The network for 'humoral immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

humoral immune response

An immune response mediated through a body fluid.

NameDescriptionProbabilityFunc Analog Organism
PGRP-LCPeptidoglycan recognition protein LC0.999
SPESpatzle-Processing Enzyme0.996
grassGram-positive Specific Serine protease0.995
ird5immune response deficient 50.993
DptBDiptericin B0.986
Myd88CG2078 gene product from transcript CG2078-RA0.984
BG4CG12297 gene product from transcript CG12297-RA0.974
DreddDeath related ced-3/Nedd2-like protein0.968
PGRP-SDCG7496 gene product from transcript CG7496-RA0.962
IrcImmune-regulated catalase0.961
CG15065CG15065 gene product from transcript CG15065-RA0.952
Spn27ASerpin 27A0.941
ird1immune response deficient 10.933
PvrPDGF- and VEGF-receptor related0.931
CG15067CG15067 gene product from transcript CG15067-RA0.923
PGRP-SAPeptidoglycan recognition protein SA0.914
AGO2Argonaute 20.913
imdimmune deficiency0.861
CG13422CG13422 gene product from transcript CG13422-RA0.850
Lcp3Larval cuticle protein 30.815
NcNedd2-like caspase0.785
IM1Immune induced molecule 10.776
Spn1Serine protease inhibitor 10.740
IM4Immune induced molecule 40.688
GNBP3Gram-negative bacteria binding protein 30.676
CG5791CG5791 gene product from transcript CG5791-RA0.669
Mpk2CG5475 gene product from transcript CG5475-RB0.639
Lcp2Larval cuticle protein 20.619
CecCCecropin C0.616
Spn28DSerpin 28D0.594
r2d2CG7138 gene product from transcript CG7138-RB0.505
crolcrooked legs0.496
IM2Immune induced molecule 20.488
Sp7Serine protease 70.483
Tak1TGF-beta activated kinase 10.473
Cpr49AeCuticular protein 49Ae0.472
CecA2Cecropin A20.468
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.430
PGRP-LFPeptidoglycan recognition protein LF0.422
E(spl)Enhancer of split0.417
EgfrEpidermal growth factor receptor0.411
IM18Immune induced molecule 180.396
Cpr100ACuticular protein 100A0.392
CecA1Cecropin A10.388
CG15080CG15080 gene product from transcript CG15080-RA0.381
CG2233CG2233 gene product from transcript CG2233-RA0.356
CG32185CG32185 gene product from transcript CG32185-RA0.343
CG15515CG15515 gene product from transcript CG15515-RA0.336
emcextra macrochaetae0.323
Lcp4Larval cuticle protein 40.322
pirkpoor Imd response upon knock-in0.321
CG18594CG18594 gene product from transcript CG18594-RA0.312
snostrawberry notch0.311
rev7CG2948 gene product from transcript CG2948-RA0.309
IM10Immune induced molecule 100.307
CG4757CG4757 gene product from transcript CG4757-RA0.298
HLHmbetaE(spl) region transcript mbeta0.294
InRInsulin-like receptor0.292
PGRP-SB1CG9681 gene product from transcript CG9681-RA0.272
GNBP1Gram-negative bacteria binding protein 10.271
DuoxDual oxidase0.268
Cpr49AfCuticular protein 49Af0.254
Ndae1Na[+]-driven anion exchanger 10.239
CG11286CG11286 gene product from transcript CG11286-RA0.231
Cpr67Fa1Cuticular protein 67Fa10.231
HLHm7E(spl) region transcript m70.227
HLHmgammaE(spl) region transcript mgamma0.226
qkr58E-3quaking related 58E-30.216
IM23Immune induced molecule 230.201
CG6361CG6361 gene product from transcript CG6361-RA0.196
Traf6TNF-receptor-associated factor 60.195
PGRP-LBPeptidoglycan recognition protein LB0.192
CG15917CG15917 gene product from transcript CG15917-RA0.190
CG5778CG5778 gene product from transcript CG5778-RB0.189
RalaRas-related protein0.188
IM3Immune induced molecule 30.180
modSPmodular serine protease0.178
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
socs3asuppressor of cytokine signaling 3a0.449
c3bcomplement component c3b0.285
junbjun B proto-oncogene0.152
LOC557072caspase recruitment domain-containing protein 11-like0.147
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.123
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.086
foxi3aforkhead box I3a0.082
efnb2aephrin B2a0.077
LOC566708FL cytokine receptor-like0.072
wnt8awingless-type MMTV integration site family, member 8a0.070
LOC100000934hypothetical protein LOC1000009340.070
pycardPYD and CARD domain containing0.067
cry3cryptochrome 30.062
tbx1T-box 10.056
vwfvon Willebrand factor0.055
capns1acalpain, small subunit 1 a0.049
LOC100332505hypothetical protein LOC1003325050.046
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.045
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.045
tmem88atransmembrane protein 88 a0.042
gata6GATA-binding protein 60.042
gata1aGATA binding protein 1a0.037
nod1nucleotide-binding oligomerization domain containing 10.037
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.032
adipoql2adiponectin, C1Q and collagen domain containing, like 20.031
skianuclear oncoprotein skia0.030
acsl1acyl-CoA synthetase long-chain family member 10.030
satb2SATB homeobox 20.027
itih2inter-alpha (globulin) inhibitor H20.027
procprotein C (inactivator of coagulation factors Va and VIIIa)0.027
stat3signal transduction and activation of transcription 30.027
grnagranulin a0.027
gata5GATA-binding protein 50.025
LOC100331484hypothetical protein LOC1003314840.024
tnfatumor necrosis factor a (TNF superfamily, member 2)0.023
ef1aelongation factor 1-alpha0.021
nppanatriuretic peptide precursor A0.021
atf3activating transcription factor 30.021
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.021
gtf3abgeneral transcription factor IIIA, b0.020
esyt3extended synaptotagmin-like protein 30.020
klf2bKruppel-like factor 2b0.020
cps1carbamoyl-phosphate synthase 1, mitochondrial0.018
junjun proto-oncogene0.018
sepp1bselenoprotein P, plasma, 1b0.018
socs3bsuppressor of cytokine signaling 3b0.017
mmp9matrix metalloproteinase 90.017
caspacaspase a0.016
npy4rneuropeptide Y receptor Y40.016
ccnb2cyclin B20.016
pdcd2programmed cell death 20.015
rhagRhesus blood group-associated glycoprotein0.015
sox19aSRY-box containing gene 19a0.015
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.015
retsatlretinol saturase (all-trans-retinol 13,14-reductase) like0.014
fli1bfriend leukemia integration 1b0.014
grn1granulin 10.014
zpcxzona pellucida protein C0.014
c1qccomplement component 1, q subcomponent, C chain0.013
zp3.1zona pellucida glycoprotein 3.10.013
krt15keratin 150.013
ifnphi1interferon phi 10.013
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.013
eif4e1beukaryotic translation initiation factor 4e 1b0.013
adipor2adiponectin receptor 20.013
ifng1-2interferon, gamma 1-20.012
adipor1aadiponectin receptor 1a0.012
etv2ets variant gene 20.012
LOC557722similar to transient receptor potential cation channel, subfamily M, member 50.012
adipoqladiponectin, C1Q and collagen domain containing, like0.011
btkBruton agammaglobulinemia tyrosine kinase0.011
zp3a.1zona pellucida glycoprotein 3a.10.011
socs1suppressor of cytokine signaling 10.011
hdrhematopoietic death receptor0.011
mef2cbmyocyte enhancer factor 2cb0.011
slc4a4bsolute carrier family 4, sodium bicarbonate cotransporter, member 4b0.011
mep1a.1meprin A, alpha.10.011
anxa1aannexin A1a0.010
fbp1bfructose-1,6-bisphosphatase 1b0.010
gata4GATA-binding protein 40.010
bmp2bbone morphogenetic protein 2b0.010
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.010
npm2nucleoplasmin 20.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
JUNjun proto-oncogene0.999
HIST1H2BDhistone cluster 1, H2bd0.990
HIST1H2BFhistone cluster 1, H2bf0.986
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.984
FOSFBJ murine osteosarcoma viral oncogene homolog0.982
HIST1H2BEhistone cluster 1, H2be0.979
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.968
C1QAcomplement component 1, q subcomponent, A chain0.968
BCL3B-cell CLL/lymphoma 30.961
TEKTEK tyrosine kinase, endothelial0.945
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.918
HIST1H2AChistone cluster 1, H2ac0.913
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.884
RXRAretinoid X receptor, alpha0.870
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.869
EP300E1A binding protein p3000.860
ATF2activating transcription factor 20.837
HIST1H1Chistone cluster 1, H1c0.827
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.818
NCOA3nuclear receptor coactivator 30.779
C1Scomplement component 1, s subcomponent0.774
HIST1H2BHhistone cluster 1, H2bh0.765
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.763
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.726
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.718
ATF3activating transcription factor 30.708
C1Rcomplement component 1, r subcomponent0.682
HIST1H2BKhistone cluster 1, H2bk0.681
C3complement component 30.659
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.647
HLA-DMBmajor histocompatibility complex, class II, DM beta0.620
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.590
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.571
HDAC4histone deacetylase 40.544
NCOR2nuclear receptor corepressor 20.522
HIST1H2BIhistone cluster 1, H2bi0.500
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.464
CDK2cyclin-dependent kinase 20.461
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.460
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.446
CASP9caspase 9, apoptosis-related cysteine peptidase0.445
VEGFAvascular endothelial growth factor A0.431
LATlinker for activation of T cells0.424
HIST1H3Dhistone cluster 1, H3d0.420
HIST1H2BGhistone cluster 1, H2bg0.417
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.391
KRT19keratin 190.371
NOTCH1notch 10.364
C1QBcomplement component 1, q subcomponent, B chain0.358
SYKspleen tyrosine kinase0.347
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.336
FGAfibrinogen alpha chain0.325
SHC1SHC (Src homology 2 domain containing) transforming protein 10.323
ASF1AASF1 anti-silencing function 1 homolog A (S. cerevisiae)0.320
NCOA1nuclear receptor coactivator 10.319
DUSP1dual specificity phosphatase 10.318
ZFYVE9zinc finger, FYVE domain containing 90.291
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.290
CHD8chromodomain helicase DNA binding protein 80.276
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.275
TP63tumor protein p630.263
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.262
MAP3K8mitogen-activated protein kinase kinase kinase 80.258
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.257
XIAPX-linked inhibitor of apoptosis0.252
CASP3caspase 3, apoptosis-related cysteine peptidase0.246
FGL2fibrinogen-like 20.236
HLA-DRB5major histocompatibility complex, class II, DR beta 50.233
SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 10.233
KRT15keratin 150.229
JUNDjun D proto-oncogene0.223
HIST2H2AA4histone cluster 2, H2aa40.218
IL4Rinterleukin 4 receptor0.216
SNAP23synaptosomal-associated protein, 23kDa0.213
HLA-DPB1major histocompatibility complex, class II, DP beta 10.210
RARAretinoic acid receptor, alpha0.202
PPARAperoxisome proliferator-activated receptor alpha0.200
IL1R1interleukin 1 receptor, type I0.200
KRT17keratin 170.190
CFHcomplement factor H0.190
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.190
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)0.189
JAG1jagged 10.187
CHUKconserved helix-loop-helix ubiquitous kinase0.183
ESR1estrogen receptor 10.176
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.174
CHD7chromodomain helicase DNA binding protein 70.172
NCOA6nuclear receptor coactivator 60.171
DMBT1deleted in malignant brain tumors 10.168
TFDP2transcription factor Dp-2 (E2F dimerization partner 2)0.167
RNASE4ribonuclease, RNase A family, 40.165
HIST1H2AEhistone cluster 1, H2ae0.164
MAPK8mitogen-activated protein kinase 80.163
HIST1H2BChistone cluster 1, H2bc0.157
GSK3Bglycogen synthase kinase 3 beta0.156
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.154
CYBBcytochrome b-245, beta polypeptide0.152
HIST1H2AJhistone cluster 1, H2aj0.150
SOX10SRY (sex determining region Y)-box 100.148
HIST2H2BEhistone cluster 2, H2be0.147
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.999
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.996
Cd19CD19 antigen0.990
Lyz2lysozyme 20.986
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.979
Map3k14mitogen-activated protein kinase kinase kinase 140.971
C3complement component 30.958
FasFas (TNF receptor superfamily member 6)0.954
FosFBJ osteosarcoma oncogene0.943
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.939
Ighimmunoglobulin heavy chain complex0.933
Mapk14mitogen-activated protein kinase 140.931
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.918
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.912
RybpRING1 and YY1 binding protein0.904
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.896
Apoeapolipoprotein E0.877
Inpp5dinositol polyphosphate-5-phosphatase D0.847
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.841
Icosinducible T-cell co-stimulator0.833
Foxp3forkhead box P30.831
Ccr1chemokine (C-C motif) receptor 10.819
C1qccomplement component 1, q subcomponent, C chain0.811
H2-Aahistocompatibility 2, class II antigen A, alpha0.810
Ltalymphotoxin A0.800
Cd40CD40 antigen0.768
Notch1Notch gene homolog 1 (Drosophila)0.759
JunJun oncogene0.745
Tlr4toll-like receptor 40.743
Ltblymphotoxin B0.741
Ikbkginhibitor of kappaB kinase gamma0.725
Notch2Notch gene homolog 2 (Drosophila)0.718
Slamf1signaling lymphocytic activation molecule family member 10.711
Cxcl13chemokine (C-X-C motif) ligand 130.705
Psen1presenilin 10.701
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.697
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.675
C1qbcomplement component 1, q subcomponent, beta polypeptide0.670
Ikzf1IKAROS family zinc finger 10.653
FcrlaFc receptor-like A0.638
C3ar1complement component 3a receptor 10.618
Il1r1interleukin 1 receptor, type I0.588
Ccl2chemokine (C-C motif) ligand 20.583
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.580
Trp53transformation related protein 530.579
H2-Eb1histocompatibility 2, class II antigen E beta0.569
Egfrepidermal growth factor receptor0.563
Socs1suppressor of cytokine signaling 10.559
Pou2af1POU domain, class 2, associating factor 10.554
Cd28CD28 antigen0.545
H2-Ab1histocompatibility 2, class II antigen A, beta 10.543
Itgb2integrin beta 20.536
H2-DMb2histocompatibility 2, class II, locus Mb20.521
Ifngr1interferon gamma receptor 10.510
Fcgr2bFc receptor, IgG, low affinity IIb0.504
C1qacomplement component 1, q subcomponent, alpha polypeptide0.490
Kdrkinase insert domain protein receptor0.490
Pax2paired box gene 20.488
Ccr6chemokine (C-C motif) receptor 60.482
Ccr7chemokine (C-C motif) receptor 70.465
Ifnginterferon gamma0.461
Rnf2ring finger protein 20.430
CblCasitas B-lineage lymphoma0.422
Pax5paired box gene 50.412
Il4interleukin 40.409
Zeb1zinc finger E-box binding homeobox 10.409
BtkBruton agammaglobulinemia tyrosine kinase0.394
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.392
Rxraretinoid X receptor alpha0.385
F9coagulation factor IX0.380
Ikbkbinhibitor of kappaB kinase beta0.380
Cxcr5chemokine (C-X-C motif) receptor 50.379
Lyz1lysozyme 10.374
Stat3signal transducer and activator of transcription 30.368
E2f1E2F transcription factor 10.368
Il1rninterleukin 1 receptor antagonist0.357
Selpselectin, platelet0.356
Nckap1lNCK associated protein 1 like0.354
S1pr2sphingosine-1-phosphate receptor 20.354
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.353
Casp4caspase 4, apoptosis-related cysteine peptidase0.353
Cd59aCD59a antigen0.336
Stat6signal transducer and activator of transcription 60.333
Mrc1mannose receptor, C type 10.331
Csf1colony stimulating factor 1 (macrophage)0.329
Sfpi1SFFV proviral integration 10.327
Saa4serum amyloid A 40.322
Mapk8mitogen-activated protein kinase 80.318
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.316
Vpreb3pre-B lymphocyte gene 30.307
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.304
Zfp36zinc finger protein 360.300
Grb2growth factor receptor bound protein 20.297
Cd44CD44 antigen0.297
Jag1jagged 10.295
Dll1delta-like 1 (Drosophila)0.294
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.293
Itgaxintegrin alpha X0.292
Shc1src homology 2 domain-containing transforming protein C10.291
Cd40lgCD40 ligand0.290
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fggfibrinogen gamma chain0.142
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.111
Cfbcomplement factor B0.103
C4bcomplement component 4B (Chido blood group)0.098
Zfp36zinc finger protein 360.097
C3complement component 30.090
Pzppregnancy-zone protein0.080
Btg2BTG family, member 20.073
JunJun oncogene0.064
Cficomplement factor I0.056
Csf1rcolony stimulating factor 1 receptor0.040
C2complement component 20.038
RT1-BaRT1 class II, locus Ba0.038
C1scomplement component 1, s subcomponent0.037
Chiachitinase, acidic0.033
Egr1early growth response 10.032
Dusp1dual specificity phosphatase 10.030
Cd53Cd53 molecule0.028
Emr1EGF-like module containing, mucin-like, hormone receptor-like 10.026
C4bpacomplement component 4 binding protein, alpha0.025
Kng1kininogen 10.024
Hckhemopoietic cell kinase0.022
Fgafibrinogen alpha chain0.021
C1qbcomplement component 1, q subcomponent, B chain0.021
F10coagulation factor X0.017
Alox5aparachidonate 5-lipoxygenase activating protein0.017
Il1binterleukin 1 beta0.016
Cpb2carboxypeptidase B2 (plasma)0.015
Il6interleukin 60.014
Klf6Kruppel-like factor 60.014
Gzmmgranzyme M (lymphocyte met-ase 1)0.014
Ptprcprotein tyrosine phosphatase, receptor type, C0.013
Junbjun B proto-oncogene0.013
Clec4a3C-type lectin domain family 4, member a30.013
Wipf1WAS/WASL interacting protein family, member 10.013
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.012
FosFBJ osteosarcoma oncogene0.012
RT1-Db1RT1 class II, locus Db10.012
Nfe2l2nuclear factor, erythroid derived 2, like 20.012
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.011
LOC100363145stabilin 10.011
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.010
Lbplipopolysaccharide binding protein0.010
Errfi1ERBB receptor feedback inhibitor 10.010
Vwfvon Willebrand factor0.010
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism