The network for 'skeletal myofibril assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skeletal myofibril assembly

The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.

NameDescriptionProbabilityFunc Analog Organism
Tm2Tropomyosin 20.618
wupAwings up A0.487
Actnalpha actinin0.309
Mlc2Myosin light chain 20.180
MhcMyosin heavy chain0.159
Zasp52Z band alternatively spliced PDZ-motif protein 520.111
Zasp66Z band alternatively spliced PDZ-motif protein 660.086
Gpo-1Glycerophosphate oxidase-10.064
Act5CActin 5C0.027
Cf2Chorion factor 20.025
howheld out wings0.018
Act88FActin 88F0.018
salssarcomere length short0.018
Cdc42CG12530 gene product from transcript CG12530-RA0.014
CG7145CG7145 gene product from transcript CG7145-RD0.013
Rab11Rab-protein 110.012
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-15Protein UNC-150.414
emb-9Protein EMB-90.112
T21B6.3Protein T21B6.30.097
C53C9.2Protein C53C9.20.062
myo-3Protein MYO-30.053
unc-45Protein UNC-450.037
T25F10.6Protein T25F10.60.034
T12D8.9Protein T12D8.90.023
ketn-1Protein KETN-10.020
act-4Protein ACT-40.017
mig-6Protein MIG-60.014
ncx-2Protein NCX-20.013
zyx-1Protein ZYX-10.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
myhz2myosin, heavy polypeptide 2, fast muscle specific0.997
smyhc1slow myosin heavy chain 10.995
smyd1bSET and MYND domain containing 1b0.992
unc45bunc-45 homolog B (C. elegans)0.985
tnnc1btroponin C type 1b (slow)0.974
tnnt1troponin T1, skeletal, slow0.973
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.944
tnni1altroponin I, skeletal, slow like0.917
mylz2myosin, light polypeptide 2, skeletal muscle0.875
smyhc2slow myosin heavy chain 20.867
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.866
actn3aactinin alpha 3a0.834
hsp90a.1heat shock protein 90-alpha 10.794
myhc4myosin heavy chain 40.774
tnni1btroponin I, skeletal, slow b0.745
myod1myogenic differentiation 10.689
ttnatitin a0.652
mef2camyocyte enhancer factor 2ca0.574
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.558
tnni2a.4troponin I, skeletal, fast 2a.40.515
actn3bactinin alpha 3b0.396
ckmacreatine kinase, muscle a0.393
tnnt3atroponin T3a, skeletal, fast0.368
mef2cbmyocyte enhancer factor 2cb0.351
smyhc1lslow myosin heavy chain 1, like0.345
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.317
tnnc2troponin C type 2 (fast)0.296
xirp1xin actin-binding repeat containing 10.262
flncbfilamin C, gamma b (actin binding protein 280)0.201
myl1myosin, light chain 1, alkali; skeletal, fast0.188
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.124
mef2dmyocyte enhancer factor 2d0.113
vgll2bvestigial like 2b0.099
apobec2aapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a0.086
eng1aengrailed 1a0.075
flncafilamin C, gamma a (actin binding protein 280)0.075
hspb1heat shock protein, alpha-crystallin-related, 10.070
actn2actinin, alpha 20.066
popdc2popeye domain containing 20.050
ryr1bryanodine receptor 1b (skeletal)0.048
myf5myogenic factor 50.048
mef2amyocyte enhancer factor 2a0.043
ryr1aryanodine receptor 1a (skeletal)0.043
fabp3fatty acid binding protein 3, muscle and heart0.041
dmrt2bdoublesex and mab-3 related transcription factor 2b0.041
fhlafour and a half LIM domains a0.040
eif5aeukaryotic translation initiation factor 5A0.040
smyhc3slow myosin heavy chain 30.039
hspb8heat shock protein, alpha-crystallin-related, b80.035
desmadesmin a0.034
six1bsine oculis homeobox homolog 1b0.034
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.029
lamb2laminin, beta 2 (laminin S)0.027
tnnt3btroponin T3b, skeletal, fast0.027
aldoabaldolase a, fructose-bisphosphate, b0.026
lbx2ladybird homeobox homolog 2 (Drosophila)0.025
cav3caveolin 30.025
hoxa9ahomeo box A9a0.024
sema3aasemaphorin 3aa0.023
flot1flotillin 10.022
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.021
tpm3tropomyosin 30.020
efemp2EGF-containing fibulin-like extracellular matrix protein 20.019
meox2amesenchyme homeobox 2a0.018
defbl3defensin, beta-like 30.018
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.017
eno3enolase 3, (beta, muscle)0.017
ryr3ryanodine receptor 30.017
pdlim5PDZ and LIM domain 50.017
ckmt2creatine kinase, mitochondrial 2 (sarcomeric)0.015
defbl1defensin, beta-like 10.015
myf6myogenic factor 60.015
ccng1cyclin G10.014
fxr2fragile X mental retardation, autosomal homolog 20.014
LOC566040protein notum homolog0.013
stac3SH3 and cysteine rich domain 30.012
pikfyvephosphoinositide kinase, FYVE finger containing0.012
hsp70lheat shock cognate 70-kd protein, like0.012
ampd1adenosine monophosphate deaminase 1 (isoform M)0.011
muskmuscle, skeletal, receptor tyrosine kinase0.011
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ACTBactin, beta0.855
ACTG1actin, gamma 10.840
TRIM63tripartite motif containing 630.784
CFL1cofilin 1 (non-muscle)0.698
ARHGAP1Rho GTPase activating protein 10.599
MYOZ1myozenin 10.517
ANK1ankyrin 1, erythrocytic0.325
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.244
TNNC1troponin C type 1 (slow)0.200
RHOAras homolog gene family, member A0.189
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.188
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.171
MYH9myosin, heavy chain 9, non-muscle0.154
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.145
HDAC4histone deacetylase 40.145
TUBA1Btubulin, alpha 1b0.095
MYH11myosin, heavy chain 11, smooth muscle0.087
HNF4Ahepatocyte nuclear factor 4, alpha0.084
CASP10caspase 10, apoptosis-related cysteine peptidase0.083
CASP8caspase 8, apoptosis-related cysteine peptidase0.080
CNN2calponin 20.077
ACTN1actinin, alpha 10.076
CAPN3calpain 3, (p94)0.072
CFL2cofilin 2 (muscle)0.071
FASFas (TNF receptor superfamily, member 6)0.066
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.056
TAGLN2transgelin 20.049
ACTA1actin, alpha 1, skeletal muscle0.047
HDAC9histone deacetylase 90.045
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.045
TPM4tropomyosin 40.036
SUGT1SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)0.035
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.035
CACYBPcalcyclin binding protein0.033
OBSL1obscurin-like 10.031
FLNAfilamin A, alpha0.029
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.026
TPM1tropomyosin 1 (alpha)0.026
ACTA2actin, alpha 2, smooth muscle, aorta0.025
SNRPEsmall nuclear ribonucleoprotein polypeptide E0.024
CAPZBcapping protein (actin filament) muscle Z-line, beta0.023
ACTC1actin, alpha, cardiac muscle 10.023
TNNI2troponin I type 2 (skeletal, fast)0.022
ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)0.021
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.021
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.020
NR5A2nuclear receptor subfamily 5, group A, member 20.020
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.019
RHOCras homolog gene family, member C0.019
ACTN2actinin, alpha 20.019
PFN1profilin 10.019
SPTBN1spectrin, beta, non-erythrocytic 10.019
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.019
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.018
MEF2Amyocyte enhancer factor 2A0.018
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.017
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.017
SREBF2sterol regulatory element binding transcription factor 20.016
VASPvasodilator-stimulated phosphoprotein0.016
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.015
MYOZ2myozenin 20.015
HSPH1heat shock 105kDa/110kDa protein 10.015
MYLK2myosin light chain kinase 20.015
CKMcreatine kinase, muscle0.015
CAPNS1calpain, small subunit 10.015
MYH7myosin, heavy chain 7, cardiac muscle, beta0.015
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.015
ENO3enolase 3 (beta, muscle)0.015
PKM2pyruvate kinase, muscle0.014
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.014
OSTF1osteoclast stimulating factor 10.014
MYL4myosin, light chain 4, alkali; atrial, embryonic0.014
LDB3LIM domain binding 30.014
EPAS1endothelial PAS domain protein 10.014
CSRP1cysteine and glycine-rich protein 10.013
ANKRD1ankyrin repeat domain 1 (cardiac muscle)0.013
TNNC2troponin C type 2 (fast)0.013
WDR1WD repeat domain 10.013
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.013
DSTNdestrin (actin depolymerizing factor)0.013
PDLIM7PDZ and LIM domain 7 (enigma)0.013
MYH6myosin, heavy chain 6, cardiac muscle, alpha0.013
MRPL41mitochondrial ribosomal protein L410.012
TNNT3troponin T type 3 (skeletal, fast)0.012
MYBPC2myosin binding protein C, fast type0.012
ACTN4actinin, alpha 40.012
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.012
ST3GAL3ST3 beta-galactoside alpha-2,3-sialyltransferase 30.012
SPTBspectrin, beta, erythrocytic0.012
MYBPHmyosin binding protein H0.011
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.011
TMSB10thymosin beta 100.011
FBXO25F-box protein 250.011
EHD4EH-domain containing 40.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.998
Pfn1profilin 10.996
Actc1actin, alpha, cardiac muscle 10.985
Tnnt3troponin T3, skeletal, fast0.958
Ldb3LIM domain binding 30.944
Actn2actinin alpha 20.892
Myl3myosin, light polypeptide 30.833
Tnni2troponin I, skeletal, fast 20.823
Acta1actin, alpha 1, skeletal muscle0.813
Rac1RAS-related C3 botulinum substrate 10.777
Tnnc1troponin C, cardiac/slow skeletal0.740
Csrp3cysteine and glycine-rich protein 30.710
Tnnc2troponin C2, fast0.697
Myom1myomesin 10.649
Myl9myosin, light polypeptide 9, regulatory0.643
Actg1actin, gamma, cytoplasmic 10.620
Ckmt2creatine kinase, mitochondrial 20.613
Casq2calsequestrin 20.607
Pgam2phosphoglycerate mutase 20.606
Hrchistidine rich calcium binding protein0.589
Cnn1calponin 10.502
Hdac4histone deacetylase 40.500
Tpm4tropomyosin 40.497
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.466
Myl1myosin, light polypeptide 10.465
Capzbcapping protein (actin filament) muscle Z-line, beta0.430
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.421
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.420
Tnnt2troponin T2, cardiac0.413
Myh3myosin, heavy polypeptide 3, skeletal muscle, embryonic0.404
Cox8bcytochrome c oxidase, subunit VIIIb0.318
Actbactin, beta0.282
Cfl1cofilin 1, non-muscle0.281
Myh8myosin, heavy polypeptide 8, skeletal muscle, perinatal0.275
Actg2actin, gamma 2, smooth muscle, enteric0.273
Tnnt1troponin T1, skeletal, slow0.266
Tpm2tropomyosin 2, beta0.264
Wdr1WD repeat domain 10.253
Myom2myomesin 20.251
Ryr1ryanodine receptor 1, skeletal muscle0.241
Pdlim3PDZ and LIM domain 30.237
Myh4myosin, heavy polypeptide 4, skeletal muscle0.218
Hspb2heat shock protein 20.217
Nrapnebulin-related anchoring protein0.212
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.191
Cav3caveolin 30.185
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.184
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.171
Tuba1atubulin, alpha 1A0.171
Arf1ADP-ribosylation factor 10.170
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.168
Actn3actinin alpha 30.160
Ckmcreatine kinase, muscle0.157
Acta2actin, alpha 2, smooth muscle, aorta0.156
Cryabcrystallin, alpha B0.155
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.153
Prkceprotein kinase C, epsilon0.147
Eef1a1eukaryotic translation elongation factor 1 alpha 10.146
Hspb7heat shock protein family, member 7 (cardiovascular)0.144
Kbtbd5kelch repeat and BTB (POZ) domain containing 50.135
Csrp1cysteine and glycine-rich protein 10.135
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.130
Myh9myosin, heavy polypeptide 9, non-muscle0.129
Actr3ARP3 actin-related protein 3 homolog (yeast)0.123
Vaspvasodilator-stimulated phosphoprotein0.121
Itgb1bp2integrin beta 1 binding protein 20.120
Flncfilamin C, gamma0.119
Myoz2myozenin 20.118
Mef2cmyocyte enhancer factor 2C0.117
Casq1calsequestrin 10.110
Mrvi1MRV integration site 10.110
Xirp1xin actin-binding repeat containing 10.108
Tmsb4xthymosin, beta 4, X chromosome0.107
Map3k5mitogen-activated protein kinase kinase kinase 50.095
Trim54tripartite motif-containing 540.093
Cnn2calponin 20.093
Tnni3troponin I, cardiac 30.092
Arhgap1Rho GTPase activating protein 10.089
Srpk3serine/arginine-rich protein specific kinase 30.087
Hdac5histone deacetylase 50.087
Rhoaras homolog gene family, member A0.077
Lmod2leiomodin 2 (cardiac)0.074
Pygmmuscle glycogen phosphorylase0.073
Fbxo32F-box protein 320.071
Popdc3popeye domain containing 30.069
Calm1calmodulin 10.068
HopxHOP homeobox0.067
Gnb1guanine nucleotide binding protein (G protein), beta 10.067
Mef2dmyocyte enhancer factor 2D0.064
Arpc4actin related protein 2/3 complex, subunit 40.064
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide 20.062
Myl7myosin, light polypeptide 7, regulatory0.061
Myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.060
Lmod3leiomodin 3 (fetal)0.059
Tpm1tropomyosin 1, alpha0.058
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism