The network for 'negative regulation of purine nucleotide catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of purine nucleotide catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.

NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.093
Rpb11CG6840 gene product from transcript CG6840-RA0.083
CG6540CG6540 gene product from transcript CG6540-RA0.073
CG9797CG9797 gene product from transcript CG9797-RA0.062
SetCG4299 gene product from transcript CG4299-RA0.059
LSm7CG13277 gene product from transcript CG13277-RA0.048
CG4646CG4646 gene product from transcript CG4646-RA0.040
SC35CG5442 gene product from transcript CG5442-RC0.037
CG16903CG16903 gene product from transcript CG16903-RA0.037
CG2091CG2091 gene product from transcript CG2091-RA0.032
escextra sexcombs0.029
poloCG12306 gene product from transcript CG12306-RA0.028
Rpb5CG11979 gene product from transcript CG11979-RA0.027
CG11267CG11267 gene product from transcript CG11267-RA0.027
Prosbeta2Proteasome beta2 subunit0.026
thoc7CG17143 gene product from transcript CG17143-RB0.026
Prx5Peroxiredoxin 50.024
RpII140RNA polymerase II 140kD subunit0.024
dupdouble parked0.022
CG4866CG4866 gene product from transcript CG4866-RB0.021
RanGapRan GTPase activating protein0.021
ncdnon-claret disjunctional0.019
Srp19Signal recognition particle protein 190.019
Mcm2Minichromosome maintenance 20.019
CG1307CG1307 gene product from transcript CG1307-RB0.019
CG13364CG13364 gene product from transcript CG13364-RA0.018
mRpL17mitochondrial ribosomal protein L170.018
CG17266CG17266 gene product from transcript CG17266-RA0.018
NHP2CG5258 gene product from transcript CG5258-RA0.017
dpadisc proliferation abnormal0.017
Fas2Fasciclin 20.016
CG32708CG32708 gene product from transcript CG32708-RA0.016
OscpOligomycin sensitivity-conferring protein0.015
RpLP0-likeRibosomal protein LP0-like0.015
CG2021CG2021 gene product from transcript CG2021-RA0.013
dgt2dim gamma-tubulin 20.013
BgbBig brother0.013
HopHsp70/Hsp90 organizing protein homolog0.013
marsCG17064 gene product from transcript CG17064-RB0.013
CG15735CG15735 gene product from transcript CG15735-RA0.013
D1D1 chromosomal protein0.013
U4-U6-60KU4-U6 small nuclear riboprotein factor 60K0.013
shotshort stop0.012
CG4769CG4769 gene product from transcript CG4769-RA0.012
CG3436CG3436 gene product from transcript CG3436-RA0.012
Rrp42CG8395 gene product from transcript CG8395-RA0.012
CG17282CG17282 gene product from transcript CG17282-RA0.012
Bap60Brahma associated protein 60kD0.012
CG7950CG7950 gene product from transcript CG7950-RB0.012
Su(var)205Suppressor of variegation 2050.011
CG8108CG8108 gene product from transcript CG8108-RA0.011
Rho1CG8416 gene product from transcript CG8416-RB0.011
crncrooked neck0.010
Caf1Chromatin assembly factor 1 subunit0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TNNC1troponin C type 1 (slow)0.177
CALM1calmodulin 1 (phosphorylase kinase, delta)0.067
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.051
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.050
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 110.033
HAP1huntingtin-associated protein 10.029
RALBP1ralA binding protein 10.028
LMAN1lectin, mannose-binding, 10.028
YAP1Yes-associated protein 10.027
RND1Rho family GTPase 10.027
MAP3K5mitogen-activated protein kinase kinase kinase 50.027
HMOX2heme oxygenase (decycling) 20.023
ARRB1arrestin, beta 10.023
TBCDtubulin folding cofactor D0.022
TRIM63tripartite motif containing 630.019
AMOTL1angiomotin like 10.017
THOC5THO complex 50.015
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.014
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.013
DDX39BDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.013
RALGDSral guanine nucleotide dissociation stimulator0.013
MCM3minichromosome maintenance complex component 30.011
MST1Rmacrophage stimulating 1 receptor (c-met-related tyrosine kinase)0.011
TFRCtransferrin receptor (p90, CD71)0.011
EPAS1endothelial PAS domain protein 10.011
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.011
GMPR2guanosine monophosphate reductase 20.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Srsf9serine/arginine-rich splicing factor 90.965
Spry4sprouty homolog 4 (Drosophila)0.895
Lsm2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.843
Thoc4THO complex 40.541
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.523
Ppp4cprotein phosphatase 4, catalytic subunit0.490
Neurl1aneuralized homolog 1A (Drosophila)0.417
Refbp2RNA and export factor binding protein 20.385
Banf1barrier to autointegration factor 10.338
Spry2sprouty homolog 2 (Drosophila)0.333
Tubb5tubulin, beta 50.242
Prmt1protein arginine N-methyltransferase 10.241
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.184
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.183
Spry1sprouty homolog 1 (Drosophila)0.182
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.163
Ptmaprothymosin alpha0.151
Vegfavascular endothelial growth factor A0.130
Eif4a1eukaryotic translation initiation factor 4A10.128
Tomm40translocase of outer mitochondrial membrane 40 homolog (yeast)0.120
Hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.105
Cdt1chromatin licensing and DNA replication factor 10.094
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.092
Arpc4actin related protein 2/3 complex, subunit 40.090
Pfn1profilin 10.082
Hnrnpmheterogeneous nuclear ribonucleoprotein M0.081
Epas1endothelial PAS domain protein 10.077
Siah2seven in absentia 20.075
Rcc2regulator of chromosome condensation 20.074
Adcy9adenylate cyclase 90.073
Rab5aRAB5A, member RAS oncogene family0.068
Kif1bkinesin family member 1B0.061
Cpeb2cytoplasmic polyadenylation element binding protein 20.060
Ranbp1RAN binding protein 10.059
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.058
Cpeb4cytoplasmic polyadenylation element binding protein 40.057
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.056
Gipc1GIPC PDZ domain containing family, member 10.056
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.055
Stim2stromal interaction molecule 20.054
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.053
Pcbp1poly(rC) binding protein 10.052
Fgfr3fibroblast growth factor receptor 30.050
Dlg1discs, large homolog 1 (Drosophila)0.050
Rfc5replication factor C (activator 1) 50.047
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.045
P4htmprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)0.044
Nr2f1nuclear receptor subfamily 2, group F, member 10.044
U2af1U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 10.043
Ptprnprotein tyrosine phosphatase, receptor type, N0.043
Txn2thioredoxin 20.039
Yap1yes-associated protein 10.038
Rsl24d1ribosomal L24 domain containing 10.036
Dab1disabled homolog 1 (Drosophila)0.036
Ppil1peptidylprolyl isomerase (cyclophilin)-like 10.036
Sult4a1sulfotransferase family 4A, member 10.036
Cdk4cyclin-dependent kinase 40.035
Rb1cc1RB1-inducible coiled-coil 10.034
Srmspermidine synthase0.034
Ubtfupstream binding transcription factor, RNA polymerase I0.033
Raf1v-raf-leukemia viral oncogene 10.033
Tsc22d2TSC22 domain family, member 20.033
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.031
Itsn1intersectin 1 (SH3 domain protein 1A)0.031
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.031
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.031
Rnf11ring finger protein 110.030
H2afxH2A histone family, member X0.028
Tuba1btubulin, alpha 1B0.028
Mbd3methyl-CpG binding domain protein 30.027
Varsvalyl-tRNA synthetase0.027
Cab39calcium binding protein 390.026
Lmo7LIM domain only 70.026
Gar1GAR1 ribonucleoprotein homolog (yeast)0.025
Cdc34cell division cycle 34 homolog (S. cerevisiae)0.025
Gsrglutathione reductase0.024
Timelesstimeless homolog (Drosophila)0.024
SnrkSNF related kinase0.023
1110008P14RikRIKEN cDNA 1110008P14 gene0.023
Josd2Josephin domain containing 20.022
Sos2son of sevenless homolog 2 (Drosophila)0.022
Cpeb3cytoplasmic polyadenylation element binding protein 30.022
Pfdn2prefoldin 20.022
Prkaa2protein kinase, AMP-activated, alpha 2 catalytic subunit0.022
Dag1dystroglycan 10.021
Hivep1human immunodeficiency virus type I enhancer binding protein 10.020
Eea1early endosome antigen 10.020
Cks1bCDC28 protein kinase 1b0.020
Psat1phosphoserine aminotransferase 10.020
Trak1trafficking protein, kinesin binding 10.020
YrdcyrdC domain containing (E.coli)0.019
Gm16517predicted gene, Gm165170.019
Dohhdeoxyhypusine hydroxylase/monooxygenase0.019
Tnnc1troponin C, cardiac/slow skeletal0.018
Tob1transducer of ErbB-2.10.018
Kif21akinesin family member 21A0.018
Mef2amyocyte enhancer factor 2A0.018
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.018
Rb1retinoblastoma 10.018
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism