The network for 'positive regulation of autophagy' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of autophagy

Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

NameDescriptionProbabilityFunc Analog Organism
Atg18Autophagy-specific gene 180.998
Pi3K59FPhosphotidylinositol 3 kinase 59F0.943
Atg1Autophagy-specific gene 10.909
S6kRPS6-p70-protein kinase0.839
Atg13Autophagy-specific gene 130.796
Atg8aAutophagy-specific gene 8a0.768
Dcp-1Death caspase-10.765
Atg2Autophagy-specific gene 20.756
LnkCG17367 gene product from transcript CG17367-RC0.695
Atg9Autophagy-specific gene 90.668
Sir2CG5216 gene product from transcript CG5216-RA0.664
Pi3K92ECG4141 gene product from transcript CG4141-RB0.617
carcarnation0.589
grimCG4345 gene product from transcript CG4345-RA0.572
RASSF8CG5053 gene product from transcript CG5053-RA0.546
Mekk1CG7717 gene product from transcript CG7717-RB0.535
Atg7Autophagy-specific gene 70.515
bratbrain tumor0.514
spinspinster0.456
Sox14Sox box protein 140.391
ird1immune response deficient 10.354
debcldeath executioner Bcl-2 homologue0.348
RelRelish0.303
Atg4Autophagy-specific gene 40.288
p38bCG7393 gene product from transcript CG7393-RA0.279
rprreaper0.276
lokloki0.249
ParpPoly-(ADP-ribose) polymerase0.241
Akt1CG4006 gene product from transcript CG4006-RA0.210
chicoCG5686 gene product from transcript CG5686-RB0.201
ththread0.200
ari-2ariadne 20.187
ykiyorkie0.185
wtswarts0.176
IceCG7788 gene product from transcript CG7788-RA0.174
Toll-7CG8595 gene product from transcript CG8595-RA0.159
RhebCG1081 gene product from transcript CG1081-RA0.132
bifbifocal0.124
X11LCG5675 gene product from transcript CG5675-RB0.097
BG4CG12297 gene product from transcript CG12297-RA0.096
imdimmune deficiency0.095
lmglemming0.094
CG31033CG31033 gene product from transcript CG31033-RC0.088
egreiger0.087
drprdraper0.087
Toll-6CG7250 gene product from transcript CG7250-RA0.085
NFATNFAT homolog0.083
CG11877CG11877 gene product from transcript CG11877-RA0.082
Eip74EFEcdysone-induced protein 74EF0.079
SNF4AgammaSNF4/AMP-activated protein kinase gamma subunit0.079
kibrakibra ortholog0.076
certceramide transfer protein0.069
l(3)82FdCG32464 gene product from transcript CG32464-RR0.063
dvedefective proventriculus0.059
NT1Neurotrophin 10.059
AGO2Argonaute 20.057
Pi3K21BCG2699 gene product from transcript CG2699-RA0.055
DabDisabled0.055
SuURSuppressor of Under-Replication0.052
giggigas0.052
Mt2Methyltransferase 20.051
hephemipterous0.050
ArkApaf-1-related-killer0.045
p53CG33336 gene product from transcript CG33336-RB0.045
Traf6TNF-receptor-associated factor 60.045
sinaseven in absentia0.045
Adf1Adh transcription factor 10.044
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.043
CG5794CG5794 gene product from transcript CG5794-RB0.043
Traf4TNF-receptor-associated factor 40.043
CG9063CG9063 gene product from transcript CG9063-RA0.042
kluklumpfuss0.041
eygeyegone0.040
Myd88CG2078 gene product from transcript CG2078-RA0.037
Pink1PTEN-induced putative kinase 10.037
rinrasputin0.036
Lis-1Lissencephaly-10.036
jingCG9397 gene product from transcript CG9397-RI0.035
RfabgRetinoid- and fatty acid-binding glycoprotein0.034
ThorCG8846 gene product from transcript CG8846-RA0.034
Tip60CG6121 gene product from transcript CG6121-RA0.033
RicRas which interacts with Calmodulin0.032
DfdDeformed0.032
CG1021CG1021 gene product from transcript CG1021-RE0.032
Rpn6Proteasome p44.5 subunit0.031
CG12081CG12081 gene product from transcript CG12081-RA0.030
Rab7Rab-protein 70.030
lqfRliquid facets-Related0.030
CG3589CG3589 gene product from transcript CG3589-RA0.030
simsingle-minded0.029
RhoGAP68FCG6811 gene product from transcript CG6811-RA0.028
srasarah0.026
PargPoly(ADP-ribose) glycohydrolase0.026
CG18754CG18754 gene product from transcript CG18754-RB0.026
TORCCG6064 gene product from transcript CG6064-RA0.025
CG11534CG11534 gene product from transcript CG11534-RA0.025
Eip93FCG18389 gene product from transcript CG18389-RB0.025
Rac1CG2248 gene product from transcript CG2248-RA0.025
trioCG18214 gene product from transcript CG18214-RA0.024
Syx17Syntaxin 170.024
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GABARAPL2GABA(A) receptor-associated protein-like 20.997
SQSTM1sequestosome 10.992
GABARAPGABA(A) receptor-associated protein0.987
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.985
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.981
CREBBPCREB binding protein0.971
TSC2tuberous sclerosis 20.929
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.841
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.837
ATG5ATG5 autophagy related 5 homolog (S. cerevisiae)0.672
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.642
ATG4BATG4 autophagy related 4 homolog B (S. cerevisiae)0.566
ARandrogen receptor0.490
TRIM63tripartite motif containing 630.465
KAT2BK(lysine) acetyltransferase 2B0.381
JUNjun proto-oncogene0.365
GFM1G elongation factor, mitochondrial 10.322
ULK1unc-51-like kinase 1 (C. elegans)0.313
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.272
NBR1neighbor of BRCA1 gene 10.234
SCHIP1schwannomin interacting protein 10.224
RB1CC1RB1-inducible coiled-coil 10.212
FOXO3forkhead box O30.201
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.185
IRAK2interleukin-1 receptor-associated kinase 20.182
MAPK8mitogen-activated protein kinase 80.173
TSC1tuberous sclerosis 10.170
BADBCL2-associated agonist of cell death0.167
NCOA1nuclear receptor coactivator 10.167
GABARAPL1GABA(A) receptor-associated protein like 10.160
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.155
S100BS100 calcium binding protein B0.140
NCOA2nuclear receptor coactivator 20.136
AMBRA1autophagy/beclin-1 regulator 10.115
TFRCtransferrin receptor (p90, CD71)0.111
ARNTaryl hydrocarbon receptor nuclear translocator0.110
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.109
ACACAacetyl-CoA carboxylase alpha0.107
ATG16L1ATG16 autophagy related 16-like 1 (S. cerevisiae)0.104
ARRB1arrestin, beta 10.093
MRPL41mitochondrial ribosomal protein L410.086
EP300E1A binding protein p3000.081
OTUD6BOTU domain containing 6B0.080
FOXO1forkhead box O10.078
TTNtitin0.075
EGLN1egl nine homolog 1 (C. elegans)0.070
SESN2sestrin 20.068
COASYCoA synthase0.064
PINK1PTEN induced putative kinase 10.064
NCOA6nuclear receptor coactivator 60.064
DAPK1death-associated protein kinase 10.063
ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)0.060
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.053
VHLvon Hippel-Lindau tumor suppressor0.049
AKT1v-akt murine thymoma viral oncogene homolog 10.049
PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.048
SIRT1sirtuin 10.047
ATG14ATG14 autophagy related 14 homolog (S. cerevisiae)0.045
NEBnebulin0.045
EGLN3egl nine homolog 3 (C. elegans)0.044
ACTA1actin, alpha 1, skeletal muscle0.044
RUNX1runt-related transcription factor 10.039
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.038
HDAC5histone deacetylase 50.038
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.036
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.035
MBIPMAP3K12 binding inhibitory protein 10.035
CIZ1CDKN1A interacting zinc finger protein 10.035
PIK3C3phosphoinositide-3-kinase, class 30.035
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.035
NFE2L2nuclear factor (erythroid-derived 2)-like 20.033
TP53BP2tumor protein p53 binding protein, 20.033
CHIC2cysteine-rich hydrophobic domain 20.032
SREBF2sterol regulatory element binding transcription factor 20.031
TNNT1troponin T type 1 (skeletal, slow)0.031
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.030
SMAD3SMAD family member 30.030
EEF1Geukaryotic translation elongation factor 1 gamma0.030
BCL2L1BCL2-like 10.029
BCL2B-cell CLL/lymphoma 20.028
IRS2insulin receptor substrate 20.026
HDAC4histone deacetylase 40.026
KDM2Alysine (K)-specific demethylase 2A0.026
STBD1starch binding domain 10.025
CRTC2CREB regulated transcription coactivator 20.024
VCPIP1valosin containing protein (p97)/p47 complex interacting protein 10.024
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.024
FAM190Bfamily with sequence similarity 190, member B0.024
MYOZ1myozenin 10.023
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.023
EXOC8exocyst complex component 80.023
OPTNoptineurin0.023
IRF3interferon regulatory factor 30.023
TCAPtitin-cap (telethonin)0.022
ZFYVE1zinc finger, FYVE domain containing 10.021
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.021
FNIP1folliculin interacting protein 10.021
UVRAGUV radiation resistance associated gene0.021
NF2neurofibromin 2 (merlin)0.020
DAZAP2DAZ associated protein 20.020
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.987
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.763
Tsc2tuberous sclerosis 20.664
Tsc1tuberous sclerosis 10.505
Rb1retinoblastoma 10.338
Hif1ahypoxia inducible factor 1, alpha subunit0.320
Nf2neurofibromatosis 20.280
Atf2activating transcription factor 20.269
Mapk14mitogen-activated protein kinase 140.239
Mapk8mitogen-activated protein kinase 80.228
Mdm2transformed mouse 3T3 cell double minute 20.207
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.201
Sesn2sestrin 20.187
Cftrcystic fibrosis transmembrane conductance regulator homolog0.175
Foxa2forkhead box A20.166
Vhlvon Hippel-Lindau tumor suppressor0.138
Pim2proviral integration site 20.133
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.128
Egln1EGL nine homolog 1 (C. elegans)0.125
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.119
Sqstm1sequestosome 10.099
Atg13ATG13 autophagy related 13 homolog (S. cerevisiae)0.093
Nr3c1nuclear receptor subfamily 3, group C, member 10.087
Leprleptin receptor0.074
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.068
Socs1suppressor of cytokine signaling 10.066
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.066
Gsk3bglycogen synthase kinase 3 beta0.051
Rint1RAD50 interactor 10.048
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.048
Ctnnb1catenin (cadherin associated protein), beta 10.047
Apcadenomatosis polyposis coli0.047
Ulk1Unc-51 like kinase 1 (C. elegans)0.046
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.045
Igbp1immunoglobulin (CD79A) binding protein 10.045
Pim1proviral integration site 10.042
Keap1kelch-like ECH-associated protein 10.041
Dmap1DNA methyltransferase 1-associated protein 10.041
Mark4MAP/microtubule affinity-regulating kinase 40.039
Gopcgolgi associated PDZ and coiled-coil motif containing0.038
Ppargperoxisome proliferator activated receptor gamma0.038
Ikbkginhibitor of kappaB kinase gamma0.037
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.037
Pik3c3phosphoinositide-3-kinase, class 30.035
RoraRAR-related orphan receptor alpha0.032
Zbtb24zinc finger and BTB domain containing 240.032
Arid1bAT rich interactive domain 1B (SWI-like)0.030
Sav1salvador homolog 1 (Drosophila)0.029
Hbb-b1hemoglobin, beta adult major chain0.029
Eporerythropoietin receptor0.029
Foxa1forkhead box A10.028
Rxraretinoid X receptor alpha0.028
Atg12autophagy-related 12 (yeast)0.028
Errfi1ERBB receptor feedback inhibitor 10.028
Foxo1forkhead box O10.026
Prkceprotein kinase C, epsilon0.024
Atxn1ataxin 10.024
Ticam1toll-like receptor adaptor molecule 10.023
Clockcircadian locomotor output cycles kaput0.023
Arntlaryl hydrocarbon receptor nuclear translocator-like0.023
Klc1kinesin light chain 10.022
Cdx2caudal type homeobox 20.021
Grb2growth factor receptor bound protein 20.021
Hbb-b2hemoglobin, beta adult minor chain0.020
Nkx2-1NK2 homeobox 10.019
Xpaxeroderma pigmentosum, complementation group A0.019
Mapkbp1mitogen-activated protein kinase binding protein 10.018
Mecp2methyl CpG binding protein 20.018
Axin1axin 10.018
Bsdc1BSD domain containing 10.017
Mapk1mitogen-activated protein kinase 10.017
P4htmprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)0.016
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.016
Dmtf1cyclin D binding myb-like transcription factor 10.015
Chmp1bchromatin modifying protein 1B0.015
Pdpk13-phosphoinositide dependent protein kinase 10.015
Msh2mutS homolog 2 (E. coli)0.015
Htatip2HIV-1 tat interactive protein 2, homolog (human)0.015
Pim3proviral integration site 30.014
Mib1mindbomb homolog 1 (Drosophila)0.014
Rfwd2ring finger and WD repeat domain 20.014
Gabarapl1gamma-aminobutyric acid (GABA) A receptor-associated protein-like 10.013
Emx1empty spiracles homolog 1 (Drosophila)0.013
Egln3EGL nine homolog 3 (C. elegans)0.012
Sox9SRY-box containing gene 90.012
Nbr1neighbor of Brca1 gene 10.012
E2f1E2F transcription factor 10.012
Ep300E1A binding protein p3000.012
Rbl1retinoblastoma-like 1 (p107)0.011
Stat6signal transducer and activator of transcription 60.011
Ep400E1A binding protein p4000.011
Ubcubiquitin C0.011
Dnm1ldynamin 1-like0.011
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.011
Cdh1cadherin 10.011
Rbl2retinoblastoma-like 20.011
Yap1yes-associated protein 10.010
Rb1cc1RB1-inducible coiled-coil 10.010
Ptp4a2protein tyrosine phosphatase 4a20.010
BrafBraf transforming gene0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism