0.922
dctdopachrome tautomerase0.913
nf1aneurofibromin 1a0.899
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.895
tshbthyroid stimulating hormone, beta subunit0.848
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.847
crb2acrumbs homolog 2a0.736
cx41.8connexin 41.80.734
foxi3aforkhead box I3a0.707
tfap2atranscription factor AP-2 alpha0.701
sox19aSRY-box containing gene 19a0.682
rx3retinal homeobox gene 30.673
slc4a1bsolute carrier family 4, anion exchanger, member 1b0.655
tbx2bT-box 2b0.654
fcho2FCH domain only 20.643
eya1eyes absent homolog 10.625
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.619
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.610
atp6v1fATPase, H+ transporting, V1 subunit F0.589
gh1growth hormone 10.570
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.565
trpm7transient receptor potential cation channel, subfamily M, member 70.560
foxa3forkhead box A30.539
fabp11afatty acid binding protein 11a0.538
paicsphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase0.491
foxi1forkhead box I10.482
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.470
col2a1acollagen type II, alpha-1a0.453
tyrp1btyrosinase-related protein 1b0.433
mlphbmelanophilin b0.424
cdh5cadherin 50.398
mitfbmicrophthalmia-associated transcription factor b0.396
adipoqladiponectin, C1Q and collagen domain containing, like0.382
atp6v1e1bATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b0.379
hmx4H6 family homeobox 40.374
crabp2acellular retinoic acid binding protein 2, a0.348
snai1bsnail homolog 1b (Drosophila)0.343
gata5GATA-binding protein 50.331
ednrb1endothelin receptor B0.330
tfectranscription factor EC0.317
tfap2etranscription factor AP-2 epsilon0.296
pnp4apurine nucleoside phosphorylase 4a0.292
dync1h1dynein, cytoplasmic 1, heavy chain 10.291
barhl1.2BarH-like 1.20.282
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.275
tmietransmembrane inner ear0.270
slc4a4asolute carrier family 4, member 4a0.268
sf3b1splicing factor 3b, subunit 10.265
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.259
es1es1 protein0.258
fgfr3fibroblast growth factor receptor 30.257
pomcaproopiomelanocortin a0.238
jam2bjunctional adhesion molecule 2b0.238
kctd15apotassium channel tetramerisation domain containing 15a0.236
tfe3btranscription factor binding to IGHM enhancer 3b0.235
gja3gap junction protein, alpha 30.231
eng2aengrailed 2a0.229
tp63tumor protein p630.228
lrp2low density lipoprotein-related protein 20.226
mecp2methyl CpG binding protein 20.224
disc1disrupted in schizophrenia 10.220
sox7SRY-box containing gene 70.220
grhl1grainyhead-like 1 (Drosophila)0.215
foxp2forkhead box P20.208
mtpmicrosomal triglyceride transfer protein0.203
kif17kinesin family member 170.197
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.196
lhx1aLIM homeobox 1a0.195
foxc1aforkhead box C1a0.193
fn1fibronectin 10.191
ocrloculocerebrorenal syndrome of Lowe0.187
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.187
cnn2calponin 20.186
drd2bdopamine receptor D2b0.184
pak1p21/Cdc42/Rac1-activated kinase 10.180
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DTNBP1dystrobrevin binding protein 10.532
PLDNpallidin homolog (mouse)0.487
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.447
BCL2L1BCL2-like 10.325
RAB27ARAB27A, member RAS oncogene family0.284
EP300E1A binding protein p3000.264
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.232
PSEN1presenilin 10.232
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.224
VIPARVPS33B interacting protein, apical-basolateral polarity regulator0.216
AP2B1adaptor-related protein complex 2, beta 1 subunit0.206
POU3F2POU class 3 homeobox 20.198
WWP2WW domain containing E3 ubiquitin protein ligase 20.189
MAPK1mitogen-activated protein kinase 10.180
SMURF2SMAD specific E3 ubiquitin protein ligase 20.174
MEOX2mesenchyme homeobox 20.157
POU5F1POU class 5 homeobox 10.156
EPS15epidermal growth factor receptor pathway substrate 150.108
GSK3Bglycogen synthase kinase 3 beta0.102
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.098
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.090
MAPK3mitogen-activated protein kinase 30.081
BLOC1S1biogenesis of lysosomal organelles complex-1, subunit 10.075
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.065
CTBP1C-terminal binding protein 10.061
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.060
BAZ2Bbromodomain adjacent to zinc finger domain, 2B0.059
COPB2coatomer protein complex, subunit beta 2 (beta prime)0.059
ARRB1arrestin, beta 10.047
ADORA2Aadenosine A2a receptor0.046
BCAP31B-cell receptor-associated protein 310.045
SNAPINSNAP-associated protein0.045
PGK1phosphoglycerate kinase 10.044
MUTEDmuted homolog (mouse)0.044
BAK1BCL2-antagonist/killer 10.044
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.042
TM9SF2transmembrane 9 superfamily member 20.042
RAB14RAB14, member RAS oncogene family0.041
APLP2amyloid beta (A4) precursor-like protein 20.041
SMAD1SMAD family member 10.040
CLASP1cytoplasmic linker associated protein 10.039
DSG2desmoglein 20.038
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A0.038
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.037
PDZD11PDZ domain containing 110.036
EXOC7exocyst complex component 70.035
TMED10transmembrane emp24-like trafficking protein 10 (yeast)0.034
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.034
BLOC1S3biogenesis of lysosomal organelles complex-1, subunit 30.033
RAB10RAB10, member RAS oncogene family0.033
EEF2Keukaryotic elongation factor-2 kinase0.033
UBQLN1ubiquilin 10.032
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.031
HDAC2histone deacetylase 20.031
SH3BP4SH3-domain binding protein 40.031
CTNND1catenin (cadherin-associated protein), delta 10.031
EPS15L1epidermal growth factor receptor pathway substrate 15-like 10.030
KITLGKIT ligand0.030
BBS2Bardet-Biedl syndrome 20.029
OCRLoculocerebrorenal syndrome of Lowe0.029
JUPjunction plakoglobin0.027
PCM1pericentriolar material 10.027
RAB11FIP1RAB11 family interacting protein 1 (class I)0.027
FLNBfilamin B, beta0.026
TCF4transcription factor 40.025
GRB7growth factor receptor-bound protein 70.025
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.025
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.025
GDI2GDP dissociation inhibitor 20.025
ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B20.025
PDIA3protein disulfide isomerase family A, member 30.024
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.023
PTPRJprotein tyrosine phosphatase, receptor type, J0.023
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.022
ATP6V0CATPase, H+ transporting, lysosomal 16kDa, V0 subunit c0.022
BECN1beclin 1, autophagy related0.021
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.021
BBS1Bardet-Biedl syndrome 10.021
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.021
RABEP1rabaptin, RAB GTPase binding effector protein 10.021
DUSP3dual specificity phosphatase 30.020
CTSAcathepsin A0.019
COPGcoatomer protein complex, subunit gamma0.018
ATP6V0BATPase, H+ transporting, lysosomal 21kDa, V0 subunit b0.018
YY1YY1 transcription factor0.018
ATP6V0D1ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d10.017
QKIquaking homolog, KH domain RNA binding (mouse)0.017
CDC37cell division cycle 37 homolog (S. cerevisiae)0.017
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.017
MYO5Amyosin VA (heavy chain 12, myoxin)0.017
CDH3cadherin 3, type 1, P-cadherin (placental)0.016
PKM2pyruvate kinase, muscle0.016
TGIF1TGFB-induced factor homeobox 10.016
RNF144Bring finger protein 144B0.016
PRSS8protease, serine, 80.016
ZFYVE1zinc finger, FYVE domain containing 10.016
FXYD3FXYD domain containing ion transport regulator 30.016
MTF1metal-regulatory transcription factor 10.016
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mitfmicrophthalmia-associated transcription factor1.000
Lystlysosomal trafficking regulator1.000
Kitkit oncogene1.000
Oca2oculocutaneous albinism II0.998
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.996
Trp53transformation related protein 530.996
Gli3GLI-Kruppel family member GLI30.996
Pax3paired box gene 30.995
Pax6paired box gene 60.994
Kitlkit ligand0.989
Tyrp1tyrosinase-related protein 10.984
Sox10SRY-box containing gene 100.974
Vegfavascular endothelial growth factor A0.967
Sox2SRY-box containing gene 20.965
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.960
Ednrbendothelin receptor type B0.957
Ap3d1adaptor-related protein complex 3, delta 1 subunit0.950
Hps6Hermansky-Pudlak syndrome 60.942
Pitx2paired-like homeodomain transcription factor 20.915
Cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.889
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.870
Rab27aRAB27A, member RAS oncogene family0.864
Zeb1zinc finger E-box binding homeobox 10.828
Zic2zinc finger protein of the cerebellum 20.808
Fzd4frizzled homolog 4 (Drosophila)0.805
Bbs1Bardet-Biedl syndrome 1 (human)0.783
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.780
Bcl2B-cell leukemia/lymphoma 20.777
Runx2runt related transcription factor 20.751
Msx2homeobox, msh-like 20.728
Kdrkinase insert domain protein receptor0.714
Tgfb1transforming growth factor, beta 10.697
Nrp1neuropilin 10.681
Nos3nitric oxide synthase 3, endothelial cell0.669
Meox2mesenchyme homeobox 20.667
Foxc1forkhead box C10.659
Axin1axin 10.653
Fgf8fibroblast growth factor 80.636
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.627
Isl1ISL1 transcription factor, LIM/homeodomain0.563
Hdac5histone deacetylase 50.558
Pmelpremelanosome protein0.533
Shhsonic hedgehog0.508
Nf1neurofibromatosis 10.508
Gpi1glucose phosphate isomerase 10.507
Cux1cut-like homeobox 10.497
EdaraddEDAR (ectodysplasin-A receptor)-associated death domain0.491
Mgrn1mahogunin, ring finger 10.483
Acvr1activin A receptor, type 10.479
Leprleptin receptor0.466
Bmp4bone morphogenetic protein 40.465
CblCasitas B-lineage lymphoma0.452
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.415
BaxBCL2-associated X protein0.385
Rspo2R-spondin 2 homolog (Xenopus laevis)0.374
Mef2cmyocyte enhancer factor 2C0.368
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.362
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.361
Atp6v0bATPase, H+ transporting, lysosomal V0 subunit B0.355
Pou5f1POU domain, class 5, transcription factor 10.354
Kif5bkinesin family member 5B0.348
Nr3c1nuclear receptor subfamily 3, group C, member 10.346
Tcfap2atranscription factor AP-2, alpha0.337
En1engrailed 10.326
Hand1heart and neural crest derivatives expressed transcript 10.323
Ctsdcathepsin D0.321
Adamts9a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 90.321
Bbs4Bardet-Biedl syndrome 4 (human)0.313
Ptenphosphatase and tensin homolog0.299
Cdh11cadherin 110.288
Flt1FMS-like tyrosine kinase 10.284
Gli2GLI-Kruppel family member GLI20.279
SharpinSHANK-associated RH domain interacting protein0.278
Psen1presenilin 10.277
Dctn1dynactin 10.275
Gucy1b3guanylate cyclase 1, soluble, beta 30.274
Notch1Notch gene homolog 1 (Drosophila)0.268
Ctnnb1catenin (cadherin associated protein), beta 10.248
Bmpr1abone morphogenetic protein receptor, type 1A0.244
Notch2Notch gene homolog 2 (Drosophila)0.242
Zic3zinc finger protein of the cerebellum 30.240
Rab38RAB38, member of RAS oncogene family0.238
Tcfap2btranscription factor AP-2 beta0.238
Ren1renin 1 structural0.231
Fgfr2fibroblast growth factor receptor 20.229
Adamts20a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 200.224
Pi4kbphosphatidylinositol 4-kinase, catalytic, beta polypeptide0.224
Hif1ahypoxia inducible factor 1, alpha subunit0.224
Vegfcvascular endothelial growth factor C0.214
Smad2MAD homolog 2 (Drosophila)0.210
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.208
Mapk3mitogen-activated protein kinase 30.206
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism